array:23 [
  "pii" => "S1579212906603686"
  "issn" => "15792129"
  "doi" => "10.1016/S1579-2129(06)60368-6"
  "estado" => "S300"
  "fechaPublicacion" => "2004-11-01"
  "aid" => "60368"
  "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)"
  "copyrightAnyo" => "2004"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "sco"
  "cita" => "Arch Bronconeumol. 2004;40:534-6"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 2694
    "formatos" => array:3 [
      "EPUB" => 124
      "HTML" => 1871
      "PDF" => 699
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1579212906603698"
    "issn" => "15792129"
    "doi" => "10.1016/S1579-2129(06)60369-8"
    "estado" => "S300"
    "fechaPublicacion" => "2004-11-01"
    "aid" => "60369"
    "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "sco"
    "cita" => "Arch Bronconeumol. 2004;40:537-9"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 2901
      "formatos" => array:3 [
        "EPUB" => 88
        "HTML" => 1975
        "PDF" => 838
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case Reports</span>"
      "titulo" => "Lymphoid Interstitial Pneumonia Resolved Through Antiretroviral Therapy in an Adult Infected by Human Immunodeficiency Virus"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "537"
          "paginaFinal" => "539"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "R&#46; Garc&#237;a Luj&#225;n, J&#46;M&#46; Echave-Sustaeta, C&#46; Garc&#237;a Quero, V&#46; P&#233;rez Gonz&#225;lez, V&#46; Villena Garrido, A&#46; L&#243;pez Encuentra"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Garc&#237;a Luj&#225;n"
            ]
            1 => array:2 [
              "nombre" => "J&#46;M&#46;"
              "apellidos" => "Echave-Sustaeta"
            ]
            2 => array:3 [
              "preGrado" => "Dr&#46;"
              "nombre" => "C&#46;"
              "apellidos" => "Garc&#237;a Quero"
            ]
            3 => array:2 [
              "nombre" => "V&#46;"
              "apellidos" => "P&#233;rez Gonz&#225;lez"
            ]
            4 => array:2 [
              "nombre" => "V&#46;"
              "apellidos" => "Villena Garrido"
            ]
            5 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "L&#243;pez Encuentra"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212906603698?idApp=UINPBA00003Z"
    "url" => "/15792129/0000004000000011/v1_201305141823/S1579212906603698/v1_201305141823/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S1579212906603674"
    "issn" => "15792129"
    "doi" => "10.1016/S1579-2129(06)60367-4"
    "estado" => "S300"
    "fechaPublicacion" => "2004-11-01"
    "aid" => "60367"
    "copyright" => "Sociedad Espa&#241;ola de Neumolog&#237;a y Cirug&#237;a Tor&#225;cica &#40;SEPAR&#41;"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Arch Bronconeumol. 2004;40:518-33"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 4765
      "formatos" => array:3 [
        "EPUB" => 97
        "HTML" => 3906
        "PDF" => 762
      ]
    ]
    "en" => array:8 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Recommendations</span>"
      "titulo" => "Recommendations for the Treatment of Severe Nosocomial Pneumonia"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "518"
          "paginaFinal" => "533"
        ]
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "R&#46; Jord&#224; Marcos, A&#46; Torres Mart&#237;, F&#46;J&#46; Ariza Cardenal, F&#46; &#193;lvarez Lerma, F&#46; Barcenilla Gaite"
          "autores" => array:8 [
            0 => array:3 [
              "preGrado" => "Dr&#46;"
              "nombre" => "R&#46;"
              "apellidos" => "Jord&#224; Marcos"
            ]
            1 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Torres Mart&#237;"
            ]
            2 => array:2 [
              "nombre" => "F&#46;J&#46;"
              "apellidos" => "Ariza Cardenal"
            ]
            3 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "&#193;lvarez Lerma"
            ]
            4 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "Barcenilla Gaite"
            ]
            5 => array:1 [
              "colaborador" => "the Expert Committee of the Working Group on Infectious Diseases of the Spanish Society of Intensive Care Medicine&#44; Critical and Coronary Units &#40;GTEI-SEMICYUC&#41;"
            ]
            6 => array:1 [
              "colaborador" => "the Assembly on Tuberculosis and Respiratory Infections of the Spanish Society of Pulmonology and Thoracic Surgery &#40;TIR-SEPAR&#41;"
            ]
            7 => array:1 [
              "colaborador" => "the Nosocomial Infection Study Group of the Spanish Society of Infectious Diseases and Clinical Microbiology &#40;GEIH-SEIMC&#41;&#46;"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212906603674?idApp=UINPBA00003Z"
    "url" => "/15792129/0000004000000011/v1_201305141823/S1579212906603674/v1_201305141823/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case Reports</span>"
    "titulo" => "Lung Scintigraphy With Technetium 99m Depreotide in the Assessment of Solitary Pulmonary Nodules"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "534"
        "paginaFinal" => "536"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "A&#46;C&#46; Rebollo, J&#46;M&#46; Jim&#233;nez-Hoyuela, M&#46;D&#46; Mart&#237;nez del Valle, C&#46; Fern&#225;ndez Aguirre, C&#46; Soria, J&#46;L&#46; Velasco"
        "autores" => array:6 [
          0 => array:3 [
            "nombre" => "A&#46;C&#46;"
            "apellidos" => "Rebollo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
            ]
          ]
          1 => array:5 [
            "preGrado" => "Dr&#46;"
            "nombre" => "J&#46;M&#46;"
            "apellidos" => "Jim&#233;nez-Hoyuela"
            "email" => array:1 [
