Original Articles
Sleep Disorders in Patients on a Kidney Transplant Waiting List
Bernabé Jurado Gámeza,
, Alejandro Martín-Malob, Mari Carmen Fernández Marína, Alberto Rodríguez-Benotb, Natalia Pascuala, Luis Muñoz Cabreraa, Pedro Aljamab
Corresponding author
bjg01co@hotmail.com
Correspondence: Dr B. Jurado Gámez, Servicio de Neumología (UTRS), Hospital Reina Sofía, Avda. Menéndez Pidal, s/n, 14004 Cordoba, Spain
Correspondence: Dr B. Jurado Gámez, Servicio de Neumología (UTRS), Hospital Reina Sofía, Avda. Menéndez Pidal, s/n, 14004 Cordoba, Spain
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Jurado Gámez, Servicio de Neumología (UTRS), Hospital Reina Sofía, Avda. Menéndez Pidal, s/n, 14004 Cordoba, Spain" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2007-06-19" "fechaAceptado" => "2007-11-07" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec155316" "palabras" => array:6 [ 0 => "Apnea-hypopnea index" 1 => "Oxygen desaturation index" 2 => "Chronic renal failure" 3 => "Kidney transplantation" 4 => "Sleep disorders" 5 => "Sleep-disordered breathing" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec155317" "palabras" => array:6 [ 0 => "Índice de apneas-hipopneas del sueño" 1 => "Índice de desaturación" 2 => "Insuficiencia renal crónica" 3 => "Trasplante renal" 4 => "Trastornos del sueño" 5 => "Trastornos respiratorios del sueño" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To evaluate the prevalence of sleep disorders in patients awaiting kidney transplants compared to a control group.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">We carried out an observational study of 23 patients on a kidney transplant waiting list in comparison with 20 healthy volunteers matched for age, sex, and body mass index (BMI). Overnight polysomnography was performed and a diagnosis of sleep apnea-hypopnea syndrome (SAHS) established when the apnea-hypopnea index (AHI) was 10 or higher.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Eighty-two percent of the patients awaiting kidney transplants (16 men and 7 women with a mean [SD] age of 51 [15] years and a mean BMI of 25 [3.8] kg/m<span class="elsevierStyleSup">2</span>) had some type of sleep disorder. The most frequent disorders were SAHS (48%) and insomnia and periodic limb movement disorder (30%). Patients showed poorer sleep efficiency compared to the control group (75.4% vs 87.8%; <span class="elsevierStyleItalic">P</span>=.01) and a lower percentage of slow-wave and rapid eye movement sleep (24.5% vs 40%; <span class="elsevierStyleItalic">P</span>=.001). Those with sleep-disordered breathing had a higher AHI (17.7 vs 3.6; <span class="elsevierStyleItalic">P</span>=.00l) and oxygen desaturation index (31.5 compared to 8.2; P=.00l).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Sleep disorders are common in patients awaiting kidney transplants. Such patients show reduced quantity and quality of sleep compared to controls and a significantly elevated number of respiratory events that may affect morbidity and mortality.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Valorar la prevalencia de los trastornos del sueno en pacientes en lista de espera de trasplante renal, comparados con un grupo control.