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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">It is well known that lung function referencevalues differ between populations&#44; hence the apparentimportance of establishing such values&#46; The aim of thisstudy was to develop prediction equations for spirometryfor healthy children and adolescents in Galicia&#44; Spain&#46;</p> <span class="elsevierStyleSectionTitle">Population and methods</span><p class="elsevierStyleSimplePara elsevierViewall">We studied children andadolescents aged 6 to 18 years from randomly selectedschools in 14 municipalities in Galicia&#46; Spirometric valueswere measured following the protocols established by the American Thoracic Society in 1987&#44; with real-timemonitoring of flow-volume curves&#46; The prediction equationswere derived using multivariate linear regression&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">We developed equations to predict the mainspirometry parameters for this age group according to sex&#44; height&#44; and weight&#46; Mean spirometry values in relation toheight were higher for boys than for girls&#44; except in the 140-160 cm range&#44; where they were higher for girls&#46; Equations published in other studies in similar populationsgave different predictions&#44; ranging from an underestimationof forced midexpiratory flow rate &#40;FEF<span class="elsevierStyleInf">25&#37;-75&#37;</span>&#41; by 16&#37; incomparison to ours to an overestimation of peak expiratoryflow &#40;PEF&#41; rate by 15&#37; for an average boy&#46; For a girl&#44; thecorresponding differences ranged from an underestimationof FEF<span class="elsevierStyleInf">25&#37;-75&#37;</span> by 17&#37; to an overestimation of PEF by 19&#37;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">These results support the importance ofusing population-specific prediction equations to establishlung function reference values&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Son conocidas las diferencias entre distintaspoblaciones en cuanto a los valores de referencia de la fun-ci&#243;n respiratoria&#44; por lo cual parece importante establecer-los&#46; El objetivo del estudio ha sido establecer las ecuacionesde predicci&#243;n de par&#225;metros espirom&#233;tricos en ni&#241;os y ado-lescentes sanos de Galicia&#46;</p> <span class="elsevierStyleSectionTitle">Poblaci&#243;n y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Hemos estudiado a ni&#241;os y adoles-centes sanos de 6 a 18 a&#241;os de edad&#44; de colegios seleccionadosaleatoriamente en 14 municipios de Galicia&#46; Las maniobrasespirom&#233;tricas se realizaron de acuerdo con los protocolos dela American Thoracic Society de 1987&#44; con evaluaci&#243;n conti-nua de los espirogramas&#46; Se obtuvieron las ecuaciones depredicci&#243;n mediante regresi&#243;n lineal multivariante&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Con este estudio se obtuvieron las ecuaciones depredicci&#243;n de los principales par&#225;metros espirom&#233;tricos en estegrupo de edad&#44; en funci&#243;n de la edad&#44; el sexo&#44; la talla y el peso&#46; Los valores medios de los par&#225;metros espirom&#233;tricos&#44; en funci&#243;nde la estatura&#44; son superiores en la poblaci&#243;n masculina com-parada con la femenina&#44; excepto en el rango entre 140 y 160 cmde altura&#44; donde las mujeres superan a los varones&#46; Para unvar&#243;n medio de nuestra poblaci&#243;n&#44; los par&#225;metros de funci&#243;npulmonar obtenidos con las ecuaciones de predicci&#243;n referidaspor otros autores en poblaciones similares difieren de los nues-tros&#44; desde una infraestimaci&#243;n de un 16&#37; para el flujo mesoes-piratorio forzado hasta una sobreestimaci&#243;n de un 15&#37; para elpico de flujo espiratorio&#59; para una mujer&#44; las discrepancias vandesde la infraestimaci&#243;n del flujo mesoespiratorio forzado del 17&#37;hasta la sobreestimaci&#243;n del pico de flujo espiratorio de un 19&#37;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Estos resultados refuerzan la importanciade utilizar ecuaciones de predicci&#243;n espec&#237;ficas para cadapoblaci&#243;n&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara">This study was partially funded by the Xunta de Galicia &#40;60904&#46;44055&#41;&#46; Dr Cadarso&#39;s statistical work was financed with grants from the Spanish Ministry of Education and Science in collaboration with the European Regional Development Fund &#40;MTM2005-00818&#41;&#46;</p>"
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Vol. 44. Issue 6.
Pages 295-302 (January 2008)
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Vol. 44. Issue 6.
Pages 295-302 (January 2008)
Original Articles
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Lung Function Reference Values in Children and Adolescents Aged 6 to 18 Years in Galicia
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Francisco Javier González Barcalaa,
Corresponding author
fjgbarcala@telefonica.net