              0 => "jjimenezhog&#64;commalaga&#46;org"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor1"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "M&#46;D&#46;"
            "apellidos" => "Mart&#237;nez del Valle"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "C&#46;"
            "apellidos" => "Fern&#225;ndez Aguirre"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "C&#46;"
            "apellidos" => "Soria"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "J&#46;L&#46;"
            "apellidos" => "Velasco"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Nuclear Medicine Department&#44; Hospital Universitario Virgen de la Victoria&#44; M&#225;laga&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff1"
          ]
          1 => array:3 [
            "entidad" => "Pneumology Department&#44; Hospital Universitario Virgen de la Victoria&#44; M&#225;laga&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff2"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor1"
            "etiqueta" => "&#42;"
            "correspondencia" => "Correspondence&#58; Dr&#46; J&#46;M&#46; Jim&#233;nez-Hoyuela&#46; Servicio de Medicina Nuclear&#46; Hospital Universitario Virgen de la Victoria&#46; Campus Universitario de Teatinos&#44; s&#47;n&#46; 29010 M&#225;laga&#46; Espa&#241;a"
          ]
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2004-02-19"
    "fechaAceptado" => "2004-03-30"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key Words"
          "identificador" => "xpalclavsec153187"
          "palabras" => array:3 [
            0 => "Solitary pulmonary nodule &#40;SPN&#41;"
            1 => "Technetium Tc<span class="elsevierStyleSup">99m</span> depreotide"
            2 => "Lung scintigraphy"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec153188"
          "palabras" => array:3 [
            0 => "N&#243;dulo pulmonar solitario"
            1 => "<span class="elsevierStyleSup">99m</span>Tc-depre&#243;tida"
            2 => "Gammagraf&#237;a pulmonar"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:1 [
        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">A solitary pulmonary nodule &#40;SPN&#41; is defined as a parenchymal lesion measuring less than 3 cm in diameter that is not associated with other lesions&#46; Ninety percent of SPNs are discovered incidentally and most are benign&#46; The management of radiographically indeterminate SPNs has not been established and invasive procedures must be undertaken in order to understand the nature of the nodule&#46; We review our experience with the use of somatostatin receptor scintigraphy with technetium Tc<span class="elsevierStyleSup">99m</span> depreotide in 10 patients with suspected malignant SPN&#46; We discuss the limitations and applications of this technique in the evaluation of whether SPNs are benign or malignant for the purpose of identifying patients for biopsy&#46; For this application&#44; this technique can be considered an alternative to positron emission tomography using fluorine-18 fluordeoxyglucose&#46;</p>"
      ]
      "es" => array:1 [
        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">El n&#243;dulo pulmonar solitario &#40;NPS&#41; se define como una lesi&#243;n parenquimatosa &#250;nica&#44; con un tama&#241;o inferior a 3 cm de di&#225;metro y no asociada a otras lesiones&#46; El 90&#37; se descu-bre de forma casual y la mayor&#237;a es de naturaleza benigna&#46; El tratamiento de los NPS radiol&#243;gicamente indeterminados no est&#225; del todo establecido&#44; y es necesaria la realizaci&#243;n de t&#233;cnicas invasivas con el fin de conocer la naturaleza de la lesi&#243;n&#46;</p><p class="elsevierStyleSimplePara elsevierViewall">Presentamos nuestra experiencia en la gammagraf&#237;a de receptores de somatostatina con <span class="elsevierStyleSup">99m</span>Tc-depre&#243;tida en 10 pa-cientes con NPS sospechosos de malignidad&#46; Discutimos las limitaciones y aplicaciones de esta t&#233;cnica en la diferencia-ci&#243;n de la naturaleza benigna o maligna de las lesiones para seleccionar a los pacientes candidatos a biopsia&#44; terreno donde puede considerarse una alternativa a la tomograf&#237;a por emisi&#243;n de positrones con <a class="elsevierStyleCrossRef" href="#bib18"><span class="elsevierStyleSup">18</span></a>fluordesoxiglucosa&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "REFERENCES"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:20 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Solitary pulmonary nodules&#58; part I&#46; Morphologic evaluation for differentiation of benign and malignant lesions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "JJ Erasmus"
                            1 => "JE Connolly"
                            2 => "HP McAdams"
                            3 => "VL Roggli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1148/radiographics.20.1.g00ja0343"
                      "Revista" => array:6 [
                        "tituloSerie" => "Radiographics"
                        "fecha" => "2000"
                        "volumen" => "20"
                        "paginaInicial" => "43"
                        "paginaFinal" => "58"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10682770"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Analytical decision model for the cost-effective management of solitary pulmonary nodules"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "SS Gambhir"
                            1 => "JE Shepherd"
                            2 => "BD Shah"
                            3 => "E Hart"
                            4 => "CK Hoh"
                            5 => "PE Valk"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1200/jco.1998.16.6.2113"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Oncol"
