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                        "volumen" => "49"
                        "paginaInicial" => "591"
                        "paginaFinal" => "596"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4371672"
                            "web" => "Medline"
                          ]
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                          "pii" => "S0140673605677318"
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                          "issn" => "01406736"
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              "identificador" => "bib0090"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Effects of 22 months of treatment with inhaled corticosteroids and&#47;or beta-2-agonists on lung function&#44; airway responsiveness&#44; and symptoms in children with asthma"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
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                            2 => "H&#46;J&#46; Waalkens"
                          ]
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                    0 => array:2 [
                      "doi" => "10.1164/ajrccm/146.3.547"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1992"
                        "volumen" => "146"
                        "paginaInicial" => "547"
                        "paginaFinal" => "554"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1355640"
                            "web" => "Medline"
                          ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Safety of 1 year treatment with budesonide in young children with asthma"
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                          "etal" => false
                          "autores" => array:4 [
                            0 => "I&#46; Varsano"
                            1 => "B&#46; Volovitz"
                            2 => "H&#46; Malik"
                            3 => "Y&#46; Amir"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "J Allergy Clin Immunol"
                        "fecha" => "1990"
                        "volumen" => "85"
                        "paginaInicial" => "914"
                        "paginaFinal" => "920"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2332566"
                            "web" => "Medline"
                          ]
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                        "itemHostRev" => array:3 [
                          "pii" => "S0140673607616353"
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                          "issn" => "01406736"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "A 1 year follow-up of children and adolescens receiving regular beclomethasone dipropionate"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46;M&#46; Gwynn"
                            1 => "J&#46; Morrison Smith"
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Allergy"
                        "fecha" => "1974"
                        "volumen" => "4"
                        "paginaInicial" => "325"
                        "paginaFinal" => "330"
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673603125202"
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                          "issn" => "01406736"
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            20 => array:3 [
              "identificador" => "bib0105"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A 12 months tolerance study with budesonide in asthmatic children"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "L&#46;B&#46; Ribeiro"
                          ]
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Glucocorticosteroids in childhood asthma&#46;"
                        "paginaInicial" => "95"
                        "paginaFinal" => "109"
                        "serieFecha" => "1987"
                      ]
                    ]
                  ]
                ]
              ]
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            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Longterm beclomethasone dipropionate aerosol therapy in juvenile asthma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46;S&#46; Francis"
                          ]
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "1976"
                        "volumen" => "31"
                        "paginaInicial" => "309"
                        "paginaFinal" => "314"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/781906"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
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                ]
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            22 => array:3 [
              "identificador" => "bib0115"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A three to five-year follow-up of the use of aerosol steroid&#44; beclomethasone dipropionate&#44; in childhood asthma"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46; Godfrey"
                            1 => "L&#46; Balfour-Lynn"
                            2 => "M&#46; Tooley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Allergy Clin Immunol"
                        "fecha" => "1978"
                        "volumen" => "62"
                        "paginaInicial" => "335"
                        "paginaFinal" => "339"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/712019"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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            23 => array:3 [
              "identificador" => "bib0120"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Beclomethasone dipropionate aerosols in the treatment of asthma in childhood"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "H&#46;M&#46; Brown"
                            1 => "M&#46; Bhowmik"
                            2 => "F&#46;A&#46; Jackson"
                            3 => "N&#46; Thantrey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Practitioner"
                        "fecha" => "1980"
                        "volumen" => "224"
                        "paginaInicial" => "847"
                        "paginaFinal" => "851"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7433404"
                            "web" => "Medline"
                          ]
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              "identificador" => "bib0125"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Controlled trial of budesonide by the nebuhaler in preschool children with asthma"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;G&#46;A&#46; Gleeson"
                            1 => "J&#46;F&#46; Price"
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "BMJ"
                        "fecha" => "1988"
                        "volumen" => "297"
                        "paginaInicial" => "163"
                        "paginaFinal" => "166"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3044506"
                            "web" => "Medline"
                          ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Changes in bronchial reactivity in asthmatic children after treatment with beclomethasone alone or in association with salbutamol"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46; Benati"
                            1 => "G&#46;L&#46; Piacentini"
                            2 => "D&#46;G&#46; Peroni"
                            3 => "L&#46; Sette"
                            4 => "R&#46; Testi"
                            5 => "A&#46;L&#46; Boner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Asthma"
                        "fecha" => "1989"
                        "volumen" => "26"
                        "paginaInicial" => "359"
