Original Articles
Lung Cancer at a University Hospital: Epidemiological and Histological Characteristics of a Recent and a Historical Series
M.J. Santos-Martíneza, V. Curulla,
, M.L. Blancoa, F. Maciàb, S. Mojalc, J. Vilac, J.M. Broquetasa
Corresponding author
vcurull@imas.imim.es
Correspondence: Dr. V. Curull. Servei de Pneumologia. Hospital del Mar. Pg. Marítim, 25-29. 08003 Barcelona. España
Correspondence: Dr. V. Curull. Servei de Pneumologia. Hospital del Mar. Pg. Marítim, 25-29. 08003 Barcelona. España
a Servei de Pneumologia, Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, Spain
b Servei d'Avaluació i Epidemiologia Clínica, Hospital del Mar, Barcelona, Spain
c Assesorament Metodològic a la Investigació Biomédica (AMIB), Institut Municipal d'Investigació Mèdica (IMIM), Barcelona, Spain
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"apellidos" => "Santos-Martínez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 1 => array:5 [ "preGrado" => "Dr." "nombre" => "V." "apellidos" => "Curull" "email" => array:1 [ 0 => "vcurull@imas.imim.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 2 => array:3 [ "nombre" => "M.L." "apellidos" => "Blanco" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 3 => array:3 [ "nombre" => "F." "apellidos" => "Macià" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 4 => array:3 [ "nombre" => "S." 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"apellidos" => "Broquetas" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servei de Pneumologia, Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servei d'Avaluació i Epidemiologia Clínica, Hospital del Mar, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Assesorament Metodològic a la Investigació Biomédica (AMIB), Institut Municipal d'Investigació Mèdica (IMIM), Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dr. V. Curull. Servei de Pneumologia. Hospital del Mar. Pg. Marítim, 25-29. 08003 Barcelona. España" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2004-05-20" "fechaAceptado" => "2004-12-14" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec154084" "palabras" => array:3 [ 0 => "Lung cancer" 1 => "Epidemiology" 2 => "Histological type" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec154085" "palabras" => array:3 [ 0 => "Cáncer de pulmón" 1 => "Epidemiología" 2 => "Tipos histológicos" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">TO describe the clinical, histological, and epidemiological characteristics of patients diagnosed with lung cancer in our hospital over a period of 5 years and compare them with those of historical cases treated at the same hospital.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">The cases of patients diagnosed with lung cancer from January 1998 through December 2002 were studied retrospectively and compared with data published for the period from 1978 through March 1981.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">A total of 678 patients (89% men, mean age 67 years) were studied. Fifty-six percent of the men and 38% of the women were smokers (<span class="elsevierStyleItalic">P</span> <.001). The most common histological types were squamous cell carcinoma (33%) and adenocarcinoma (30%): squamous carcinoma in men (36%) and adenocarcinoma in women (56%). Metastasis was present in 42% of the patients with non-small cell lung cancer and in 55% of those with small cell lung