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"apellidos" => "Ordoñez gallego" ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Garcia giron" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Feliu batlle" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Oncología Médica. Hospital La Paz. Madrid" "identificador" => "aff0005" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1986-09-29" "fechaAceptado" => "1987-03-23" "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:81 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "El cáncer bronquial microcelular" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D. Anthoine" 1 => "X. Feintrenie" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Press Méd (ed. esp.)" "fecha" => "1985" "volumen" => "4" "paginaInicial" => "230" "paginaFinal" => "235" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Segundo carcinoma pulmonar broncógeno después de un carcinoma de células pequeñas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J. Craig" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am J Med (ed. esp.)" "fecha" => "1984" "volumen" => "76" "paginaInicial" => "1.013" "paginaFinal" => "1.020" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cambios en las características morfológicas y bioquímicas del carcinoma de células pequeñas de pulmón" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.D. Abeloff" 1 => "J. Eggleston" 2 => "G. Mendelsohn" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am J Med (ed. esp.)" "fecha" => "1979" "volumen" => "66" "paginaInicial" => "351" "paginaFinal" => "364" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A unified concept of lung cancer histopathology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R. Yesner" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am Soc Clin Onc Proc" "fecha" => "1977" "volumen" => "1" "paginaInicial" => "271" "paginaFinal" => "275" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Biológica! heterogeneity of small cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D.N. Carney" 1 => "A.F. Gazdar" 2 => "M. Nau" 3 => "J.D. Minna" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Semin Oncol" "fecha" => "1985" "volumen" => "12" "paginaInicial" => "289" "paginaFinal" => "303" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2996148" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Current status of therapy for small cell carcinoma of the lung" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D.C. Ihde" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1984" "volumen" => "54" "paginaInicial" => "2.722" "paginaFinal" => "2.728" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6548658" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lung cancer." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.J. Straus" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:5 [ "fecha" => "1983" "paginaInicial" => "21" "paginaFinal" => "35" "editorial" => "GruneStratton" "editorialLocalizacion" => "New York, London" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Surgical resection in the management of small cell carcinoma of the lung" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "T.W. Shields" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Thorac Cardiovasc Surg" "fecha" => "1982" "volumen" => "83" "paginaInicial" => "12" "paginaFinal" => "19" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6275212" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Small-cell carcinoma of the broncus" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "Editorial" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S1473-3099(01)00062-7" "Revista" => array:5 [ "tituloSerie" => "Lancet" "fecha" => "1980" "volumen" => "1" "paginaInicial" => "77" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11871479" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Revue de l’état actuel du traitment des cancer anaplasiques bronchiques à petites cellules" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Irisson" 1 => "C. Boutin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Poumon Coeur" "fecha" => "1980" "volumen" => "36" "paginaInicial" => "197" "paginaFinal" => "204" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6253976" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lung cancer. En: Cancer chemotherapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "H.H. Hansen" 1 => "M. Rorth" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "1985" "editorial" => "Ed. Pinedo, Chabner-Elsevier" "editorialLocalizacion" => "Amsterdam" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chemotherapy of advanced small cell anaplastic carcinoma: supperiority of a four-drug combination to a three-drug combination" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "H.H. Hansen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Int Med" "fecha" => "1978" "volumen" => "89" "paginaInicial" => "177" "paginaFinal" => "181" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/209710" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "El cáncer pulmonar microcelular, enfermedad curable" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R.K. Oldham" 1 => "F.A. Greco" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer chemother. Pharmacol" "fecha" => "1980" "volumen" => "4" "paginaInicial" => "173" "paginaFinal" => "177" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6249514" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Small cell carcinoma of the lung: staging, paraneoplastic syndromes, treatment and survival" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R.T. Eagan" 1 => "L.H. Maurier" 2 => "R.J. Forcier" 3 => "M. Tulloh" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1974" "volumen" => "33" "paginaInicial" => "527" "paginaFinal" => "541" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4812770" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Combination chemotherapy for small cell carcinoma of the lung" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J. Aisner" 1 => "M. Whitacre" 2 => "D.A. Vanecho" 3 => "P.H. Wienik" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Treat Rep" "fecha" => "1982" "volumen" => "66" "paginaInicial" => "221" "paginaFinal" => "230" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6275987" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Combination chemotherapy with cisplatin, adriamycin, etoposide and cyclophosphamide in small cell lung carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J. Klastersky" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Proc