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El trasplante pulmonar es un procedimiento que se va imcorporando día a día en nuestros hospitales. Por ello los aspectos relacionados con la técnica empleada tienen un gran interés. Las técnicas de preservación del injerto son importantes por la fragilidad del pulmón a la isquemia. En este trabajo se presentan las técnicas de preservación del injerto y los métodos para detectar la viabilidad pulmonar tras la preservación.
Pulmonary transplant is a new procedure which is being progressively introduced in our hospitals. Therefore, all technical aspects related with the procedure are of relevant clinical interest. Methods of lung preservation are specially important in view of the extreme sensitivity of the lung to ischemia. In this study we report the techniques of preservation and the procedures to detect the viability of the lung under preservation.
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Bibliografía
[1.]
L.S. Fragomeni, M.P. Kaye.
The Registry of the International Society for Heart Transplantation: Fifth Official Report 1988.
J Heart Transplant, 7 (1988), pp. 249-253
[2.]
B.A. Reichart, D. Novitzky, D.K.C. Cooper, M.S. Cunningham, A.G. Rose.
Successful orthotopic heart-lung transplantation in the baboon after five hours of cold ischemia with cardioplegia and Collins'solution.
J Heart Transplant, 6 (1987), pp. 15-22
[3.]
J.P. McGoldrick, J. Scott, A. Jamieson, R. Smyth, T. Higenbottam, J. Wallwork.
Early graft function following heart and lung transplantation.
Transplant Int, 2 (1989), pp. 68-72
[4.]
J.D. Cooper, F.G. Pearson, G.A. Patterson, et al.
Technique of successful lung transplantation in humans.
J Thorac Cardiovasc Surg, 93 (1987), pp. 173-181
[5.]
R.L. Hardesty, B.P. Griffith.
Procurement for combined heartlung transplantation. Bilateral thoracotomy with sternal transection, cardiopulmonary bypass, and profound hypothermia.
J Thorac Cardiovasc Surg, 89 (1985), pp. 795-799
[6.]
S.W. Jamieson, J. Baldwin, E.B. Stinson, et al.
Clinical heart-lung transplantation.
Transplantation, 37 (1984), pp. 81-84
[7.]
F. Robicsek, P.W. Sanger, F.H. Taylor.
Simple method of keeping the heart “alive” and functioning outside of the body for prolonged period.
Surgery, 53 (1963), pp. 525-530
[8.]
F. Robicsek, W. Tam, H.K. Daugherty, L.K. Robicsek.
The stabilized autoperfusing heart-lung perparation as a vehicle for extracorporeal perservation.
Transplant Proc, 1 (1969), pp. 834-839
[9.]
R.L. Hardesty, B.P. Griffith.
Autoperfusion of the heart and lungs for preservation during distant procurement.
J Thorac Cardiovasc Surg, 93 (1987), pp. 11-18
[10.]
G.B. Hajjar, L.H. Tolero-Pereyra, G.H. Mackenzie.
Twenty four hour heart-lung preservation and oxygen free radical scavengers.
Transplant Proc, 19 (1987), pp. 1342-1344
[11.]
R.S. Stuart, W.A. Baumgartner, Am Borkon, et al.
Successful 4-hour hypothermic lung storage wirg Euro-Collins solution: A simplified model assessing preservation.
J Heart Transplant, 3 (1984), pp. 346-350
[12.]
D.E. Paull, B.A. Keagy, E.J. Kron, B.R. Wilcox.
Reperfusion injury in the lung preserved for 24 hours.
Ann Thorac Surg, 47 (1989), pp. 187-192
[13.]
E. Canalis, J. Pac, W. Torre.
Valoración de la preservación pulmonar con pulmón de rata ex-vivo.
Jomadas sobre Trasplantes de Órganos y Tejidos. Bilbao, (1988),
[14.]
F.J. Veith, K. Richards.
Lung transplantation with simultaneous contralateral pulmonary artery ligation.
Surg Gynecol Obstet, 129 (1969), pp. 768-774
[15.]
F.J. Veith, S.S. Siegelman, J.C. Sougherty.
Long-term survival after lung autotransplantation and immediate contralateral pulmonary artery ligation.
Surg Gynecol Obstet, 133 (1971), pp. 425-432
[16.]
L.H. Toledo-Pereyra, R.M. Condie.
Lung transplantation. Hypothermic storage for 24 hours in a colloid hyperosmolar solution.