                        "paginaFinal" => "364"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2702243"
                            "web" => "Medline"
                          ]
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                ]
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              "identificador" => "bib0135"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of long-term treatment with inhaled corticosteroids and betaagonists on the bronchial responsiveness in children with asthma"
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                          "etal" => false
                          "autores" => array:3 [
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                            2 => "H&#46;J&#46; Neijens"
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Allergy Clin Immunol"
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                        "paginaInicial" => "653"
                        "paginaFinal" => "659"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3549842"
                            "web" => "Medline"
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              "identificador" => "bib0140"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "The effect of two months of treatment with inhaled budesonide on bronchial responsiveness to histamine and house-dust mite antigen in asthmatic children"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
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                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm/142.3.581"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1990"
                        "volumen" => "142"
                        "paginaInicial" => "581"
                        "paginaFinal" => "586"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2389909"
                            "web" => "Medline"
                          ]
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            28 => array:3 [
              "identificador" => "bib0145"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of budesonide on pulmonary hyperinflation in young asthmatic children"
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                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Greenough"
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                            2 => "J&#46;G&#46;A&#46; Gleeson"
                            3 => "J&#46;F&#46; Price"
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                    ]
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                  "host" => array:1 [
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                        "tituloSerie" => "Thorax"
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                        "paginaInicial" => "937"
                        "paginaFinal" => "938"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3065976"
                            "web" => "Medline"
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            29 => array:3 [
              "identificador" => "bib0150"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Budesonide and terbutaline alone in children with mild asthma&#58; effects on bronchial hyperresponsiveness and diurnal variation in peak flow"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                  "host" => array:1 [
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                        "paginaFinal" => "503"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1877037"
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                    0 => array:2 [
                      "titulo" => "Inhaled budesonide for treatment of recurrent wheezing in early childhood"
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                          "etal" => false
                          "autores" => array:5 [
                            0 => "H&#46; Bisgaard"
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                            4 => "S&#46;V&#46; Ohlsson"
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                        "paginaFinal" => "651"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1975851"
                            "web" => "Medline"
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                    0 => array:2 [
                      "titulo" => "Inhaled budesonide for chronic wheezing under 18 months of age"
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                          "etal" => false
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                  "host" => array:1 [
                    0 => array:1 [
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                        "tituloSerie" => "Arch Dis Child"
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                        "paginaInicial" => "285"
                        "paginaFinal" => "288"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1575550"
                            "web" => "Medline"
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            32 => array:3 [
              "identificador" => "bib0165"
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                    0 => array:2 [
                      "titulo" => "Analysis of linerar growth using a mathematical model"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Karlbeg"
                            1 => "I&#46; Engstrom"
                            2 => "P&#46; Karlberg"
                            3 => "J&#46;G&#46; Fryer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "From birth to three years&#46; Acta Paediatr Scand"
                        "fecha" => "1987"
                        "volumen" => "76"
                        "paginaInicial" => "478"
                        "paginaFinal" => "488"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3604665"
                            "web" => "Medline"
                          ]
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                ]
              ]
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            33 => array:3 [
              "identificador" => "bib0170"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Adrenal androgens in children with short stature"
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                            3 => "R&#46; David"
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Horm Res"
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                        "volumen" => "29"
                        "paginaInicial" => "151"
                        "paginaFinal" => "155"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2851519"
                            "web" => "Medline"
                          ]
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                ]
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            34 => array:3 [
              "identificador" => "bib0175"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Effects of asthma and asthma treatment on children&#39;s growth"
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                          "etal" => false
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                    0 => array:1 [
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                        "tituloSerie" => "Eur Respir Rew"
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                        "paginaFinal" => "316"
                        "itemHostRev" => array:3 [
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            35 => array:3 [
              "identificador" => "bib0180"
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                0 => array:2 [
