Lung Cancer at a University Hospital: Epidemiological and Histological Characteristics of a Recent and a Historical Series

Santos-Martínez, M.J.; Curull, V.; Blanco, M.L.; Macià, F.; Mojal, S.; Vila, J.; Broquetas, J.M.

doi:10.1016/S1579-2129(06)60230-9

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Capelastegui, P.P. España, J.M. Quintana, I. Gorordo, A. Martínez Urquiri, I. Idoiaga, A. Bilbao" "autores" => array:7 [ 0 => array:3 [ "preGrado" => "Dr." "nombre" => "A." "apellidos" => "Capelastegui" ] 1 => array:2 [ "nombre" => "P.P." "apellidos" => "España" ] 2 => array:2 [ "nombre" => "J.M." "apellidos" => "Quintana" ] 3 => array:2 [ "nombre" => "I." "apellidos" => "Gorordo" ] 4 => array:2 [ "nombre" => "A." "apellidos" => "Martínez Urquiri" ] 5 => array:2 [ "nombre" => "I." "apellidos" => "Idoiaga" ] 6 => array:2 [ "nombre" => "A." 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"apellidos" => "Curull" "email" => array:1 [ 0 => "vcurull@imas.imim.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor1" ] ] ] 2 => array:3 [ "nombre" => "M.L." "apellidos" => "Blanco" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff1" ] ] ] 3 => array:3 [ "nombre" => "F." "apellidos" => "Macià" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff2" ] ] ] 4 => array:3 [ "nombre" => "S." "apellidos" => "Mojal" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "c" "identificador" => "aff3" ] ] ] 5 => array:3 [ "nombre" => "J." "apellidos" => "Vila" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "c" "identificador" => "aff3" ] ] ] 6 => array:3 [ "nombre" => "J.M." "apellidos" => "Broquetas" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servei de Pneumologia, Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, Spain" "etiqueta" => "a" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servei d'Avaluació i Epidemiologia Clínica, Hospital del Mar, Barcelona, Spain" "etiqueta" => "b" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Assesorament Metodològic a la Investigació Biomédica (AMIB), Institut Municipal d'Investigació Mèdica (IMIM), Barcelona, Spain" "etiqueta" => "c" "identificador" => "aff3" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dr. V. Curull. Servei de Pneumologia. Hospital del Mar. Pg. Marítim, 25-29. 08003 Barcelona. España" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2004-05-20" "fechaAceptado" => "2004-12-14" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec154084" "palabras" => array:3 [ 0 => "Lung cancer" 1 => "Epidemiology" 2 => "Histological type" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec154085" "palabras" => array:3 [ 0 => "Cáncer de pulmón" 1 => "Epidemiología" 2 => "Tipos histológicos" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "ObjectiveTO describe the clinical, histological, and epidemiological characteristics of patients diagnosed with lung cancer in our hospital over a period of 5 years and compare them with those of historical cases treated at the same hospital. Patients and methodsThe cases of patients diagnosed with lung cancer from January 1998 through December 2002 were studied retrospectively and compared with data published for the period from 1978 through March 1981. ResultsA total of 678 patients (89% men, mean age 67 years) were studied. Fifty-six percent of the men and 38% of the women were smokers (P <.001). The most common histological types were squamous cell carcinoma (33%) and adenocarcinoma (30%): squamous carcinoma in men (36%) and adenocarcinoma in women (56%). Metastasis was present in 42% of the patients with non-small cell lung cancer and in 55% of those with small cell lung cancer. In patients with a history of neoplastic disease, laryngeal tumors were most common in patients with squamous carcinoma whereas bladder tumors were the most frequent in patients with adenocarcinoma. The ratio of men to women was lower in the recent series than in the historical one. The percentage of squamous carcinoma was lower and that of adenocarcinoma higher (P <.001). The percentage of patients diagnosed with regional involvement was greater in the recent series (P <.001). ConclusionsSquamous cell carcinoma continues to be the most frequent histological type. Male sex and smoking are associated with squamous carcinoma and female sex is associated with adenocarcinoma. Epidemiological and histological patterns have changed, possibly in relation to changes in smoking habits." ] "es" => array:1 [ "resumen" => "ObjetivoDescribir las características clínicas, histológicas y epidemiológicas de los pacientes diagnosticados de cáncer de pulmón en nuestro hospital durante un período de 5 años y compararlas con las de una serie histórica del mismo centro. Pacientes y métodosSe incluyó retrospectivamente a todos los pacientes diagnosticados de cáncer de pulmón des-de enero de 1998 hasta diciembre de 2002, y se compararon con los datos obtenidos durante el período comprendido en-tre enero de 1978 y marzo de 1981. ResultadosEl total de pacientes fue de 678 y la edad media, de 67 años. De los varones (89%), el 56% eran fumadores, y de las mujeres, el 62% eran no fumadoras (p < 0,001). Los ti-pos histológicos más frecuentes fueron el carcinoma escamoso (33%) y el adenocarcinoma (30%). El carcinoma escamoso fue el más frecuente en varones (36%) y el adenocarcinoma en mujeres (56%). En el momento del diagnóstico presentaban metástasis el 42% de los pacientes con carcinoma no microcítico y el 55% de los microcíticos. Las neoplasias previas más frecuentes fueron la de laringe entre los pacientes con carcinoma escamoso y la de vejiga entre los afectados de adenocarcinoma. Al comparar con la serie histórica observamos que ac-tualmente la relación varón:mujer es menor, la proporción de carcinoma escamoso es inferior y la de adenocarcinoma superior (p < 0,001) y el porcentaje de pacientes diagnosticados en estadio regional es mayor (p < 0,001). ConclusionesEl tipo histológico más frecuente sigue sien-do el carcinoma escamoso. Ser varón y fumador se asocia a carcinoma escamoso, y ser mujer, a adenocarcinoma. En comparación con la serie histórica observamos cambios en las características epidemiológicas e histológicas, posiblemente en relación con las modificaciones en el hábito tabáquico." ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:21 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recent decline in cancer mortality in Catalonia (Spain). 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Archivos de Bronconeumología