ASCO" "fecha" => "1985" "volumen" => "4" "paginaInicial" => "78" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Platinum, doxorrubicin, cyclophosphamide and etoposide, PACE, for small cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J. Aisner" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Proc ASCO" "fecha" => "1985" "volumen" => "4" "paginaInicial" => "181" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Combination chemotherapy with adriamycin, etoposide and cyclophosphamide for small cell carcinoma of the lung" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J. Klastersky" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1985" "volumen" => "56" "paginaInicial" => "71" "paginaFinal" => "75" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2988738" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Patients with small cell lung cancer treated with combination chemotherapy with or without irradiation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "B.E. Johnson" 1 => "D.C. Ihde" 2 => "P.A. Bunn" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Int Med" "fecha" => "1985" "volumen" => "103" "paginaInicial" => "430" "paginaFinal" => "438" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2992337" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Small cell carcinoma of the lung: therapeutic management" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R.B. Weiss" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Int Med" "fecha" => "1978" "volumen" => "88" "paginaInicial" => "522" "paginaFinal" => "531" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/205153" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Is chest radiotherapy necessary in any of all patients with small cell carcinoma of the lung?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R.W. Byhard" 1 => "J.D. Cox" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Yes. Cancer Treat Rep" "fecha" => "1983" "volumen" => "67" "paginaInicial" => "209" "paginaFinal" => "215" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6299546" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Is thoracic radition therapy necessary for patients with limited-stage small cell lung cancer?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.H. Cohen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "No. Cancer Treat Rep" "fecha" => "1983" "volumen" => "67" "paginaInicial" => "217" "paginaFinal" => "221" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6299547" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chemotherapy versus chemotherapy plus radiotherapy in regional small cell carcinoma of the lung: a randomized trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "H.H. Hansen" 1 => "P. Dombernowsky" 2 => "H.S. Hansen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Proc Am Assoc Cancer Res" "fecha" => "1979" "volumen" => "20" "paginaInicial" => "277" ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0120" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of limited small cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "E. Stevens" 1 => "L. Einhorn" 2 => "R. Rohn" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Proc Am Soc Clin Oncol" "fecha" => "1979" "volumen" => "20" "paginaInicial" => "435" ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0125" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Randomized trial of chemotherapy versus chemotherapy plus radiotherapy in limited stage small cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P. Bunn" 1 => "M. Cohen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Proc Am Soc Clin Oncol" "fecha" => "1983" "volumen" => "2" "paginaInicial" => "200" ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0130" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Preliminary report of a randomized trial of radiotherapy to the torax in limited small cell carcinoma of the lung treated with multiagent chemotherapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C.A. Pérez" 1 => "L. Einhorn" 2 => "R.K. Oldham" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Proc Am Soc Clin Oncol" "fecha" => "1983" "volumen" => "2" "paginaInicial" => "190" ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0135" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Radiotherapy in small cell cancer of the lung treated with combination chemotherapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R.L. Souhami" 1 => "D.M. Geddes" 2 => "S.G. Spiro" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Br Med J" "fecha" => "1984" "volumen" => "288" "paginaInicial" => "1.643" "paginaFinal" => "1.644" ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0140" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Randomized trial of radiotherapy to the thorax in limited small-cell carcinoma of the lung treated with multiagent chemotherapy and elective brain irradiation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C.A. Pérez" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/jco.1984.2.12.1366" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "1984" "volumen" => "2" "paginaInicial" => "1.200" "paginaFinal" => "1.206" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6439835" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0145" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Morbidity of cranial relapse in small cell lung cancer and the impact of radiation therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C.F. Lucas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Treat Rep" "fecha" => "1986" "volumen" => "70" "paginaInicial" => "565" "paginaFinal" => "570" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2423235" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0150" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Disturbing central nervous system complications following combination chemotherapy and prophylactic whole-brain irradiation in patients with small cell lung cáncer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.T.W. Licciardelli" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Treat Rep" "fecha" => "1985" "volumen" => "69" "paginaInicial" => "1.429" "paginaFinal" => "1.434" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4075316" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0155" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neurologic, neuropsychologic and computed cranial tomography scan abnormalities in 2 to 10 years survivors of