array:24 [
  "pii" => "S1579212913002073"
  "issn" => "15792129"
  "doi" => "10.1016/j.arbr.2013.12.001"
  "estado" => "S300"
  "fechaPublicacion" => "2014-01-01"
  "aid" => "793"
  "copyright" => "SEPAR"
  "copyrightAnyo" => "2013"
  "documento" => "simple-article"
  "crossmark" => 0
  "subdocumento" => "crp"
  "cita" => "Arch Bronconeumol. 2014;50:40-1"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 4077
    "formatos" => array:3 [
      "EPUB" => 134
      "HTML" => 3176
      "PDF" => 767
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0300289613001804"
      "issn" => "03002896"
      "doi" => "10.1016/j.arbres.2013.05.010"
      "estado" => "S300"
      "fechaPublicacion" => "2014-01-01"
      "aid" => "793"
      "copyright" => "SEPAR"
      "documento" => "simple-article"
      "crossmark" => 0
      "subdocumento" => "crp"
      "cita" => "Arch Bronconeumol. 2014;50:40-1"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 10516
        "formatos" => array:3 [
          "EPUB" => 136
          "HTML" => 9467
          "PDF" => 913
        ]
      ]
      "es" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Nota cl&#237;nica</span>"
        "titulo" => "Enfermedad pulmonar venooclusiva en una mujer jardinera"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "40"
            "paginaFinal" => "41"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Pulmonary Veno-Occlusive Disease in a Female Gardener"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 658
                "Ancho" => 900
                "Tamanyo" => 112414
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Tomograf&#237;a computarizada tor&#225;cica en la que se demuestra un patr&#243;n en vidrio deslustrado bilateral&#44; con &#225;reas de consolidaci&#243;n y n&#243;dulos pulmonares bilaterales de hasta 1<span class="elsevierStyleHsp" style=""></span>cm de di&#225;metro&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Paula Rodr&#237;guez Rodr&#237;guez, Fernando Pedraza Serrano, Liliana Patricia Mor&#225;n Caicedo, Maria Carmen Rodr&#237;guez de Guzm&#225;n, Mar&#237;a Cebollero Presmanes, Javier de Miguel D&#237;ez"
            "autores" => array:6 [
              0 => array:2 [
                "nombre" => "Paula"
                "apellidos" => "Rodr&#237;guez Rodr&#237;guez"
              ]
              1 => array:2 [
                "nombre" => "Fernando"
                "apellidos" => "Pedraza Serrano"
              ]
              2 => array:2 [
                "nombre" => "Liliana Patricia"
                "apellidos" => "Mor&#225;n Caicedo"
              ]
              3 => array:2 [
                "nombre" => "Maria Carmen"
                "apellidos" => "Rodr&#237;guez de Guzm&#225;n"
              ]
              4 => array:2 [
                "nombre" => "Mar&#237;a"
                "apellidos" => "Cebollero Presmanes"
              ]
              5 => array:2 [
                "nombre" => "Javier"
                "apellidos" => "de Miguel D&#237;ez"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1579212913002073"
          "doi" => "10.1016/j.arbr.2013.12.001"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212913002073?idApp=UINPBA00003Z"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289613001804?idApp=UINPBA00003Z"
      "url" => "/03002896/0000005000000001/v1_201401160024/S0300289613001804/v1_201401160024/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1579212913002115"
    "issn" => "15792129"
    "doi" => "10.1016/j.arbr.2013.12.005"
    "estado" => "S300"
    "fechaPublicacion" => "2014-01-01"
    "aid" => "794"
    "copyright" => "SEPAR"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "crp"
    "cita" => "Arch Bronconeumol. 2014;50:42-3"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 2668
      "formatos" => array:3 [
        "EPUB" => 123
        "HTML" => 1907
        "PDF" => 638
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case Report</span>"
      "titulo" => "Bronchovascular Reconstruction With a Bovine Pericardial Conduit and Surgical Reintervention Due to Thrombosis With Revascularisation"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "42"
          "paginaFinal" => "43"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Reconstrucci&#243;n broncovascular con conducto de pericardio bovino y reintervenci&#243;n quir&#250;rgica por trombosis con revascularizaci&#243;n"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 479
              "Ancho" => 1400
              "Tamanyo" => 89688
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">&#40;a&#41; Chest X-ray four days after left lower lobectomy&#46; Alveolar infiltrate can be seen in the remaining lung&#46; &#40;b&#41; Low uptake can be seen on the axial slice of the CT in the left pulmonary artery suggestive of thrombus and changes in lung parenchyma related with interstitial edema&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Emilio Pe&#241;a, Montserrat Blanco, Teresa Otero"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Emilio"
              "apellidos" => "Pe&#241;a"
            ]
            1 => array:2 [
              "nombre" => "Montserrat"
              "apellidos" => "Blanco"
            ]
            2 => array:2 [
              "nombre" => "Teresa"
              "apellidos" => "Otero"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0300289613001841"
        "doi" => "10.1016/j.arbres.2013.05.011"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289613001841?idApp=UINPBA00003Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212913002115?idApp=UINPBA00003Z"
    "url" => "/15792129/0000005000000001/v1_201402160026/S1579212913002115/v1_201402160026/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1579212913002097"
    "issn" => "15792129"
    "doi" => "10.1016/j.arbr.2013.12.003"
    "estado" => "S300"
    "fechaPublicacion" => "2014-01-01"
    "aid" => "811"
    "copyright" => "SEPAR"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Arch Bronconeumol. 2014;50:34-9"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 5696
      "formatos" => array:3 [
        "EPUB" => 145
        "HTML" => 4771
        "PDF" => 780
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Special Article</span>"
