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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se revisan diecinueve pacientes que presentaron toxicidad hep&#225;tica grave en el curso del tratamiento con drogas antituberculosas&#46; Se comenta la incidencia de la he-patotoxicidad y la relaci&#243;n en ocasiones con factores predisponentes o con sobredosificaci&#243;n de dichas drogas&#46; Puede aparecer en cualquier momento del tratamiento&#44; aunque es m&#225;s frecuente en los dos primeros meses&#59; en m&#225;s de la mitad de nuestros pacientes&#44; la toxicidad hep&#225;tica apareci&#243; en los primeros 15 d&#237;as&#46; Los s&#237;ntomas son fundamentalmente digestivos&#46; Observamos en 14 pacientes ictericia y en siete s&#237;ntomas de insuficiencia hep&#225;tica&#46; Un paciente falleci&#243; y el resto recuper&#243; la normalidad cl&#237;nica y bioqu&#237;mica entre los 4 y 30 d&#237;as tras dejar el tratamiento antituberculoso&#46; Estos reanudaron el tratamiento con drogas no hepatot&#243;xicas siguiendo una evoluci&#243;n favorable hasta el final del tratamiento&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Nineteen patients with severe hepatic toxicity due to tuberculostatics were included in a study on the incidence of hepatic toxicity and the relationship with predisposing factors or drug overdose&#46; Hepatic toxicity may appear at any time during treatment but occurs most frequently during the first two months after starting treatment&#59; all 19 patients in our study presented toxicity within 15 days&#46; Symptoms were principally digestive ones and 14 patients had ictericia and 7 presented symptoms of hepatic insuf-ficiency&#46; One patient died&#46; In the remaining 18 patients&#44; clinical and biochemical data returned to normal within 4 to 30 days after suspension of the antituberculosis therapy&#46; Treatment was continued with non-hepatotoxic drugs and elicited a favourable response in all patients&#46;</p></span>"
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                            0 => "H&#46; Randolph"
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                      "titulo" => "Isoniazid-associated hepatitis Report of an outbreak"
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                      "titulo" => "Hepatitis cases in isoniazid treated groups and in control groups"
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                      "titulo" => "Isoniazid-associated hepatitis in 114 patients"
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                          "autores" => array:5 [
                            0 => "M&#46; Black"
                            1 => "J&#46;R&#46; Mitchell"
                            2 => "H&#46;J&#46; Zimmerman"
                            3 => "K&#46;G&#46; Ishak"
                            4 => "G&#46;R&#46; Epler"
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                      "titulo" => "Metabolismo y efectos hep&#225;ticos de la rifampicina"
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                      "titulo" => "Rifampicin hepatitis clinical and hystological study"
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                            3 => "S&#46; Sherlock"
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