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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">TO detect the tumor marker carcinoembryonic antigen &#40;CEA&#41; in pleural lavage fluid taken during surgery from patients with pulmonary carcinoma without associated pleural effusion and assess its possible prognostic implications&#46;</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">A prospective&#44; observational study was undertaken to include consecutive patients who underwent surgical treatment for lung carcinoma in which pleural lavage was performed prior to closure of the thoracic cavity &#40;study group&#41;&#46; The same techniques and measurements were used in patients undergoing thoracotomy for benign disease &#40;control group&#41;&#46; The preoperative blood level of CEA was also quantified&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">In the study group&#44; the median CEA levels in blood and pleural lavage fluid were 2&#46;90 ng&#47;mL and 0&#46;40 ng&#47;mL respectively&#59; these figures are higher than those corresponding to the control group&#46; A CEA level of 0&#46;30 ng&#47;mL in pleural lavage fluid was established as a cutoff point&#44; based on the corresponding receiver operating characteristic curve&#44; with a sensitivity of 68&#46;4&#37; and a specificity of 35&#46;7&#37;&#46; A graph of survival in relation to this cutoff point revealed a statistically significant effect &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;05&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">It is possible to detect CEA in pleural lavage fluid from the thoracic cavity of patients with lung carcinoma&#46; The values obtained are higher than those found in fluid from patients without neoplastic disease&#44; and this parameter functions as an independent predictor of disease course&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Detectar el marcador tumoral ant&#237;geno carcinoembrionario &#40;CEA&#41; en lavados pleurales de pacientes con carcinoma pulmonar sin derrame pleural asociado&#44; en el momento de la cirug&#237;a&#44; a fin de estudiar sus posibles implicaciones pron&#243;sticas&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes Y M&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se trata de un estudio observacional prospectivo que recoge de forma consecutiva a los pacientes intervenidos de carcinoma pulmonar a los que se realiz&#243; lavado pleural de la cavidad tor&#225;cica al finalizar su apertura &#40;grupo de estudio&#41;&#46; Se practicaron la misma t&#233;cnica y medici&#243;n en pacientes toracotomizados por enfermeda-des benignas &#40;grupo control&#41;&#46; Tambi&#233;n se cuantific&#243; el valor del CEA sangu&#237;neo preoperatorio&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">El CEA &#40;mediana&#41; sangu&#237;neo en el grupo de estudio fue de 2&#44;90 ng&#47;ml y en el lavado pleural de 0&#44;40 ng&#47;ml&#44; cifras superiores a las correspondientes del grupo control&#46; Se estableci&#243; como punto de corte del CEA en el lavado pleural el valor de 0&#44;30 ng&#47;ml&#44; establecido seg&#250;n la curva de eficacia diagn&#243;stica correspondiente&#44; con una sensibilidad del 68&#44;4&#37; y una especificidad del 35&#44;7&#37;&#46; La gr&#225;fica de supervivencia en funci&#243;n de este punto de corte mostr&#243; significaci&#243;n estad&#237;stica &#40;p &#60; 0&#44;05&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Es posible detectar CEA en lavados pleurales de la cavidad tor&#225;cica en pacientes con carcinoma pulmonar&#44; con valores superiores a los encontrados en pacientes sin enfermedad neopl&#225;sica&#46; La medici&#243;n de dicho valor es un factor pron&#243;stico independiente en la evoluci&#243;n de la enfermedad&#46;</p>"
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Vol. 41. Issue 4.
Pages 185-188 (April 2005)
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Vol. 41. Issue 4.
Pages 185-188 (April 2005)
Original Articles
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Prognostic Value of the Carcinoembryonic Antigen Found in Pleural Lavage Fluid From Patients With Lung Carcinoma
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J.M. Galbis Caravajala,
Corresponding author
josegalbis@telepolis.com

Correspondence: Dr. J.M. Galbis Caravajal. Ayora, 35, 1.°, 1.a. 46018 Valencia. España
, S. Benlloch Carriónb, J. Sánchez Payác, J.J. Mafé Madueñoa, B. Baschwitz Gómeza, J.M. Rodríguez Paniaguaa
a Servicio de Cirugía Torácica, Hospital General Universitario de Alicante, Alicante, Spain
b Unidad de Investigación, Hospital General Universitario de Alicante, Alicante, Spain
c Unidad de Epidemiología, Hospital General Universitario de Alicante, Alicante, Spain
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Article information
Objective

TO detect the tumor marker carcinoembryonic antigen (CEA) in pleural lavage fluid taken during surgery from patients with pulmonary carcinoma without associated pleural effusion and assess its possible prognostic implications.

Patients and methods

A prospective, observational study was undertaken to include consecutive patients who underwent surgical treatment for lung carcinoma in which pleural lavage was performed prior to closure of the thoracic cavity (study group). The same techniques and measurements were used in patients undergoing thoracotomy for benign disease (control group). The preoperative blood level of CEA was also quantified.

Results

In the study group, the median CEA levels in blood and pleural lavage fluid were 2.90 ng/mL and 0.40 ng/mL respectively; these figures are higher than those corresponding to the control group. A CEA level of 0.30 ng/mL in pleural lavage fluid was established as a cutoff point, based on the corresponding receiver operating characteristic curve, with a sensitivity of 68.4% and a specificity of 35.7%. A graph of survival in relation to this cutoff point revealed a statistically significant effect (P<.05).

Conclusions

It is possible to detect CEA in pleural lavage fluid from the thoracic cavity of patients with lung carcinoma. The values obtained are higher than those found in fluid from patients without neoplastic disease, and this parameter functions as an independent predictor of disease course.

Key Words:
Carcinoembryonic antigen
Pleural lavage
Pulmonary carcinoma
Objetivo

Detectar el marcador tumoral antígeno carcinoembrionario (CEA) en lavados pleurales de pacientes con carcinoma pulmonar sin derrame pleural asociado, en el momento de la cirugía, a fin de estudiar sus posibles implicaciones pronósticas.

Pacientes Y Métodos

Se trata de un estudio observacional prospectivo que recoge de forma consecutiva a los pacientes intervenidos de carcinoma pulmonar a los que se realizó lavado pleural de la cavidad torácica al finalizar su apertura (grupo de estudio). Se practicaron la misma técnica y medición en pacientes toracotomizados por enfermeda-des benignas (grupo control). También se cuantificó el valor del CEA sanguíneo preoperatorio.

Resultados

El CEA (mediana) sanguíneo en el grupo de estudio fue de 2,90 ng/ml y en el lavado pleural de 0,40 ng/ml, cifras superiores a las correspondientes del grupo control. Se estableció como punto de corte del CEA en el lavado pleural el valor de 0,30 ng/ml, establecido según la curva de eficacia diagnóstica correspondiente, con una sensibilidad del 68,4% y una especificidad del 35,7%. La gráfica de supervivencia en función de este punto de corte mostró significación estadística (p < 0,05).

Conclusiones

Es posible detectar CEA en lavados pleurales de la cavidad torácica en pacientes con carcinoma pulmonar, con valores superiores a los encontrados en pacientes sin enfermedad neoplásica. La medición de dicho valor es un factor pronóstico independiente en la evolución de la enfermedad.

Palabras clave:
Antígeno carcinoembrionario
Lavado pleural
Carcinoma pulmonar
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Copyright © 2005. Sociedad Española de Neumología y Cirugía Torácica (SEPAR)
Archivos de Bronconeumología
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