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                      "titulo" => "Extrapulmonary effects on maintenance corticosteroid therapy with alternate-day prednisone and inhaled beclomethasone in children with chronic asthma"
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                            3 => "K&#46; Brown"
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                      ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Allergy Clin Immunol"
                        "fecha" => "1987"
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                        "paginaInicial" => "518"
                        "paginaFinal" => "529"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3668116"
                            "web" => "Medline"
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                      "titulo" => "Adrenocortical function in children on high-dose steroid aerosol therapy"
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                          "autores" => array:3 [
                            0 => "P&#46; Prahl"
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                            2 => "H&#46; Bjerregard-Andersen"
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Allergy"
                        "fecha" => "1987"
                        "volumen" => "42"
                        "paginaInicial" => "541"
                        "paginaFinal" => "544"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8323452"
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                    0 => array:2 [
                      "titulo" => "Long-term effect of inhaled corticosteroids on growth rate in adolescents with asthma"
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                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;F&#46;M&#46; Merkus"
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                            2 => "E&#46;J&#46; Duiverman"
                            3 => "H&#46;C&#46; van Houwelingen"
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                            5 => "P&#46;H&#46; Quanjer"
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatrics"
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                        "paginaInicial" => "1&#46;121"
                        "paginaFinal" => "1&#46;126"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8502524"
                            "web" => "Medline"
                          ]
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              "identificador" => "bib0195"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Asthma&#44; inhaled corticosteroid treatment&#44; and growth"
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                          "etal" => false
                          "autores" => array:2 [
                            0 => "T&#46; Ninan"
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dis Child"
                        "fecha" => "1992"
                        "volumen" => "67"
                        "paginaInicial" => "703"
                        "paginaFinal" => "705"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1626989"
                            "web" => "Medline"
                          ]
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                    0 => array:2 [
                      "titulo" => "Growth and childhood asthma"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "L&#46; Balfour-Lynn"
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dis Child"
                        "fecha" => "1986"
                        "volumen" => "61"
                        "paginaInicial" => "1&#46;049"
                        "paginaFinal" => "1&#46;055"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3813614"
                            "web" => "Medline"
                          ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Growth of asthmatic children during treatment with budesonide&#58; a double blind trial"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "O&#46;D&#46; Wolthers"
                            1 => "D&#46; Pedersen"
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "BMJ"
                        "fecha" => "1991"
                        "volumen" => "303"
                        "paginaInicial" => "163"
                        "paginaFinal" => "165"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1878641"
                            "web" => "Medline"
                          ]
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              ]
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            41 => array:3 [
              "identificador" => "bib0210"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Short term growth during treatment with inhaled fiuticasone propionate and beclomethasone dipropionate"
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                          "etal" => false
                          "autores" => array:2 [
                            0 => "O&#46;D&#46; Wolthers"
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                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Arch Dis Child"
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                        "volumen" => "68"
                        "paginaInicial" => "673"
                        "paginaFinal" => "676"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8323338"
                            "web" => "Medline"
                          ]
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                          "pii" => "S0140673606682433"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Evaluation of growth rate in height over periods of less than one year"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "W&#46; Marshall"
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dis Child"
                        "fecha" => "1971"
                        "volumen" => "46"
                        "paginaInicial" => "414"
                        "paginaFinal" => "420"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5565455"
                            "web" => "Medline"
                          ]
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            43 => array:3 [
              "identificador" => "bib0220"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The cyclical nature of prepubertal growth"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46;E&#46; Butler"
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                            2 => "S&#46;G&#46; Ratcliffe"
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Hum Biol"
                        "fecha" => "1990"
                        "volumen" => "17"
                        "paginaInicial" => "177"
                        "paginaFinal" => "198"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2337324"
                            "web" => "Medline"
                          ]
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            44 => array:3 [
              "identificador" => "bib0225"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Knemometry and its practical application"
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                        0 => array:2 [
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                          "autores" => array:2 [
                            0 => "C&#46;A&#46; Mackenzie"
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                      ]
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                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Eur Respir Rev"
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                        "volumen" => "3"
                        "paginaInicial" => "321"
