Estudio de la expresión del antígeno nuclear de proliferación celular y pl85 en el carcinoma no microcítico de pulmón
Study of proliferating cell nuclear antigen and pl85 in non-small cell lung cancer
Servicio de Anatomía Patológica. Hospital General Universitario de Valencia
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Salvador Villalba, E. Martínez Leandro" "autores" => array:4 [ 0 => array:3 [ "nombre" => "P." "apellidos" => "Alemany Monraval" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Martorell Cebollada" ] 2 => array:2 [ "nombre" => "I." "apellidos" => "Salvador Villalba" ] 3 => array:2 [ "nombre" => "E." "apellidos" => "Martínez Leandro" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Anatomía Patológica. Hospital General Universitario de Valencia" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: General Avilés, 48, 2.°. 46015 Valencia." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Study of proliferating cell nuclear antigen and pl85 in non-small cell lung cancer" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1995-07-07" "fechaAceptado" => "1995-11-21" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec546131" "palabras" => array:2 [ 0 => "Antígeno nuclear de proliferación celular p185" 1 => "Carcinoma no microcítico de pulmón" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec546130" "palabras" => array:2 [ 0 => "Proliferating cell nuclear antigen pl85" 1 => "Non-small cell lung cancer" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">En este estudio hemos realizado una valoración de la expresión inmunohistoquímica de pl85 y antígeno nuclear de proliferación celular (PCNA) en 68 carcinomas no microcíticos de pulmón sometidos a tratamiento quirúrgico.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El adenocarcinoma de pulmón fue el tipo histológico que con mayor frecuencia expresó pl85 a niveles superiores al 10%, con relación estadísticamente significativa; mientras que el carcinoma epidermoide se asoció a índices de proliferación más elevados.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Aunque estos dos marcadores no mostraron carácter pronóstico en el estudio de la supervivencia, debe señalarse que las supervivencias más prolongadas se obtuvieron en los pacientes que expresaron pl85 en menos del 10% de las células neoplásicas.</p></span>" ] "en" => array:1 [ "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">We assessed immunohistochemical expression of pl85 and the proliferating cell nuclear antigen (PCNA) in 68 patients undergoing surgery for non-small cell lung cancer.</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Adenocarcinoma of the lung was the histological type whose expression of pl85 at levels exceeding 10% was greater to a statistically signifícant degree. Epidermoid carcinoma, on the other hand, was associated with the highest PCNA indices.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Although these 2 markers had no prognostic value in the survival study, it must be pointed out that the longest survivors were patients with pl85 expression less than 10% in neoplastic cells.</p></span>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:31 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Exposición ambiental al humo del tabaco y cáncer de pulmón" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Agudo" 1 => "C.A. González" 2 => "M. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 5 | 8 | 13 |
