array:23 [ "pii" => "S030028961530689X" "issn" => "03002896" "doi" => "10.1016/S0300-2896(15)30689-X" "estado" => "S300" "fechaPublicacion" => "1996-12-01" "aid" => "70759" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica" "copyrightAnyo" => "1996" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 1996;32:527-34" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 44155 "formatos" => array:3 [ "EPUB" => 90 "HTML" => 964 "PDF" => 43101 ] ] "itemSiguiente" => array:18 [ "pii" => "S0300289615306906" "issn" => "03002896" "doi" => "10.1016/S0300-2896(15)30690-6" "estado" => "S300" "fechaPublicacion" => "1996-12-01" "aid" => "70760" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 1996;32:535-40" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3164 "formatos" => array:3 [ "EPUB" => 96 "HTML" => 2001 "PDF" => 1067 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Libros publicados en España sobre tabaquismo" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "535" "paginaFinal" => "540" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "The publication of books on tobacco dependence in Spain" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "E. Guardiola, J. Sánchez-Carbonell" "autores" => array:2 [ 0 => array:2 [ "nombre" => "E." "apellidos" => "Guardiola" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Sánchez-Carbonell" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615306906?idApp=UINPBA00003Z" "url" => "/03002896/0000003200000010/v1_201506230103/S0300289615306906/v1_201506230103/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0300289615306888" "issn" => "03002896" "doi" => "10.1016/S0300-2896(15)30688-8" "estado" => "S300" "fechaPublicacion" => "1996-12-01" "aid" => "70758" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 1996;32:523-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1495 "formatos" => array:3 [ "EPUB" => 69 "HTML" => 686 "PDF" => 740 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Estudio comparativo de los niveles de receptor soluble de interleucina 2 y adenosín-desaminasa en líquidos pleurales tuberculosos y de otras etiologías" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "523" "paginaFinal" => "526" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Comparative assessment of soluble interleukin 2 receptor and adenosin-desaminase levels in pleural fluid of patients with tubercsulosis or other diseases" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:2 [ 0 => array:2 [ "autoresLista" => "M.J. Avilés Inglés, C. Contessotto" "autores" => array:2 [ 0 => array:2 [ "nombre" => "M.J." "apellidos" => "Avilés Inglés" ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Contessotto" ] ] ] 1 => array:2 [ "autoresLista" => "J. Ontañón, M. Muro, P. Berlinches, J. de la Torre, F. Sánchez Gascón, M.R. Álvarez López" "autores" => array:6 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Ontañón" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Muro" ] 2 => array:2 [ "nombre" => "P." "apellidos" => "Berlinches" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "de la Torre" ] 4 => array:2 [ "nombre" => "F." "apellidos" => "Sánchez Gascón" ] 5 => array:2 [ "nombre" => "M.R." "apellidos" => "Álvarez López" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615306888?idApp=UINPBA00003Z" "url" => "/03002896/0000003200000010/v1_201506230103/S0300289615306888/v1_201506230103/es/main.assets" ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Mecanismos de acción de los glucocorticoides. Aplicación al tratamiento de la inflamación respiratoria" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "527" "paginaFinal" => "534" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J. Mullol, L. Pujols, C. Picado" "autores" => array:3 [ 0 => array:3 [ "nombre" => "J." "apellidos" => "Mullol" "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "L." "apellidos" => "Pujols" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "C." "apellidos" => "Picado" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Neumología. Departament de Medicina. Universitat de Barcelona. Barcelona" "etiqueta" => "*" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Alergia Respiratoria. Fundació Clínic per a la Recerca Biomédica. Hospital Clínic i Universitari. Departament de Medicina. Universitat de Barcelona" "etiqueta" => "**" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia: Servicio de Neumología y Alergia Respiratoria. Hospital Clínic i Universitari. Villarroel, 170. 08036 Barcelona." ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1996-04-23" "fechaAceptado" => "1996-04-30" "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:83 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "On the constitutional and local effects of disease of the suprarenal capsules" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "T. Addison" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "1855" "editorial" => "Samuel Highley" "editorialLocalizacion" => "Londres" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Glucocorticosteroids. Their mechanisms of action and use in allergic diseases." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R.P. Schleimer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Allergy. Principies and Practice" "paginaInicial" => "893" "paginaFinal" => "925" "serieFecha" => "1993" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The basophil adenomas of the pituitary body and their clinical manifestations" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "H. Cushing" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Bull Johns Hopkins Hosp" "fecha" => "1932" "volumen" => "50" "paginaInicial" => "137" "paginaFinal" => "195" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chemistry of corticotrophin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "E.B. Astwood" 1 => "M.S. Raben" 2 => "R.W. Payne" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Recent Prog Horm Res" "fecha" => "1952" "volumen" => "7" "paginaInicial" => "1" "paginaFinal" => "57" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neural control of the pituitary gland" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G.W. Harris" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Physiol Rev" "fecha" => "1948" "volumen" => "28" "paginaInicial" => "139" "paginaFinal" => "179" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18865220" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and β-endorphin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "W. Vale" 1 => "J. Spiess" 2 => "C. Rivier" 3 => "J. Rivier" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Science" "fecha" => "1981" "volumen" => "213" "paginaInicial" => "1.394" "paginaFinal" => "1.397" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7268441" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effect of a hormone of the adrenal cortex (17-hydroxy-l1-dehydrocorticosterone; compound E) and of pituitary adrenocorticotropic hormone on rheumatoid arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P.S. Hensch" 1 => "E.C. Kendall" 2 => "C.H. Slocumb" 3 => "H.F. Polley" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Proc Staff Meet Mayo Clinic" "fecha" => "1949" "volumen" => "24" "paginaInicial" => "181" "paginaFinal" => "197" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adrenocorticotropic hormone: adrenocortical steroids and their synthetic analogs; inhibitor of the synthesis and actions of adrenocortical hormones" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P. Schimmer" 1 => "K.L. Parker" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Goodman & Gilman's the pharmacological basis of therapeutics" "paginaInicial" => "1.459" "paginaFinal" => "1.485" "serieFecha" => "1996" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Daily cortisol production rate in man determined by stable isotope dilution/mass spectrometry" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N.V. Esteban" 1 => "T. Loughlin" 2 => "A.L. Yergey" 3 => "J.K. Zawadzki" 4 => "J.D. Booth" 5 => "J.C. Winterer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/jcem-72-1-39" "Revista" => array:6 [ "tituloSerie" => "J Clin Endocrinol Metab" "fecha" => "1991" "volumen" => "72" "paginaInicial" => "39" "paginaFinal" => "45" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1986026" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efficacy and safety of inhaled corticosteroids in asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P.J. Barnes" 1 => "S. Pedersen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1993" "volumen" => "148" "paginaInicial" => "1" "paginaFinal" => "26" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fluticasone propionate: an update on preclinical and clinical experience" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R. Fuller" 1 => "M. Johnson" 2 => "A. Bye" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Resp Med" "fecha" => "1995" "volumen" => "89" "numero" => "Supl A" "paginaInicial" => "3" "paginaFinal" => "18" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Two signáis mediate hormone-dependent nuclear localization of the glucocorticoid receptor" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D. Picard" 1 => "K.R. Yamamoto" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "EMBO J" "fecha" => "1987" "volumen" => "6" "paginaInicial" => "3.333" "paginaFinal" => "3.340" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16453815" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intracellular localisation of the glucocorticoid receptor: evidence for cytoplasmic and nuclear