array:24 [
  "pii" => "S1579212915002876"
  "issn" => "15792129"
  "doi" => "10.1016/j.arbr.2015.08.002"
  "estado" => "S300"
  "fechaPublicacion" => "2015-10-01"
  "aid" => "1129"
  "copyright" => "SEPAR"
  "copyrightAnyo" => "2014"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "cor"
  "cita" => "Arch Bronconeumol. 2015;51:526-7"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 2229
    "formatos" => array:3 [
      "EPUB" => 122
      "HTML" => 1495
      "PDF" => 612
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0300289615000666"
      "issn" => "03002896"
      "doi" => "10.1016/j.arbres.2014.10.015"
      "estado" => "S300"
      "fechaPublicacion" => "2015-10-01"
      "aid" => "1129"
      "copyright" => "SEPAR"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "cor"
      "cita" => "Arch Bronconeumol. 2015;51:526-7"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 3315
        "formatos" => array:3 [
          "EPUB" => 125
          "HTML" => 2620
          "PDF" => 570
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta al Director</span>"
        "titulo" => "Linfadenitis granulomatosa mediast&#237;nica tras tratamiento con bacilo Calmette-Gu&#233;rin intravesical que simula met&#225;stasis distante de carcinoma vesical primario"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "526"
            "paginaFinal" => "527"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Mediastinal granulomatous lymphadenitis after intravesical bacillus Calmette-Guerin treatment mimicking distant metastasis of primary bladder carcinoma"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 551
                "Ancho" => 1452
                "Tamanyo" => 172213
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#41; Vista ecogr&#225;fica endobronquial de la lesi&#243;n sospechosa&#46; B&#41; Formaci&#243;n granulomatosa &#40;tinci&#243;n hematoxilina-eosina &#215;200&#41;&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Deniz Dogan, Murat Zor, Tuncer Ozkisa, Omer Ayten, Nuri Yigit, Ismail Yavas"
            "autores" => array:6 [
              0 => array:2 [
                "nombre" => "Deniz"
                "apellidos" => "Dogan"
              ]
              1 => array:2 [
                "nombre" => "Murat"
                "apellidos" => "Zor"
              ]
              2 => array:2 [
                "nombre" => "Tuncer"
                "apellidos" => "Ozkisa"
              ]
              3 => array:2 [
                "nombre" => "Omer"
                "apellidos" => "Ayten"
              ]
              4 => array:2 [
                "nombre" => "Nuri"
                "apellidos" => "Yigit"
              ]
              5 => array:2 [
                "nombre" => "Ismail"
                "apellidos" => "Yavas"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1579212915002876"
          "doi" => "10.1016/j.arbr.2015.08.002"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212915002876?idApp=UINPBA00003Z"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615000666?idApp=UINPBA00003Z"
      "url" => "/03002896/0000005100000010/v1_201509302001/S0300289615000666/v1_201509302001/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1579212915002815"
    "issn" => "15792129"
    "doi" => "10.1016/j.arbr.2015.07.007"
    "estado" => "S300"
    "fechaPublicacion" => "2015-10-01"
    "aid" => "1108"
    "copyright" => "SEPAR"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Arch Bronconeumol. 2015;51:527-8"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 1647
      "formatos" => array:3 [
        "EPUB" => 114
        "HTML" => 1080
        "PDF" => 453
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "Spirometry in Public Hospitals in Navarre&#46; A Comparative Analysis of the 3E Study"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "527"
          "paginaFinal" => "528"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "La espirometr&#237;a en la Neumolog&#237;a p&#250;blica en Navarra&#46; An&#225;lisis contrastado del estudio 3E"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Pilar Cebollero Rivas, Javier Hueto P&#233;rez de Heredia"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "Pilar Cebollero"
              "apellidos" => "Rivas"
            ]
            1 => array:2 [
              "nombre" => "Javier Hueto P&#233;rez"
              "apellidos" => "de Heredia"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0300289614004918"
        "doi" => "10.1016/j.arbres.2014.12.006"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289614004918?idApp=UINPBA00003Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212915002815?idApp=UINPBA00003Z"
    "url" => "/15792129/0000005100000010/v1_201509302252/S1579212915002815/v1_201509302252/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1579212915002827"
    "issn" => "15792129"
    "doi" => "10.1016/j.arbr.2015.07.008"
    "estado" => "S300"
    "fechaPublicacion" => "2015-10-01"
    "aid" => "1096"
    "copyright" => "SEPAR"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Arch Bronconeumol. 2015;51:525-6"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 2451
      "formatos" => array:3 [
        "EPUB" => 123
        "HTML" => 1740
        "PDF" => 588
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "Hematic Pleural Effusion in a 17-Year-Old Woman"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "525"
          "paginaFinal" => "526"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Derrame pleural hem&#225;tico en mujer de 17 a&#241;os de edad"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 683
              "Ancho" => 995
              "Tamanyo" => 191688
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Image of the thoracic cavity during autopsy&#58; multiple nodular neoplastic implants are seen in the visceral pleura&#44; along with a moderate amount of serous&#44; bloody pleural fluid&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Eva V&#225;zquez-Gandullo, Jos&#233; Manuel Bravo Nieto, Michael Alwakil Olbah"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Eva"
              "apellidos" => "V&#225;zquez-Gandullo"
            ]
            1 => array:2 [
              "nombre" => "Jos&#233; Manuel"
              "apellidos" => "Bravo Nieto"
            ]
            2 => array:2 [
              "nombre" => "Michael"
              "apellidos" => "Alwakil Olbah"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0300289614004621"
        "doi" => "10.1016/j.arbres.2014.11.013"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289614004621?idApp=UINPBA00003Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212915002827?idApp=UINPBA00003Z"