                        "paginaFinal" => "325"
                      ]
                    ]
                  ]
                ]
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            45 => array:3 [
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Measurement of the effects of drugs on growth"
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                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46;A&#46; Preece"
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Eur Respir Rev"
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                        "paginaFinal" => "320"
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                  ]
                ]
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                0 => array:2 [
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                      "titulo" => "Crecimiento y desarrollo humano"
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                        "titulo" => "Crecimiento y desarrollo humanos y sus trastornos&#46;"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Inhaled corticosteroids and growth"
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                            0 => "S&#46;R&#46; Zeitlin"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Effects of dose and dosing schedule of inhaled budesonide on bone turnover"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;H&#46; Toogood"
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                            2 => "A&#46;B&#46; Hodsman"
                            3 => "J&#46; Baskerville"
                            4 => "L&#46;J&#46; Fraher"
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Allergy Clin Immunol"
                        "fecha" => "1991"
                        "volumen" => "88"
                        "paginaInicial" => "572"
                        "paginaFinal" => "580"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1918724"
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                    0 => array:2 [
                      "titulo" => "Effects of inhaled budesonide on serum markers of bone metabolism in children with asthma"
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                          "etal" => false
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                            0 => "R&#46; Sorva"
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                  "host" => array:1 [
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                        "tituloSerie" => "J Allergy Clin Immunol"
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                        "paginaInicial" => "808"
                        "paginaFinal" => "815"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1430706"
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                            4 => "S&#46; Pedersen"
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                  "host" => array:1 [
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                        "tituloSerie" => "Eur Respir J"
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                    0 => array:2 [
                      "titulo" => "Bone densitometry in children treated for 3-6 years with high dose inhaled budesonide"
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                      "titulo" => "Effect of beclomethasone &#40;BDP&#41; on bone mineral content assessed by dual energy X-ray absortiometry in asthmatic children"
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            53 => array:3 [
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Changes in carbohydrate and lipid metabolism in children with asthma inhaling budesonide"
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                  "host" => array:1 [
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                        "tituloSerie" => "J Allergy Clin Immunol"
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                        "paginaInicial" => "384"
                        "paginaFinal" => "389"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1890267"
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                    0 => array:2 [
                      "titulo" => "Effect of high dose inhaled beclomethasone dipropionate on carbohydrate and lipid metabolism in normal subjects"
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                          "etal" => false
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                            3 => "N&#46;J&#46; Cooke"
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                  "host" => array:1 [
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                        "tituloSerie" => "Thorax"
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                        "paginaFinal" => "884"
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                          0 => array:2 [
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                        "paginaInicial" => "821"
                        "paginaFinal" => "826"
                        "link" => array:1 [
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                  "contribucion" => array:1 [
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                      "titulo" => "Effect of dosing schedule on efficacy of beclomethasone dipropionate aerosol in chronic asthma"
                      "autores" => array:1 [
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                          "autores" => array:4 [
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                        "fecha" => "1985"
                        "volumen" => "131"
                        "paginaInicial" => "732"
                        "paginaFinal" => "736"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4003917"
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                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46;L&#46; Bhan"
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                            2 => "J&#46; Morrison Smith"
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                        "fecha" => "1980"
                        "volumen" => "1"
                        "paginaInicial" => "96"
                        "paginaFinal" => "97"
                        "link" => array:1 [
                          0 => array:2 [
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                          "etal" => false
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                  "host" => array:1 [
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                        "volumen" => "72"
                        "paginaInicial" => "60"
                        "paginaFinal" => "64"
                        "link" => array:1 [
                          0 => array:2 [
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                        "paginaFinal" => "529"
                        "link" => array:1 [
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                            4 => "J&#46;O&#46; Warner"
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                        "paginaFinal" => "944"
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                            4 => "N&#46; Foged"
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                        "tituloSerie" => "J Allergy Clin Immunol"
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                        "paginaInicial" => "1&#46;088"
                        "paginaFinal" => "1&#46;095"
                        "link" => array:1 [
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Vol. 30. Issue 7.
