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      "titulo" => "Afectacion costal en un caso de enfermedad de castleman"
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          "autoresLista" => "M.A. De Gregorio Ariza, M. Roca Espiau, I. Ariño Galve, R. Marco Larraga, S. Bello Dronda, M. Vila Justribo"
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          "autoresLista" => "M. Marín Górriz"
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      "titulo" => "Frecuencia dependencia de la resistencia de las vias aereas en las estenosis de vias aereas superiores extratoracicas (EVAS): utilidad diagnostica de unos nuevos indices"
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          "autoresLista" => "C. Escudero Bueno, L. Molinos Martin, A. Gonzalez Panizo, C. Orejas Garcia, J. Ordiales Fernandez, J. Martinez Gonzalez-Rio"
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            0 => array:2 [
              "nombre" => "C."
              "apellidos" => "Escudero Bueno"
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    "titulo" => "Estudio del efecto de la nifedipina sobre las vias aereas en pacientes afectos de broncopatia obstructiva cronica"
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        "autoresLista" => "J.A. Madrigal Vilata, R. Llopis Llombart, J. Merino Sesma, J. Muñoz Gil, L. Insa Perez, V. Lopez Merino"
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          0 => array:2 [
            "nombre" => "J.A."
            "apellidos" => "Madrigal Vilata"
          ]
          1 => array:2 [
            "nombre" => "R."
            "apellidos" => "Llopis Llombart"
          ]
          2 => array:2 [
            "nombre" => "J."
            "apellidos" => "Merino Sesma"
          ]
          3 => array:2 [
            "nombre" => "J."
            "apellidos" => "Muñoz Gil"
          ]
          4 => array:2 [
            "nombre" => "L."
            "apellidos" => "Insa Perez"
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          5 => array:2 [
            "nombre" => "V."
            "apellidos" => "Lopez Merino"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Servicio de Cardiología. Hospital Clínico Universitario. Valencia"
            "identificador" => "aff0005"
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        ]
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        "titulo" => "The effect of nifedipine on the airways in chronic obstructive bronchial disorders"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Hemos estudiado el efecto que la nifedipina&#44; un antagonista de los canales lentos del calcio&#44; ejerce sobre las v&#237;as a&#233;reas&#44; compar&#225;ndolo con el ejercido por el salbutamol&#44; habiendo encontrado que la nifedipina mejora ligeramente la obstrucci&#243;n bronquial increment&#225;ndose la VC en 6&#44;7&#37; &#40;P &#60; 0&#44;01&#41;&#44; el FEV<span class="elsevierStyleInf">1</span> en 9&#44;1&#37; &#40;P &#60; 0&#44;01&#41;&#44; el MEF<span class="elsevierStyleInf">50&#37;</span><span class="elsevierStyleSmallCaps">vc</span> en 15&#44;8&#37; &#40;P &#60; 0&#44;01&#41;&#44; el MMFR en 19&#44;7&#37; &#40;P &#60; 0&#44;05&#41;&#44; el PEF en 8&#44;5&#37; &#40;P &#60; 0&#44;05&#41; y la conductancia espec&#237;fica de v&#237;as &#225;reas en 39&#44;9&#37; &#40;P &#60; 0&#44;01&#41;&#44; y disminuyendo la resistencia de v&#237;as a&#233;reas en 25&#44;7&#37; &#40;P &#60; 0&#44;001&#41;&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Los resultados obtenidos no justifican el uso de la nifedipina como f&#225;rmaco broncodilatador&#44; pero s&#237; la convierten en alternativa v&#225;lida a otros f&#225;rmacos que pueden estar contraindicados en casos en los que se asocia una patolog&#237;a respiratoria a otra cardiovascular&#46;</p></span>"
      ]
      "en" => array:1 [
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Nifedipine&#44; which interferes with the passage of calcium ions was compared to salbutamol for its effect on the airways in obstructive bronchial disorders&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Nifedipine was found to slightly improve bronchial obstruction by increasing VC by 6&#46;7&#37; &#40;p &#60; 0&#46;01&#41;&#59; FEV<span class="elsevierStyleInf">1</span> by 9&#46;1&#37; &#40;p &#60; 0&#46;01&#41;&#59; MEF<span class="elsevierStyleInf">50&#37;</span><span class="elsevierStyleSmallCaps">vc</span> by 15&#46;8&#37; &#40;p &#60; 0&#46;01&#41;&#59; MMRF by 19&#46;7&#37; &#40;p &#60; 0&#46;05&#41;&#59; PEF by 8&#46;5&#37; &#40;p &#60; 0&#46;05&#41; and specific airways flow by 39&#46;9&#37; &#40;p &#60; 0&#46;01&#41; while decreasing airways resistance by 25&#46;7&#37; &#40;p &#60; 0&#46;001&#41;&#46; These findings do not justify the use of nifedipine as a broncbodilator although it is a valid altemative in cases where there is concommitant respiratory and cardiovascular disorder and other agents are not viable&#46;</p></span>"
      ]
    ]
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      "titulo" => "Bibliografia"
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        0 => array:2 [
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            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1&#46;"
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                0 => array:2 [
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                    0 => array:2 [
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                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46; Leff"
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                  "host" => array:1 [
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                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1982"
                        "volumen" => "81"
                        "paginaInicial" => "224"
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                            "web" => "Medline"
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            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2&#46;"
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                0 => array:2 [
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              "etiqueta" => "3&#46;"
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                            1 => "R&#46; Morice"
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                  "host" => array:1 [
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                        "fecha" => "1983"
                        "volumen" => "127"
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                    ]