J Thorac Cardiovasc Durg, 76 (1978),
[17.]
C.A. Ross, R.F. Alves.
Preservation of canine lung for reimplantation using hypothermia and hyperbaric oxygen. Survival following contralateral pneumonectomy.
Thorax, 24 (1969), pp. 336-341
[18.]
B.A. Reitz, N.A. Burton, S.W. Jamieson, et al.
Heart and lung transplantation. Autotransplantation and allotransplantation in primates with extended survival.
J Thorac Cardiovasc Surg, 80 (1980), pp. 360-372
[19.]
T.P. Downing, A.M. Sadehi, W.A. Baumgartner, et al.
Acute physiological changes following heart-lung allotransplantation in dogs.
Ann Thorac Surg, 37 (1984), pp. 479-483
[20.]
S. Nakae, W.R. Webb, T. Theodorides, W.L. Sugg.
Respiratory function following cardiopulmonary dennervation in dog, cat and monkey.
Surg Gynecol Obstet, 125 (1967), pp. 1.285-1.292
[21.]
H. Reichenspurner, W. Ertel, B. Reichart, et al.
A new model for hetero-orthotopic heart-lung transplantation in the dog.
J Surg Res, 41 (1986), pp. 301-307
[22.]
T. Wahlers, A. Haverich, H.G. Fieguth, H.J. Schäfers, T. Takayama, H.G. Borst.
Flush-perfusion using Euro-Collins solution vs cooling by means of extracorporeal circulation in heart-lung preservation.
J Heart Transplant, 5 (1986), pp. 89-98
[23.]
K. Bando, S. Teramoto, M. Tago, et al.
Core-cooling, heartperfusion, lung-immersion technique provides successful cardiopulmonary preservation for heart-lung transplantation.
Ann Thorac Surg, 46 (1988), pp. 625-630
[24.]
M. Kaneko, N.J. Perrotta, J.G. Copeland.
A simple, working heart and lung transplant model for assessing preservation methods in the rabbit.
Transplantation, 46 (1988), pp. 624-626
[25.]
P.J. Asimacopoulos, F.A. Molokhia, C.A. Pegg, J.C. Norman.
Lung transplantation in the rat.
Transplant Proc, 3 (1971), pp. 583-585
[26.]
K.W. Marck, C.R.H. Wildevuur.
Lung transplantation in the rat: I-Technique and survival.
Ann Thorac Surg, 34 (1982), pp. 74-80
[27.]
J. Prop, M.G. Ehrie, J.D. Crapo, P. Nieuwenhuis, C.R.H. Wildevuur.
Reimplantation response in isografted rat lungs. Analysis of causal factors.
J Thorac Cardiovasc Surg, 87 (1984), pp. 702-711
[28.]
F. Shionozaki, T. Kondo, S. Fujimura, T. Nakada.
Technical establishment and detection of rejection in rat lung transplantation.
Transplant Proc, 17 (1985), pp. 244-247
[29.]
F.J. Veith, R. Crane, M. Torres, et al.
Effective preservation and transportation of lung transplants.
J Thorac Cardiovasc Surg, 72 (1976), pp. 97-105
[30.]
D.L. Modry, B.W. Walpoth, R.B. Cohen, et al.
Heart-lung preservation in the dog followed by lung transplantation: a new model for assessment of lung preservation.
J Heart Transplant, 2 (1983), pp. 287-298
[31.]
T.J. Locke, T.L. Hooper, P.A. Fleknell, C.G.A. McGregor.
Preservation of the lung. Comparison of topical cooling and cold crystalloid pulmonary perfusion.
J Thorac Cardiovasc Surg 1988;, 96 (1988),
[32.]
S.S. Siegelman, S.B.P. Sinha, F.J. Veith.
Pulmonary reimplantation response.
Ann Surg, 177 (1973), pp. 30-36
[33.]
T.W. Feeley, F.G. Mihm, T.P. Downing, et al.
The effect of hypothermic preservation of the heart and lungs on cardiorrespiratory function following canine heart-lung transplantation.
Ann Thorac Surg, 39 (1985), pp. 558-562
[34.]
K. Harada, T. Fukuda, K. Inoue.
Viability of canine lung after temporary ischemia under cooling.
An electron miscroscopy study. Eur Surg Res, 13 (1981), pp. 344-353
[35.]