Pages 327-330 (August - September 1994)
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Vol. 30. Issue 7.
Pages 327-330 (August - September 1994)
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Riesgos de los glucocorticoides inhalados en el asma infantil
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E. González Pérez-Yarza*
Sección de Neumología Pediátrica. Unidad de Asma. Hospital Aránzazu. San Sebastián
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Bibliografía
[1.]
E. Cutz, H. Levison, D.M. Cooper.
Ultrastructure of airway in children with asthma.
Histophatology, 2 (1978), pp. 407-421
[2.]
A.C. Ferguson, F.W.M. Wong.
Bronchial hyperresponsiveness in asthmatic children. Correlation with macrophages and eosinophils in broncholavage fluid.
Chest, 96 (1989), pp. 988-991
[3.]
A.R. Leff, K.J. Hamann, C.D. Wegner.
Inflammation and cell-cell interactions in airway hyperresponsivennes.
Am J Physiol, 260 (1991), pp. L189-L206
[4.]
A.B. Kay.
Asthma and inflammation.
J Allergy Clin Immunol, 87 (1991), pp. 893-910
[5.]
P.J. Barnes.
Neuropeptides and asthma.
Am Rev Respir Dis, 143 (1991), pp. 28-32
[6.]
A. Munck, D.B. Mendel, L.I. Smith, E. Orti.
Glucocorticoid receptors and actions.
Am Rev Respir Dis, 141 (1990), pp. S2-S10
[7.]
I.K. Taylor, R.J. Shaw.
The mechanism of action of corticosteroids in asthma.
Respir Med, 87 (1993), pp. 261-277
[8.]
S.F. Smith.
A potential mechanism for some antiinflammatory effects of the glucocorticoid? [editorial].
Respir Med, 84 (1990), pp. 435-436
[9.]
C.M. Fraser, J.C. Venter.
The synthesis of beta adrenergic receptors in cultured human lung cells: induction by glucocorticoids.
Biochem Biophys Res Commun, 94 (1980), pp. 390-397
[10.]
N. Svedmyr.
Action of corticosteroids on beta-adrenergic receptors.
Am Rev Respir Dis, 141 (1990), pp. S31-S38
[11.]
International consensus report on the diagnosis, management of asthma.
Clin Exp Allergy, 22 (1992), pp. 1-72
[12.]
National Heart, Lung, Blood Institute, National Asthma Education Program, Expert Panel Report.
Guidelines for the diagnosis and management of asthma.
J Allergy Clin Immunol, 88 (1991), pp. 425-533
[13.]
Guidelines for the management of asthma in adults.
1-Chronic persistent asthma. Statement by the British Thoracic Society, Research Unit of the Royal College of Physicians of London, King's Fund Centre, National Asthma Campaign.
BMJ, 301 (1990), pp. 651-653
[14.]
Guidelines on the management of asthma.
Thorax, 48 (1993), pp. S1-S24
[15.]
C. Picado, E. Benlloch, P. Casan, F. Duce, F. Manresa, M. Perpiñá, J. Sanchís.
Recomendaciones para el tratamiento del asma en los adultos.
Arch Bronconeumol, 29 (1993), pp. 8-13
[16.]
International Paediatric Asthma Consensus Group.
Asthma, a follow-up statement.
Arch Dis Child, 67 (1992), pp. 240-248
[17.]