ISSN: 0300-2896

Archivos de Bronconeumologia is an international journal that publishes original studies whose content is based upon results of research initiatives dealing with several aspects of respiratory medicine including epidemiology, respiratory physiology, pathophysiology of respiratory diseases, clinical management, thoracic surgery, pediatric lung diseases, respiratory critical care, respiratory allergy and basic research. Other types of articles such as editorials, reviews, and different types of letters are also published in the journal. Additionally, the journal expresses the voice of the following scientific societies: the Spanish Respiratory Society of Pneumology and Thoracic Surgery (SEPAR; https://www.separ.es/), the Latin American Thoracic Society (ALAT; https://alatorax.org/), and the Iberian American Association of Thoracic Surgery (AIACT; http://www.aiatorax.com/).

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Vol. 41. Issue 6.

Pages 307-312 (June 2005)

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Pages 307-312 (June 2005)

Original Articles

DOI: 10.1016/S1579-2129(06)60230-9

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Lung Cancer at a University Hospital: Epidemiological and Histological Characteristics of a Recent and a Historical Series

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M.J. Santos-Martíneza, V. Curulla,

Corresponding author

vcurull@imas.imim.es

Correspondence: Dr. V. Curull. Servei de Pneumologia. Hospital del Mar. Pg. Marítim, 25-29. 08003 Barcelona. España

, M.L. Blancoa, F. Maciàb, S. Mojalc, J. Vilac, J.M. Broquetasa

a Servei de Pneumologia, Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, Spain

b Servei d'Avaluació i Epidemiologia Clínica, Hospital del Mar, Barcelona, Spain

c Assesorament Metodològic a la Investigació Biomédica (AMIB), Institut Municipal d'Investigació Mèdica (IMIM), Barcelona, Spain

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Objective

TO describe the clinical, histological, and epidemiological characteristics of patients diagnosed with lung cancer in our hospital over a period of 5 years and compare them with those of historical cases treated at the same hospital.

Patients and methods

The cases of patients diagnosed with lung cancer from January 1998 through December 2002 were studied retrospectively and compared with data published for the period from 1978 through March 1981.

Results

A total of 678 patients (89% men, mean age 67 years) were studied. Fifty-six percent of the men and 38% of the women were smokers (P <.001). The most common histological types were squamous cell carcinoma (33%) and adenocarcinoma (30%): squamous carcinoma in men (36%) and adenocarcinoma in women (56%). Metastasis was present in 42% of the patients with non-small cell lung cancer and in 55% of those with small cell lung cancer. In patients with a history of neoplastic disease, laryngeal tumors were most common in patients with squamous carcinoma whereas bladder tumors were the most frequent in patients with adenocarcinoma. The ratio of men to women was lower in the recent series than in the historical one. The percentage of squamous carcinoma was lower and that of adenocarcinoma higher (P <.001). The percentage of patients diagnosed with regional involvement was greater in the recent series (P <.001).

Conclusions

Squamous cell carcinoma continues to be the most frequent histological type. Male sex and smoking are associated with squamous carcinoma and female sex is associated with adenocarcinoma. Epidemiological and histological patterns have changed, possibly in relation to changes in smoking habits.

Key words:

Lung cancer

Epidemiology

Histological type

Objetivo

Describir las características clínicas, histológicas y epidemiológicas de los pacientes diagnosticados de cáncer de pulmón en nuestro hospital durante un período de 5 años y compararlas con las de una serie histórica del mismo centro.

Pacientes y métodos

Se incluyó retrospectivamente a todos los pacientes diagnosticados de cáncer de pulmón des-de enero de 1998 hasta diciembre de 2002, y se compararon con los datos obtenidos durante el período comprendido en-tre enero de 1978 y marzo de 1981.

Resultados

El total de pacientes fue de 678 y la edad media, de 67 años. De los varones (89%), el 56% eran fumadores, y de las mujeres, el 62% eran no fumadoras (p < 0,001). Los ti-pos histológicos más frecuentes fueron el carcinoma escamoso (33%) y el adenocarcinoma (30%). El carcinoma escamoso fue el más frecuente en varones (36%) y el adenocarcinoma en mujeres (56%). En el momento del diagnóstico presentaban metástasis el 42% de los pacientes con carcinoma no microcítico y el 55% de los microcíticos. Las neoplasias previas más frecuentes fueron la de laringe entre los pacientes con carcinoma escamoso y la de vejiga entre los afectados de adenocarcinoma. Al comparar con la serie histórica observamos que ac-tualmente la relación varón:mujer es menor, la proporción de carcinoma escamoso es inferior y la de adenocarcinoma superior (p < 0,001) y el porcentaje de pacientes diagnosticados en estadio regional es mayor (p < 0,001).

Conclusiones

El tipo histológico más frecuente sigue sien-do el carcinoma escamoso. Ser varón y fumador se asocia a carcinoma escamoso, y ser mujer, a adenocarcinoma. En comparación con la serie histórica observamos cambios en las características epidemiológicas e histológicas, posiblemente en relación con las modificaciones en el hábito tabáquico.

Palabras clave:

Cáncer de pulmón

Epidemiología

Tipos histológicos

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