                        "fecha" => "1998"
                        "volumen" => "16"
                        "paginaInicial" => "2113"
                        "paginaFinal" => "2125"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9626211"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "N&#243;dulo pulmonar solitario&#58; &#94;que ha cambiado en su evaluaci&#243;n diagn&#243;stica&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R Moreno"
                            1 => "L Fern&#225;ndez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2003"
                        "volumen" => "39"
                        "paginaInicial" => "246"
                        "paginaFinal" => "248"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12797938"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The solitary pulmonary nodule&#58; update on evaluation and treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "RH Poe"
                            1 => "RH Israel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Journal of Critical Illness"
                        "fecha" => "2000"
                        "volumen" => "15"
                        "paginaInicial" => "569"
                        "paginaFinal" => "580"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Solitary pulmonary nodules&#58; part II&#46; Evaluation of the indeterminate nodule"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "JJ Erasmus"
                            1 => "HP McAdams"
                            2 => "JE Connolly"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1148/radiographics.20.1.g00ja0259"
                      "Revista" => array:6 [
                        "tituloSerie" => "Radiographics"
                        "fecha" => "2000"
                        "volumen" => "20"
                        "paginaInicial" => "59"
                        "paginaFinal" => "66"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10682771"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Somatostatin receptor subtype specificity and in vivo binding of a novel tumor tracer&#44; 99mTc-P829"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "I Virgolini"
                            1 => "M Leimer"
                            2 => "H Handmaker"
                            3 => "S Lastoria"
                            4 => "C Bischof"
                            5 => "P Muto"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Res"
                        "fecha" => "1998"
                        "volumen" => "58"
                        "paginaInicial" => "1850"
                        "paginaFinal" => "1859"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9581824"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Role of nuclear medicine in the evaluation of the solitary pulmonary nodule"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "SJ Goldsmith"
                            1 => "L Kostakoglu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Semin Ultrasound CTMRI"
                        "fecha" => "2000"
                        "volumen" => "21"
                        "paginaInicial" => "129"
                        "paginaFinal" => "138"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A multicenter trial with a somatostatin analog 99mTc depreotide in the evaluation of solitary pulmonary nodules"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "the Neotect Solitary Pulmonary Nodule Study Group"
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J Blum"
                            1 => "H Handmaker"
                            2 => "J Lister-James"
                            3 => "N Rinne"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2000"
                        "volumen" => "1 17"
                        "paginaInicial" => "1232"
                        "paginaFinal" => "1238"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The utility of a somatostatin type receptor binding peptide radiopharmaceutical &#40;P829&#41; in the evaluation of solitary pulmonary nodules"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J Blum"
                            1 => "H Handmaker"
                            2 => "NA Rinne"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1999"
                        "volumen" => "115"
                        "paginaInicial" => "224"
                        "paginaFinal" => "232"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9925088"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Efficacy of Tc-99m depreotide scintigraphy in the evaluation of solitary pulmonary nodules"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "RK Grewal"
                            1 => "S Dadparvar"
                            2 => "JQ Yu"
                            3 => "CJ Babaria"
                            4 => "T Cavanaugh"
                            5 => "M Sherman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer J"
                        "fecha" => "2002"
                        "volumen" => "8"
                        "paginaInicial" => "400"
                        "paginaFinal" => "404"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12416898"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "False-positive technetium 99m depreotide scintigraphy resulting from round atelectasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "LP Thomas"
                            1 => "AG Balingit"
                            2 => "DS Morison"
                            3 => "MD Gilman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Thorac Imaging"
                        "fecha" => "2003"
                        "volumen" => "18"
                        "paginaInicial" => "97"
