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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To evaluate the prevalence of sleep disorders in patients awaiting kidney transplants compared to a control group&#46;</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">We carried out an observational study of 23 patients on a kidney transplant waiting list in comparison with 20 healthy volunteers matched for age&#44; sex&#44; and body mass index &#40;BMI&#41;&#46; Overnight polysomnography was performed and a diagnosis of sleep apnea-hypopnea syndrome &#40;SAHS&#41; established when the apnea-hypopnea index &#40;AHI&#41; was 10 or higher&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Eighty-two percent of the patients awaiting kidney transplants &#40;16 men and 7 women with a mean &#91;SD&#93; age of 51 &#91;15&#93; years and a mean BMI of 25 &#91;3&#46;8&#93; kg&#47;m<span class="elsevierStyleSup">2</span>&#41; had some type of sleep disorder&#46; The most frequent disorders were SAHS &#40;48&#37;&#41; and insomnia and periodic limb movement disorder &#40;30&#37;&#41;&#46; Patients showed poorer sleep efficiency compared to the control group &#40;75&#46;4&#37; vs 87&#46;8&#37;&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;01&#41; and a lower percentage of slow-wave and rapid eye movement sleep &#40;24&#46;5&#37; vs 40&#37;&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;001&#41;&#46; Those with sleep-disordered breathing had a higher AHI &#40;17&#46;7 vs 3&#46;6&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;00l&#41; and oxygen desaturation index &#40;31&#46;5 compared to 8&#46;2&#59; P&#61;&#46;00l&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Sleep disorders are common in patients awaiting kidney transplants&#46; Such patients show reduced quantity and quality of sleep compared to controls and a significantly elevated number of respiratory events that may affect morbidity and mortality&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Valorar la prevalencia de los trastornos del sueno en pacientes en lista de espera de trasplante renal&#44; comparados con un grupo control&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha realizado un estudio observacional en 23 pacientes en lista de espera para trasplante renal&#44; cuyos resultados se compararon con los de 20 personas sanas que accedieron voluntariamente a participar en &#233;l&#46; Se empare-jaron por edad&#44; sexo e indice de masa corporal&#46; Se efectu&#243; una polisomnograf&#237;a de noche completa y el diagn&#243;stico de s&#237;ndro-me de apneas-hipopneas durante el sue&#241;o se estableci&#243; cuando el &#237;ndice de apneas-hipopneas era como m&#237;nimo de 10&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Los pacientes en lista de espera para trasplante renal &#40;16 varones y 7 mujeres&#59; edad media &#177; desviaci&#243;n est&#225;andar&#58; 51 &#177; 15 a&#241;os&#59; &#237;ndice de masa corporal&#58; 25 &#177; 3&#44;8 kg&#47;m<span class="elsevierStyleSup">2</span>&#41; presentaron en un 82&#37; de los casos alg&#250;n trastorno del sue&#241;o&#46; Los m&#225;s frecuentes fueron el s&#237;ndrome de apneas-hipopneas durante el sue&#241;ssso &#40;48&#37;&#41; e insomnio y s&#237;ndrome de movimiento peri&#243;dico de piernas &#40;30&#37;&#41;&#46; Los pacientes presentaron&#44; respecto al grupo control&#44; una menor eficiencia del sue&#241;o &#40;el 75&#44;4 frente al 87&#44;8&#37;&#59; p &#61; 0&#44;01&#41; y un menor porcentaje de sue&#241;o de ondas lentas y REM &#40;un 24&#44;5 frente a un 40&#37;&#59; p &#61; 0&#44;001&#41;&#44; mientras que los trastornos respiratorios del sue&#241;o mostraron un mayor &#237;ndice de apneas-hipopneas &#40;17&#44;7 frente a 3&#44;6&#59; p &#61; 0&#44;001&#41; e indice de desaturaci&#243;n &#40;31&#44;5 frente a 8&#44;2&#59; p &#61; 0&#44;001&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Los trastornos del sue&#241;o son frecuentes en pacientes en lista de espera para trasplante renal&#44; quienes&#44; respecto al grupo control&#44; tienen una menor cantidad y calidad del sue&#241;o&#44; con un n&#250;mero significativamente elevado de eventos respiratorios&#44; que pueden influir en la morbimortalidad&#46;</p>"
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Vol. 44. Issue 7.
Pages 371-375 (January 2008)
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Vol. 44. Issue 7.
Pages 371-375 (January 2008)
Original Articles
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Sleep Disorders in Patients on a Kidney Transplant Waiting List
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Bernabé Jurado Gámeza,
Corresponding author
bjg01co@hotmail.com

