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En este estudio hemos realizado una valoración de la expresión inmunohistoquímica de pl85 y antígeno nuclear de proliferación celular (PCNA) en 68 carcinomas no microcíticos de pulmón sometidos a tratamiento quirúrgico.
El adenocarcinoma de pulmón fue el tipo histológico que con mayor frecuencia expresó pl85 a niveles superiores al 10%, con relación estadísticamente significativa; mientras que el carcinoma epidermoide se asoció a índices de proliferación más elevados.
Aunque estos dos marcadores no mostraron carácter pronóstico en el estudio de la supervivencia, debe señalarse que las supervivencias más prolongadas se obtuvieron en los pacientes que expresaron pl85 en menos del 10% de las células neoplásicas.
Palabras clave:
Antígeno nuclear de proliferación celular p185
Carcinoma no microcítico de pulmón
We assessed immunohistochemical expression of pl85 and the proliferating cell nuclear antigen (PCNA) in 68 patients undergoing surgery for non-small cell lung cancer.
Adenocarcinoma of the lung was the histological type whose expression of pl85 at levels exceeding 10% was greater to a statistically signifícant degree. Epidermoid carcinoma, on the other hand, was associated with the highest PCNA indices.
Although these 2 markers had no prognostic value in the survival study, it must be pointed out that the longest survivors were patients with pl85 expression less than 10% in neoplastic cells.
Key words:
Proliferating cell nuclear antigen pl85
Non-small cell lung cancer
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