localisation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A.C. Wikstrom" 1 => "O. Bakke" 2 => "S. Okret" 3 => "M. Brönnegärd" 4 => "J.A. Gustafsson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/endo-120-6-2529" "Revista" => array:6 [ "tituloSerie" => "Endocrinology" "fecha" => "1987" "volumen" => "120" "paginaInicial" => "1.232" "paginaFinal" => "1.242" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3569142" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The steroid and thyroid hormone receptor superfamily" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R.M. Evans" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Science" "fecha" => "1988" "volumen" => "247" "paginaInicial" => "889" "paginaFinal" => "895" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary structure and expression of a functional human glucocorticoid receptor cDNA" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S.M. Hollenberg" 1 => "C. Weinberger" 2 => "E.S. Ong" 3 => "G. Cerelli" 4 => "A. Oro" 5 => "R. Lebo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Nature" "fecha" => "1985" "volumen" => "318" "paginaInicial" => "635" "paginaFinal" => "641" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2867473" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The genomic structure of the human glucocorticoid receptor" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "I.J. Encío" 1 => "S.D. Detera-Wadleigh" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Biol Chem" "fecha" => "1991" "volumen" => "266" "paginaInicial" => "7.182" "paginaFinal" => "7.188" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1840597" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Functional domains of the human glucocorticoid receptor" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "V. Ciguère" 1 => "S.M. Hollenberg" 2 => "M.G. Rosenfield" 3 => "R.M. Evans" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cell" "fecha" => "1986" "volumen" => "46" "paginaInicial" => "645" "paginaFinal" => "652" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3742595" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Múltiple and cooperative trans-activation domains of the human glucocorticoid receptor" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S.M. Hollenberg" 1 => "R.M. Evans" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cell" "fecha" => "1988" "volumen" => "55" "paginaInicial" => "899" "paginaFinal" => "906" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3191531" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Delineation of a small región within the major transactivation domain of the human glucocorticoid receptor that mediates transactivation of gene expression" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "K. Dahlman-Wright" 1 => "T. Almlof" 2 => "I.J. McEwan" 3 => "J.A. Gustafsson" 4 => "A.P.H. Wright" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Proc Natl Acad Sci USA" "fecha" => "1994" "volumen" => "91" "paginaInicial" => "1.619" "paginaFinal" => "1.623" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11607502" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Protein components of the nonactivated glucocorticoids receptor" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Rexin" 1 => "W. Busch" 2 => "U. Gehring" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Biol Chem" "fecha" => "1991" "volumen" => "266" "paginaInicial" => "24.601" "paginaFinal" => "24.605" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1761564" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Regulation of glucocorticoid receptors by glucocorticoids in cultured HeLa S, cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.A. Cidlowski" 1 => "N.B. Cidlowski" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/endo-109-6-2264" "Revista" => array:7 [ "tituloSerie" => "Endocrinology" "fecha" => "1981" "volumen" => "109" "paginaInicial" => "1.975" "paginaFinal" => "1.981" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7308153" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0210569109001739" "estado" => "S300" "issn" => "02105691" ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mechanism of glucocorticoid receptor down-regulation by glucocorticoids" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S. Rosewicz" 1 => "A.R. McDonald" 2 => "B.A. Maddux" 3 => "I.D. Goldfine" 4 => "R.L. Miesfield" 5 => "C.D. Logsdon" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Biol Chem" "fecha" => "1988" "volumen" => "263" "paginaInicial" => "2.581" "paginaFinal" => "2.584" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3198651" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intragenic sequences of the human glucocorticoid receptor complementary DNA mediate hormone-inducible receptor messenger RNA downregulation through multiple mechanisms" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K.L. Burnstein" 1 => "C.M. Jewell" 2 => "M. Sar" 3 => "J.A. Cidlowski" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/mend.8.12.7708066" "Revista" => array:7 [ "tituloSerie" => "Mol Endocrinol" "fecha" => "1994" "volumen" => "8" "paginaInicial" => "1.764" "paginaFinal" => "1.773" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7708066" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0210569111003457" "estado" => "S300" "issn" => "02105691" ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0120" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genes newly identified as regulated by glucocorticoids in murine thymocytes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "G. Baughman" 1 => "M.T. Harrigan" 2 => "N.F. Campbell" 3 => "S.J. Nurrish" 4 => "S. Bourgeois" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/mend-5-5-637" "Revista" => array:6 [ "tituloSerie" => "Mol Endocrinol" "fecha" => "1991" "volumen" => "5" "paginaInicial" => "637" "paginaFinal" => "644" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2072923" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0125" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transcription factor interactions: selectors of positive or negative regulation from a single DNA element" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.I. Diamond" 1 => "J.N. Miner" 2 => "S.K. Yoshinaga" 3 => "K.R. Yamamoto" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Science" "fecha" => "1990" "volumen" => "249" "paginaInicial" => "1.266" "paginaFinal" => "1.272" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2218499" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0130" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Glucocorticoid resistance in asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P.J. Barnes" 1 => "A.P. Greening" 2 => "G.K. Crompton" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.152.6.8520795" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "1995" "volumen" => "152" "paginaInicial" => "5.125" "paginaFinal" => "5.142" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8520795" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0135" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The inducible transcription factor NF-kB: structure-function relationship of its protein subunits" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S.M. Grimm" 1 => "P.A. Baeurle" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Biochem J" "fecha" => "1993" "volumen" => "290" "paginaInicial" => "297" "paginaFinal" => "308" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8452515" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0140" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cytokine signal transduction" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "T. Kishimoto" 1 => "R. Taga" 2 => "S. Akira" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cell" "fecha" => "1994" "volumen" => "76" "paginaInicial" => "253" "paginaFinal" => "262" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8293462" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0145" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of dexamethasone on cytokine and phorbol ester stimulated c-Fos and c-Jun DNA binding and gene expression in human lung" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "I.M. Adcock" 1 => "C.R. Brown" 2 => "H. Shirasaki" 3 => "P.J. Barnes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "1994" "volumen" => "7" "paginaInicial" => "2.117" "paginaFinal" => "2.123" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7713210" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0150" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of glucocorticoids on transcription factor activation in human peripheral blood mononuclear cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "I.M. Adcock" 1 => "C.R. Brown" 2 => "C.M. Gelder" 3 => "H. Shirasaki" 4 => "M.J. Peters" 5 => "P.J. Barnes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Physiol" "fecha" => "1995" "volumen" => "268" "paginaInicial" => "C331" "paginaFinal" => "C338" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7864072" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0155" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Actions of the glucocorticoid receptor on transcription factors within the cytoplasma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "I.M. Adcock" 1 => "P.J. Barnes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "1995" "volumen" => "151" "paginaInicial" => "A195" ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0160" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Characterization of mechanisms involved in transrepression of NF-kB by activated glucocorticoid receptors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R.I. Scheinman" 1 => "A. Gualberto" 2 => "C.M. Jewell" 3 => "J.A. Cidlowski" 4 => "A.S. Baldwin Jr." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Mol Cell Biol" "fecha" => "1995" "volumen" => "15" "paginaInicial" => "943" "paginaFinal" => "953" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7823959" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0165" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Glucocorticoid receptor-cAMP response element-binding protein interaction and the response of the phosphoenolpyruvate carboxykinase gene to glucocorticoids" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "F. Imai" 1 => "J.N. Minger" 2 => "J.A. Mitchell" 3 => "K.R. Yamamoto" 4 => "D.K. Granner" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Biol Chem" "fecha" => "1993" "volumen" => "268" "paginaInicial" => "5.353" "paginaFinal" => "5.356" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8262987" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0170" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Beta-adrenoceptor agonists interfere with glucocorticoid receptor DNA-binding in rat lung" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.J. Peters" 1 => "I.M. Adcock" 2 => "C.R. Brown" 3 => "P.J. Barnes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Eur J Pharmacol (Mol Pharm)" "fecha" => "1995" "volumen" => "289" "paginaInicial" => "275" "paginaFinal" => "281" ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0175" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Glucocorticoid effects on the production and action of immune cytokines" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P.M. Guyre" 1 => "M.T. Girard" 2 => "P.M. Morganelli" 3 => "P.D. Manginiello" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Steroid Biochem" "fecha" => "1988" "volumen" => "30" "paginaInicial" => "89" "paginaFinal" => "93" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2968487" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib0180" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dexamethaso-ne inhibition of interleukin-l-beta production by human monocytes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.A. Kem" 1 => "R.J. Lamb" 2 => "J.L. Reed" 3 => "R.P. Daniele" 4 => "P.L. Nowell" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Post-transcriptional mechanisms. J Clin Invest" "fecha" => "1988" "volumen" => "81" "paginaInicial" => "237" "paginaFinal" => "244" ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0185" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Expression of interleukin-2, interferon-γ, and the IL-2 receptor by human peripheral blood lymphocytes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "K. Grabstein" 1 => "S. Dower" 2 => "S. Gillis" 3 => "V. Urdal" 4 => "A. Larsen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Immunol" "fecha" => "1986" "volumen" => "136" "paginaInicial" => "4.503" "paginaFinal" => "4.508" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3711662" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib0190" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Glucocorticoids inhibit the expression of an inducible, but not the constitutive nitric oxide synthase in vascular endothelial cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.W. Radomski" 1 => "R.M.J. Palmer" 2 => "S. Moneada" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Proc Natl Acad Sci USA" "fecha" => "1990" "volumen" => "87" "paginaInicial" => "10.043" "paginaFinal" => "10.049" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2263643" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib0195" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Glucocorticoid-andnon-glucocorticoid induction of lipocortins (annexins) 1 and 2 in rat peritoneal leucocytes in vivo" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S.H. Peers" 1 => "F. Smillie" 2 => "A.J. Elderfield" 3 => "R.J. Flower" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Pharmacol" "fecha" => "1993" "volumen" => "108" "paginaInicial" => "66" "paginaFinal" => "72" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8428216" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib0200" "etiqueta" => "40." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cytokineand forskolin-induced synthesis of group II phospholipase A2 and prostaglandin E, in rat mesangial cells is prevented hy dexamethasone" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C. Schalkwijk" 1 => "M. Vervoordeldonk" 2 => "J. Pfeilschifter" 3 => "F. Marki" 4 => "H. Vanden Bosch" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Biochem Biophys Res Commun" "fecha" => "1991" "volumen" => "180" "paginaInicial" => "46" "paginaFinal" => "52" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1930239" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib0205" "etiqueta" => "41." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.K. O’Banion" 1 => "V.D. Winn" 2 => "D.A. Young" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Proc Natl Acad Sci USA" "fecha" => "1992" "volumen" => "89" "paginaInicial" => "4.888" "paginaFinal" => "4.892" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1465455" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib0210" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Glucocorticoids induce neutral endopeptidase in transformed human tracheal epithelial cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.B. Borson" 1 => "S. Jew" 2 => "D.C. Gruenert" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Physiol" "fecha" => "1991" "volumen" => "260" "paginaInicial" => "L83" "paginaFinal" => "L89" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1847594" "web" => "Medline" ] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib0215" "etiqueta" => "43." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Leukotriene B4 stimulates c-fos and c-jun gene transcription and AP-1 binding activity in human monocytes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Stankova" 1 => "M. Rola-Pleszczynski" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Biochem J" "fecha" => "1992" "volumen" => "282" "paginaInicial" => "625" "paginaFinal" => "629" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1313226" "web" => "Medline" ] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib0220" "etiqueta" => "44." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Glucocorticosteroids increase beta 2-adrenergic receptor transcription in human lung" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.C. Mak" 1 => "M. Nishikawa" 2 => "P.J. Barnes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Physiol" "fecha" => "1995" "volumen" => "268" "paginaInicial" => "L41" "paginaFinal" => "L46" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7840227" "web" => "Medline" ] ] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib0225" "etiqueta" => "45." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased tachykinin receptor gene expression in asthmatic lung and its modulation by steroids" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "I.M. Adcock" 1 => "M. Peters" 2 => "C. Gelder" 3 => "H. Shirasaki" 4 => "C.R. Brown" 5 => "P.J. Barnes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Mol Endocrinol" "fecha" => "1993" "volumen" => "11" "paginaInicial" => "1" "paginaFinal" => "7" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8240667" "web" => "Medline" ] ] ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib0230" "etiqueta" => "46." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule-1 and intercellular adhesion molecule-1" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "B.N. Cronstein" 1 => "S.C. Kimmel" 2 => "R.I. Levin" 3 => "F. Martiniuk" 4 => "G. Weissmann" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Proc Natl Acad Sci USA" "fecha" => "1992" "volumen" => "89" "paginaInicial" => "9.991" "paginaFinal" => "9.995" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1465455" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0210569111000763" "estado" => "S300" "issn" => "02105691" ] ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib0235" "etiqueta" => "47." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of the role of nasal polyp and normal nasal mucosal epithelial cells on in vitro eosinophil survival. Mediation by GM-CSF and inhibition of dexamethasone" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Xaubet" 1 => "J. Mullol" 2 => "E. López" 3 => "J. Roca-Ferrer" 4 => "M. Rozman" 5 => "M. Carrión" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Exp Allergy" "fecha" => "1994" "volumen" => "24" "paginaInicial" => "307" "paginaFinal" => "317" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8039016" "web" => "Medline" ] ] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib0240" "etiqueta" => "48." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of topical steroids on cytokine release from human nasal epithelial cells in vitro" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. Xaubet" 1 => "J. Mullol" 2 => "J. Roca-Ferrer" 3 => "E. López" 4 => "J.C. Fernández" 5 => "C. Picado" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "1995" "volumen" => "151" "paginaInicial" => "A367" ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib0245" "etiqueta" => "49." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Identification of mRNAs associated with programmed cell death in immature thymocytes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G.P. Owens" 1 => "W.E. Hahn" 2 => "J.J. Cohen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Mol Cell Biol" "fecha" => "1991" "volumen" => "11" "paginaInicial" => "4.177" "paginaFinal" => "4.188" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1944288" "web" => "Medline" ] ] ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib0250" "etiqueta" => "50." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Glucocorticoids inhibit cytokine-mediated eosinophil survival" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "N. Wallen" 1 => "H. Kita" 2 => "D. Weiler" 3 => "G.J. Gleich" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Immunol" "fecha" => "1991" "volumen" => "147" "paginaInicial" => "3.490" "paginaFinal" => "3.495" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1836480" "web" => "Medline" ] ] ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bib0255" "etiqueta" => "51." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vasocort: a novel glucocorticoid-induced anti-inflammatory protein" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R. Carnuccio" 1 => "M. Di Rosa" 2 => "B. Guerrasio" 3 => "T. Iuvone" 4 => "L. Satebin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J. Pharmacol" "fecha" => "1987" "volumen" => "90" "paginaInicial" => "443" "paginaFinal" => "445" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2952212" "web" => "Medline" ] ] ] ] ] ] ] ] 51 => array:3 [ "identificador" => "bib0420" "etiqueta" => "52." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dexamethasone inhibits respiratory glycoconjugate secretion from feline airways in vitro by the induction of lipocortin (lipomodulin) synthesis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.D. Lundgren" 1 => "F. Hirata" 2 => "Z. Marom" 3 => "C. Logun" 4 => "L. Steel" 5 => "M. Kaliner" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm/137.2.353" "Revista" => array:6 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1988" "volumen" => "137" "paginaInicial" => "353" "paginaFinal" => "357" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2963568" "web" => "Medline" ] ] ] ] ] ] ] ] 52 => array:3 [ "identificador" => "bib0265" "etiqueta" => "53." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Direct inhibitory action of glucocorticoids on glycoconjugate secretion from airway submucosal glands" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S. Shimura" 1 => "T. Sasaki" 2 => "K. Ikeda" 3 => "K. Yamauchi" 4 => "H. Sasaki" 5 => "T. Takishima" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm/141.6.1569" "Revista" => array:6 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1990" "volumen" => "141" "paginaInicial" => "1.044" "paginaFinal" => "1.049" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2350100" "web" => "Medline" ] ] ] ] ] ] ] ] 53 => array:3 [ "identificador" => "bib0270" "etiqueta" => "54." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S.J. Pilkis" 1 => "D.K. Granner" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1146/annurev.ph.54.030192.004321" "Revista" => array:6 [ "tituloSerie" => "Annu Rev Physiol" "fecha" => "1992" "volumen" => "54" "paginaInicial" => "885" "paginaFinal" => "909" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1562196" "web" => "Medline" ] ] ] ] ] ] ] ] 54 => array:3 [ "identificador" => "bib0275" "etiqueta" => "55." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G.P. Chrousos" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199506293322611" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1995" "volumen" => "332" "paginaInicial" => "1.351" "paginaFinal" => "1.362" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7760898" "web" => "Medline" ] ] ] ] ] ] ] ] 55 => array:3 [ "identificador" => "bib0280" "etiqueta" => "56." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of systemic and inhaled glucocorticoid on eosinophil survival induced by epithelial cells from inflammatory and non-inflammatory respiratory mucosa" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J. Mullol" 1 => "A. Xaubet" 2 => "E. López" 3 => "J. Roca-Ferrer" 4 => "J.M. Fabra" 5 => "C. Picado" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "1995" "volumen" => "50" "paginaInicial" => "270" "paginaFinal" => "274" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7660341" "web" => "Medline" ] ] ] ] ] ] ] ] 56 => array:3 [ "identificador" => "bib0285" "etiqueta" => "57." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Corticosteroid-induced osteoporosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.D. Adachi" 1 => "W.G. Bensen" 2 => "A.B. Hodsman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Semin Arthritis Rheum" "fecha" => "1993" "volumen" => "22" "paginaInicial" => "375" "paginaFinal" => "384" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8342044" "web" => "Medline" ] ] ] ] ] ] ] ] 57 => array:3 [ "identificador" => "bib0290" "etiqueta" => "58." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neurosteroids: biochemistry, modes of action, and clinical relevance" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "S.H. Mellon" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/jcem.78.6.7515391" "Revista" => array:4 [ "tituloSerie" => "J Clin Endocrinol Metab" "fecha" => "1994" "volumen" => "78" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7515391" "web" => "Medline" ] ] ] ] ] ] ] ] 58 => array:3 [ "identificador" => "bib0295" "etiqueta" => "59." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Steroid resistance in bronchial asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "H.J. Schwartz" 1 => "F.C. Lowell" 2 => "J.C. Melby" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am J Int Med" "fecha" => "1968" "volumen" => "69" "paginaInicial" => "493" "paginaFinal" => "499" ] ] ] ] ] ] 59 => array:3 [ "identificador" => "bib0300" "etiqueta" => "60." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Familial and iatrogenic cortisol receptor resistance" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.W. Lamberts" 1 => "J.W. Koper" 2 => "F.H. De Jong" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Steroid Biochem Mol Biol" "fecha" => "1992" "volumen" => "43" "paginaInicial" => "385" "paginaFinal" => "388" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1390287" "web" => "Medline" ] ] ] ] ] ] ] ] 60 => array:3 [ "identificador" => "bib0305" "etiqueta" => "61." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Glucocorticoid therapy for asthma: clinical pharmacology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "S. Szefler" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "1991" "volumen" => "88" "paginaInicial" => "147" "paginaFinal" => "165" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1880315" "web" => "Medline" ] ] ] ] ] ] ] ] 61 => array:3 [ "identificador" => "bib0310" "etiqueta" => "62." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Glucocorticoid resistance in chronic asthma. Glucocorticoid pharmacokinetics, glucocorticoid receptor characteristics, and inhibition of peripheral blood T cell proliferation by glucocorticoids in vitro" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.J. Corrigan" 1 => "P.H. Brown" 2 => "N.C. Barnes" 3 => "S.J. Szefler" 4 => "J.J. Tsai" 5 => "A.J. Frew" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm/144.6.1342" "Revista" => array:6 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1991" "volumen" => "144" "paginaInicial" => "1.016" "paginaFinal" => "1.025" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1835825" "web" => "Medline" ] ] ] ] ] ] ] ] 62 => array:3 [ "identificador" => "bib0315" "etiqueta" => "63." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Steroid-resistant asthma: immunologic and pharmacologic features" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J. Álvarez" 1 => "W. Surs" 2 => "D.Y. Leung" 3 => "D. Ikle" 4 => "E.W. Gelfand" 5 => "S.J. Szefler" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "1992" "volumen" => "89" "paginaInicial" => "714" "paginaFinal" => "721" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1545093" "web" => "Medline" ] ] ] ] ] ] ] ] 63 => array:3 [ "identificador" => "bib0320" "etiqueta" => "64." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Steroid-resistant asthma. Cellular mechanisms contributing to inadequate response to glucocorticoid therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E.R. Sher" 1 => "D.Y.M. Leung" 2 => "W. Surs" 3 => "J.C. Kam" 4 => "G. Zieg" 5 => "A.K. Kamada" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1172/JCI116963" "Revista" => array:6 [ "tituloSerie" => "J Clin Invest" "fecha" => "1994" "volumen" => "93" "paginaInicial" => "33" "paginaFinal" => "39" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8282803" "web" => "Medline" ] ] ] ] ] ] ] ] 64 => array:3 [ "identificador" => "bib0325" "etiqueta" => "65." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Combination of IL-2 and IL-4 reduces glucocorticoid-receptor binding affinity and T cell response to glucocorticoid" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.C. Kam" 1 => "S.J. Szefler" 2 => "W. Surs" 3 => "F.R. Sher" 4 => "D.Y.M. Leung" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Immunol" "fecha" => "1993" "volumen" => "151" "paginaInicial" => "3.460" "paginaFinal" => "3.466" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8258725" "web" => "Medline" ] ] ] ] ] ] ] ] 65 => array:3 [ "identificador" => "bib0330" "etiqueta" => "66." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reduced glucocorticoid binding affinity in asthma is related to ongoing allergic inflammation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.D. Spahn" 1 => "D.Y.M. Leung" 2 => "W. Surs" 3 => "R.J. Harbeck" 4 => "S. Nimmagadda" 5 => "S.J. Szefler" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.151.6.7767560" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "1995" "volumen" => "151" "paginaInicial" => "1.709" "paginaFinal" => "1.714" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7767560" "web" => "Medline" ] ] ] ] ] ] ] ] 66 => array:3 [ "identificador" => "bib0335" "etiqueta" => "67." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Circulating autoantibodies to recombinant lipocortin-1 in asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K.F. Chung" 1 => "M.R. Podgorski" 2 => "N.J. Goulding" 3 => "J.L. Godolphin" 4 => "P.R. Sharland" 5 => "B. O’Connor" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Respir Med" "fecha" => "1991" "volumen" => "85" "paginaInicial" => "121" "paginaFinal" => "124" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1832234" "web" => "Medline" ] ] ] ] ] ] ] ] 67 => array:3 [ "identificador" => "bib0340" "etiqueta" => "68." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Differences in binding of glucocorticoid receptor to DNA in steroid-resistant asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "I.M. Adcock" 1 => "S.J. Lane" 2 => "C.R. Brown" 3 => "M.J. Peters" 4 => "T.H. Lee" 5 => "P.J. Barnes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Immunol" "fecha" => "1995" "volumen" => "154" "paginaInicial" => "3.500" "paginaFinal" => "3.505" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7759895" "web" => "Medline" ] ] ] ] ] ] ] ] 68 => array:3 [ "identificador" => "bib0345" "etiqueta" => "69." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Abnormal glucocorticoid receptor-interaction in steroid-resistant asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "I.M. Adcock" 1 => "S.J. Lane" 2 => "C.R. Brown" 3 => "T.H. Lee" 4 => "P.J. Barnes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Exp Med" "fecha" => "1995" "volumen" => "182" "paginaInicial" => "1.951" "paginaFinal" => "1.958" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7500055" "web" => "Medline" ] ] ] ] ] ] ] ] 69 => array:3 [ "identificador" => "bib0350" "etiqueta" => "70." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cross-coupling of signal transduction pathways: zinc finger meets leucine zipper" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R. Schüle" 1 => "R.M. Evans" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Trends Genet" "fecha" => "1991" "volumen" => "7" "paginaInicial" => "377" "paginaFinal" => "381" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1668190" "web" => "Medline" ] ] ] ] ] ] ] ] 70 => array:3 [ "identificador" => "bib0355" "etiqueta" => "71." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "High concentrations of beta-adrenergic agonists inhibit DNA binding of glucocorticoids in human lung in vitro" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "I.M. Adcock" 1 => "M.J. Peters" 2 => "C.R. Brown" 3 => "D.A. Stevens" 4 => "P.J. Barnes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Biochem Soc Trans" "fecha" => "1995" "volumen" => "23" "paginaInicial" => "217" ] ] ] ] ] ] 71 => array:3 [ "identificador" => "bib0360" "etiqueta" => "72." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "National Asthma Education Program. Expert Panel Report. Guidelines for the diagnosis and management of asthma" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "National Heart. Lung Blood Institute" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "1991" "volumen" => "83" "paginaInicial" => "425" "paginaFinal" => "534" ] ] ] ] ] ] 72 => array:3 [ "identificador" => "bib0365" "etiqueta" => "73." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Asthma\" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R.A. Goldstein" 1 => "W.E. Paul" 2 => "D.D. Metcalfe" 3 => "W.W. Busse" 4 => "E.R. Reece" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Intern Med" "fecha" => "1994" "volumen" => "121" "paginaInicial" => "698" "paginaFinal" => "708" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7944080" "web" => "Medline" ] ] ] ] ] ] ] ] 73 => array:3 [ "identificador" => "bib0370" "etiqueta" => "74." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "Drugs used in the treatment of asthma" ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Goodman & Gilman's the pharmacological basis of therapeutics." "paginaInicial" => "659" "paginaFinal" => "682" "serieFecha" => "1996" ] ] ] ] ] ] 74 => array:3 [ "identificador" => "bib0375" "etiqueta" => "75." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "International Rhinitis Management Group" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:8 [ "titulo" => "International Consensus Report on the diagnosis and management of rhinitis" "tituloSerie" => "Allergy" "fecha" => "1994" "volumen" => "49" "numero" => "Supl 19" "paginaInicial" => "5" "paginaFinal" => "34" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10707472" "web" => "Medline" ] ] ] ] ] ] ] ] 75 => array:3 [ "identificador" => "bib0380" "etiqueta" => "76." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Practical application of the international consensus on the management of rhinitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "V.J. Lund" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clin Immunother" "fecha" => "1995" "volumen" => "4" "paginaInicial" => "270" "paginaFinal" => "278" ] ] ] ] ] ] 76 => array:3 [ "identificador" => "bib0385" "etiqueta" => "77." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "Position statement on nasal polyposis" ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rhinology" "fecha" => "1994" "volumen" => "32" "paginaInicial" => "1.256" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7701224" "web" => "Medline" ] ] ] ] ] ] ] ] 77 => array:3 [ "identificador" => "bib0390" "etiqueta" => "78." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical pharmacology of corticosteroids in bronchial asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "B.J. Lipworth" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pharmacol Ther" "fecha" => "1993" "volumen" => "58" "paginaInicial" => "173" "paginaFinal" => "209" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8415878" "web" => "Medline" ] ] ] ] ] ] ] ] 78 => array:3 [ "identificador" => "bib0395" "etiqueta" => "79." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pharmacokinetic optimisation of asthma treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.M. Taburet" 1 => "B. Schmit" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2165/00003088-199426050-00006" "Revista" => array:6 [ "tituloSerie" => "Clin Pharmacokinet" "fecha" => "1994" "volumen" => "26" "paginaInicial" => "396" "paginaFinal" => "418" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7914480" "web" => "Medline" ] ] ] ] ] ] ] ] 79 => array:3 [ "identificador" => "bib0400" "etiqueta" => "80." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inhaled glucocorticoids for asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "P.J. Barnes" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199503303321307" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1995" "volumen" => "332" "paginaInicial" => "868" "paginaFinal" => "875" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7870143" "web" => "Medline" ] ] ] ] ] ] ] ] 80 => array:3 [ "identificador" => "bib0405" "etiqueta" => "81." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Regular inhaled beta-agonist treatment in hronchial asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.R. Sears" 1 => "D.R. Taylor" 2 => "C.G. Print" 3 => "D.G. Lake" 4 => "Q. Li" 5 => "E.M. Flannery" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1990" "volumen" => "336" "paginaInicial" => "1.391" "paginaFinal" => "1.396" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1979414" "web" => "Medline" ] ] ] ] ] ] ] ] 81 => array:3 [ "identificador" => "bib0410" "etiqueta" => "82." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "β2-agonists and corticosteroids: new developments and controversies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.E. Tattersfield" 1 => "P.J. Barnes" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm/146.6.1582" "Revista" => array:6 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1992" "volumen" => "146" "paginaInicial" => "1.637" "paginaFinal" => "1.641" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1456579" "web" => "Medline" ] ] ] ] ] ] ] ] 82 => array:3 [ "identificador" => "bib0415" "etiqueta" => "83." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Regulation of β-adrenergic receptors by steroid hormones" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.O. Davies" 1 => "R.J. Lefkowitz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1146/annurev.ph.46.030184.001003" "Revista" => array:6 [ "tituloSerie" => "Annu Rev Physiol" "fecha" => "1984" "volumen" => "46" "paginaInicial" => "119" "paginaFinal" => "130" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6324653" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/03002896/0000003200000010/v1_201506230103/S030028961530689X/v1_201506230103/es/main.assets" "Apartado" => array:4 [ "identificador" => "9299" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Revisiones" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/03002896/0000003200000010/v1_201506230103/S030028961530689X/v1_201506230103/es/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S030028961530689X?idApp=UINPBA00003Z" ]
Journal Information
Vol. 32. Issue 10.