S. Godfrey, P. König.
Treatment of childhood asthma for 13 months and longer with beclomethasone dipropionate aerosol.
Arch Dis Child, 49 (1974), pp. 591-596
[18.]
E.E. Van Essen-Zandvliet, M.D. Hughues, H.J. Waalkens, et al.
Effects of 22 months of treatment with inhaled corticosteroids and/or beta-2-agonists on lung function, airway responsiveness, and symptoms in children with asthma.
Am Rev Respir Dis, 146 (1992), pp. 547-554
[19.]
I. Varsano, B. Volovitz, H. Malik, Y. Amir.
Safety of 1 year treatment with budesonide in young children with asthma.
J Allergy Clin Immunol, 85 (1990), pp. 914-920
[20.]
C.M. Gwynn, J. Morrison Smith.
A 1 year follow-up of children and adolescens receiving regular beclomethasone dipropionate.
Clin Allergy, 4 (1974), pp. 325-330
[21.]
L.B. Ribeiro.
A 12 months tolerance study with budesonide in asthmatic children.
Glucocorticosteroids in childhood asthma., pp. 95-109
[22.]
R.S. Francis.
Longterm beclomethasone dipropionate aerosol therapy in juvenile asthma.
Thorax, 31 (1976), pp. 309-314
[23.]
S. Godfrey, L. Balfour-Lynn, M. Tooley.
A three to five-year follow-up of the use of aerosol steroid, beclomethasone dipropionate, in childhood asthma.
J Allergy Clin Immunol, 62 (1978), pp. 335-339
[24.]
H.M. Brown, M. Bhowmik, F.A. Jackson, N. Thantrey.
Beclomethasone dipropionate aerosols in the treatment of asthma in childhood.
Practitioner, 224 (1980), pp. 847-851
[25.]
J.G.A. Gleeson, J.F. Price.
Controlled trial of budesonide by the nebuhaler in preschool children with asthma.
BMJ, 297 (1988), pp. 163-166
[26.]
D. Benati, G.L. Piacentini, D.G. Peroni, L. Sette, R. Testi, A.L. Boner, et al.
Changes in bronchial reactivity in asthmatic children after treatment with beclomethasone alone or in association with salbutamol.
J Asthma, 26 (1989), pp. 359-364
[27.]
K.F. Kerrebijn, E.E.M. van Essen-Zandvliet, H.J. Neijens.
Effect of long-term treatment with inhaled corticosteroids and betaagonists on the bronchial responsiveness in children with asthma.
J Allergy Clin Immunol, 79 (1987), pp. 653-659
[28.]
F.M. De Baets, M. Goeteyn, K.F. Kerrebijn.
The effect of two months of treatment with inhaled budesonide on bronchial responsiveness to histamine and house-dust mite antigen in asthmatic children.
Am Rev Respir Dis, 142 (1990), pp. 581-586
[29.]
A. Greenough, J. Pool, J.G.A. Gleeson, J.F. Price.
Effect of budesonide on pulmonary hyperinflation in young asthmatic children.
Thorax, 43 (1988), pp. 937-938
[30.]
H.J. Waalkens, J. Gerritsen, G.H. Koëter, F.H. Kronwells, W.M.C. Van Aalderen, K. Knol, et al.
Budesonide and terbutaline alone in children with mild asthma: effects on bronchial hyperresponsiveness and diurnal variation in peak flow.
Thorax, 46 (1991), pp. 499-503
[31.]
H. Bisgaard, S.J. Munck, J.P. Nielsen, W. Petersen, S.V. Ohlsson.
Inhaled budesonide for treatment of recurrent wheezing in early childhood.
Lancet, 336 (1990), pp. 649-651
[32.]
V. Noble, N. Ruggins, M.L. Everard, A.D. Milner.
Inhaled budesonide for chronic wheezing under 18 months of age.
Arch Dis Child, 67 (1992), pp. 285-288
[33.]