    "url" => "/15792129/0000005100000010/v1_201509302252/S1579212915002827/v1_201509302252/en/main.assets"
  ]
  "en" => array:16 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
    "titulo" => "Mediastinal Granulomatous Lymphadenitis After Intravesical Bacillus Calmette&#8211;Gu&#233;rin Treatment Mimicking Distant Metastasis of Primary Bladder Carcinoma"
    "tieneTextoCompleto" => true
    "saludo" => "To the Editor&#44;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "526"
        "paginaFinal" => "527"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Deniz Dogan, Murat Zor, Tuncer Ozkisa, Omer Ayten, Nuri Yigit, Ismail Savas"
        "autores" => array:6 [
          0 => array:3 [
            "nombre" => "Deniz"
            "apellidos" => "Dogan"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          1 => array:4 [
            "nombre" => "Murat"
            "apellidos" => "Zor"
            "email" => array:1 [
              0 => "murat804&#64;yahoo&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Tuncer"
            "apellidos" => "Ozkisa"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Omer"
            "apellidos" => "Ayten"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Nuri"
            "apellidos" => "Yigit"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Ismail"
            "apellidos" => "Savas"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:4 [
          0 => array:3 [
            "entidad" => "Department of Pulmonary Diseases&#44; Gulhane Military Hospital&#44; Ankara&#44; Turkey"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Department of Pulmonary Diseases&#44; Gulhane Military Hospital&#44; Istanbul&#44; Turkey"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Department of Pathology&#44; Gulhane Military Hospital&#44; Ankara&#44; Turkey"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Department of Pulmonary Diseases&#44; Ankara University Medical Faculty&#44; Ankara&#44; Turkey"
            "etiqueta" => "d"
            "identificador" => "aff0020"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Linfadenitis granulomatosa mediast&#237;nica tras tratamiento con bacilo Calmette&#8211;Gu&#233;rin intravesical que simula met&#225;stasis distante de carcinoma vesical primario"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 551
            "Ancho" => 1452
            "Tamanyo" => 175326
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Endobronchial ultrasound view of the suspicious lesion&#46; &#40;B&#41; Granulomatous formation &#40;hematoxylin&#8211;eosin staining &#215;200&#41;&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 38-year-old man was admitted to our department with a 1-month history of chest pain and sensitivity that had gradually worsened in the previous few days&#46; Systemic examination and vital signs were normal&#46; His medical record indicated a history of asymptomatic microscopic hematuria diagnosed as bladder carcinoma 3 years previously&#46; He had completed 16 cycles of bacillus Calmette&#8211;Gu&#233;rin &#40;BCG&#41; approximately 16 months earlier&#46; A whole body bone scan was performed to rule out distance metastasis in the chest wall&#44; but after detecting increased activity at the level of the 5th rib&#44; we decided to perform whole body positron emission tomography&#47;computed tomography &#40;PET&#47;CT&#41; with <span class="elsevierStyleSup">18</span>F-fluoro-2-deoxy-<span class="elsevierStyleSmallCaps">d</span>-glucose &#40;<span class="elsevierStyleSup">18</span>F-FDG PET&#47;CT&#41;&#46; This revealed increased activity &#40;SUV<span class="elsevierStyleInf">max</span>&#58; 5&#46;6&#41; in lymph node station 11L&#44; in the left hilar region&#46; Although the preliminary diagnosis had been primary bladder carcinoma metastasis&#44; histological analysis of the samples obtained by endobronchial ultrasound-guided fine needle aspiration &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41; revealed granulomatous lymphadenitis &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46; The patient therefore received empirical quadruple pharmacological tuberculosis treatment&#44; consisting of isoniazide &#40;300<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#41;&#44; rifampicin &#40;600<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#41;&#44; ethambutol &#40;800<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#41; and pyrazinamide &#40;1<span class="elsevierStyleHsp" style=""></span>g&#47;day&#41; for 6 months&#46; Follow-up PET performed 6 months later showed a decrease in FDG uptake &#40;SUV<span class="elsevierStyleInf">max</span>&#58; 1&#46;1&#41; compared to previous levels&#46; The patient did not report any discomfort at his 1-year check-up&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">BCG is an important adjuvant treatment option for reducing the risk of recurrence and progression of bladder carcinoma&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> Although rare&#44; intravesical BCG treatment can present systemic and localized complications&#46; Most localized adverse effects are generally self-limiting&#44; and include hematuria&#44; dysuria&#44; cystitis&#44; prostatitis&#44; and orchitis&#46; Systemic adverse effects&#44; however&#44; are less common&#44; and can range from simple febricula to potentially fatal multi-organ failure&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Several cases of pulmonary or extra-pulmonary granulomatous lymphadenitis secondary to BCG instillation have been described in the English-language literature&#46; However&#44; there is considerable debate on whether the infectious complications secondary to BCG are due to a hypersensitivity reaction or to active infection&#46; Some studies have found viable bacteria in different tissues&#44; such as the lung&#44; pancreas and liver&#44; suggesting active infection&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">3&#44;4</span></a> The hypersensitivity hypothesis&#44; meanwhile&#44; is supported by studies in which microorganisms could not be isolated&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> This was the case in our patient&#44; as we were unable to demonstrate the presence of acid-fast bacilli in 3 sputum samples and 1 bronchoalveolar lavage sample&#59; culture results were also negative&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">In summary&#44; this case is of interest insofar as it illustrates a characteristic complication of intravesical BCG instillation&#46; We hope this report will highlight the importance of bearing in mind the different complications of intravesical BCG treatment&#44; even when there is clinical suspicion of BCG infection&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of interests</span><p id="par0025" class="elsevierStylePara elsevierViewall">The authors have no conflict of interests or funding to declare&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:2 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Conflict of interests"