Pages 527-534 (December 1996)
Vol. 32. Issue 10.
Pages 527-534 (December 1996)
Full text access
Mecanismos de acción de los glucocorticoides. Aplicación al tratamiento de la inflamación respiratoria
Visits
158086
This item has received
Article information
Full text is only aviable in PDF
Bibliografía
[1.]
T. Addison.
On the constitutional and local effects of disease of the suprarenal capsules.
Samuel Highley, (1855),
[2.]
R.P. Schleimer.
Glucocorticosteroids. Their mechanisms of action and use in allergic diseases..
Allergy. Principies and Practice, pp. 893-925
[3.]
H. Cushing.
The basophil adenomas of the pituitary body and their clinical manifestations.
Bull Johns Hopkins Hosp, 50 (1932), pp. 137-195
[4.]
E.B. Astwood, M.S. Raben, R.W. Payne.
Chemistry of corticotrophin.
Recent Prog Horm Res, 7 (1952), pp. 1-57
[6.]
W. Vale, J. Spiess, C. Rivier, J. Rivier.
Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and β-endorphin.
Science, 213 (1981), pp. 1.394-1.397
[7.]
P.S. Hensch, E.C. Kendall, C.H. Slocumb, H.F. Polley.
The effect of a hormone of the adrenal cortex (17-hydroxy-l1-dehydrocorticosterone; compound E) and of pituitary adrenocorticotropic hormone on rheumatoid arthritis.
Proc Staff Meet Mayo Clinic, 24 (1949), pp. 181-197
[8.]
P. Schimmer, K.L. Parker.
Adrenocorticotropic hormone: adrenocortical steroids and their synthetic analogs; inhibitor of the synthesis and actions of adrenocortical hormones.
Goodman & Gilman's the pharmacological basis of therapeutics, pp. 1.459-1.485
[9.]
N.V. Esteban, T. Loughlin, A.L. Yergey, J.K. Zawadzki, J.D. Booth, J.C. Winterer, et al.
Daily cortisol production rate in man determined by stable isotope dilution/mass spectrometry.
J Clin Endocrinol Metab, 72 (1991), pp. 39-45
[10.]
P.J. Barnes, S. Pedersen.
Efficacy and safety of inhaled corticosteroids in asthma.
Am Rev Respir Dis, 148 (1993), pp. 1-26
[11.]
R. Fuller, M. Johnson, A. Bye.
Fluticasone propionate: an update on preclinical and clinical experience.
Resp Med, 89 (1995), pp. 3-18
[12.]
D. Picard, K.R. Yamamoto.
Two signáis mediate hormone-dependent nuclear localization of the glucocorticoid receptor.
EMBO J, 6 (1987), pp. 3.333-3.340
[13.]
A.C. Wikstrom, O. Bakke, S. Okret, M. Brönnegärd, J.A. Gustafsson.
Intracellular localisation of the glucocorticoid receptor: evidence for cytoplasmic and nuclear localisation.
Endocrinology, 120 (1987), pp. 1.232-1.242
[14.]
R.M. Evans.
The steroid and thyroid hormone receptor superfamily.
Science, 247 (1988), pp. 889-895
[15.]
S.M. Hollenberg, C. Weinberger, E.S. Ong, G. Cerelli, A. Oro, R. Lebo, et al.
Primary structure and expression of a functional human glucocorticoid receptor cDNA.
Nature, 318 (1985), pp. 635-641
[16.]
I.J. Encío, S.D. Detera-Wadleigh.
The genomic structure of the human glucocorticoid receptor.
J Biol Chem, 266 (1991), pp. 7.182-7.188
[17.]
V. Ciguère, S.M. Hollenberg, M.G. Rosenfield, R.M. Evans.
Functional domains of the human glucocorticoid receptor.
Cell, 46 (1986), pp. 645-652
[18.]
S.M. Hollenberg, R.M. Evans.
Múltiple and cooperative trans-activation domains of the human glucocorticoid receptor.
Cell, 55 (1988), pp. 899-906
[19.]
K. Dahlman-Wright, T. Almlof, I.J. McEwan, J.A. Gustafsson, A.P.H. Wright.
Delineation of a small región within the major transactivation domain of the human glucocorticoid receptor that mediates transactivation of gene expression.
Proc Natl Acad Sci USA, 91 (1994), pp. 1.619-1.623
[20.]
M. Rexin, W. Busch, U. Gehring.
Protein components of the nonactivated glucocorticoids receptor.
J Biol Chem, 266 (1991), pp. 24.601-24.605
[21.]
J.A. Cidlowski, N.B. Cidlowski.
Regulation of glucocorticoid receptors by glucocorticoids in cultured HeLa S, cells.
Endocrinology, 109 (1981), pp. 1.975-1.981
[22.]
S. Rosewicz, A.R. McDonald, B.A. Maddux, I.D. Goldfine, R.L. Miesfield, C.D. Logsdon.
Mechanism of glucocorticoid receptor down-regulation by glucocorticoids.
J Biol Chem, 263 (1988), pp. 2.581-2.584
[23.]
K.L. Burnstein, C.M. Jewell, M. Sar, J.A. Cidlowski.
Intragenic sequences of the human glucocorticoid receptor complementary DNA mediate hormone-inducible receptor messenger RNA downregulation through multiple mechanisms.
Mol Endocrinol, 8 (1994), pp. 1.764-1.773
[24.]