                        "paginaFinal" => "99"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12700484"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Biodistribution on Tc-99m labeled somatostatin receptor binding peptide &#40;Depreotide&#44; Neotect&#41; planar and SPECT studies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "WJ Shih"
                            1 => "E Hirschowitz"
                            2 => "E Bensadoun"
                            3 => "J Woodring"
                            4 => "Y Ryo"
                            5 => "S Kraman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Nucl Med"
                        "fecha" => "2002"
                        "volumen" => "16"
                        "paginaInicial" => "213"
                        "paginaFinal" => "219"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12126047"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Qualitative analyses of indeterminate solitary pulmonary nodules using 99mTc depreotide &#40;NeoTect&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A Bostaph"
                            1 => "JS Miliziano"
                            2 => "YC Bradley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Radiology"
                        "fecha" => "2002"
                        "volumen" => "225"
                        "numero" => "Suppl"
                        "paginaInicial" => "560P"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Is semi-quantitative NeoTect&#174; scintigraphy the new gold standard for solitary pulmonary nodules&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "RJ Zucker"
                            1 => "YC Bradley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Radiology"
                        "fecha" => "2001"
                        "volumen" => "221"
                        "numero" => "Suppl"
                        "paginaInicial" => "564P"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tc-99m-labeled somatostatin receptor-binding peptide &#40;depreotide&#44; NeoTect&#41; for solitary pulmonary nodules&#58; semi-quantitative ratio tumor to contralateral normal lung"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "W Shih"
                            1 => "EA Hirschowitz"
                            2 => "ES Bensadoun"
                            3 => "JH Woodring"
                            4 => "UY Ryo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Radiology"
                        "fecha" => "2002"
                        "volumen" => "225"
                        "numero" => "Suppl"
                        "paginaInicial" => "197P"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Analysis of the cost effectiveness of a somatostatin analog-Tc99m-depreotide &#40;Neotect&#41; in the scintigraphic evaluation of solitary pulmonary nodules &#40;SPN&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "SS Gambhir"
                            1 => "H Shepherd"
                            2 => "H Handmaker"
                            3 => "J Blum"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Nucl Med"
                        "fecha" => "1999"
                        "volumen" => "40"
                        "numero" => "Suppl"
                        "paginaInicial" => "57P"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Utilidad de la cirug&#237;a videotoracosc&#243;pica en el diagn&#243;stico de los n&#243;dulos pulmonares solitarios"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M Congregado"
                            1 => "JC Gir&#243;n"
                            2 => "R Jim&#233;nez"
                            3 => "A Arroyo"
                            4 => "C Arenas"
                            5 => "J Ayarra"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2002"
                        "volumen" => "38"
                        "paginaInicial" => "415"
                        "paginaFinal" => "420"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12237012"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Somatostatin receptor imaging of non-small cell lung cancer with 99mTc depreotide"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "Y Menda"
                            1 => "D Kahn"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/snuc.2002.31564"
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Nucl Med"
                        "fecha" => "2002"
                        "volumen" => "32"
                        "paginaInicial" => "92"
                        "paginaFinal" => "96"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11965604"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The diagnostic strategy for lung cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "SV Spagnolo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2000"
                        "volumen" => "117"
                        "paginaInicial" => "1219"
                        "paginaFinal" => "1220"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10807799"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Metabolic imaging of a solitary pulmonary nodule"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "QH Siraj"
                            1 => "MA Masoomi"
                            2 => "P Griffiths"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Eur J Nucl Med"
                        "fecha" => "2003"
                        "volumen" => "29"
                        "paginaInicial" => "578"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15792129/0000004000000011/v1_201305141823/S1579212906603686/v1_201305141823/en/main.assets"
  "Apartado" => null
  "PDF" => "https://static.elsevier.es/multimedia/15792129/0000004000000011/v1_201305141823/S1579212906603686/v1_201305141823/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212906603686?idApp=UINPBA00003Z"
]
Share
Journal Information
Vol. 40. Issue 11.
