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Journal Information
Vol. 21. Issue 3.
Pages 105-108 (May - June 1985)
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Vol. 21. Issue 3.
Pages 105-108 (May - June 1985)
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Toxicidad hepatica grave por drogas antituberculosas. Revision de 19 casos
Severe hepatic toxicity due to tuberculostatics. A review of 19 cases
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M.aL. Martinez Martinez, R. Vidal Pla, R. Esteban Mur, J. Ruiz Manzano, E. Fite Reig, E. Monso Molas
Sección de Neumología. Departamento de Medicina Interna. Ciudad Sanitaria Valle de Hebrón. Barcelona
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Se revisan diecinueve pacientes que presentaron toxicidad hepática grave en el curso del tratamiento con drogas antituberculosas. Se comenta la incidencia de la he-patotoxicidad y la relación en ocasiones con factores predisponentes o con sobredosificación de dichas drogas. Puede aparecer en cualquier momento del tratamiento, aunque es más frecuente en los dos primeros meses; en más de la mitad de nuestros pacientes, la toxicidad hepática apareció en los primeros 15 días. Los síntomas son fundamentalmente digestivos. Observamos en 14 pacientes ictericia y en siete síntomas de insuficiencia hepática. Un paciente falleció y el resto recuperó la normalidad clínica y bioquímica entre los 4 y 30 días tras dejar el tratamiento antituberculoso. Estos reanudaron el tratamiento con drogas no hepatotóxicas siguiendo una evolución favorable hasta el final del tratamiento.

Nineteen patients with severe hepatic toxicity due to tuberculostatics were included in a study on the incidence of hepatic toxicity and the relationship with predisposing factors or drug overdose. Hepatic toxicity may appear at any time during treatment but occurs most frequently during the first two months after starting treatment; all 19 patients in our study presented toxicity within 15 days. Symptoms were principally digestive ones and 14 patients had ictericia and 7 presented symptoms of hepatic insuf-ficiency. One patient died. In the remaining 18 patients, clinical and biochemical data returned to normal within 4 to 30 days after suspension of the antituberculosis therapy. Treatment was continued with non-hepatotoxic drugs and elicited a favourable response in all patients.

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Copyright © 1985. Sociedad Española de Neumología y Cirugía Torácica
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