W. Torre, M. Gómez-Fleitas, R. Ondiviela, J.M. Villar.
Effect du temps d’ischiémie sur le poumon préservé par prostaglandine E1: étude au microscope électronique.
Journées Présidentielles de la Société de Chirugie Thoracique et Cardio-Vasculaire de Langue Française, (1990),
[36.]
F.G. Mihm, T.W. Feeley, M.H. Rosenthal, F. Lewis.
Measurement of extravascular lung water in dogs using the thermal-green dye indicator dilution method.
Anesthesiology, 57 (1982), pp. 116-122
[37.]
K. Hino, J.B. Grogan, J.D. Hardy.
Viability of stored lungs.
Transplantation, 6 (1968), pp. 25-32
[38.]
E.W. Fonkalsrud, I. Higashijima, A.K. Sarwat, E. Arima, M. Sánchez.
Evaluation of pulmonary function in the ischemic, nonventilated canine lung.
Surgery, 76 (1974), pp. 527-532
[39.]
J.R. Benfield, R. Coon.
The role of the left atrial anastomosis in pulmonary reimplantation.
J Thorac Cardiovasc Surg, 53 (1967), pp. 676-684
[40.]
C.H.R. Wildevuur, H. Heemstra, G.J. Tammeling, et al.
Longterm observations of the changes in pulmonary arterial pressure after reimplantation of the canine lung.
J Thorac Cardiovasc Surg, 56 (1968), pp. 799-807
[41.]
P.A. Ebert, B.H. Hudson.
Pulmonary hemodynamics following lung autotransplantation: studies in unanesthetized dogs with the opposite pulmonary artery ligated.
J Thorac Cardiovasc Surg, 62 (1971), pp. 188-192
[42.]
M. Hachida, D.S.B. Hoon, D.L. Morton.
A comparison of Solutions for lung preservation using pulmonary alveolar type II cell viability.
Ann Thorac Surg, 45 (1988), pp. 643-646
[43.]
K.C. Weber, M.B. Visscher.
Metabolism of the isolated canine lung.
Amer J Physiol, 217 (1969), pp. 1.044-1.052
[44.]
P. von Wichert.
Studies on the metabolism of ischemic rabbit lungs. Conclusions for lung transplantation.
J Thorac Cardiovasc Surg, 63 (1972), pp. 284-291
[45.]
K. Shimada, W.D. Davidson, J.R. Benfield.
Metabolic changes in ischemic lungs for evaluation of graft viability.
J Thorac Cardiovasc Surg, 66 (1973), pp. 137-144
[46.]
J. Hoyer, L. Garbe, S. Delpierre, A. Prieur, G. Macquart-Moulin, M. Noirclerc.
Functional evaluation of the transplant lung after long-term preservation.
Respiration, 39 (1980), pp. 323-332
[47.]
A.B. Malik, M.B. Perlman, J.A. Cooper, T. Noonan, R. Bizios.
Pulmonary microvascular effects of arachidonic acid metabolites and their role in lung vascular injury.
Fed Proc, 44 (1985), pp. 36-42
[48.]
S. Moncada, J.E.R. Vane.
Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2 and prostacyclin.
Pharmacol Rev, 30 (1978), pp. 293-331
[49.]
P.J. Kadowitz, E.W. Spannhake, J.L. Levin, A.L. Hyman.
Differential actions of the prostaglandins on the pulmonary vascular bed.
Adv Prostaglandin & Thromboxane Res, 7 (1980), pp. 731-743
[50.]
A.W. Ford-Hutchinson.
Leukotrienes: their formation and role as inflammatory mediators.
Fed Proc, 44 (1985), pp. 25-29
[51.]
R.R. García-Szabo, M.B. Peterson, W.D. Watkins, R. Bizios, D.L. Kong, A.B. Malik.
Thromboxane generation after thrombin. Protective effect of thromboxane synthetase inhibition on lung fluid balance.
Cir Res, 53 (1983), pp. 214-222
[52.]
J.W. McDonald, M. Ali, E. Morgan, E.R. Townsend, J.D. Cooper.
Thromboxane synthesis by sources other than platelets in association with complement-induced pulmonary leukostasis and pulmonary hypertension in sheep.
Cir Res, 52 (1983), pp. 1-6
[53.]
P. Santillan-Doherty, A. Odor-Morales, R. Jasso-Victoria, et al.
Urinary thromboxane B2 as an indicator of acute rejection in lung allotransplantation.
Transplantation, 45 (1988), pp. 852-856
[54.]