      "titulo" => "Respiratory Health in Latin America&#58; Number of Specialists and Human Resources Training"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "34"
          "paginaFinal" => "39"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Salud respiratoria en Am&#233;rica Latina&#58; n&#250;mero de especialistas y formaci&#243;n de recursos humanos"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1008
              "Ancho" => 1657
              "Tamanyo" => 152093
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Proportion of pulmonologists&#47;100<span class="elsevierStyleHsp" style=""></span>000 inhabitants in 19 countries in Latin America and the Caribbean&#46; Spain&#44; United States&#44; mean European and UK proportions are included for comparison&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Juan-Carlos V&#225;zquez-Garc&#237;a, Jorge Salas-Hern&#225;ndez, Rogelio P&#233;rez Padilla, Mar&#237;a Montes de Oca"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Juan-Carlos"
              "apellidos" => "V&#225;zquez-Garc&#237;a"
            ]
            1 => array:2 [
              "nombre" => "Jorge"
              "apellidos" => "Salas-Hern&#225;ndez"
            ]
            2 => array:2 [
              "nombre" => "Rogelio"
              "apellidos" => "P&#233;rez Padilla"
            ]
            3 => array:2 [
              "nombre" => "Mar&#237;a"
              "apellidos" => "Montes de Oca"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0300289613002299"
        "doi" => "10.1016/j.arbres.2013.07.011"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289613002299?idApp=UINPBA00003Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212913002097?idApp=UINPBA00003Z"
    "url" => "/15792129/0000005000000001/v1_201402160026/S1579212913002097/v1_201402160026/en/main.assets"
  ]
  "en" => array:18 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case Report</span>"
    "titulo" => "Pulmonary Veno-Occlusive Disease in a Female Gardener"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "40"
        "paginaFinal" => "41"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Paula Rodr&#237;guez Rodr&#237;guez, Fernando Pedraza Serrano, Liliana Patricia Mor&#225;n Caicedo, Maria Carmen Rodr&#237;guez de Guzm&#225;n, Mar&#237;a Cebollero Presmanes, Javier de Miguel D&#237;ez"
        "autores" => array:6 [
          0 => array:3 [
            "nombre" => "Paula"
            "apellidos" => "Rodr&#237;guez Rodr&#237;guez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Fernando"
            "apellidos" => "Pedraza Serrano"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Liliana Patricia"
            "apellidos" => "Mor&#225;n Caicedo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Maria Carmen"
            "apellidos" => "Rodr&#237;guez de Guzm&#225;n"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Mar&#237;a"
            "apellidos" => "Cebollero Presmanes"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          5 => array:4 [
            "nombre" => "Javier"
            "apellidos" => "de Miguel D&#237;ez"
            "email" => array:1 [
              0 => "jmiguel&#46;hgugm&#64;salud&#46;madrid&#46;org"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de Neumolog&#237;a&#44; Hospital General Universitario Gregorio Mara&#241;&#243;n&#44; IiSGM&#44; Universidad Complutense de Madrid&#44; Madrid&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Departamento de Anatom&#237;a Patol&#243;gica&#44; Hospital General Universitario Gregorio Mara&#241;&#243;n&#44; Madrid&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Enfermedad pulmonar venooclusiva en una mujer jardinera"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Fig&#46; 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 510
            "Ancho" => 1400
            "Tamanyo" => 179327
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Pulmonary parenchyma with&#58; &#40;A&#41; Passive capillary congestion and foci of hematic extravasation&#46; &#40;B&#41; Medium caliber vessel with thickened wall due to fibrous proliferation of the tunica media&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Pulmonary veno-occlusive disease &#40;PVOD&#41; is an entity that occurs infrequently among a group of conditions causing pulmonary arterial hypertension &#40;PAH&#41;&#46; Risk factors include exposure to toxins&#44; such as anorexigens and some chemotherapeutic agents&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Exposure to naturally occurring pyrrolizidine alkaloids has until now only been related with hepatic veno-occlusive disease&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> We present a case of PVOD in a female gardener&#44; with a slow and complicated course and late diagnosis of the disease&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Clinical Case</span><p id="par0010" class="elsevierStylePara elsevierViewall">Female&#44; 51 years of age&#44; ex-smoker&#44; working as a gardener&#44; seen in another center for progressive dyspnea and dry cough which began 8 months previously&#46; Initial spirometry showed severe obstructive disease&#46; Bilateral pseudonodular opacities were seen on simple chest X-ray&#46; Computed tomography &#40;CT&#41; of the chest revealed patchy&#44; bilateral ground-glass opacities tending to converge in the upper lobes&#44; with areas of consolidation in the right middle and lower lobes&#44; and nodular images of up to 1<span class="elsevierStyleHsp" style=""></span>cm in diameter &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; In view of these findings&#44; fiberoptic bronchoscopy was performed&#44; giving negative cytology and microbiology results&#46; Transbronchial biopsy did not provide any significant findings&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Wide-spectrum antibiotics&#44; antifungals and high-dose systemic corticosteroids were subsequently started&#44; but respiratory function continued to decline&#46; Transthoracic ultrasound was then requested&#44; showing severe pulmonary hypertension &#40;pulmonary artery systolic pressure 95<span class="elsevierStyleHsp" style=""></span>mmHg&#41;&#44; dilation and slightly reduced right ventricular systolic function and mild-to-moderate tricuspid insufficiency&#46; Thromboembolic disease was ruled out on a repeat chest CT scan&#44; although