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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">Rhinitis and asthma share an inflammatory mechanism&#44; epidemiological patterns&#44; and symptoms that affect both the nose and the bronchi&#46; The RINAIR study examined the prevalence and characteristics of rhinitis in asthma patients in Spain</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">This prospective epidemiological study was carried out with the participation of 15&#37; of Spanish respiratory medicine specialists sampled randomly from different geographic areas&#46; The study population was composed of 703 asthmatic patients aged over 16 years who were enrolled between February and September 2005&#46; Patient characteristics&#44; prevalence of rhinitis&#44; lung function&#44; allergy test results&#44; and treatment of rhinitis were analyzed&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Seventy-one percent &#40;n&#61;499&#41; of the asthmatic patients had rhinitis&#46; These patients were younger &#40;43&#46;8 years vs 55&#46;4 years&#59; <span class="elsevierStyleItalic">P</span>&#60;&#46;0001&#41; and had less severe asthma &#40;forced expiratory volume in 1 second &#91;FEV<span class="elsevierStyleInf">1</span>&#93;&#44; 85&#46;7&#37; vs 79&#46;7&#37; &#91;<span class="elsevierStyleItalic">P</span>&#60;&#46;001&#93;&#41; than asthmatic patients who did not have rhinitis&#46; A correlation was observed between the severity of asthma and the severity of rhinitis &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#46; Atopy was significantly associated with rhinitis &#40;odds ratio&#44; 6&#46;25&#59; 95&#37; confidence interval&#44; 4&#46;3-9&#46;1&#41;&#58; 84&#37; of atopic patients and 51&#37; of nonatopic patients had rhinitis&#46; Treatment of rhinitis was associated with an increase in FEV<span class="elsevierStyleInf">1</span> &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;057&#41;&#44; irrespective of sex&#44; age&#44; severity of asthma&#44; or smoking&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Seventy-one percent of asthmatic patients who attended respiratory medicine clinics had rhinitis&#46; These patients were younger and had milder asthma than asthmatics who did not have rhinitis&#46; Furthermore&#44; atopy was correlated with asthma associated with rhinitis&#46; Treatment of rhinitis tended to improve lung function&#46; These findings highlight the need to study and treat the upper and lower respiratory tract as a single airway&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Rinitis y asma est&#225;n ligadas por una epidemiolog&#237;a&#44; cl&#237;nica y mecanismo inflamatorio comunes que interrelacionan nariz y bronquio&#46; El objetivo del estudio RINAIR ha sido estudiar la prevalencia y caracter&#237;sticas de la rinitis en pacientes con asma en Espa&#241;a&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha realizado un estudio epidemiol&#243;gico de car&#225;cter prospectivo con la participaci&#243;n del 15&#37; de los neum&#243;logos espa&#241;oles&#44; distribuidos aleatoriamente por &#225;reas geogr&#225;ficas&#46; Se incluy&#243; a 703 asm&#225;ticos mayores de 16 a&#241;os entre febrero y septiembre de 2005&#46; Se analizaron datos demogr&#225;ficos&#44; prevalencia de rinitis&#44; funci&#243;n pulmonar&#44; pruebas al&#233;rgicas y tratamiento de la rinitis&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Un 71&#37; &#40;n &#61; 499&#41; de los asm&#225;ticos presentaba rinitis&#46; &#201;stos eran m&#225;s j&#243;venes &#40;43&#44;8 frente a 55&#44;4 a&#241;os&#59; p &#60; 0&#44;0001&#41; y presentaban un asma menos grave &#8212;volumen espiratorio forzado en el primer segundo &#40;FEV<span class="elsevierStyleInf">1</span>&#41;&#58; un 85&#44;7 frente a un 79&#44;7&#37; &#40;p &#60; 0&#44;001&#41;&#8212; que los asm&#225;ticos sin rinitis&#46; Se observ&#243; una correlaci&#243;n entre la gravedad del asma y la gravedad de la rinitis &#40;p &#60; 0&#44;001&#41;&#46; La atopia se asoci&#243; significativamente con la presencia de rinitis &#40;<span class="elsevierStyleItalic">odds ratio</span> &#61; 6&#44;25&#59; intervalo de confianza del 95&#37;&#44; 4&#44;3-9&#44;1&#41;&#58; el 84&#37; de los at&#243;picos y el 51&#37; de los no at&#243;picos ten&#237;an rinitis&#46; El tratamiento de la rinitis se asoci&#243; &#40;p &#61; 0&#44;057&#41; con un incremento del FEV<span class="elsevierStyleInf">1</span>&#44; con independencia del sexo&#44; la edad&#44; la gravedad del asma y el h&#225;bito de fumar&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Un 71&#37; de los asm&#225;ticos atendidos en las consultas de neumolog&#237;a tiene rinitis&#46; Estos pacientes son m&#225;s j&#243;venes y presentan un asma m&#225;s leve que los asm&#225;ticos sin rinitis&#46; Por otro lado&#44; la atopia se relaciona con el asma asociada a rinitis&#46; El tratamiento de la rinitis tiende a mejorar funci&#243;n pulmonar&#46; Estos hallazgos indican la necesidad de estudiar y tratar toda la v&#237;a respiratoria de forma integral&#46;</p>"
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Vol. 44. Issue 11.
Pages 597-603 (January 2008)
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Vol. 44. Issue 11.
Pages 597-603 (January 2008)
Original Articles
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Rhinitis and Asthma Comorbidity in Spain: The RINAIR Study
Visits
5116
José Antonio
Corresponding author
11437jac@comb.es