Correspondence: Dr B. Jurado Gámez, Servicio de Neumología (UTRS), Hospital Reina Sofía, Avda. Menéndez Pidal, s/n, 14004 Cordoba, Spain
, Alejandro Martín-Malob, Mari Carmen Fernández Marína, Alberto Rodríguez-Benotb, Natalia Pascuala, Luis Muñoz Cabreraa, Pedro Aljamab
a Servicio de Neumología, Hospital Universitario Reina Sofía, Córdoba, Spain
b Servicio de Nefrología, Hospital Universitario Reina Sofía, Córdoba, Spain
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Article information
Objective

To evaluate the prevalence of sleep disorders in patients awaiting kidney transplants compared to a control group.

Patients and methods

We carried out an observational study of 23 patients on a kidney transplant waiting list in comparison with 20 healthy volunteers matched for age, sex, and body mass index (BMI). Overnight polysomnography was performed and a diagnosis of sleep apnea-hypopnea syndrome (SAHS) established when the apnea-hypopnea index (AHI) was 10 or higher.

Results

Eighty-two percent of the patients awaiting kidney transplants (16 men and 7 women with a mean [SD] age of 51 [15] years and a mean BMI of 25 [3.8] kg/m2) had some type of sleep disorder. The most frequent disorders were SAHS (48%) and insomnia and periodic limb movement disorder (30%). Patients showed poorer sleep efficiency compared to the control group (75.4% vs 87.8%; P=.01) and a lower percentage of slow-wave and rapid eye movement sleep (24.5% vs 40%; P=.001). Those with sleep-disordered breathing had a higher AHI (17.7 vs 3.6; P=.00l) and oxygen desaturation index (31.5 compared to 8.2; P=.00l).

Conclusions

Sleep disorders are common in patients awaiting kidney transplants. Such patients show reduced quantity and quality of sleep compared to controls and a significantly elevated number of respiratory events that may affect morbidity and mortality.

Key words:
Apnea-hypopnea index
Oxygen desaturation index
Chronic renal failure
Kidney transplantation
Sleep disorders
Sleep-disordered breathing
Objetivo

Valorar la prevalencia de los trastornos del sueno en pacientes en lista de espera de trasplante renal, comparados con un grupo control.

Pacientes y métodos

Se ha realizado un estudio observacional en 23 pacientes en lista de espera para trasplante renal, cuyos resultados se compararon con los de 20 personas sanas que accedieron voluntariamente a participar en él. Se empare-jaron por edad, sexo e indice de masa corporal. Se efectuó una polisomnografía de noche completa y el diagnóstico de síndro-me de apneas-hipopneas durante el sueño se estableció cuando el índice de apneas-hipopneas era como mínimo de 10.

Resultados

Los pacientes en lista de espera para trasplante renal (16 varones y 7 mujeres; edad media ± desviación estáandar: 51 ± 15 años; índice de masa corporal: 25 ± 3,8 kg/m2) presentaron en un 82% de los casos algún trastorno del sueño. Los más frecuentes fueron el síndrome de apneas-hipopneas durante el sueñssso (48%) e insomnio y síndrome de movimiento periódico de piernas (30%). Los pacientes presentaron, respecto al grupo control, una menor eficiencia del sueño (el 75,4 frente al 87,8%; p = 0,01) y un menor porcentaje de sueño de ondas lentas y REM (un 24,5 frente a un 40%; p = 0,001), mientras que los trastornos respiratorios del sueño mostraron un mayor índice de apneas-hipopneas (17,7 frente a 3,6; p = 0,001) e indice de desaturación (31,5 frente a 8,2; p = 0,001).

Conclusiones

Los trastornos del sueño son frecuentes en pacientes en lista de espera para trasplante renal, quienes, respecto al grupo control, tienen una menor cantidad y calidad del sueño, con un número significativamente elevado de eventos respiratorios, que pueden influir en la morbimortalidad.

Palabras clave:
Índice de apneas-hipopneas del sueño
Índice de desaturación
Insuficiencia renal crónica
Trasplante renal
Trastornos del sueño
Trastornos respiratorios del sueño
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