J. Karlbeg, I. Engstrom, P. Karlberg, J.G. Fryer.
Analysis of linerar growth using a mathematical model.
From birth to three years. Acta Paediatr Scand, 76 (1987), pp. 478-488
[34.]
L.Q. Lew, C.A. Sklar, D.J. Yoon, R. David.
Adrenal androgens in children with short stature.
Horm Res, 29 (1988), pp. 151-155
[35.]
P.C. Hindmarsh, S. Crowley, C.G.D. Brook.
Effects of asthma and asthma treatment on children's growth.
Eur Respir Rew, 3 (1993), pp. 313-316
[36.]
E. Nassif, M. Winberger, P. Sherman, K. Brown.
Extrapulmonary effects on maintenance corticosteroid therapy with alternate-day prednisone and inhaled beclomethasone in children with chronic asthma.
J Allergy Clin Immunol, 80 (1987), pp. 518-529
[37.]
P. Prahl, T. Jensen, H. Bjerregard-Andersen.
Adrenocortical function in children on high-dose steroid aerosol therapy.
Allergy, 42 (1987), pp. 541-544
[38.]
J.F.M. Merkus, E.E.M. van Essen-Zandvliet, E.J. Duiverman, H.C. van Houwelingen, K.F. Kerrebijn, P.H. Quanjer.
Long-term effect of inhaled corticosteroids on growth rate in adolescents with asthma.
Pediatrics, 91 (1993), pp. 1.121-1.126
[39.]
T. Ninan, G. Russell.
Asthma, inhaled corticosteroid treatment, and growth.
Arch Dis Child, 67 (1992), pp. 703-705
[40.]
L. Balfour-Lynn.
Growth and childhood asthma.
Arch Dis Child, 61 (1986), pp. 1.049-1.055
[41.]
O.D. Wolthers, D. Pedersen.
Growth of asthmatic children during treatment with budesonide: a double blind trial.
BMJ, 303 (1991), pp. 163-165
[42.]
O.D. Wolthers, S. Pedersen.
Short term growth during treatment with inhaled fiuticasone propionate and beclomethasone dipropionate.
Arch Dis Child, 68 (1993), pp. 673-676
[43.]
W. Marshall.
Evaluation of growth rate in height over periods of less than one year.
Arch Dis Child, 46 (1971), pp. 414-420
[44.]
G.E. Butler, M. McKie, S.G. Ratcliffe.
The cyclical nature of prepubertal growth.
Ann Hum Biol, 17 (1990), pp. 177-198
[45.]
C.A. Mackenzie, J.K.H. Wales.
Knemometry and its practical application.
Eur Respir Rev, 3 (1993), pp. 321-325
[46.]
M.A. Preece.
Measurement of the effects of drugs on growth.
Eur Respir Rev, 3 (1993), pp. 317-320
[47.]
M. Bueno.
Crecimiento y desarrollo humano.
Crecimiento y desarrollo humanos y sus trastornos., pp. 3-27
[48.]
S.R. Zeitlin, S. Crowley, P.C. Hidmarsh, C.G.D. Brook.
Inhaled corticosteroids and growth.
Eur Respir Dis, 3 (1993), pp. 333-397
[49.]
J.H. Toogood, B. Jennings, A.B. Hodsman, J. Baskerville, L.J. Fraher.
Effects of dose and dosing schedule of inhaled budesonide on bone turnover.
J Allergy Clin Immunol, 88 (1991), pp. 572-580
[50.]
R. Sorva, M. Turpeinen, K. Juntunen-Backman, S.L. Karonen, A. Sorva.
Effects of inhaled budesonide on serum markers of bone metabolism in children with asthma.
J Allergy Clin Immunol, 90 (1992), pp. 808-815
[51.]
O.D. Wolthers, A. Juul, M. Hansen, J. Müller, S. Pedersen.
Growth factors and collagen markers in asthmatic children treated with inhaled budesonide.
Eur Respir J, 6 (1993), pp. 261
[52.]