A. Muskett, N.A. Burton, M. Grossman, W.A. Gay.
The rabbit autoperfusing heart-lung preparation.
J Surg Res, 44 (1988), pp. 104-108
[55.]
S. Chien, E.P. Todd, J.N. Diana, W.N. O’Connor.
A simple technique for multiorgan preservation.
J Thorac Cardiovasc Surg, 95 (1988), pp. 55-61
[56.]
M. Gómez-Fleitas, C. Moreno, M. Morales, et al.
A new technique for multiorgan harvesting in block and organ preservation by autoperfusion system for organ transplantation.
An experimental study. III Congress of the European Society for Organ Transplantation, (1987),
[57.]
B. Blades, H.C. Pierpont, A. Samadi, R.P. Hill.
The effect of experimental lung ischemia on pulmonary function.
Surg Forum, 4 (1953), pp. 255-260
[58.]
G.H. Stevens, M.M. Sánchez, G.L. Chapell.
Enhancement of lung preservation by prevention of lung collapse.
J Surg Res, 14 (1973), pp. 400-405
[59.]
F.J. Veith, S.B.P. Sinha, J.S. Graves, S.J. Boley, J.C. Dougherty.
Ischemic tolerance of the lung. The effect of ventilation and inflation.
J Thorac Cardiovasc Surg, 61 (1971), pp. 804-810
[60.]
P.A. Thomas, R.J. Buchmann.
Successful 20-hour preservation of ischemic canine lung by hypothermia combined with minimal ventilation.
J Thorac Cardiovasc Surg, 62 (1971), pp. 176-182
[61.]
L.H. Toledo-Pereyra, W.F. Northrup, E.D. Humphrey, J.S. Najarian.
Maintenance of lung viability for transplantation after long periods of hypothermic perfusion.
J Surg Res, 18 (1975), pp. 99-106
[62.]
F.O. Belzer, J.H. Southard.
Principles of solid-organ preservation by cold storage.
Transplantation, 45 (1988), pp. 673-676
[63.]
A. Haverich, W.C. Scott, S.W. Jamieson.
Twenty years of lung preservation: a review.
J Heart Transplant, 4 (1985), pp. 234-240
[64.]
G. Okaniwa, T. Nakada, M. Kawakami, et al.
Studies on the preservation of canine lung at subzero temperatures.
J Thorac Cardiovasc Surg, 65 (1973), pp. 180-186
[65.]
W.L. Joseph, D.L. Morton, P.C. Adkins.
Influence of ischemia and hypothermia on the ability of the transplanted primate lung to provide immediate and total respiratory support.
J Thorac Cardiovasc Surg, 62 (1971), pp. 752-762
[66.]
Y. Kondo, M.D. Turner, J.V. Cockrell, J.D. Hardy.
Ischemic tolerance of the canine autotransplanted lung.
Surgery, 76 (1974), pp. 447-453
[67.]
A. Harjula, J.C. Baldwin, N.E. Schumway.
Donor deep hypothermia or donor pretreatment with prostaglandin E1 and single pulmonary artery flush for heart-lung graft preservation: and experimental primate study.
Ann Thorac Surg, 46 (1988), pp. 553-555
[68.]
T.S. Lie, M. Ukikusa.
Significance of alkaline preservation Solutions in liver transplantation.
Transplant Proc, 16 (1984), pp. 134-137
[69.]
L.H. Toledo-Pereyra, T. Hau, R.L. Simmons, J.S. Najarian.
Lung preservation technique.
Ann Thorac Surg, 23 (1977), pp. 487-494
[70.]
E.S. Bücherl, P. Lesch, M. Nasseri, B.V. Prondzynski.
Lungenfunktionsstudien nach Homo and Autotransplantation bzw. Denervation der linken Lunge und anschliesseuder Unterbindung der rechten Pulmonalarterie.
Thorax Chirurgie, 11 (1964), pp. 540-554
[71.]
E. Mayer, T. Ueno, T. Oka, H. Oelert, G.A. Patterson.
A superior method of lung preservation.
Thorac Cardiovasc Surgeon, 38 (1990), pp. 112
[72.]
F.J. Veith.
Lung transplantation.
Surg Clin Morth Am, 58 (1978), pp. 357-364
[73.]
G.M. Collins, M. Bravo-Shugarman, P.I. Terasaki.
Kidney preservation for transplantation.