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha realizado un estudio observacional en 23 pacientes en lista de espera para trasplante renal, cuyos resultados se compararon con los de 20 personas sanas que accedieron voluntariamente a participar en él. Se empare-jaron por edad, sexo e indice de masa corporal. Se efectuó una polisomnografía de noche completa y el diagnóstico de síndro-me de apneas-hipopneas durante el sueño se estableció cuando el índice de apneas-hipopneas era como mínimo de 10.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Los pacientes en lista de espera para trasplante renal (16 varones y 7 mujeres; edad media ± desviación estáandar: 51 ± 15 años; índice de masa corporal: 25 ± 3,8 kg/m<span class="elsevierStyleSup">2</span>) presentaron en un 82% de los casos algún trastorno del sueño. Los más frecuentes fueron el síndrome de apneas-hipopneas durante el sueñssso (48%) e insomnio y síndrome de movimiento periódico de piernas (30%). Los pacientes presentaron, respecto al grupo control, una menor eficiencia del sueño (el 75,4 frente al 87,8%; p = 0,01) y un menor porcentaje de sueño de ondas lentas y REM (un 24,5 frente a un 40%; p = 0,001), mientras que los trastornos respiratorios del sueño mostraron un mayor índice de apneas-hipopneas (17,7 frente a 3,6; p = 0,001) e indice de desaturación (31,5 frente a 8,2; p = 0,001).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Los trastornos del sueño son frecuentes en pacientes en lista de espera para trasplante renal, quienes, respecto al grupo control, tienen una menor cantidad y calidad del sueño, con un número significativamente elevado de eventos respiratorios, que pueden influir en la morbimortalidad.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:44 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "JM Marín" 1 => "SJ Carrizo" 2 => "F Vicente" 3 => "A Agustí" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(05)71141-7" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "2005" "volumen" => "365" "paginaInicial" => "1046" "paginaFinal" => "1053" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15781100" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Obstructive sleep apnea as a risk factor for stroke and death" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "HK Yaggi" 1 => "J Concato" 2 => "WN Kernan" 3 => "JH Lichtman" 4 => "LM Brass" 5 => "V Mohsenin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa043104" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2005" "volumen" => "353" "paginaInicial" => "2034" "paginaFinal" => "2041" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16282178" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Informe de diálisis y trasplante correspondiente al año 2002 de la Sociedad Española de Nefrología y Registro Autonómicos" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M Ceballos" 1 => "K López-Revuelta" 2 => "R Saracho" 3 => "F García López" 4 => "P Castro" 5 => "JA Gutiérrez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Nefrología" "fecha" => "2005" "volumen" => "25" "paginaInicial" => "121" "paginaFinal" => "129" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15912648" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "United States Renal Data System-USRDS. 2003. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 2 | 5 | 7 |
| 2024 October | 30 | 18 | 48 |
| 2024 September | 20 | 25 | 45 |
| 2024 August | 44 | 37 | 81 |
| 2024 July | 26 | 22 | 48 |
| 2024 June | 29 | 38 | 67 |
| 2024 May | 45 | 26 | 71 |
| 2024 April | 19 | 24 | 43 |
| 2024 March | 19 | 18 | 37 |
| 2024 February | 18 | 20 | 38 |
