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Prognostic Value of the Carcinoembryonic Antigen Found in Pleural Lavage Fluid From Patients With Lung Carcinoma
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"apellidos" => "Galbis Caravajal" "email" => array:1 [ 0 => "josegalbis@telepolis.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "S." "apellidos" => "Benlloch Carrión" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 2 => array:3 [ "nombre" => "J." "apellidos" => "Sánchez Payá" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] 3 => array:3 [ "nombre" => "J.J." "apellidos" => "Mafé Madueño" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 4 => array:3 [ "nombre" => "B." "apellidos" => "Baschwitz Gómez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 5 => array:3 [ "nombre" => "J.M." "apellidos" => "Rodríguez Paniagua" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Cirugía Torácica, Hospital General Universitario de Alicante, Alicante, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Unidad de Investigación, Hospital General Universitario de Alicante, Alicante, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Unidad de Epidemiología, Hospital General Universitario de Alicante, Alicante, Spain" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dr. J.M. Galbis Caravajal. Ayora, 35, 1.°, 1.<span class="elsevierStyleSup">a</span>. 46018 Valencia. España" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2004-06-08" "fechaAceptado" => "2004-10-26" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key Words" "identificador" => "xpalclavsec154015" "palabras" => array:3 [ 0 => "Carcinoembryonic antigen" 1 => "Pleural lavage" 2 => "Pulmonary carcinoma" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec154016" "palabras" => array:3 [ 0 => "Antígeno carcinoembrionario" 1 => "Lavado pleural" 2 => "Carcinoma pulmonar" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">TO detect the tumor marker carcinoembryonic antigen (CEA) in pleural lavage fluid taken during surgery from patients with pulmonary carcinoma without associated pleural effusion and assess its possible prognostic implications.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">A prospective, observational study was undertaken to include consecutive patients who underwent surgical treatment for lung carcinoma in which pleural lavage was performed prior to closure of the thoracic cavity (study group). The same techniques and measurements were used in patients undergoing thoracotomy for benign disease (control group). The preoperative blood level of CEA was also quantified.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">In the study group, the median CEA levels in blood and pleural lavage fluid were 2.90 ng/mL and 0.40 ng/mL respectively; these figures are higher than those corresponding to the control group. A CEA level of 0.30 ng/mL in pleural lavage fluid was established as a cutoff point, based on the corresponding receiver operating characteristic curve, with a sensitivity of 68.4% and a specificity of 35.7%. A graph of survival in relation to this cutoff point revealed a statistically significant effect (<span class="elsevierStyleItalic">P</span><.05).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">It is possible to detect CEA in pleural lavage fluid from the thoracic cavity of patients with lung carcinoma. The values obtained are higher than those found in fluid from patients without neoplastic disease, and this parameter functions as an independent predictor of disease course.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Detectar el marcador tumoral antígeno carcinoembrionario (CEA) en lavados pleurales de pacientes con carcinoma pulmonar sin derrame pleural asociado, en el momento de la cirugía, a fin de estudiar sus posibles implicaciones pronósticas.</p> <span class="elsevierStyleSectionTitle">Pacientes Y Métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se trata de un estudio observacional prospectivo que recoge de forma consecutiva a los pacientes intervenidos de carcinoma pulmonar a los que se realizó lavado pleural de la cavidad torácica al finalizar su apertura (grupo de estudio). Se practicaron la misma técnica y medición en pacientes toracotomizados por enfermeda-des benignas (grupo control). También se cuantificó el valor del CEA sanguíneo preoperatorio.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">El CEA (mediana) sanguíneo en el grupo de estudio fue de 2,90 ng/ml y en el lavado pleural de 0,40 ng/ml, cifras superiores a las correspondientes del grupo control. Se estableció como punto de corte del CEA en el lavado pleural el valor de 0,30 ng/ml, establecido según la curva de eficacia diagnóstica correspondiente, con una sensibilidad del 68,4% y una especificidad del 35,7%. La gráfica de supervivencia en función de este punto de corte mostró significación estadística (p < 0,05).