in this examination&#44; progression of pulmonary interstitial involvement was observed&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The patient&#39;s condition continued to worsen&#44; so she was transferred to our center and admitted to the intensive care unit&#44; where progression of the lung lesions was confirmed by radiology&#46; A lung biopsy was performed by thoracotomy&#44; but the patient could not be extubated after the procedure and died a few days later&#46; Autopsy showed signs of severe pulmonary hypertension&#44; with peripheral areas of ischemic infarction and foci of interstitial fibrosis&#8211;all compatible with PVOD &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0025" class="elsevierStylePara elsevierViewall">PVOD is an uncommon and underdiagnosed manifestation that is frequently misclassified among the group of idiopathic PAHs &#40;IPAHs&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Early diagnosis is important&#44; due to its poor prognosis and poor response to pulmonary vasodilators&#44; which can cause severe pulmonary edema&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">In contrast to IPAH&#44; which is associated with mainly precapillary involvement&#44; the physiopathological effect of PVOD is to produce lesions in the post-capillary pulmonary vessels&#46; There is media hypertrophy and intimal fibrosis&#44; causing occlusion of the vascular lumen&#46; Muscle cell proliferation&#44; calcium accumulation in the vascular wall&#44; thrombotic occlusion of the microvessels and occult pulmonary hemorrhage due to post-capillary blockage are also often observed&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Diagnosis is complicated by a clinical presentation similar to that of IPAH&#46; The most common symptom is progressively increasing dyspnea&#46; There may be mild hemoptysis and chronic cough&#46; When pulmonary hypertension is severe&#44; cyanosis&#44; chest pain or syncope with exercise may be observed&#46; Infrequent presentations include diffuse alveolar hemorrhage and sudden death&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Open lung biopsy is the reference test for diagnosis&#46; However&#44; it must be taken into account that while histological proof is needed for diagnosis&#44; the risks presented to patients by this procedure limit its extensive use&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The diffusing capacity of carbon monoxide is usually reduced&#44; and in most cases ventilation is restricted&#46; Hypoxemia is more severe than in IPAH&#44; since it is negatively affected by pulmonary edema&#44; alveolar hemorrhage and extensive vascular obstruction due to fibrosis&#46; The most frequent findings on CT are centrilobular ground-glass opacities&#44; septal lines and mediastinal lymphadenopathies&#46; Pleural effusion may occur in the final stages of the disease&#46; Hemosiderin-laden macrophages may be found in bronchoalveolar lavage&#46; Transbronchial biopsy does not usually lead to a diagnosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;4</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">PVOD has a poorer prognosis than other forms of PAH&#46; The only curative treatment option is lung transplant&#46; Mean survival is 24 months from diagnosis and mortality usually is a result of severe right ventricular dysfunction and massive pulmonary edema&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Risk factors for this disease include BMPR2 gene mutations&#46; PVOD has also been associated with various connective tissue diseases&#46; Association with toxin exposure has also been documented&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;4</span></a> Although there have been cases of hepatic veno-occlusive disease due to inhalation of pyrrolizidine&#44; a naturally occurring alkaloid present in various trees and bushes&#44;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> until now&#44; no case of PVOD associated with this toxin has been reported&#46; Our patient was a gardener and may have been exposed to this type of agent&#44; although it cannot be definitively established that this was the cause of her disease&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:8 [
        0 => array:2 [
          "identificador" => "xres312890"
          "titulo" => "Abstract"
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec295986"
          "titulo" => "Keywords"
        ]
        2 => array:2 [
          "identificador" => "xres312889"
          "titulo" => "Resumen"
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec295985"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Clinical Case"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Discussion"
        ]
        7 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec295986"
          "palabras" => array:4 [
            0 => "Pulmonary veno-occlusive disease"
            1 => "Pulmonary arterial hypertension"
            2 => "Pulmonary edema"
            3 => "Open lung biopsy"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec295985"
          "palabras" => array:4 [
            0 => "Enfermedad pulmonar venooclusiva"
            1 => "Hipertensi&#243;n arterial pulmonar"
            2 => "Edema pulmonar"
            3 => "Biopsia pulmonar abierta"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Pulmonary veno-occlusive disease &#40;PVOD&#41; is a subgroup of pulmonary arterial hypertension with a poor prognosis&#46; The diagnosis is usually delayed and treatment options other than lung transplantation are unfortunately limited&#46; We report the case of a 51-year-old female gardener diagnosed with PVOD by open lung biopsy before her death&#46; Although there are many reported cases of hepatic veno-occlusive disease due to toxic agents present in nature&#44; such as pyrrolizidine alkaloid exposure&#44; to date this has not been linked to PVOD&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La enfermedad pulmonar venooclusiva es una forma infrecuente de hipertensi&#243;n arterial pulmonar y su pron&#243;stico es sombr&#237;o&#46; El diagn&#243;stico suele ser tard&#237;o y el &#250;nico tratamiento curativo en la actualidad es el trasplante pulmonar&#46; Presentamos el caso de una mujer jardinera de 51<span class="elsevierStyleHsp" style=""></span>a&#241;os cuyo diagn&#243;stico se obtuvo por biopsia pulmonar abierta realizada previamente a su fallecimiento&#46; Si bien existen casos reportados de enfermedad venooclusiva hep&#225;tica secundaria a agentes t&#243;xicos presentes en la naturaleza&#44; como el alcaloide pirrolizidina&#44; hasta el momento no se han relacionado con la enfermedad a nivel pulmonar&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Rodr&#237;guez Rodr&#237;guez P&#44; Pedraza Serrano F&#44; Mor&#225;n Caicedo LP&#44; Rodr&#237;guez de Guzm&#225;n MC&#44; Cebollero Presmanes M&#44; de Miguel D&#237;ez J&#46; Enfermedad pulmonar venooclusiva en una mujer jardinera&#46; Arch Bronconeumol&#46; 2014&#59;50&#58;40&#8211;41&#46;</p>"