cancer. In patients with a history of neoplastic disease, laryngeal tumors were most common in patients with squamous carcinoma whereas bladder tumors were the most frequent in patients with adenocarcinoma. The ratio of men to women was lower in the recent series than in the historical one. The percentage of squamous carcinoma was lower and that of adenocarcinoma higher (<span class="elsevierStyleItalic">P</span> <.001). The percentage of patients diagnosed with regional involvement was greater in the recent series (<span class="elsevierStyleItalic">P</span> <.001).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Squamous cell carcinoma continues to be the most frequent histological type. Male sex and smoking are associated with squamous carcinoma and female sex is associated with adenocarcinoma. Epidemiological and histological patterns have changed, possibly in relation to changes in smoking habits.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Describir las características clínicas, histológicas y epidemiológicas de los pacientes diagnosticados de cáncer de pulmón en nuestro hospital durante un período de 5 años y compararlas con las de una serie histórica del mismo centro.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se incluyó retrospectivamente a todos los pacientes diagnosticados de cáncer de pulmón des-de enero de 1998 hasta diciembre de 2002, y se compararon con los datos obtenidos durante el período comprendido en-tre enero de 1978 y marzo de 1981.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">El total de pacientes fue de 678 y la edad media, de 67 años. De los varones (89%), el 56% eran fumadores, y de las mujeres, el 62% eran no fumadoras (p < 0,001). Los ti-pos histológicos más frecuentes fueron el carcinoma escamoso (33%) y el adenocarcinoma (30%). El carcinoma escamoso fue el más frecuente en varones (36%) y el adenocarcinoma en mujeres (56%). En el momento del diagnóstico presentaban metástasis el 42% de los pacientes con carcinoma no microcítico y el 55% de los microcíticos. Las neoplasias previas más frecuentes fueron la de laringe entre los pacientes con carcinoma escamoso y la de vejiga entre los afectados de adenocarcinoma. Al comparar con la serie histórica observamos que ac-tualmente la relación varón:mujer es menor, la proporción de carcinoma escamoso es inferior y la de adenocarcinoma superior (p < 0,001) y el porcentaje de pacientes diagnosticados en estadio regional es mayor (p < 0,001).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">El tipo histológico más frecuente sigue sien-do el carcinoma escamoso. Ser varón y fumador se asocia a carcinoma escamoso, y ser mujer, a adenocarcinoma. En comparación con la serie histórica observamos cambios en las características epidemiológicas e histológicas, posiblemente en relación con las modificaciones en el hábito tabáquico.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:21 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recent decline in cancer mortality in Catalonia (Spain). 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 4 | 4 | 8 |
| 2024 October | 26 | 14 | 40 |
| 2024 September | 32 | 15 | 47 |
| 2024 August | 39 | 31 | 70 |
| 2024 July | 25 | 23 | 48 |
| 2024 June | 32 | 17 | 49 |
| 2024 May | 39 | 24 | 63 |
| 2024 April | 23 | 24 | 47 |
| 2024 March | 15 | 17 | 32 |
| 2024 February | 20 | 20 | 40 |
| 2023 March | 1 | 3 | 4 |