Initial perfusion and 30 hours ice storage. Lancet, 2 (1969), pp. 1.219-1.222
[74.]
S.A. Sacks, P.H. Petritsch, J.J. Kaufman.
Canine kidney preservation using a new perfusate.
Lancet, 1 (1973), pp. 1.024-1.028
[75.]
T.D. Starkey, N. Sakakibara, R.C. Hagberg, H.D. Razelaar, J.C. Baldwin, S.W. Jamieson.
Successful six-hour cardiopulmonary preservation with simple hypothermic crystalloid flush.
J Heart Transplant, 5 (1986), pp. 291-297
[76.]
T.W. Feeley, F.G. Mihm, T.P. Downing, et al.
Hypothermic preservation of the heart and lungs with Collins solution: Effect on cardiorrespiratory function folowing heart-lung allotransplantation in dogs.
Ann Thorac Surg, 41 (1986), pp. 301-306
[77.]
J.S. Ladowski, R.L. Hardesty, B.P. Griffith.
Protection of the heart-lung allograft during procurement.
J Heart Transplant, 3 (1984), pp. 351-354
[78.]
M. Hachida, D.L. Morton.
A new solution (UCLA formula) for lung preservation.
J Thorac Cardiovasc Surg, 97 (1989), pp. 513-520
[79.]
J.L. Whittenberger, M. McGregor, E. Berglund, H.G. Borst.
Influence of State of inflation of the lung on pulmonary vascular resistance.
J Appl Physiol, 15 (1960), pp. 878-882
[80.]
J.T. Castagna, E. Shors, J.R. Benfield.
The role of perfusion in lung preservation.
J Thorac Cardiovasc Surg, 63 (1972), pp. 521-526
[81.]
T.J. Otto, M. Trenkner, A. Stopczyk, M. Gawdzinski, B. Chelstowska.
Perfusion and ventilation of isolated canine lungs.
Thorax, 23 (1968), pp. 645-651
[82.]
O. Crosjean, M. Noirclerc, J.F. Duvinage, et al.
Mise au point d’un procédé simple de conservation du poumon assurant une reprise immediate de fonction aprés vingt-quatre heures d’ischémie.
Acta Chir Belg, 71 (1972), pp. 321-333
[83.]
A. Haverich, S. Aziz, W.C. Scott, S.W. Jamieson, N.E. Schumway.
Improved lung preservation using Euro-Collins solution for flushperfusion.
Thorac Cardiovasc Surgeon, 34 (1986), pp. 368-376
[84.]
G.J. Dusting, S. Moncada, J.R. Vane.
Recirculation of prostacyclin (PG I2 in the dog.
Br J Pharmacol, 64 (1978), pp. 315-320
[85.]
B.B. Weksler, C.W. Ley, E.A. Jaffe.
Stimulation of endothelial cell prostacyclin production by thrombin, trypsin, and the ionophore A23187.
J Clin Invest, 62 (1978), pp. 923-930
[86.]
J. Dodds.
Platelet function in animals.
Platelets: a multidisciplinary approach, pp. 45-90
[87.]
L.A. Boxer, J.M. Allen, M. Schmidt, M. Yoder, R.L. Baehner.
Inhibition of polymorphonuclear leukocyte adherence by prostaeyelin.
J Lab Clin Med, 95 (1980), pp. 672-678
[88.]
R. Gunther, C. Zaiss, R.H. Demling.
Pulmonary microvascular response to prostaeyelin (PG I2) infusion in unanesthetized sheep. Microvascular response to prostaglandin.
J Appl Physiol, 52 (1982), pp. 1.338-1.342
[89.]
M.E. Smith, R. Funther, C. Zaiss, R.H. Demling.
Prostaglandin. infusion and endotoxin-induced lung injury.
Arch Surg, 117 (1982), pp. 175-180
[90.]
K. Ueda, M. Hatanaka, S. Kyo, et al.
Effect of prostaeyelin analog on pulmonary edema in isolated heart-lung autoperfusion model.
J Heart Transplant, 6 (1987), pp. 155-161
[91.]
W. Klepetko, M.R. Müller, G. Khünl-Brady, et al.
Beneficial effect of iloprost on early pulmonary function after lung preservation with modified Eurocollins solution.
Thorac Cardiovasc Surgeon, 37 (1989), pp. 174-179
[92.]
T. Tyler, C. Leffler, R. Wallis, S. Cassin.
Effecs of prostaglandins of the Eseries on pulmonary and systemic circulations of newborn goats during normoxia and hypoxia.
