Estudio del efecto de la nifedipina sobre las vias aereas en pacientes afectos de broncopatia obstructiva cronica
The effect of nifedipine on the airways in chronic obstructive bronchial disorders
J.A. Madrigal Vilata, R. Llopis Llombart, J. Merino Sesma, J. Muñoz Gil, L. Insa Perez, V. Lopez Merino
Servicio de Cardiología. Hospital Clínico Universitario. Valencia
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Escudero Bueno, L. Molinos Martin, A. Gonzalez Panizo, C. Orejas Garcia, J. Ordiales Fernandez, J. Martinez Gonzalez-Rio" "autores" => array:6 [ 0 => array:2 [ "nombre" => "C." "apellidos" => "Escudero Bueno" ] 1 => array:2 [ "nombre" => "L." "apellidos" => "Molinos Martin" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Gonzalez Panizo" ] 3 => array:2 [ "nombre" => "C." "apellidos" => "Orejas Garcia" ] 4 => array:2 [ "nombre" => "J." "apellidos" => "Ordiales Fernandez" ] 5 => array:2 [ "nombre" => "J." "apellidos" => "Martinez Gonzalez-Rio" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615322080?idApp=UINPBA00003Z" "url" => "/03002896/0000002100000001/v1_201509151141/S0300289615322080/v1_201509151141/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "titulo" => "Estudio del efecto de la nifedipina sobre las vias aereas en pacientes afectos de broncopatia obstructiva cronica" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "29" "paginaFinal" => "33" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "J.A. Madrigal Vilata, R. Llopis Llombart, J. Merino Sesma, J. Muñoz Gil, L. Insa Perez, V. Lopez Merino" "autores" => array:6 [ 0 => array:2 [ "nombre" => "J.A." "apellidos" => "Madrigal Vilata" ] 1 => array:2 [ "nombre" => "R." "apellidos" => "Llopis Llombart" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Merino Sesma" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "Muñoz Gil" ] 4 => array:2 [ "nombre" => "L." "apellidos" => "Insa Perez" ] 5 => array:2 [ "nombre" => "V." "apellidos" => "Lopez Merino" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Cardiología. Hospital Clínico Universitario. Valencia" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "The effect of nifedipine on the airways in chronic obstructive bronchial disorders" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1984-05-22" "fechaAceptado" => "1984-07-05" "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Hemos estudiado el efecto que la nifedipina, un antagonista de los canales lentos del calcio, ejerce sobre las vías aéreas, comparándolo con el ejercido por el salbutamol, habiendo encontrado que la nifedipina mejora ligeramente la obstrucción bronquial incrementándose la VC en 6,7% (P < 0,01), el FEV<span class="elsevierStyleInf">1</span> en 9,1% (P < 0,01), el MEF<span class="elsevierStyleInf">50%</span><span class="elsevierStyleSmallCaps">vc</span> en 15,8% (P < 0,01), el MMFR en 19,7% (P < 0,05), el PEF en 8,5% (P < 0,05) y la conductancia específica de vías áreas en 39,9% (P < 0,01), y disminuyendo la resistencia de vías aéreas en 25,7% (P < 0,001).</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Los resultados obtenidos no justifican el uso de la nifedipina como fármaco broncodilatador, pero sí la convierten en alternativa válida a otros fármacos que pueden estar contraindicados en casos en los que se asocia una patología respiratoria a otra cardiovascular.</p></span>" ] "en" => array:1 [ "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Nifedipine, which interferes with the passage of calcium ions was compared to salbutamol for its effect on the airways in obstructive bronchial disorders.