        ]
        1 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Dogan D&#44; Zor M&#44; Ozkisa T&#44; Ayten O&#44; Yigit N&#44; Yavas I&#46; Linfadenitis granulomatosa mediast&#237;nica tras tratamiento con bacilo Calmette&#8211;Gu&#233;rin intravesical que simula met&#225;stasis distante de carcinoma vesical primario&#46; Arch Bronconeumol&#46; 2015&#59;51&#58;526&#8211;527&#46;</p>"
      ]
    ]
    "multimedia" => array:1 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 551
            "Ancho" => 1452
            "Tamanyo" => 175326
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Endobronchial ultrasound view of the suspicious lesion&#46; &#40;B&#41; Granulomatous formation &#40;hematoxylin&#8211;eosin staining &#215;200&#41;&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:5 [
            0 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Guideline for the management of nonmuscle invasive bladder cancer &#40;stages Ta&#44; T1&#44; and Tis&#41;&#58; 2007 update"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;C&#46; Hall"
                            1 => "S&#46;S&#46; Chang"
                            2 => "G&#46; Dalbagni"
                            3 => "R&#46;S&#46; Pruthi"
                            4 => "J&#46;D&#46; Seigne"
                            5 => "E&#46;C&#46; Skinner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.juro.2007.09.003"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Urol"
                        "fecha" => "2007"
                        "volumen" => "178"
                        "paginaInicial" => "2314"
                        "paginaFinal" => "2330"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17993339"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mycobacterial infection after intravesical bacillus Calmette&#8211;Gu&#233;rin treatment for bladder cancer&#58; a case report"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "C&#46;H&#46; Park"
                            1 => "M&#46;A&#46; Jang"
                            2 => "Y&#46;H&#46; Ahn"
                            3 => "Y&#46;Y&#46; Hwang"
                            4 => "C&#46;S&#46; Ki"
                            5 => "N&#46;Y&#46; Lee"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3343/kjlm.2011.31.3.197"
                      "Revista" => array:6 [
                        "tituloSerie" => "Korean J Lab Med"
                        "fecha" => "2011"
                        "volumen" => "31"
                        "paginaInicial" => "197"
                        "paginaFinal" => "200"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21779195"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Miliary <span class="elsevierStyleItalic">Mycobacterium bovis</span> induced by intravesical bacille Calmette&#8211;Gu&#233;rin immunotherapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "C&#46; McParland"
                            1 => "D&#46;J&#46; Cotton"
                            2 => "K&#46;S&#46; Gowda"
                            3 => "V&#46;H&#46; Hoeppner"
                            4 => "W&#46;T&#46; Martin"
                            5 => "P&#46;F&#46; Weckworth"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm/146.5_Pt_1.1330"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1992"
                        "volumen" => "146"
                        "paginaInicial" => "1330"
                        "paginaFinal" => "1333"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1443892"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Peritoneal tuberculosis and granulomatous hepatitis secondary to treatment of bladder cancer with bacillus Calmette&#8211;Gu&#233;rin"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Soylu"
                            1 => "A&#46;T&#46; Ince"
                            2 => "H&#46; Polat"
                            3 => "N&#46; Yasar"
                            4 => "A&#46; Ciltas"
                            5 => "S&#46; Ozkara"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1476-0711-8-12"
                      "Revista" => array:5 [
                        "tituloSerie" => "Ann Clin Microbiol Antimicrob"
                        "fecha" => "2009"
                        "volumen" => "8"
                        "paginaInicial" => "12"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19368735"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Disseminated <span class="elsevierStyleItalic">Mycobacterium bovis</span> after intravesicular bacillus Calmette&#8211;Gu&#233;rin treatments for bladder cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Elkabani"
                            1 => "J&#46;N&#46; Greene"
                            2 => "A&#46;L&#46; Vincent"
                            3 => "S&#46; VanHook"
                            4 => "R&#46;L&#46; Sandin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Control"
                        "fecha" => "2000"
                        "volumen" => "7"
                        "paginaInicial" => "476"
                        "paginaFinal" => "481"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11000618"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15792129/0000005100000010/v1_201509302252/S1579212915002876/v1_201509302252/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "14576"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Letters to the editor"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15792129/0000005100000010/v1_201509302252/S1579212915002876/v1_201509302252/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212915002876?idApp=UINPBA00003Z"
]
Share
Journal Information
Vol. 51. Issue 10.
Pages 526-527 (October 2015)
Vol. 51. Issue 10.
Pages 526-527 (October 2015)
Letter to the Editor
Full text access
Mediastinal Granulomatous Lymphadenitis After Intravesical Bacillus Calmette–Guérin Treatment Mimicking Distant Metastasis of Primary Bladder Carcinoma
Linfadenitis granulomatosa mediastínica tras tratamiento con bacilo Calmette–Guérin intravesical que simula metástasis distante de carcinoma vesical primario
Visits
5978
Deniz Dogana, Murat Zora,
Corresponding author
murat804@yahoo.com