Pages 534-536 (November 2004)
Share
Share
Download PDF
More article options
Vol. 40. Issue 11.
Pages 534-536 (November 2004)
Case Reports
Full text access
Lung Scintigraphy With Technetium 99m Depreotide in the Assessment of Solitary Pulmonary Nodules
Visits
4572
A.C. Rebolloa, J.M. Jiménez-Hoyuelaa,
Corresponding author
jjimenezhog@commalaga.org

Correspondence: Dr. J.M. Jiménez-Hoyuela. Servicio de Medicina Nuclear. Hospital Universitario Virgen de la Victoria. Campus Universitario de Teatinos, s/n. 29010 Málaga. España
, M.D. Martínez del Vallea, C. Fernández Aguirreb, C. Soriab, J.L. Velascob
a Nuclear Medicine Department, Hospital Universitario Virgen de la Victoria, Málaga, Spain
b Pneumology Department, Hospital Universitario Virgen de la Victoria, Málaga, Spain
This item has received
Article information
Abstract
Bibliography
Download PDF
Statistics

A solitary pulmonary nodule (SPN) is defined as a parenchymal lesion measuring less than 3 cm in diameter that is not associated with other lesions. Ninety percent of SPNs are discovered incidentally and most are benign. The management of radiographically indeterminate SPNs has not been established and invasive procedures must be undertaken in order to understand the nature of the nodule. We review our experience with the use of somatostatin receptor scintigraphy with technetium Tc99m depreotide in 10 patients with suspected malignant SPN. We discuss the limitations and applications of this technique in the evaluation of whether SPNs are benign or malignant for the purpose of identifying patients for biopsy. For this application, this technique can be considered an alternative to positron emission tomography using fluorine-18 fluordeoxyglucose.

Key Words:
Solitary pulmonary nodule (SPN)
Technetium Tc99m depreotide
Lung scintigraphy

El nódulo pulmonar solitario (NPS) se define como una lesión parenquimatosa única, con un tamaño inferior a 3 cm de diámetro y no asociada a otras lesiones. El 90% se descu-bre de forma casual y la mayoría es de naturaleza benigna. El tratamiento de los NPS radiológicamente indeterminados no está del todo establecido, y es necesaria la realización de técnicas invasivas con el fin de conocer la naturaleza de la lesión.

Presentamos nuestra experiencia en la gammagrafía de receptores de somatostatina con 99mTc-depreótida en 10 pa-cientes con NPS sospechosos de malignidad. Discutimos las limitaciones y aplicaciones de esta técnica en la diferencia-ción de la naturaleza benigna o maligna de las lesiones para seleccionar a los pacientes candidatos a biopsia, terreno donde puede considerarse una alternativa a la tomografía por emisión de positrones con 18fluordesoxiglucosa.

Palabras clave:
Nódulo pulmonar solitario
99mTc-depreótida
Gammagrafía pulmonar
Full text is only aviable in PDF
REFERENCES
[1]
JJ Erasmus, JE Connolly, HP McAdams, VL Roggli.
Solitary pulmonary nodules: part I. Morphologic evaluation for differentiation of benign and malignant lesions.
[2]
SS Gambhir, JE Shepherd, BD Shah, E Hart, CK Hoh, PE Valk, et al.
Analytical decision model for the cost-effective management of solitary pulmonary nodules.
J Clin Oncol, 16 (1998), pp. 2113-2125
[3]
R Moreno, L Fernández.
Nódulo pulmonar solitario: ^que ha cambiado en su evaluación diagnóstica?.
