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Vol. 60. Issue 6.
Pages 364-373 (June 2024)
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Vol. 60. Issue 6.
Pages 364-373 (June 2024)
Review Article
Improving the Diagnosis and Treatment of Paediatric Bronchiectasis Through Research and Translation
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Anne B. Changa,b,
Corresponding author
anne.chang@menzies.edu.au

Corresponding author.
, Shyamali C. Dharmagec, Julie M. Marchanta, Gabrielle B. McCallumb, Peter S. Morrisb,d, Andre Schultze,f, Maree Toombsb,g, Danielle F. Wurzelc, Stephanie T. Yerkovicha,b, Keith Grimwoodh,i, CRE extended group 1
a Australian Centre for Health Services Innovation, Queensland University of Technology, Brisbane, QLD, Australia
b NHMRC Centre for Research Excellence in Paediatric Bronchiectasis (AusBREATHE), Child and Maternal Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia
c Allergy and Lung Health Unit, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia
d Department of Paediatrics, Royal Darwin Hospital, Darwin, NT, Australia
e Wal-yan Respiratory Research Centre, Telethon Kids Institute and Division of Paediatrics, Faculty of Medicine, University of Western Australia, Perth, WA, Australia
f Department of Respiratory Medicine, Perth Children's Hospital, Perth, WA, Australia
g School of Public Health, University of Sydney, Sydney, NSW, Australia
h Departments of Infectious Disease and Paediatrics, Gold Coast Health, Gold Coast, QLD, Australia
i School of Medicine and Dentistry, Griffith University, Gold Coast, QLD, Australia
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Tables (3)
Table 1. Planned and current studies within AusBREATHE (Australian Bronchiectasis Centre of Research Excellence) that seek to reduce the burden of bronchiectasis in children.
Table 2. Repository of resources available for paediatric bronchiectasis.
Table 3. The top 10 research priorities derived from an international survey and consensus.a
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Abstract

Bronchiectasis, particularly in children, is an increasingly recognised yet neglected chronic lung disorder affecting individuals in both low-to-middle and high-income countries. It has a high disease burden and there is substantial inequity within and between settings. Furthermore, compared with other chronic lung diseases, considerably fewer resources are available for children with bronchiectasis. The need to prevent bronchiectasis and to reduce its burden also synchronously aligns with its high prevalence and economic costs to health services and society.

Like many chronic lung diseases, bronchiectasis often originates early in childhood, highlighting the importance of reducing the disease burden in children. Concerted efforts are therefore needed to improve disease detection, clinical management and equity of care. Modifiable factors in the causal pathways of bronchiectasis, such as preventing severe and recurrent lower respiratory infections should be addressed, whilst also acknowledging the role played by social determinants of health.

Here, we highlight the importance of early recognition/detection and optimal management of bronchiectasis in children, and outline our research, which is attempting to address important clinical knowledge gaps discussed in a recent workshop. The research is grouped under three themes focussing upon primary prevention, improving diagnosis and disease characterisation, and providing better management. Our hope is that others in multiple settings will undertake additional studies in this neglected field to further improve the lives of people with bronchiectasis. We also provide a resource list with links to help inform consumers and healthcare professionals about bronchiectasis and its recognition and management.

Keywords:
Resources
Lung health
Bronchiectasis
Children
Abbreviations:
ABR
ALRI
APP
Azithro
BAL
BAR
CB-QoL
CF
CFTR
COPD
CRE
CT
CWC
ERS
FEV1
HIC
LMIC
MRFF
NHMRC
PBB
QoL
RCT
TSANZ
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