Correspondence: Dr F.J. Álvarez-Gutiérrez Servicio de Neumoloxía, Complexo Hospitalario Clínico Universitario Choupana, s/n, 15706 Teo, A Coruña, Spain
, Carmen Cadarso Suárezb, Luis Valdés Cuadradoa, Rosaura Leisc, Rodrigo Cabanasc, Rafael Tojoc
a Servicio de Neumoloxía, Complexo Hospitalario Clínico Universitario, Santiago de Compostela, A Coruña, Spain
b Departamento de Bioestadística e Investigación Operativa, Universidad de Santiago de Compostela, Santiago de Compostela, A Coruña, Spain
c Departamento de Pediatría, Universidad de Santiago de Compostela, Santiago de Compostela, A Coruña, Spain
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Objective

It is well known that lung function referencevalues differ between populations, hence the apparentimportance of establishing such values. The aim of thisstudy was to develop prediction equations for spirometryfor healthy children and adolescents in Galicia, Spain.

Population and methods

We studied children andadolescents aged 6 to 18 years from randomly selectedschools in 14 municipalities in Galicia. Spirometric valueswere measured following the protocols established by the American Thoracic Society in 1987, with real-timemonitoring of flow-volume curves. The prediction equationswere derived using multivariate linear regression.

Results

We developed equations to predict the mainspirometry parameters for this age group according to sex, height, and weight. Mean spirometry values in relation toheight were higher for boys than for girls, except in the 140-160 cm range, where they were higher for girls. Equations published in other studies in similar populationsgave different predictions, ranging from an underestimationof forced midexpiratory flow rate (FEF25%-75%) by 16% incomparison to ours to an overestimation of peak expiratoryflow (PEF) rate by 15% for an average boy. For a girl, thecorresponding differences ranged from an underestimationof FEF25%-75% by 17% to an overestimation of PEF by 19%.

Conclusions

These results support the importance ofusing population-specific prediction equations to establishlung function reference values.

Key words:
Spirometry
Healthy children
Reference values
Objetivo

Son conocidas las diferencias entre distintaspoblaciones en cuanto a los valores de referencia de la fun-ción respiratoria, por lo cual parece importante establecer-los. El objetivo del estudio ha sido establecer las ecuacionesde predicción de parámetros espirométricos en niños y ado-lescentes sanos de Galicia.

Población y métodos

Hemos estudiado a niños y adoles-centes sanos de 6 a 18 años de edad, de colegios seleccionadosaleatoriamente en 14 municipios de Galicia. Las maniobrasespirométricas se realizaron de acuerdo con los protocolos dela American Thoracic Society de 1987, con evaluación conti-nua de los espirogramas. Se obtuvieron las ecuaciones depredicción mediante regresión lineal multivariante.

Resultados

Con este estudio se obtuvieron las ecuaciones depredicción de los principales parámetros espirométricos en estegrupo de edad, en función de la edad, el sexo, la talla y el peso. Los valores medios de los parámetros espirométricos, en funciónde la estatura, son superiores en la población masculina com-parada con la femenina, excepto en el rango entre 140 y 160 cmde altura, donde las mujeres superan a los varones. Para unvarón medio de nuestra población, los parámetros de funciónpulmonar obtenidos con las ecuaciones de predicción referidaspor otros autores en poblaciones similares difieren de los nues-tros, desde una infraestimación de un 16% para el flujo mesoes-piratorio forzado hasta una sobreestimación de un 15% para elpico de flujo espiratorio; para una mujer, las discrepancias vandesde la infraestimación del flujo mesoespiratorio forzado del 17%hasta la sobreestimación del pico de flujo espiratorio de un 19%.

Conclusiones

Estos resultados refuerzan la importanciade utilizar ecuaciones de predicción específicas para cadapoblación.

Palabras clave:
Espirometría forzada
Niños sanos
Valores dereferencia
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This study was partially funded by the Xunta de Galicia (60904.44055). Dr Cadarso's statistical work was financed with grants from the Spanish Ministry of Education and Science in collaboration with the European Regional Development Fund (MTM2005-00818).

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