Corresponding author.
, Tuncer Ozkisaa, Omer Aytenb, Nuri Yigitc, Ismail Savasd
a Department of Pulmonary Diseases, Gulhane Military Hospital, Ankara, Turkey
b Department of Pulmonary Diseases, Gulhane Military Hospital, Istanbul, Turkey
c Department of Pathology, Gulhane Military Hospital, Ankara, Turkey
d Department of Pulmonary Diseases, Ankara University Medical Faculty, Ankara, Turkey
This item has received
Article information
Full Text
Bibliography
Download PDF
Statistics
Figures (1)
Full Text
To the Editor,

A 38-year-old man was admitted to our department with a 1-month history of chest pain and sensitivity that had gradually worsened in the previous few days. Systemic examination and vital signs were normal. His medical record indicated a history of asymptomatic microscopic hematuria diagnosed as bladder carcinoma 3 years previously. He had completed 16 cycles of bacillus Calmette–Guérin (BCG) approximately 16 months earlier. A whole body bone scan was performed to rule out distance metastasis in the chest wall, but after detecting increased activity at the level of the 5th rib, we decided to perform whole body positron emission tomography/computed tomography (PET/CT) with 18F-fluoro-2-deoxy-d-glucose (18F-FDG PET/CT). This revealed increased activity (SUVmax: 5.6) in lymph node station 11L, in the left hilar region. Although the preliminary diagnosis had been primary bladder carcinoma metastasis, histological analysis of the samples obtained by endobronchial ultrasound-guided fine needle aspiration (Fig. 1A) revealed granulomatous lymphadenitis (Fig. 1B). The patient therefore received empirical quadruple pharmacological tuberculosis treatment, consisting of isoniazide (300mg/day), rifampicin (600mg/day), ethambutol (800mg/day) and pyrazinamide (1g/day) for 6 months. Follow-up PET performed 6 months later showed a decrease in FDG uptake (SUVmax: 1.1) compared to previous levels. The patient did not report any discomfort at his 1-year check-up.