      ]
    ]
    "multimedia" => array:2 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 655
            "Ancho" => 899
            "Tamanyo" => 114363
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Chest computed tomography showing a bilateral ground-glass pattern&#44; with areas of consolidation and bilateral pulmonary nodes of up to 1<span class="elsevierStyleHsp" style=""></span>cm in diameter&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Fig&#46; 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 510
            "Ancho" => 1400
            "Tamanyo" => 179327
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Pulmonary parenchyma with&#58; &#40;A&#41; Passive capillary congestion and foci of hematic extravasation&#46; &#40;B&#41; Medium caliber vessel with thickened wall due to fibrous proliferation of the tunica media&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:5 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pulmonary venooclusive disease&#58; clinical&#44; functional&#44; radiologic&#44; hemodynamic characteristics and outcome of 24 cases confirmed by histology"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46; Montani"
                            1 => "L&#46; Achouch"
                            2 => "P&#46; Dorfmuller"
                            3 => "J&#46; le Pavec"
                            4 => "B&#46; Sztrymf"
                            5 => "Tch&#233;rakian"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Medicine &#40;Baltimore&#41;"
                        "fecha" => "2008"
                        "volumen" => "87"
                        "paginaInicial" => "220"
                        "paginaFinal" => "233"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "An epidemic of veno-occlusive disease of liver in central India"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "B&#46;N&#46; Tandon"
                            1 => "H&#46;D&#46; Tandon"
                            2 => "R&#46;K&#46; Tandon"
                            3 => "M&#46; Narndranathan"
                            4 => "Y&#46;K&#46; Joshi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1976"
                        "volumen" => "2"
                        "paginaInicial" => "271"
                        "paginaFinal" => "272"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2569072"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Massive pulmonary edema and death after prostacyclin infusion in a patient with pulmonary veno-occlusive disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46;M&#46; Palmer"
                            1 => "L&#46;J&#46; Robinson"
                            2 => "A&#46; Wang"
                            3 => "J&#46;R&#46; Gossage"
                            4 => "T&#46; Bashore"
                            5 => "V&#46;F&#46; Tapson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1998"
                        "volumen" => "113"
                        "paginaInicial" => "237"
                        "paginaFinal" => "240"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9440597"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pulmonary veno-occlusive disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46; Montani"
                            1 => "L&#46;C&#46; Price"
                            2 => "P&#46; Dorfmuller"
                            3 => "L&#46; Achouch"
                            4 => "X&#46; Ja&#239;s"
                            5 => "A&#46; Ya&#239;ci"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/09031936.00090608"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2009"
                        "volumen" => "33"
                        "paginaInicial" => "189"
                        "paginaFinal" => "200"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19118230"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Herbal tea induced hepatic veno-occlusive disease&#58; quantification of toxic alkaloid exposure in adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "C&#46;R&#46; Kumana"
                            1 => "M&#46; Ng"
                            2 => "H&#46;L&#46; Lin"
                            3 => "W&#46; Ko"
                            4 => "P&#46;C&#46; Wu"
                            5 => "D&#46; Todd"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Gut"
                        "fecha" => "1985"
                        "volumen" => "26"
                        "paginaInicial" => "101"
                        "paginaFinal" => "104"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3965360"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15792129/0000005000000001/v1_201402160026/S1579212913002073/v1_201402160026/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "9347"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Case reports"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15792129/0000005000000001/v1_201402160026/S1579212913002073/v1_201402160026/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212913002073?idApp=UINPBA00003Z"
]
Share
Journal Information
Vol. 50. Issue 1.
Pages 40-41 (January 2014)
Visits
7510
Vol. 50. Issue 1.
Pages 40-41 (January 2014)
Case Report
Full text access
Pulmonary Veno-Occlusive Disease in a Female Gardener
Enfermedad pulmonar venooclusiva en una mujer jardinera
Visits
7510
Paula Rodríguez Rodrígueza, Fernando Pedraza Serranoa, Liliana Patricia Morán Caicedoa, Maria Carmen Rodríguez de Guzmána, María Cebollero Presmanesb, Javier de Miguel Díeza,
Corresponding author
jmiguel.hgugm@salud.madrid.org