Prostaglandins, 10 (1975), pp. 263-269
[93.]
R.L. Kinlough-Rathbone, M.A. Packham, J.F. Mustard.
The effect of prostaglandin E1 on platelet function in vitro and in vivo.
Br J Haematol, 19 (1970), pp. 559-571
[94.]
J. Szcrekelik, J.S. Dubiel, M. Mysik, Z. Pyzic, R. Krol, T. Horzela.
Effects of prostaglandin E1 on pulmonary circulation in patients with pulmonary hypertension.
Br Heart J, 40 (1978), pp. 1.397-1.401
[95.]
W.C. Shoemaker, P.L. Appel.
Effects of prostaglandin E, in adult respiratory distress syndrome.
Surgery, 99 (1986), pp. 275-282
[96.]
J.W. Holcroft, M.J. Vassar, C.J. Weber, E. Prostaglandin.
and survival in partients with the adult rerspiratory distress syndrome. A prospective trial.
Ann Surg, 203 (1985), pp. 371-3778
[97.]
W. Torre.
Evaluación experimental de la utilización de prostaglandina E, en la preservación prolongada del pulmón para el transplante pulmonar.
Tesis Doctoral, (1989),
[98.]
P.M. McCarthy, V.A. Starnes, J. Theodore, E.B. Stinson, P.E. Oyer, N.E. Shumway.
Improved survival after heart-lung transplantation.
J Thorac Cardiovasc Surg, 99 (1990), pp. 54-60
[100.]
J. Nakano, B. Cole.
Effects of prostaglandins E1 and F2alpha on systemic, pulmonary and splanchnic circulations in dogs.
Amer J Physiol, 217 (1969), pp. 222-227
[101.]
A.C. Issekutz, H.Z. Movat.
The effect of vasodilatador prostaglandins on polymorphonuclear leukocyte infiltration and vascular injury.
Am J Pathol, 107 (1982), pp. 300-309
[102.]
B. Samuelsson.
Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation.
Science, 220 (1983), pp. 568-575
[103.]
C.E. Ganote, J.P. Kaltenbach.
Oxygeninduced enzyme release: early events and a proposed mechanism.
J Mol Cell Cardiol, 11 (1979), pp. 389-406
[104.]
C. Guarnieri, F. Flamigni, C.M. Caldarera.
Role of oxygen in the cellular damage induced by re-oxygenation of hypoxic heart.
J Moll Cell Cardiol, 12 (1980), pp. 797-808
[105.]
Y. Gauduel, M.A. Dunelleroy.
Role of oxygen radicals in cardiac injury due to reoxygenation.
J Moll Cell Cardiol, 16 (1984), pp. 459-470
[106.]
J.M. McCord.
Oxygenderived free radicals in postischemic tissue injury.
N Engl J Med, 312 (1985), pp. 159-163
[107.]
D.W. Granger, G. Rutili, J.M. McCord.
Superoxide radicals in feline intestinal ischemia.
Gastroenterology, 81 (1981), pp. 22-29
[108.]
B. Takayama, A. Auerswald, H.J. Schafers, L. Dammenhayn, A. Haverich.
The protective effect of superoxide dismutase during reperfusion of the ischemic lung.
Transplant Proc, 19 (1987), pp. 1.332-1.333
[109.]
R.M. Tate, K.M. Vanbenthuysen, D.M. Shasby, I.F. McMurtry, J.E. Repine.
Oxygenradical mediated permeability edema and vasoconstriction in isolated perfused rabbit lungs.
Am Rev Respir Dis, 126 (1982), pp. 802-806
[110.]
S.J. Weiss, J. Young, A.F. Lobuglio, A. Slivka, N.F. Nimeh.
Role of hydrogen peroxide in neutrophil-mediated destruction of cultured endothelial cells.
J Clin Invest, 68 (1981), pp. 714-721
[111.]
J.R. Stewart, E.B. Gerhardt, C.J. Wehr, et al.
Free radical scavengers and myocardial preservation during transplantation.
Ann Thorac Surg, 42 (1986), pp. 390-393
[112.]
L.H. Toledo-Pereyra, R.L. Simmons, J.S. Najarian.
Effect of allopurinol on the preservation of ischemic kidneys perfused with plasma or plasma substitutes.
Ann Surg, 180 (1974), pp. 780-782
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