| 2023 March | 7 | 6 | 13 |
| 2023 February | 20 | 26 | 46 |
| 2023 January | 17 | 27 | 44 |
| 2022 December | 26 | 48 | 74 |
| 2022 November | 27 | 22 | 49 |
| 2022 October | 23 | 33 | 56 |
| 2022 September | 22 | 26 | 48 |
| 2022 August | 17 | 38 | 55 |
| 2022 July | 22 | 38 | 60 |
| 2022 June | 15 | 33 | 48 |
| 2022 May | 18 | 30 | 48 |
| 2022 April | 15 | 30 | 45 |
| 2022 March | 21 | 31 | 52 |
| 2022 February | 12 | 22 | 34 |
| 2022 January | 18 | 40 | 58 |
| 2021 December | 18 | 46 | 64 |
| 2021 November | 17 | 47 | 64 |
| 2021 October | 19 | 52 | 71 |
| 2021 September | 11 | 59 | 70 |
| 2021 August | 13 | 39 | 52 |
| 2021 July | 18 | 25 | 43 |
| 2021 June | 25 | 30 | 55 |
| 2021 May | 24 | 29 | 53 |
| 2021 April | 46 | 39 | 85 |
| 2021 March | 14 | 30 | 44 |
| 2021 February | 10 | 19 | 29 |
| 2021 January | 15 | 14 | 29 |
| 2020 December | 17 | 21 | 38 |
| 2020 November | 10 | 8 | 18 |
| 2020 October | 26 | 16 | 42 |
| 2020 September | 20 | 6 | 26 |
| 2020 August | 9 | 10 | 19 |
| 2020 July | 18 | 19 | 37 |
| 2020 June | 12 | 6 | 18 |
| 2020 May | 13 | 15 | 28 |
| 2020 April | 25 | 22 | 47 |
| 2020 March | 12 | 11 | 23 |
| 2020 February | 17 | 17 | 34 |
| 2020 January | 15 | 17 | 32 |
| 2019 December | 14 | 21 | 35 |
| 2019 November | 13 | 10 | 23 |
| 2019 October | 15 | 8 | 23 |
| 2019 September | 7 | 14 | 21 |
| 2019 August | 12 | 8 | 20 |
| 2019 July | 19 | 20 | 39 |
| 2019 June | 6 | 7 | 13 |
| 2019 May | 17 | 11 | 28 |
| 2019 April | 23 | 22 | 45 |
| 2019 March | 15 | 22 | 37 |
| 2019 February | 13 | 8 | 21 |
| 2019 January | 6 | 8 | 14 |
| 2018 December | 10 | 10 | 20 |
| 2018 November | 10 | 18 | 28 |
| 2018 October | 16 | 12 | 28 |
| 2018 September | 12 | 6 | 18 |
| 2018 May | 1 | 0 | 1 |
| 2018 April | 6 | 5 | 11 |
| 2018 March | 1 | 5 | 6 |
| 2018 February | 6 | 9 | 15 |
| 2018 January | 2 | 5 | 7 |
| 2017 December | 3 | 11 | 14 |
| 2017 November | 5 | 11 | 16 |
| 2017 October | 5 | 10 | 15 |
| 2017 September | 6 | 7 | 13 |
| 2017 August | 9 | 10 | 19 |
| 2017 July | 3 | 3 | 6 |
| 2017 June | 12 | 18 | 30 |
| 2017 May | 4 | 9 | 13 |
| 2017 April | 2 | 6 | 8 |
| 2017 March | 4 | 4 | 8 |
| 2017 February | 1 | 5 | 6 |
| 2017 January | 2 | 4 | 6 |
| 2016 December | 7 | 6 | 13 |
| 2016 November | 10 | 7 | 17 |
| 2016 October | 14 | 11 | 25 |
| 2016 September | 9 | 4 | 13 |
| 2016 August | 16 | 5 | 21 |
| 2016 July | 10 | 7 | 17 |
| 2016 March | 2 | 0 | 2 |
| 2015 December | 2 | 0 | 2 |
| 2015 October | 48 | 10 | 58 |
| 2015 September | 44 | 5 | 49 |
| 2015 August | 39 | 9 | 48 |
| 2015 July | 41 | 6 | 47 |
| 2015 June | 36 | 2 | 38 |
| 2015 May | 36 | 5 | 41 |
| 2015 April | 28 | 9 | 37 |
| 2015 March | 21 | 6 | 27 |
| 2015 February | 24 | 3 | 27 |
| 2015 January | 22 | 9 | 31 |
| 2014 December | 27 | 5 | 32 |
| 2014 November | 43 | 4 | 47 |
| 2014 October | 71 | 8 | 79 |
| 2014 September | 32 | 12 | 44 |
| 2014 August | 25 | 9 | 34 |
| 2014 July | 28 | 10 | 38 |
| 2014 June | 40 | 7 | 47 |
| 2014 May | 41 | 10 | 51 |
| 2014 April | 42 | 4 | 46 |
| 2014 March | 53 | 11 | 64 |
| 2014 February | 36 | 10 | 46 |
| 2014 January | 36 | 7 | 43 |
| 2013 December | 37 | 7 | 44 |
| 2013 November | 37 | 4 | 41 |
| 2013 October | 29 | 10 | 39 |
| 2013 September | 38 | 7 | 45 |
| 2013 August | 36 | 9 | 45 |
| 2013 July | 51 | 16 | 67 |
| 2013 June | 29 | 7 | 36 |
| 2013 May | 32 | 9 | 41 |
| 2013 April | 14 | 6 | 20 |
| 2013 March | 7 | 3 | 10 |
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