Corresponding author.
a Servicio de Neumología, Hospital General Universitario Gregorio Marañón, IiSGM, Universidad Complutense de Madrid, Madrid, Spain
b Departamento de Anatomía Patológica, Hospital General Universitario Gregorio Marañón, Madrid, Spain
This item has received
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (2)
Abstract

Pulmonary veno-occlusive disease (PVOD) is a subgroup of pulmonary arterial hypertension with a poor prognosis. The diagnosis is usually delayed and treatment options other than lung transplantation are unfortunately limited. We report the case of a 51-year-old female gardener diagnosed with PVOD by open lung biopsy before her death. Although there are many reported cases of hepatic veno-occlusive disease due to toxic agents present in nature, such as pyrrolizidine alkaloid exposure, to date this has not been linked to PVOD.

Keywords:
Pulmonary veno-occlusive disease
Pulmonary arterial hypertension
Pulmonary edema
Open lung biopsy
Resumen

La enfermedad pulmonar venooclusiva es una forma infrecuente de hipertensión arterial pulmonar y su pronóstico es sombrío. El diagnóstico suele ser tardío y el único tratamiento curativo en la actualidad es el trasplante pulmonar. Presentamos el caso de una mujer jardinera de 51años cuyo diagnóstico se obtuvo por biopsia pulmonar abierta realizada previamente a su fallecimiento. Si bien existen casos reportados de enfermedad venooclusiva hepática secundaria a agentes tóxicos presentes en la naturaleza, como el alcaloide pirrolizidina, hasta el momento no se han relacionado con la enfermedad a nivel pulmonar.