L. Agertoft, S. Pedersen.
Bone densitometry in children treated for 3-6 years with high dose inhaled budesonide.
Eur Respir J, 6 (1993), pp. 261
[53.]
E. Baraldi, M.C. Bollini, A.M. De Marchi, A. Guglielmi, F. Zacche11o.
Effect of beclomethasone (BDP) on bone mineral content assessed by dual energy X-ray absortiometry in asthmatic children.
Eur Respir J, 6 (1993), pp. 261s
[54.]
M. Turpeinen, R. Sorva, K. Juntunen-Backman.
Changes in carbohydrate and lipid metabolism in children with asthma inhaling budesonide.
J Allergy Clin Immunol, 88 (1991), pp. 384-389
[55.]
Y.T. Kruszynska, M. Greenstone, P.D. Home, N.J. Cooke.
Effect of high dose inhaled beclomethasone dipropionate on carbohydrate and lipid metabolism in normal subjects.
Thorax, 42 (1987), pp. 881-884
[56.]
K.F. Kerrebijn.
Beclomethasone dipropionate in long-term treatment of asthma in children.
J Pediatr, 89 (1976), pp. 821-826
[57.]
E.O. Meltzer, J.P. Jemo, M.J. Welch, A.E. Orgel.
Effect of dosing schedule on efficacy of beclomethasone dipropionate aerosol in chronic asthma.
Am Rev Respir Dis, 131 (1985), pp. 732-736
[58.]
G.L. Bhan, C.M. Gwynn, J. Morrison Smith.
Growth and adrenal function of children on prolonged beclomethasone dipropionate treatment.
[59.]
D.E. Goldstein, P. Köenig.
Effect of inhaled beclomethasone dipropionate on hypothalamic-pituitary-adrenal axis function in children with asthma.
Pediatrics, 72 (1983), pp. 60-64
[60.]
R. Wyatt, J. Waschek, M. Weinberger, B. Sherman.
Effects of inhaled beclomethasone dipropionate and alternate-day prednisone on pituitary-adrenal function in children with chronic asthma.
N Engl J Med, 299 (1978), pp. 1.387-1.392
[61.]
E. Nassif, M. Weinberger, B. Sherman, K. Brown.
Extrapulmonary effects of maintenance corticosteroid therapy with alternate-day prednisone and inhaled beclomethasone in children with chronic asthma.
J Allergy Clin Immunol, 80 (1987), pp. 518-529
[62.]
R. Vaz, B. Senior, M. Morris, A. Binkiewicz.
Adrenal effects of beclomethasone inhalation therapy in asthmatic children.
J Pediatr, 100 (1982), pp. 660-662
[63.]
C.M. Law, J.L. Marchant, J.W. Honour, M.A. Preece, J.O. Warner.
Nocturnal adrenal supression in asthmatic children taking inhaled beclomethasone dipropionate.
Lancet, 1 (1986), pp. 942-944
[64.]
H. Bisgaard, M.D. Damkjaer-Nielsen, B. Andersen, P. Andersen, N. Foged, et al.
Adrenal function in children with bronchial asthma treated with beclomethasone dipropionate or budesonide.
J Allergy Clin Immunol, 81 (1988), pp. 1.088-1.095
[65.]
S. Pedersen, G. Fuglsang.
Urine cortisol excretion in children treated with high doses of inhaled corticosteroids: a comparison of budesonide and beclomethasone.
Eur J Respir Dis, 1 (1988), pp. 433-435
[66.]
E. González Pérez-Yarza.
Contribución al estudio de la función suprarrenal bajo terapia con corticoides inhalados en el asma infantil.
Tesis. Universidad del País Vasco. Bilbao., (1994),
[67.]
R.N. Brogden, D. McTavish.
Budesonida. Una revisión actualizada de sus propiedades farmacológicas y su eficacia terapéutica en asma y rinitis.
Drugs (ed. esp.), 44 (1992), pp. 376-402
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