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Nifedipine was found to slightly improve bronchial obstruction by increasing VC by 6.7% (p < 0.01); FEV<span class="elsevierStyleInf">1</span> by 9.1% (p < 0.01); MEF<span class="elsevierStyleInf">50%</span><span class="elsevierStyleSmallCaps">vc</span> by 15.8% (p < 0.01); MMRF by 19.7% (p < 0.05); PEF by 8.5% (p < 0.05) and specific airways flow by 39.9% (p < 0.01) while decreasing airways resistance by 25.7% (p < 0.001). These findings do not justify the use of nifedipine as a broncbodilator although it is a valid altemative in cases where there is concommitant respiratory and cardiovascular disorder and other agents are not viable.</p></span>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografia" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:29 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathophysiology of asthmatic bronchoconstriction" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 3 | 4 | 7 |
| 2024 October | 33 | 17 | 50 |
| 2024 September | 42 | 16 | 58 |
| 2024 August | 52 | 39 | 91 |
| 2024 July | 29 | 36 | 65 |
| 2024 June | 37 | 28 | 65 |
| 2024 May | 41 | 29 | 70 |
| 2024 April | 27 | 17 | 44 |
| 2024 March | 33 | 27 | 60 |
| 2024 February | 21 | 32 | 53 |
| 2023 December | 0 | 6 | 6 |
| 2023 November | 0 | 2 | 2 |
| 2023 October | 0 | 4 | 4 |
| 2023 August | 0 | 5 | 5 |
| 2023 July | 0 | 31 | 31 |
| 2023 June | 0 | 3 | 3 |
| 2023 March | 4 | 2 | 6 |
| 2023 February | 20 | 16 | 36 |
| 2023 January | 27 | 28 | 55 |
| 2022 December | 28 | 27 | 55 |
| 2022 November | 36 | 15 | 51 |
| 2022 October | 24 | 31 | 55 |
| 2022 September | 19 | 19 | 38 |
| 2022 August | 32 | 40 | 72 |
| 2022 July | 22 | 49 | 71 |
| 2022 June | 23 | 33 | 56 |
| 2022 May | 29 | 34 | 63 |
| 2022 April | 27 | 20 | 47 |
| 2022 March | 32 | 35 | 67 |
| 2022 February | 28 | 14 | 42 |
| 2022 January | 21 | 22 | 43 |
| 2021 December | 16 | 28 | 44 |
| 2021 November | 22 | 26 | 48 |
| 2021 October | 43 | 24 | 67 |
| 2021 September | 26 | 39 | 65 |
| 2021 August | 19 | 13 | 32 |
| 2021 July | 12 | 24 | 36 |
| 2021 June | 18 | 21 | 39 |
| 2021 May | 15 | 21 | 36 |
| 2021 April | 39 | 27 | 66 |
| 2021 March | 16 | 21 | 37 |
| 2021 February | 29 | 13 | 42 |
| 2021 January | 17 | 11 | 28 |
| 2020 December | 18 | 15 | 33 |
| 2020 November | 15 | 14 | 29 |
| 2020 October | 13 | 11 | 24 |
| 2020 September | 10 | 6 | 16 |
| 2020 August | 16 | 3 | 19 |
| 2020 July | 35 | 13 | 48 |
| 2020 June | 16 | 6 | 22 |
| 2020 May | 19 | 7 | 26 |
| 2020 April | 22 | 9 | 31 |
| 2020 March | 27 | 18 | 45 |
| 2020 February | 24 | 16 | 40 |
| 2020 January | 29 | 18 | 47 |
| 2019 December | 27 | 16 | 43 |
| 2019 November | 6 | 10 | 16 |
| 2019 October | 14 | 13 | 27 |
| 2019 September | 27 | 16 | 43 |
| 2019 August | 16 | 12 | 28 |
| 2019 July | 10 | 27 | 37 |
| 2019 June | 8 | 18 | 26 |
| 2019 May | 34 | 19 | 53 |
| 2019 April | 21 | 38 | 59 |
| 2019 March | 14 | 21 | 35 |
| 2019 February | 5 | 4 | 9 |
| 2019 January | 7 | 8 | 15 |
| 2018 December | 16 | 14 | 30 |
| 2018 November | 17 | 20 | 37 |
| 2018 October | 24 | 14 | 38 |
| 2018 September | 18 | 5 | 23 |
| 2018 May | 7 | 2 | 9 |
| 2018 April | 7 | 5 | 12 |
| 2018 March | 10 | 7 | 17 |
| 2018 February | 6 | 11 | 17 |
| 2018 January | 12 | 2 | 14 |
| 2017 December | 10 | 11 | 21 |
| 2017 November | 9 | 8 | 17 |
| 2017 October | 11 | 11 | 22 |
| 2017 September | 6 | 7 | 13 |
| 2017 August | 11 | 22 | 33 |
| 2017 July | 9 | 12 | 21 |
| 2017 June | 14 | 18 | 32 |
| 2017 May | 14 | 18 | 32 |
| 2017 April | 6 | 4 | 10 |
| 2017 March | 4 | 27 | 31 |
| 2017 February | 10 | 11 | 21 |
| 2017 January | 4 | 8 | 12 |
| 2016 December | 10 | 11 | 21 |
| 2016 November | 16 | 12 | 28 |
| 2016 October | 23 | 17 | 40 |
| 2016 September | 22 | 17 | 39 |
| 2016 August | 26 | 5 | 31 |
| 2016 July | 20 | 7 | 27 |
| 2016 June | 21 | 8 | 29 |
| 2016 May | 19 | 8 | 27 |
| 2016 April | 15 | 0 | 15 |
| 2016 March | 17 | 0 | 17 |
| 2016 February | 13 | 1 | 14 |
| 2016 January | 7 | 2 | 9 |
| 2015 December | 18 | 12 | 30 |
| 2015 November | 29 | 9 | 38 |
| 2015 October | 5 | 1 | 6 |
| 2015 September | 2 | 0 | 2 |
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