Palabras clave:
Enfermedad pulmonar venooclusiva
Hipertensión arterial pulmonar
Edema pulmonar
Biopsia pulmonar abierta
Full Text
Introduction

Pulmonary veno-occlusive disease (PVOD) is an entity that occurs infrequently among a group of conditions causing pulmonary arterial hypertension (PAH). Risk factors include exposure to toxins, such as anorexigens and some chemotherapeutic agents.1 Exposure to naturally occurring pyrrolizidine alkaloids has until now only been related with hepatic veno-occlusive disease.2 We present a case of PVOD in a female gardener, with a slow and complicated course and late diagnosis of the disease.

Clinical Case

Female, 51 years of age, ex-smoker, working as a gardener, seen in another center for progressive dyspnea and dry cough which began 8 months previously. Initial spirometry showed severe obstructive disease. Bilateral pseudonodular opacities were seen on simple chest X-ray. Computed tomography (CT) of the chest revealed patchy, bilateral ground-glass opacities tending to converge in the upper lobes, with areas of consolidation in the right middle and lower lobes, and nodular images of up to 1cm in diameter (Fig. 1). In view of these findings, fiberoptic bronchoscopy was performed, giving negative cytology and microbiology results. Transbronchial biopsy did not provide any significant findings.

Fig. 1.

Chest computed tomography showing a bilateral ground-glass pattern, with areas of consolidation and bilateral pulmonary nodes of up to 1cm in diameter.

(0.11MB).

Wide-spectrum antibiotics, antifungals and high-dose systemic corticosteroids were subsequently started, but respiratory function continued to decline. Transthoracic ultrasound was then requested, showing severe pulmonary hypertension (pulmonary artery systolic pressure 95mmHg), dilation and slightly reduced right ventricular systolic function and mild-to-moderate tricuspid insufficiency. Thromboembolic disease was ruled out on a repeat chest CT scan, although in this examination, progression of pulmonary interstitial involvement was observed.

The patient's condition continued to worsen, so she was transferred to our center and admitted to the intensive care unit, where progression of the lung lesions was confirmed by radiology. A lung biopsy was performed by thoracotomy, but the patient could not be extubated after the procedure and died a few days later. Autopsy showed signs of severe pulmonary hypertension, with peripheral areas of ischemic infarction and foci of interstitial fibrosis–all compatible with PVOD (Fig. 2).

Fig. 2.

Pulmonary parenchyma with: (A) Passive capillary congestion and foci of hematic extravasation. (B) Medium caliber vessel with thickened wall due to fibrous proliferation of the tunica media.