Correspondence: Dr J.A. Castillo Sant Joan, 10 08870 Sitges, Barcelona, Spain
, Castillo Vizuetea,b, Joaquim Mullol Miretb,c,d
a Servei d'Al·lèrgia i Pneumologia, Institut Universitari Dexeus, Barcelona, Spain
b Grupo de Trabajo de Rinitis, Área de Asma, SEPAR
c Unitat de Rinologia, Servei d'ORL, Hospital Clínic, IDIBAPS, Barcelona, Spain
d Centro de Investigación Biomédica en Red (CibeRes) de Enfermedades Respiratorias, Barcelona, Spain
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Article information
Objective

Rhinitis and asthma share an inflammatory mechanism, epidemiological patterns, and symptoms that affect both the nose and the bronchi. The RINAIR study examined the prevalence and characteristics of rhinitis in asthma patients in Spain

Patients and methods

This prospective epidemiological study was carried out with the participation of 15% of Spanish respiratory medicine specialists sampled randomly from different geographic areas. The study population was composed of 703 asthmatic patients aged over 16 years who were enrolled between February and September 2005. Patient characteristics, prevalence of rhinitis, lung function, allergy test results, and treatment of rhinitis were analyzed.

Results

Seventy-one percent (n=499) of the asthmatic patients had rhinitis. These patients were younger (43.8 years vs 55.4 years; P<.0001) and had less severe asthma (forced expiratory volume in 1 second [FEV1], 85.7% vs 79.7% [P<.001]) than asthmatic patients who did not have rhinitis. A correlation was observed between the severity of asthma and the severity of rhinitis (P<.001). Atopy was significantly associated with rhinitis (odds ratio, 6.25; 95% confidence interval, 4.3-9.1): 84% of atopic patients and 51% of nonatopic patients had rhinitis. Treatment of rhinitis was associated with an increase in FEV1 (P=.057), irrespective of sex, age, severity of asthma, or smoking.

Conclusions

Seventy-one percent of asthmatic patients who attended respiratory medicine clinics had rhinitis. These patients were younger and had milder asthma than asthmatics who did not have rhinitis. Furthermore, atopy was correlated with asthma associated with rhinitis. Treatment of rhinitis tended to improve lung function. These findings highlight the need to study and treat the upper and lower respiratory tract as a single airway.

Key words:
Rhinitis
Asthma
Comorbidity
Lung function
Exacerbation
Treatment
Objetivo

Rinitis y asma están ligadas por una epidemiología, clínica y mecanismo inflamatorio comunes que interrelacionan nariz y bronquio. El objetivo del estudio RINAIR ha sido estudiar la prevalencia y características de la rinitis en pacientes con asma en España.

Pacientes y métodos

Se ha realizado un estudio epidemiológico de carácter prospectivo con la participación del 15% de los neumólogos españoles, distribuidos aleatoriamente por áreas geográficas. Se incluyó a 703 asmáticos mayores de 16 años entre febrero y septiembre de 2005. Se analizaron datos demográficos, prevalencia de rinitis, función pulmonar, pruebas alérgicas y tratamiento de la rinitis.

Resultados

Un 71% (n = 499) de los asmáticos presentaba rinitis. Éstos eran más jóvenes (43,8 frente a 55,4 años; p < 0,0001) y presentaban un asma menos grave —volumen espiratorio forzado en el primer segundo (FEV1): un 85,7 frente a un 79,7% (p < 0,001)— que los asmáticos sin rinitis. Se observó una correlación entre la gravedad del asma y la gravedad de la rinitis (p < 0,001). La atopia se asoció significativamente con la presencia de rinitis (odds ratio = 6,25; intervalo de confianza del 95%, 4,3-9,1): el 84% de los atópicos y el 51% de los no atópicos tenían rinitis. El tratamiento de la rinitis se asoció (p = 0,057) con un incremento del FEV1, con independencia del sexo, la edad, la gravedad del asma y el hábito de fumar.

Conclusiones

Un 71% de los asmáticos atendidos en las consultas de neumología tiene rinitis. Estos pacientes son más jóvenes y presentan un asma más leve que los asmáticos sin rinitis. Por otro lado, la atopia se relaciona con el asma asociada a rinitis. El tratamiento de la rinitis tiende a mejorar función pulmonar. Estos hallazgos indican la necesidad de estudiar y tratar toda la vía respiratoria de forma integral.

Palabras clave:
Rinitis
Asma
Comorbilidad
Función pulmonar
Exacerbación
Tratamiento
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This study was carried out within the framework of the Working Group on Rhinitis of the Assembly on Asthma of SEPAR. Funding was provided by MSD España.

Copyright © 2008. Sociedad Española de Neumología y Cirugía Torácica (SEPAR)
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