Fig. 1.

(A) Endobronchial ultrasound view of the suspicious lesion. (B) Granulomatous formation (hematoxylin–eosin staining ×200).

(0.17MB).

BCG is an important adjuvant treatment option for reducing the risk of recurrence and progression of bladder carcinoma.1 Although rare, intravesical BCG treatment can present systemic and localized complications. Most localized adverse effects are generally self-limiting, and include hematuria, dysuria, cystitis, prostatitis, and orchitis. Systemic adverse effects, however, are less common, and can range from simple febricula to potentially fatal multi-organ failure.2

Several cases of pulmonary or extra-pulmonary granulomatous lymphadenitis secondary to BCG instillation have been described in the English-language literature. However, there is considerable debate on whether the infectious complications secondary to BCG are due to a hypersensitivity reaction or to active infection. Some studies have found viable bacteria in different tissues, such as the lung, pancreas and liver, suggesting active infection.3,4 The hypersensitivity hypothesis, meanwhile, is supported by studies in which microorganisms could not be isolated.5 This was the case in our patient, as we were unable to demonstrate the presence of acid-fast bacilli in 3 sputum samples and 1 bronchoalveolar lavage sample; culture results were also negative.

In summary, this case is of interest insofar as it illustrates a characteristic complication of intravesical BCG instillation. We hope this report will highlight the importance of bearing in mind the different complications of intravesical BCG treatment, even when there is clinical suspicion of BCG infection.

Conflict of interests

The authors have no conflict of interests or funding to declare.

References
[1]
M.C. Hall, S.S. Chang, G. Dalbagni, R.S. Pruthi, J.D. Seigne, E.C. Skinner, et al.
Guideline for the management of nonmuscle invasive bladder cancer (stages Ta, T1, and Tis): 2007 update.
J Urol, 178 (2007), pp. 2314-2330
[2]
C.H. Park, M.A. Jang, Y.H. Ahn, Y.Y. Hwang, C.S. Ki, N.Y. Lee.
Mycobacterial infection after intravesical bacillus Calmette–Guérin treatment for bladder cancer: a case report.
Korean J Lab Med, 31 (2011), pp. 197-200
[3]
C. McParland, D.J. Cotton, K.S. Gowda, V.H. Hoeppner, W.T. Martin, P.F. Weckworth.
Miliary Mycobacterium bovis induced by intravesical bacille Calmette–Guérin immunotherapy.
Am Rev Respir Dis, 146 (1992), pp. 1330-1333
[4]
A. Soylu, A.T. Ince, H. Polat, N. Yasar, A. Ciltas, S. Ozkara, et al.
Peritoneal tuberculosis and granulomatous hepatitis secondary to treatment of bladder cancer with bacillus Calmette–Guérin.
Ann Clin Microbiol Antimicrob, 8 (2009), pp. 12
[5]
M. Elkabani, J.N. Greene, A.L. Vincent, S. VanHook, R.L. Sandin.
Disseminated Mycobacterium bovis after intravesicular bacillus Calmette–Guérin treatments for bladder cancer.
Cancer Control, 7 (2000), pp. 476-481

Please cite this article as: Dogan D, Zor M, Ozkisa T, Ayten O, Yigit N, Yavas I. Linfadenitis granulomatosa mediastínica tras tratamiento con bacilo Calmette–Guérin intravesical que simula metástasis distante de carcinoma vesical primario. Arch Bronconeumol. 2015;51:526–527.

Copyright © 2014. SEPAR
Archivos de Bronconeumología
Article options
Tools

Are you a health professional able to prescribe or dispense drugs?