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Es posible detectar CEA en lavados pleurales de la cavidad torácica en pacientes con carcinoma pulmonar, con valores superiores a los encontrados en pacientes sin enfermedad neoplásica. La medición de dicho valor es un factor pronóstico independiente en la evolución de la enfermedad.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:15 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Revisions in the International System for Staging Lung Cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "CF Mountain" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Chest" "fecha" => "1997" "volumen" => "11" "paginaInicial" => "1710" "paginaFinal" => "1717" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognostic value of cyfra 21-1, TPS and CEA in different histologic types of non-small cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B Nisman" 1 => "G Amir" 2 => "J Lafair" 3 => "N Heching" 4 => "O Lyass" 5 => "T Peretz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Cancer Res." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 4 | 3 | 7 |
| 2024 October | 30 | 22 | 52 |
| 2024 September | 28 | 15 | 43 |
| 2024 August | 44 | 38 | 82 |
| 2024 July | 22 | 21 | 43 |
| 2024 June | 34 | 22 | 56 |
| 2024 May | 33 | 29 | 62 |
| 2024 April | 20 | 32 | 52 |
| 2024 March | 19 | 14 | 33 |
| 2024 February | 20 | 27 | 47 |
| 2023 March | 3 | 3 | 6 |
| 2023 February | 13 | 21 | 34 |
| 2023 January | 16 | 30 | 46 |
| 2022 December | 21 | 31 | 52 |
| 2022 November | 17 | 39 | 56 |
| 2022 October | 21 | 48 | 69 |
| 2022 September | 22 | 31 | 53 |
| 2022 August | 20 | 45 | 65 |
| 2022 July | 20 | 46 | 66 |
| 2022 June | 17 | 39 | 56 |
| 2022 May | 16 | 42 | 58 |
| 2022 April | 20 | 38 | 58 |
| 2022 March | 17 | 37 | 54 |
| 2022 February | 17 | 35 | 52 |
| 2022 January | 17 | 47 | 64 |
| 2021 December | 15 | 36 | 51 |
| 2021 November | 12 | 49 | 61 |
| 2021 October | 53 | 41 | 94 |
| 2021 September | 39 | 51 | 90 |
| 2021 August | 41 | 34 | 75 |
| 2021 July | 18 | 38 | 56 |
| 2021 June | 18 | 50 | 68 |
| 2021 May | 16 | 31 | 47 |
| 2021 April | 21 | 63 | 84 |
| 2021 March | 24 | 27 | 51 |
| 2021 February | 10 | 22 | 32 |
| 2021 January | 9 | 19 | 28 |
| 2020 December | 7 | 23 | 30 |
| 2020 November | 9 | 18 | 27 |
| 2020 October | 8 | 8 | 16 |
| 2020 September | 6 | 8 | 14 |
| 2020 August | 11 | 20 | 31 |
| 2020 July | 14 | 21 | 35 |
| 2020 June | 8 | 12 | 20 |
| 2020 May | 12 | 20 | 32 |
| 2020 April | 9 | 15 | 24 |
| 2020 March | 10 | 18 | 28 |
| 2020 February | 13 | 22 | 35 |
| 2020 January | 17 | 18 | 35 |
| 2019 December | 16 | 17 | 33 |
| 2019 November | 16 | 15 | 31 |
| 2019 October | 4 | 9 | 13 |
| 2019 September | 12 | 9 | 21 |
| 2019 August | 15 | 13 | 28 |
| 2019 July | 6 | 14 | 20 |
| 2019 June | 3 | 9 | 12 |
| 2019 May | 9 | 13 | 22 |
| 2019 April | 38 | 31 | 69 |
| 2019 March | 14 | 21 | 35 |
| 2019 February | 8 | 11 | 19 |
| 2019 January | 4 | 6 | 10 |
| 2018 December | 6 | 19 | 25 |
| 2018 November | 6 | 14 | 20 |
| 2018 October | 15 | 24 | 39 |
| 2018 September | 4 | 8 | 12 |
| 2018 May | 2 | 0 | 2 |
| 2018 April | 7 | 8 | 15 |
| 2018 March | 6 | 3 | 9 |
| 2018 February | 6 | 11 | 17 |
| 2018 January | 3 | 6 | 9 |
| 2017 December | 4 | 7 | 11 |
| 2017 November | 6 | 7 | 13 |
| 2017 October | 5 | 5 | 10 |
| 2017 September | 3 | 7 | 10 |
| 2017 August | 7 | 10 | 17 |
| 2017 July | 3 | 4 | 7 |
| 2017 June | 7 | 12 | 19 |
| 2017 May | 6 | 8 | 14 |
| 2017 April | 1 | 2 | 3 |
| 2017 March | 2 | 4 | 6 |
| 2017 February | 3 | 4 | 7 |
| 2017 January | 3 | 3 | 6 |
| 2016 December | 10 | 11 | 21 |
| 2016 November | 12 | 6 | 18 |
| 2016 October | 18 | 9 | 27 |
| 2016 September | 8 | 10 | 18 |
| 2016 August | 7 | 4 | 11 |
| 2016 July | 3 | 5 | 8 |
| 2016 March | 5 | 0 | 5 |
| 2015 December | 2 | 0 | 2 |
| 2015 October | 37 | 1 | 38 |
| 2015 September | 39 | 12 | 51 |
| 2015 August | 29 | 10 | 39 |
| 2015 July | 39 | 6 | 45 |
| 2015 June | 31 | 4 | 35 |
| 2015 May | 48 | 7 | 55 |
| 2015 April | 33 | 10 | 43 |
| 2015 March | 24 | 11 | 35 |
| 2015 February | 25 | 3 | 28 |
| 2015 January | 22 | 6 | 28 |
| 2014 December | 30 | 7 | 37 |
| 2014 November | 26 | 5 | 31 |
| 2014 October | 39 | 9 | 48 |
| 2014 September | 21 | 3 | 24 |
| 2014 August | 34 | 8 | 42 |
| 2014 July | 35 | 9 | 44 |
| 2014 June | 45 | 7 | 52 |
| 2014 May | 48 | 10 | 58 |
| 2014 April | 47 | 3 | 50 |
| 2014 March | 53 | 7 | 60 |
| 2014 February | 52 | 8 | 60 |
| 2014 January | 56 | 6 | 62 |
| 2013 December | 31 | 10 | 41 |
| 2013 November | 37 | 5 | 42 |
| 2013 October | 42 | 8 | 50 |
| 2013 September | 41 | 13 | 54 |
| 2013 August | 31 | 8 | 39 |
| 2013 July | 42 | 10 | 52 |
| 2013 June | 24 | 4 | 28 |
| 2013 May | 29 | 6 | 35 |
| 2013 April | 19 | 9 | 28 |
| 2013 March | 8 | 2 | 10 |
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