Morfologia de la curva dosis-respuesta a la metacolina: diferencias entre sujetos asmaticos y normales

Pellicer Ciscar, C.; Perpiña Tordera, M.; Jorquera Nieto, J.I.; Marco Martinez, V.

doi:10.1016/S0300-2896(15)31963-3

Archivos de Bronconeumología

ISSN: 0300-2896

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Vol. 23. Issue 3.

Pages 128-132 (May - June 1987)

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Pages 128-132 (May - June 1987)

DOI: 10.1016/S0300-2896(15)31963-3

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Morfologia de la curva dosis-respuesta a la metacolina: diferencias entre sujetos asmaticos y normales

The shape of the dose-response curve to methacholine: differences between asthmatic and healthy subjects

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C. Pellicer Ciscar, M. Perpiña Tordera, J.I. Jorquera Nieto, V. Marco Martinez

Servicio de Neumología. Hospital La Fe. Valencia

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El objetivo del presente estudio ha sido analizar la morfología y posición de las curvas dosis-respuesta (CDR) a la metacolina. Con este motivo, hemos construido en 17 sujetos con asma leve y 10 sujetos normales, CDR completas a metacolina, buscando su mejor adaptación a las funciones matemáticas: linear, semilogarítmica, potencial y sigmoidea. En ambos grupos, el coeficiente de correlación más alto se obtuvo para la morfología sigmoidea, sin embargo, la posición de estas curvas en el eje de coordenadas fue distinta. El estudio de los diversos factores que determinan las diferencias existentes en las CDR entre sujetos normales y asmáticos, puede contribuir al mejor conocimiento de la patogenia de la hiperreactividad bronquial.

The aim of this study was to analyze the shape and position of the dose-response curves (CDR) to methacholine.

Complete dose-response curves to methacholine were built for 17 mild asthmatic and 10 healthy subjects, looking for the best possible fitting to one of the following mathematical models: lineal, semilogarythmic, potential and sigmoid. The highest correlation coefficient was obtained for sigmoid model in both groups. The curves showed however different positions when plotted in coordinate axis. The study of the several factors responsible for the differences of CDRs between asthmatic and healthy subjects may contribute to a better insight in the pathogenesis of bronchial hyperreactivity.

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