G. Baughman, M.T. Harrigan, N.F. Campbell, S.J. Nurrish, S. Bourgeois.
Genes newly identified as regulated by glucocorticoids in murine thymocytes.
Mol Endocrinol, 5 (1991), pp. 637-644
[25.]
M.I. Diamond, J.N. Miner, S.K. Yoshinaga, K.R. Yamamoto.
Transcription factor interactions: selectors of positive or negative regulation from a single DNA element.
Science, 249 (1990), pp. 1.266-1.272
[26.]
P.J. Barnes, A.P. Greening, G.K. Crompton.
Glucocorticoid resistance in asthma.
Am J Respir Crit Care Med, 152 (1995), pp. 5.125-5.142
[27.]
S.M. Grimm, P.A. Baeurle.
The inducible transcription factor NF-kB: structure-function relationship of its protein subunits.
Biochem J, 290 (1993), pp. 297-308
[28.]
T. Kishimoto, R. Taga, S. Akira.
Cytokine signal transduction.
Cell, 76 (1994), pp. 253-262
[29.]
I.M. Adcock, C.R. Brown, H. Shirasaki, P.J. Barnes.
Effects of dexamethasone on cytokine and phorbol ester stimulated c-Fos and c-Jun DNA binding and gene expression in human lung.
Eur Respir J, 7 (1994), pp. 2.117-2.123
[30.]
I.M. Adcock, C.R. Brown, C.M. Gelder, H. Shirasaki, M.J. Peters, P.J. Barnes.
Effects of glucocorticoids on transcription factor activation in human peripheral blood mononuclear cells.
Am J Physiol, 268 (1995), pp. C331-C338
[31.]
I.M. Adcock, P.J. Barnes.
Actions of the glucocorticoid receptor on transcription factors within the cytoplasma.
Am J Respir Crit Care Med, 151 (1995), pp. A195
[32.]
R.I. Scheinman, A. Gualberto, C.M. Jewell, J.A. Cidlowski, A.S. Baldwin Jr..
Characterization of mechanisms involved in transrepression of NF-kB by activated glucocorticoid receptors.
Mol Cell Biol, 15 (1995), pp. 943-953
[33.]
F. Imai, J.N. Minger, J.A. Mitchell, K.R. Yamamoto, D.K. Granner.
Glucocorticoid receptor-cAMP response element-binding protein interaction and the response of the phosphoenolpyruvate carboxykinase gene to glucocorticoids.
J Biol Chem, 268 (1993), pp. 5.353-5.356
[34.]
M.J. Peters, I.M. Adcock, C.R. Brown, P.J. Barnes.
Beta-adrenoceptor agonists interfere with glucocorticoid receptor DNA-binding in rat lung.
Eur J Pharmacol (Mol Pharm), 289 (1995), pp. 275-281
[35.]
P.M. Guyre, M.T. Girard, P.M. Morganelli, P.D. Manginiello.
Glucocorticoid effects on the production and action of immune cytokines.
J Steroid Biochem, 30 (1988), pp. 89-93
[36.]
J.A. Kem, R.J. Lamb, J.L. Reed, R.P. Daniele, P.L. Nowell.
Dexamethaso-ne inhibition of interleukin-l-beta production by human monocytes.
Post-transcriptional mechanisms. J Clin Invest, 81 (1988), pp. 237-244
[37.]
K. Grabstein, S. Dower, S. Gillis, V. Urdal, A. Larsen.
Expression of interleukin-2, interferon-γ, and the IL-2 receptor by human peripheral blood lymphocytes.
J Immunol, 136 (1986), pp. 4.503-4.508
[38.]
M.W. Radomski, R.M.J. Palmer, S. Moneada.
Glucocorticoids inhibit the expression of an inducible, but not the constitutive nitric oxide synthase in vascular endothelial cells.
Proc Natl Acad Sci USA, 87 (1990), pp. 10.043-10.049
[39.]
S.H. Peers, F. Smillie, A.J. Elderfield, R.J. Flower.
Glucocorticoid-andnon-glucocorticoid induction of lipocortins (annexins) 1 and 2 in rat peritoneal leucocytes in vivo.
Br J Pharmacol, 108 (1993), pp. 66-72
[40.]
C. Schalkwijk, M. Vervoordeldonk, J. Pfeilschifter, F. Marki, H. Vanden Bosch.
Cytokineand forskolin-induced synthesis of group II phospholipase A2 and prostaglandin E, in rat mesangial cells is prevented hy dexamethasone.
Biochem Biophys Res Commun, 180 (1991), pp. 46-52
[41.]
M.K. O’Banion, V.D. Winn, D.A. Young.
cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase.
Proc Natl Acad Sci USA, 89 (1992), pp. 4.888-4.892
[42.]
D.B. Borson, S. Jew, D.C. Gruenert.
Glucocorticoids induce neutral endopeptidase in transformed human tracheal epithelial cells.
Am J Physiol, 260 (1991), pp. L83-L89
[43.]
J. Stankova, M. Rola-Pleszczynski.
Leukotriene B4 stimulates c-fos and c-jun gene transcription and AP-1 binding activity in human monocytes.
Biochem J, 282 (1992), pp. 625-629
[44.]
J.C. Mak, M. Nishikawa, P.J. Barnes.
Glucocorticosteroids increase beta 2-adrenergic receptor transcription in human lung.
Am J Physiol, 268 (1995), pp. L41-L46
[45.]
I.M. Adcock, M. Peters, C. Gelder, H. Shirasaki, C.R. Brown, P.J. Barnes.
Increased tachykinin receptor gene expression in asthmatic lung and its modulation by steroids.
J Mol Endocrinol, 11 (1993), pp. 1-7
[46.]
B.N. Cronstein, S.C. Kimmel, R.I. Levin, F. Martiniuk, G. Weissmann.
A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule-1 and intercellular adhesion molecule-1.
[47.]
A. Xaubet, J. Mullol, E. López, J. Roca-Ferrer, M. Rozman, M. Carrión, et al.
Comparison of the role of nasal polyp and normal nasal mucosal epithelial cells on in vitro eosinophil survival. Mediation by GM-CSF and inhibition of dexamethasone.
Clin Exp Allergy, 24 (1994), pp. 307-317
[48.]
A. Xaubet, J. Mullol, J. Roca-Ferrer, E. López, J.C. Fernández, C. Picado.
Effects of topical steroids on cytokine release from human nasal epithelial cells in vitro.
Am J Respir Crit Care Med, 151 (1995), pp. A367
[49.]
G.P. Owens, W.E. Hahn, J.J. Cohen.
Identification of mRNAs associated with programmed cell death in immature thymocytes.
Mol Cell Biol, 11 (1991), pp. 4.177-4.188
[50.]
N. Wallen, H. Kita, D. Weiler, G.J. Gleich.
Glucocorticoids inhibit cytokine-mediated eosinophil survival.
J Immunol, 147 (1991), pp. 3.490-3.495
[51.]
R. Carnuccio, M. Di Rosa, B. Guerrasio, T. Iuvone, L. Satebin.
Vasocort: a novel glucocorticoid-induced anti-inflammatory protein.
Br J. Pharmacol, 90 (1987), pp. 443-445
[52.]