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                ]
              ]
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            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The effect of calcium antagonist&#44; nifedipine&#44; in exercise-induced asthma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
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                            0 => "K&#46;R&#46; Patel"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
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                      "Revista" => array:6 [
                        "tituloSerie" => "Clinical Allergy"
                        "fecha" => "1981"
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                      ]
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                      "autores" => array:1 [
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                            1 => "A&#46; Denjean"
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                          ]
                        ]
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                  ]
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                    0 => array:2 [
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            5 => array:3 [
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                    0 => array:2 [
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                      "autores" => array:1 [
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                          "etal" => false
                          "autores" => array:3 [
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                          ]
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                      ]
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                  ]
                  "host" => array:1 [
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                        ]
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                0 => array:2 [
                  "contribucion" => array:1 [
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                      "autores" => array:1 [
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                            0 => "N&#46; Himori"
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                          ]
                        ]
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                      ]
                    ]
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            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Calcium-channel blockers and asthma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
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                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
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                        "tituloSerie" => "Thorax"
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                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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            8 => array:3 [
              "identificador" => "bib0045"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A rapid plethysmographic method for measuring thoracic gas volume&#46; A comparison with a nitrogen washout method for measuring functional residual capacity in normal subjects"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46;B&#46; Dubois"
                            1 => "S&#46;Y&#46; Botelho"
                            2 => "G&#46;N&#46; Bedell"
                            3 => "R&#46; Marsahall"
                            4 => "J&#46;H&#46; Comroe Jr&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1172/JCI103281"
                      "Revista" => array:6 [
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                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A new method for measuring in man using a body plethysmograph&#58; values in normal subjects and in patients with respiratory disease"
                      "autores" => array:1 [
                        0 => array:2 [
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January - February 1985 Estudio del efecto de la nifedipina sobre las vias aereas en pacientes afectos de...
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Vol. 21. Issue 1.
Pages 29-33 (January - February 1985)
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Vol. 21. Issue 1.
Pages 29-33 (January - February 1985)
DOI: 10.1016/S0300-2896(15)32209-2
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Estudio del efecto de la nifedipina sobre las vias aereas en pacientes afectos de broncopatia obstructiva cronica
The effect of nifedipine on the airways in chronic obstructive bronchial disorders
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J.A. Madrigal Vilata, R. Llopis Llombart, J. Merino Sesma, J. Muñoz Gil, L. Insa Perez, V. Lopez Merino
Servicio de Cardiología. Hospital Clínico Universitario. Valencia
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Hemos estudiado el efecto que la nifedipina, un antagonista de los canales lentos del calcio, ejerce sobre las vías aéreas, comparándolo con el ejercido por el salbutamol, habiendo encontrado que la nifedipina mejora ligeramente la obstrucción bronquial incrementándose la VC en 6,7% (P < 0,01), el FEV1 en 9,1% (P < 0,01), el MEF50%vc en 15,8% (P < 0,01), el MMFR en 19,7% (P < 0,05), el PEF en 8,5% (P < 0,05) y la conductancia específica de vías áreas en 39,9% (P < 0,01), y disminuyendo la resistencia de vías aéreas en 25,7% (P < 0,001).

Los resultados obtenidos no justifican el uso de la nifedipina como fármaco broncodilatador, pero sí la convierten en alternativa válida a otros fármacos que pueden estar contraindicados en casos en los que se asocia una patología respiratoria a otra cardiovascular.

Nifedipine, which interferes with the passage of calcium ions was compared to salbutamol for its effect on the airways in obstructive bronchial disorders.

Nifedipine was found to slightly improve bronchial obstruction by increasing VC by 6.7% (p < 0.01); FEV1 by 9.1% (p < 0.01); MEF50%vc by 15.8% (p < 0.01); MMRF by 19.7% (p < 0.05); PEF by 8.5% (p < 0.05) and specific airways flow by 39.9% (p < 0.01) while decreasing airways resistance by 25.7% (p < 0.001). These findings do not justify the use of nifedipine as a broncbodilator although it is a valid altemative in cases where there is concommitant respiratory and cardiovascular disorder and other agents are not viable.

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