| 2023 February | 15 | 15 | 30 |
| 2023 January | 16 | 27 | 43 |
| 2022 December | 19 | 26 | 45 |
| 2022 November | 21 | 18 | 39 |
| 2022 October | 22 | 26 | 48 |
| 2022 September | 10 | 16 | 26 |
| 2022 August | 24 | 30 | 54 |
| 2022 July | 19 | 36 | 55 |
| 2022 June | 17 | 30 | 47 |
| 2022 May | 19 | 30 | 49 |
| 2022 April | 18 | 22 | 40 |
| 2022 March | 22 | 36 | 58 |
| 2022 February | 16 | 44 | 60 |
| 2022 January | 18 | 32 | 50 |
| 2021 December | 19 | 40 | 59 |
| 2021 November | 18 | 42 | 60 |
| 2021 October | 18 | 35 | 53 |
| 2021 September | 12 | 43 | 55 |
| 2021 August | 11 | 19 | 30 |
| 2021 July | 13 | 29 | 42 |
| 2021 June | 16 | 43 | 59 |
| 2021 May | 14 | 24 | 38 |
| 2021 April | 26 | 58 | 84 |
| 2021 March | 32 | 13 | 45 |
| 2021 February | 12 | 17 | 29 |
| 2021 January | 10 | 17 | 27 |
| 2020 December | 16 | 22 | 38 |
| 2020 November | 7 | 9 | 16 |
| 2020 October | 10 | 8 | 18 |
| 2020 September | 5 | 4 | 9 |
| 2020 August | 11 | 12 | 23 |
| 2020 July | 9 | 17 | 26 |
| 2020 June | 4 | 5 | 9 |
| 2020 May | 30 | 15 | 45 |
| 2020 April | 27 | 14 | 41 |
| 2020 March | 12 | 12 | 24 |
| 2020 February | 14 | 17 | 31 |
| 2020 January | 18 | 17 | 35 |
| 2019 December | 19 | 11 | 30 |
| 2019 November | 15 | 16 | 31 |
| 2019 October | 4 | 9 | 13 |
| 2019 September | 4 | 6 | 10 |
| 2019 August | 10 | 13 | 23 |
| 2019 July | 10 | 15 | 25 |
| 2019 June | 5 | 11 | 16 |
| 2019 May | 9 | 5 | 14 |
| 2019 April | 10 | 14 | 24 |
| 2019 March | 10 | 25 | 35 |
| 2019 February | 7 | 12 | 19 |
| 2019 January | 8 | 7 | 15 |
| 2018 December | 8 | 15 | 23 |
| 2018 November | 17 | 15 | 32 |
| 2018 October | 19 | 10 | 29 |
| 2018 September | 14 | 7 | 21 |
| 2018 May | 1 | 4 | 5 |
| 2018 April | 8 | 6 | 14 |
| 2018 March | 3 | 4 | 7 |
| 2018 February | 4 | 8 | 12 |
| 2018 January | 5 | 7 | 12 |
| 2017 December | 6 | 4 | 10 |
| 2017 November | 5 | 4 | 9 |
| 2017 October | 10 | 6 | 16 |
| 2017 September | 5 | 12 | 17 |
| 2017 August | 4 | 7 | 11 |
| 2017 July | 1 | 6 | 7 |
| 2017 June | 8 | 7 | 15 |
| 2017 May | 7 | 9 | 16 |
| 2017 April | 2 | 5 | 7 |
| 2017 March | 2 | 5 | 7 |
| 2017 February | 2 | 3 | 5 |
| 2017 January | 2 | 3 | 5 |
| 2016 December | 7 | 8 | 15 |
| 2016 November | 12 | 6 | 18 |
| 2016 October | 11 | 6 | 17 |
| 2016 September | 15 | 8 | 23 |
| 2016 August | 16 | 5 | 21 |
| 2016 July | 4 | 0 | 4 |
| 2016 March | 2 | 0 | 2 |
| 2015 December | 3 | 0 | 3 |
| 2015 October | 45 | 1 | 46 |
| 2015 September | 40 | 9 | 49 |
| 2015 August | 34 | 16 | 50 |
| 2015 July | 43 | 6 | 49 |
| 2015 June | 31 | 9 | 40 |
| 2015 May | 61 | 6 | 67 |
| 2015 April | 55 | 12 | 67 |
| 2015 March | 38 | 10 | 48 |
| 2015 February | 33 | 10 | 43 |
| 2015 January | 37 | 6 | 43 |
| 2014 December | 36 | 8 | 44 |
| 2014 November | 31 | 8 | 39 |
| 2014 October | 52 | 16 | 68 |
| 2014 September | 37 | 11 | 48 |
| 2014 August | 50 | 16 | 66 |
| 2014 July | 46 | 12 | 58 |
| 2014 June | 45 | 15 | 60 |
| 2014 May | 58 | 14 | 72 |
| 2014 April | 60 | 9 | 69 |
| 2014 March | 63 | 16 | 79 |
| 2014 February | 51 | 12 | 63 |
| 2014 January | 33 | 10 | 43 |
| 2013 December | 42 | 12 | 54 |
| 2013 November | 43 | 17 | 60 |
| 2013 October | 35 | 11 | 46 |
| 2013 September | 37 | 9 | 46 |
| 2013 August | 32 | 19 | 51 |
| 2013 July | 56 | 19 | 75 |
| 2013 June | 42 | 6 | 48 |
| 2013 May | 43 | 3 | 46 |
| 2013 April | 23 | 8 | 31 |
| 2013 March | 7 | 2 | 9 |
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