J.D. Lundgren, F. Hirata, Z. Marom, C. Logun, L. Steel, M. Kaliner, et al.
Dexamethasone inhibits respiratory glycoconjugate secretion from feline airways in vitro by the induction of lipocortin (lipomodulin) synthesis.
Am Rev Respir Dis, 137 (1988), pp. 353-357
[53.]
S. Shimura, T. Sasaki, K. Ikeda, K. Yamauchi, H. Sasaki, T. Takishima.
Direct inhibitory action of glucocorticoids on glycoconjugate secretion from airway submucosal glands.
Am Rev Respir Dis, 141 (1990), pp. 1.044-1.049
[54.]
S.J. Pilkis, D.K. Granner.
Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis.
Annu Rev Physiol, 54 (1992), pp. 885-909
[55.]
G.P. Chrousos.
The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation.
N Engl J Med, 332 (1995), pp. 1.351-1.362
[56.]
J. Mullol, A. Xaubet, E. López, J. Roca-Ferrer, J.M. Fabra, C. Picado.
Effect of systemic and inhaled glucocorticoid on eosinophil survival induced by epithelial cells from inflammatory and non-inflammatory respiratory mucosa.
Thorax, 50 (1995), pp. 270-274
[57.]
J.D. Adachi, W.G. Bensen, A.B. Hodsman.
Corticosteroid-induced osteoporosis.
Semin Arthritis Rheum, 22 (1993), pp. 375-384
[58.]
S.H. Mellon.
Neurosteroids: biochemistry, modes of action, and clinical relevance.
J Clin Endocrinol Metab, 78 (1994),
[59.]
H.J. Schwartz, F.C. Lowell, J.C. Melby.
Steroid resistance in bronchial asthma.
Am J Int Med, 69 (1968), pp. 493-499
[60.]
S.W. Lamberts, J.W. Koper, F.H. De Jong.
Familial and iatrogenic cortisol receptor resistance.
J Steroid Biochem Mol Biol, 43 (1992), pp. 385-388
[61.]
S. Szefler.
Glucocorticoid therapy for asthma: clinical pharmacology.
J Allergy Clin Immunol, 88 (1991), pp. 147-165
[62.]
C.J. Corrigan, P.H. Brown, N.C. Barnes, S.J. Szefler, J.J. Tsai, A.J. Frew, et al.
Glucocorticoid resistance in chronic asthma. Glucocorticoid pharmacokinetics, glucocorticoid receptor characteristics, and inhibition of peripheral blood T cell proliferation by glucocorticoids in vitro.
Am Rev Respir Dis, 144 (1991), pp. 1.016-1.025
[63.]
J. Álvarez, W. Surs, D.Y. Leung, D. Ikle, E.W. Gelfand, S.J. Szefler.
Steroid-resistant asthma: immunologic and pharmacologic features.
J Allergy Clin Immunol, 89 (1992), pp. 714-721
[64.]
E.R. Sher, D.Y.M. Leung, W. Surs, J.C. Kam, G. Zieg, A.K. Kamada, et al.
Steroid-resistant asthma. Cellular mechanisms contributing to inadequate response to glucocorticoid therapy.
J Clin Invest, 93 (1994), pp. 33-39
[65.]
J.C. Kam, S.J. Szefler, W. Surs, F.R. Sher, D.Y.M. Leung.
Combination of IL-2 and IL-4 reduces glucocorticoid-receptor binding affinity and T cell response to glucocorticoid.
J Immunol, 151 (1993), pp. 3.460-3.466
[66.]
J.D. Spahn, D.Y.M. Leung, W. Surs, R.J. Harbeck, S. Nimmagadda, S.J. Szefler.
Reduced glucocorticoid binding affinity in asthma is related to ongoing allergic inflammation.
Am J Respir Crit Care Med, 151 (1995), pp. 1.709-1.714
[67.]
K.F. Chung, M.R. Podgorski, N.J. Goulding, J.L. Godolphin, P.R. Sharland, B. O’Connor, et al.
Circulating autoantibodies to recombinant lipocortin-1 in asthma.
Respir Med, 85 (1991), pp. 121-124
[68.]
I.M. Adcock, S.J. Lane, C.R. Brown, M.J. Peters, T.H. Lee, P.J. Barnes.
Differences in binding of glucocorticoid receptor to DNA in steroid-resistant asthma.
J Immunol, 154 (1995), pp. 3.500-3.505
[69.]
I.M. Adcock, S.J. Lane, C.R. Brown, T.H. Lee, P.J. Barnes.
Abnormal glucocorticoid receptor-interaction in steroid-resistant asthma.
J Exp Med, 182 (1995), pp. 1.951-1.958
[70.]
R. Schüle, R.M. Evans.
Cross-coupling of signal transduction pathways: zinc finger meets leucine zipper.
Trends Genet, 7 (1991), pp. 377-381
[71.]
I.M. Adcock, M.J. Peters, C.R. Brown, D.A. Stevens, P.J. Barnes.
High concentrations of beta-adrenergic agonists inhibit DNA binding of glucocorticoids in human lung in vitro.
Biochem Soc Trans, 23 (1995), pp. 217
[72.]
National Heart. Lung Blood Institute.
National Asthma Education Program. Expert Panel Report. Guidelines for the diagnosis and management of asthma.
J Allergy Clin Immunol, 83 (1991), pp. 425-534
[73.]
R.A. Goldstein, W.E. Paul, D.D. Metcalfe, W.W. Busse, E.R. Reece.
Asthma\.
Ann Intern Med, 121 (1994), pp. 698-708
[74.]
Drugs used in the treatment of asthma.
Goodman & Gilman's the pharmacological basis of therapeutics., pp. 659-682
[75.]
International Rhinitis Management Group.
International Consensus Report on the diagnosis and management of rhinitis, 49 (1994), pp. 5-34
[76.]
V.J. Lund.
Practical application of the international consensus on the management of rhinitis.
Clin Immunother, 4 (1995), pp. 270-278
[78.]
B.J. Lipworth.
Clinical pharmacology of corticosteroids in bronchial asthma.
Pharmacol Ther, 58 (1993), pp. 173-209
[79.]
A.M. Taburet, B. Schmit.
Pharmacokinetic optimisation of asthma treatment.
Clin Pharmacokinet, 26 (1994), pp. 396-418
[80.]
P.J. Barnes.
Inhaled glucocorticoids for asthma.
N Engl J Med, 332 (1995), pp. 868-875
[81.]
M.R. Sears, D.R. Taylor, C.G. Print, D.G. Lake, Q. Li, E.M. Flannery, et al.
Regular inhaled beta-agonist treatment in hronchial asthma.
Lancet, 336 (1990), pp. 1.391-1.396
[82.]
A.E. Tattersfield, P.J. Barnes.
β2-agonists and corticosteroids: new developments and controversies.
Am Rev Respir Dis, 146 (1992), pp. 1.637-1.641
[83.]
A.O. Davies, R.J. Lefkowitz.
Regulation of β-adrenergic receptors by steroid hormones.
Annu Rev Physiol, 46 (1984), pp. 119-130
Copyright © 1996. Sociedad Española de Neumología y Cirugía Torácica