| 2024 October | 34 | 47 | 81 |
| 2024 September | 45 | 40 | 85 |
| 2024 August | 45 | 45 | 90 |
| 2024 July | 45 | 46 | 91 |
| 2024 June | 74 | 39 | 113 |
| 2024 May | 59 | 36 | 95 |
| 2024 April | 41 | 28 | 69 |
| 2024 March | 46 | 36 | 82 |
| 2024 February | 28 | 33 | 61 |
| 2024 January | 0 | 2 | 2 |
| 2023 December | 0 | 11 | 11 |
| 2023 November | 0 | 4 | 4 |
| 2023 October | 0 | 2 | 2 |
| 2023 September | 0 | 3 | 3 |
| 2023 August | 0 | 1 | 1 |
| 2023 July | 0 | 17 | 17 |
| 2023 June | 0 | 3 | 3 |
| 2023 April | 1 | 0 | 1 |
| 2023 March | 4 | 3 | 7 |
| 2023 February | 23 | 15 | 38 |
| 2023 January | 22 | 23 | 45 |
| 2022 December | 32 | 34 | 66 |
| 2022 November | 40 | 15 | 55 |
| 2022 October | 29 | 27 | 56 |
| 2022 September | 26 | 15 | 41 |
| 2022 August | 27 | 45 | 72 |
| 2022 July | 26 | 32 | 58 |
| 2022 June | 19 | 26 | 45 |
| 2022 May | 31 | 22 | 53 |
| 2022 April | 37 | 28 | 65 |
| 2022 March | 27 | 34 | 61 |
| 2022 February | 27 | 20 | 47 |
| 2022 January | 29 | 39 | 68 |
| 2021 December | 15 | 29 | 44 |
| 2021 November | 28 | 34 | 62 |
| 2021 October | 18 | 38 | 56 |
| 2021 September | 10 | 34 | 44 |
| 2021 August | 16 | 23 | 39 |
| 2021 July | 23 | 30 | 53 |
| 2021 June | 19 | 38 | 57 |
| 2021 May | 17 | 31 | 48 |
| 2021 April | 19 | 69 | 88 |
| 2021 March | 40 | 39 | 79 |
| 2021 February | 19 | 26 | 45 |
| 2021 January | 15 | 47 | 62 |
| 2020 December | 20 | 48 | 68 |
| 2020 November | 12 | 39 | 51 |
| 2020 October | 9 | 31 | 40 |
| 2020 September | 9 | 48 | 57 |
| 2020 August | 23 | 47 | 70 |
| 2020 July | 22 | 34 | 56 |
| 2020 June | 10 | 21 | 31 |
| 2020 May | 21 | 42 | 63 |
| 2020 April | 23 | 22 | 45 |
| 2020 March | 15 | 32 | 47 |
| 2020 February | 35 | 29 | 64 |
| 2020 January | 25 | 16 | 41 |
| 2019 December | 33 | 27 | 60 |
| 2019 November | 13 | 9 | 22 |
| 2019 October | 10 | 13 | 23 |
| 2019 September | 13 | 14 | 27 |
| 2019 August | 16 | 8 | 24 |
| 2019 July | 16 | 27 | 43 |
| 2019 June | 14 | 10 | 24 |
| 2019 May | 27 | 29 | 56 |
| 2019 April | 58 | 40 | 98 |
| 2019 March | 17 | 20 | 37 |
| 2019 February | 12 | 10 | 22 |
| 2019 January | 12 | 16 | 28 |
| 2018 December | 13 | 13 | 26 |
| 2018 November | 25 | 20 | 45 |
| 2018 October | 21 | 13 | 34 |
| 2018 September | 21 | 11 | 32 |
| 2018 May | 6 | 2 | 8 |
| 2018 April | 8 | 17 | 25 |
| 2018 March | 8 | 20 | 28 |
| 2018 February | 5 | 11 | 16 |
| 2018 January | 10 | 14 | 24 |
| 2017 December | 10 | 9 | 19 |
| 2017 November | 4 | 6 | 10 |
| 2017 October | 9 | 15 | 24 |
| 2017 September | 6 | 8 | 14 |
| 2017 August | 12 | 19 | 31 |
| 2017 July | 7 | 5 | 12 |
| 2017 June | 16 | 15 | 31 |
| 2017 May | 21 | 9 | 30 |
| 2017 April | 14 | 41 | 55 |
| 2017 March | 30 | 19 | 49 |
| 2017 February | 18 | 11 | 29 |
| 2017 January | 9 | 8 | 17 |
| 2016 December | 17 | 5 | 22 |
| 2016 November | 22 | 11 | 33 |
| 2016 October | 36 | 26 | 62 |
| 2016 September | 28 | 12 | 40 |
| 2016 August | 15 | 4 | 19 |
| 2016 July | 14 | 5 | 19 |
| 2016 June | 23 | 10 | 33 |
| 2016 May | 16 | 7 | 23 |
| 2016 April | 14 | 0 | 14 |
| 2016 March | 8 | 0 | 8 |
| 2016 February | 16 | 1 | 17 |
| 2016 January | 26 | 11 | 37 |
| 2015 December | 26 | 12 | 38 |
| 2015 November | 31 | 6 | 37 |
| 2015 October | 5 | 2 | 7 |
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