Arch Bronconeumol, 39 (2003), pp. 246-248
[4]
RH Poe, RH Israel.
The solitary pulmonary nodule: update on evaluation and treatment.
Journal of Critical Illness, 15 (2000), pp. 569-580
[5]
JJ Erasmus, HP McAdams, JE Connolly.
Solitary pulmonary nodules: part II. Evaluation of the indeterminate nodule.
[6]
I Virgolini, M Leimer, H Handmaker, S Lastoria, C Bischof, P Muto, et al.
Somatostatin receptor subtype specificity and in vivo binding of a novel tumor tracer, 99mTc-P829.
Cancer Res, 58 (1998), pp. 1850-1859
[7]
SJ Goldsmith, L Kostakoglu.
Role of nuclear medicine in the evaluation of the solitary pulmonary nodule.
Semin Ultrasound CTMRI, 21 (2000), pp. 129-138
[8]
J Blum, H Handmaker, J Lister-James, N Rinne, the Neotect Solitary Pulmonary Nodule Study Group.
A multicenter trial with a somatostatin analog 99mTc depreotide in the evaluation of solitary pulmonary nodules.
Chest, 1 17 (2000), pp. 1232-1238
[9]
J Blum, H Handmaker, NA Rinne.
The utility of a somatostatin type receptor binding peptide radiopharmaceutical (P829) in the evaluation of solitary pulmonary nodules.
Chest, 115 (1999), pp. 224-232
[10]
RK Grewal, S Dadparvar, JQ Yu, CJ Babaria, T Cavanaugh, M Sherman, et al.
Efficacy of Tc-99m depreotide scintigraphy in the evaluation of solitary pulmonary nodules.
Cancer J, 8 (2002), pp. 400-404
[11]
LP Thomas, AG Balingit, DS Morison, MD Gilman.
False-positive technetium 99m depreotide scintigraphy resulting from round atelectasis.
J Thorac Imaging, 18 (2003), pp. 97-99
[12]
WJ Shih, E Hirschowitz, E Bensadoun, J Woodring, Y Ryo, S Kraman.
Biodistribution on Tc-99m labeled somatostatin receptor binding peptide (Depreotide, Neotect) planar and SPECT studies.
Ann Nucl Med, 16 (2002), pp. 213-219
[13]
A Bostaph, JS Miliziano, YC Bradley.
Qualitative analyses of indeterminate solitary pulmonary nodules using 99mTc depreotide (NeoTect).
Radiology, 225 (2002), pp. 560P
[14]
RJ Zucker, YC Bradley.
Is semi-quantitative NeoTect® scintigraphy the new gold standard for solitary pulmonary nodules?.
Radiology, 221 (2001), pp. 564P
[15]
W Shih, EA Hirschowitz, ES Bensadoun, JH Woodring, UY Ryo.
Tc-99m-labeled somatostatin receptor-binding peptide (depreotide, NeoTect) for solitary pulmonary nodules: semi-quantitative ratio tumor to contralateral normal lung.
Radiology, 225 (2002), pp. 197P
[16]
SS Gambhir, H Shepherd, H Handmaker, J Blum.
Analysis of the cost effectiveness of a somatostatin analog-Tc99m-depreotide (Neotect) in the scintigraphic evaluation of solitary pulmonary nodules (SPN).
J Nucl Med, 40 (1999), pp. 57P
[17]
M Congregado, JC Girón, R Jiménez, A Arroyo, C Arenas, J Ayarra, et al.
Utilidad de la cirugía videotoracoscópica en el diagnóstico de los nódulos pulmonares solitarios.
Arch Bronconeumol, 38 (2002), pp. 415-420
[18]
Y Menda, D Kahn.
Somatostatin receptor imaging of non-small cell lung cancer with 99mTc depreotide.
Semin Nucl Med, 32 (2002), pp. 92-96
[19]
SV Spagnolo.
The diagnostic strategy for lung cancer.
Chest, 117 (2000), pp. 1219-1220
[20]
QH Siraj, MA Masoomi, P Griffiths.
Metabolic imaging of a solitary pulmonary nodule.
Eur J Nucl Med, 29 (2003), pp. 578
Copyright © 2004. Sociedad Española de Neumología y Cirugía Torácica (SEPAR)
Archivos de Bronconeumología
Article options
Tools

Are you a health professional able to prescribe or dispense drugs?