(0.17MB).
Discussion

PVOD is an uncommon and underdiagnosed manifestation that is frequently misclassified among the group of idiopathic PAHs (IPAHs).1 Early diagnosis is important, due to its poor prognosis and poor response to pulmonary vasodilators, which can cause severe pulmonary edema.3

In contrast to IPAH, which is associated with mainly precapillary involvement, the physiopathological effect of PVOD is to produce lesions in the post-capillary pulmonary vessels. There is media hypertrophy and intimal fibrosis, causing occlusion of the vascular lumen. Muscle cell proliferation, calcium accumulation in the vascular wall, thrombotic occlusion of the microvessels and occult pulmonary hemorrhage due to post-capillary blockage are also often observed.

Diagnosis is complicated by a clinical presentation similar to that of IPAH. The most common symptom is progressively increasing dyspnea. There may be mild hemoptysis and chronic cough. When pulmonary hypertension is severe, cyanosis, chest pain or syncope with exercise may be observed. Infrequent presentations include diffuse alveolar hemorrhage and sudden death.

Open lung biopsy is the reference test for diagnosis. However, it must be taken into account that while histological proof is needed for diagnosis, the risks presented to patients by this procedure limit its extensive use.

The diffusing capacity of carbon monoxide is usually reduced, and in most cases ventilation is restricted. Hypoxemia is more severe than in IPAH, since it is negatively affected by pulmonary edema, alveolar hemorrhage and extensive vascular obstruction due to fibrosis. The most frequent findings on CT are centrilobular ground-glass opacities, septal lines and mediastinal lymphadenopathies. Pleural effusion may occur in the final stages of the disease. Hemosiderin-laden macrophages may be found in bronchoalveolar lavage. Transbronchial biopsy does not usually lead to a diagnosis.1,4

PVOD has a poorer prognosis than other forms of PAH. The only curative treatment option is lung transplant. Mean survival is 24 months from diagnosis and mortality usually is a result of severe right ventricular dysfunction and massive pulmonary edema.4

Risk factors for this disease include BMPR2 gene mutations. PVOD has also been associated with various connective tissue diseases. Association with toxin exposure has also been documented.1,4 Although there have been cases of hepatic veno-occlusive disease due to inhalation of pyrrolizidine, a naturally occurring alkaloid present in various trees and bushes,5 until now, no case of PVOD associated with this toxin has been reported. Our patient was a gardener and may have been exposed to this type of agent, although it cannot be definitively established that this was the cause of her disease.

References
[1]
D. Montani, L. Achouch, P. Dorfmuller, J. le Pavec, B. Sztrymf, Tchérakian, et al.
Pulmonary venooclusive disease: clinical, functional, radiologic, hemodynamic characteristics and outcome of 24 cases confirmed by histology.
Medicine (Baltimore), 87 (2008), pp. 220-233
[2]
B.N. Tandon, H.D. Tandon, R.K. Tandon, M. Narndranathan, Y.K. Joshi.
An epidemic of veno-occlusive disease of liver in central India.
Lancet, 2 (1976), pp. 271-272
[3]
S.M. Palmer, L.J. Robinson, A. Wang, J.R. Gossage, T. Bashore, V.F. Tapson.
Massive pulmonary edema and death after prostacyclin infusion in a patient with pulmonary veno-occlusive disease.
Chest, 113 (1998), pp. 237-240
[4]
D. Montani, L.C. Price, P. Dorfmuller, L. Achouch, X. Jaïs, A. Yaïci, et al.
Pulmonary veno-occlusive disease.
Eur Respir J, 33 (2009), pp. 189-200
[5]
C.R. Kumana, M. Ng, H.L. Lin, W. Ko, P.C. Wu, D. Todd.
Herbal tea induced hepatic veno-occlusive disease: quantification of toxic alkaloid exposure in adults.
Gut, 26 (1985), pp. 101-104

Please cite this article as: Rodríguez Rodríguez P, Pedraza Serrano F, Morán Caicedo LP, Rodríguez de Guzmán MC, Cebollero Presmanes M, de Miguel Díez J. Enfermedad pulmonar venooclusiva en una mujer jardinera. Arch Bronconeumol. 2014;50:40–41.

Copyright © 2013. SEPAR
Archivos de Bronconeumología
Article options
Tools

Are you a health professional able to prescribe or dispense drugs?