small-cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "B.E. Johnson" 1 => "D.C. Ihde" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/jco.1985.3.12.1678" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "1985" "volumen" => "3" "paginaInicial" => "1.669" "paginaFinal" => "1.676" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4067615" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0160" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "La quimioterapia en el cáncer pulmonar de células pequeñas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "S.G. Spiro" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Br Med J (ed. esp.)" "fecha" => "1986" "volumen" => "1" "paginaInicial" => "17" "paginaFinal" => "20" ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0165" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Short course prophylactic cranial irradiation for small cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R. Feld" 1 => "G.H. Clamon" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Clin Oncol" "fecha" => "1985" "volumen" => "8" "paginaInicial" => "371" "paginaFinal" => "376" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2998177" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0170" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Three month's treatment with chemotherapy and radiotherapy for small cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "N. Thatcher" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Cancer" "fecha" => "1985" "volumen" => "52" "paginaInicial" => "327" "paginaFinal" => "332" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2994703" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0175" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Three month's treatment with cyclophosphamide VP16213 followed by methotrexate and thoracic radiotherapy for small cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "N. Thatcher" 1 => "R.D. James" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1985" "volumen" => "56" "paginaInicial" => "1.332" "paginaFinal" => "1.336" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4052961" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib0180" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Combined modality induction therapy without maintenance chemotherapy for small cell carcinoma of the lung" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R. Feld" 1 => "W.K. Evans" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/jco.1984.2.4.294" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "1984" "volumen" => "2" "paginaInicial" => "294" "paginaFinal" => "298" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6323640" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0185" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chemotherapy of small cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "F.A. Greco" 1 => "D.H. Johnson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Sem Oncol" "fecha" => "1985" "volumen" => "4" "paginaInicial" => "31" "paginaFinal" => "37" ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib0190" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intensive chemo-therapy of small cell bronchogenic carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.H. Cohen" 1 => "P.J. Creaven" 2 => "B.E. Fossieck" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Treat Rep" "fecha" => "1977" "volumen" => "61" "paginaInicial" => "349" "paginaFinal" => "354" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/194691" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib0195" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Extensivo stage small bronchogenic carcinoma intensive induction chemotherapy with highdose cyclophosphamide plus high dose etoposide" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D.H. Johnson" 1 => "F.A. Greco" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/jco.1985.3.2.170" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "1985" "volumen" => "3" "paginaInicial" => "170" "paginaFinal" => "178" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2981981" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib0200" "etiqueta" => "40." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intensive alternating chemotherapy regimen in small cell carcinoma of the lung" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Markman" 1 => "M.D. Abelof" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Treat Rep" "fecha" => "1985" "volumen" => "69" "paginaInicial" => "161" "paginaFinal" => "166" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2982490" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib0205" "etiqueta" => "41." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Combination chemotherapy in small cell lung carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "S. Lowenbraun" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1984" "volumen" => "54" "paginaInicial" => "2.344" "paginaFinal" => "2.400" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6548658" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib0210" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Active combinations of SCLC. Discussion of the importance of dosage and scheduling" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J. Klastersky" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "1984" "editorial" => "Lung Cancer Working Party" "editorialLocalizacion" => "Bruselas" ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib0215" "etiqueta" => "43." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of intensive induction chemotherapy for extensive disease small cell bronchogenic carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Valdivieso" 1 => "F. Cabanillas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Med" "fecha" => "1984" "volumen" => "76" "paginaInicial" => "405" "paginaFinal" => "410" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6322584" "web" => "Medline" ] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib0220" "etiqueta" => "44." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intensive induction chemotherapy for small cell anaplastia carcinoma of the lung" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.R. O’Donnell" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Treat Rep" "fecha" => "1985" "volumen" => "69" "paginaInicial" => "571" "paginaFinal" => "575" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2990708" "web" => "Medline" ] ] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib0225" "etiqueta" => "45." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Late intensification in small cell lung cancer a phase I study of high doses of cyclophosphamide and etoposide with autologous bone marrow transplantation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.P. Sculier" 1 => "J. Klastersky" 2 => "P. Stryckmans" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/jco.1985.3.2.184" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "1985" "volumen" => "3" "paginaInicial" => "184" "paginaFinal" => "191" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2981983" "web" => "Medline" ] ] ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib0230" "etiqueta" => "46." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "High-dose intensification therapy with autologous bone marrow support for limited small cell bronchogenic carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G. Spitzer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/jco.1986.4.1.4" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "1986" "volumen" => "4" "paginaInicial" => "4" "paginaFinal" => "10" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3510281" "web" => "Medline" ] ] ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib0235" "etiqueta" => "47." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A randomized trial of cyclophosphamide pretreatment («priming») before short-duration chemotherapy for small cell lung carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S. Harland" 1 => "D. Pérez" 2 => "J. Millar" 3 => "I. Smith" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Cancer Clin Oncol" "fecha" => "1985" "volumen" => "21" "paginaInicial" => "61" "paginaFinal" => "66" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2982622" "web" => "Medline" ] ] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib0240" "etiqueta" => "48." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Randomized dose-response evaluation of etoposide in small cell carcinoma of the lung" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S.N. Wolff" 1 => "F.A. Greco" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Treat Rep" "fecha" => "1986" "volumen" => "70" "paginaInicial" => "583" "paginaFinal" => "587" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3011257" "web" => "Medline" ] ] ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib0245" "etiqueta" => "49." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Phase II study of vindesine, cisplatin and hexamethylmelamine in small cell carcinoma of the lung" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G. Dangaard" 1 => "H.H. Hansen" 2 => "M. Rorth" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Treat Rep" "fecha" => "1984" "volumen" => "68" "paginaInicial" => "1.179" "paginaFinal" => "1.185" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6542448" "web" => "Medline" ] ] ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib0250" "etiqueta" => "50." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of recurrent small cell lung carcinoma with vindesine and cisplatin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "N. Niederle" 1 => "J. Schutte" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Treat Rep" "fecha" => "1984" "volumen" => "68" "paginaInicial" => "791" "paginaFinal" => "795" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6327037" "web" => "Medline" ] ] ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bib0255" "etiqueta" => "51." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Combination chemotherapy with vindesine and cisplatin for refractory small cell bronchogenic carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D.F. Chiuten" 1 => "M. Valdivieso" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "Cancer Treat Rep" "fecha" => "1986" "volumen" => "70" ] ] ] ] ] ] 51 => array:3 [ "identificador" => "bib0260" "etiqueta" => "52." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "VP-16 alone and in combination with cisplatin for relapse in small cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "W.K. Evans" 1 => "D. Osoba" 2 => "R. Feld" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1984" "volumen" => "53" "paginaInicial" => "1.461" "paginaFinal" => "1.466" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6722735" "web" => "Medline" ] ] ] ] ] ] ] ] 52 => array:3 [ "identificador" => "bib0265" "etiqueta" => "53." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Etoposide and cisplatin. An effective treatment for relapse in small cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "W.K. Evans" 1 => "D. Osoba" 2 => "R. Feld" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/jco.1985.3.1.65" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "1985" "volumen" => "3" "paginaInicial" => "65" "paginaFinal" => "71" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2981293" "web" => "Medline" ] ] ] ] ] ] ] ] 53 => array:3 [ "identificador" => "bib0270" "etiqueta" => "54." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cisplatin and etoposide combination chemotherapy for refractary small cell carcinoma of the lung" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "L.L. Porter" 1 => "F.A. Greco" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Treat Rep" "fecha" => "1985" "volumen" => "69" "paginaInicial" => "479" "paginaFinal" => "484" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2988773" "web" => "Medline" ] ] ] ] ] ] ] ] 54 => array:3 [ "identificador" => "bib0275" "etiqueta" => "55." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tratamiento quimioterápico del carcinoma broncopulmonar microcelular" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Ordónez" 1 => "J. Vicente" 2 => "G. Martín" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "Comunicación al I Congreso Conjunto de las Sociedades Oncológicas Españolas" "fecha" => "1986" ] ] ] ] ] ] 55 => array:3 [ "identificador" => "bib0280" "etiqueta" => "56." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genetic instability in the development of drug resistance" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.H. Goldie" 1 => "A.J. Coldman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Sem in Oncology" "fecha" => "1985" "volumen" => "3" "paginaInicial" => "222" "paginaFinal" => "230" ] ] ] ] ] ] 56 => array:3 [ "identificador" => "bib0285" "etiqueta" => "57." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The genetic origin of drug resistance in neoplasms: implications for systemic therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.H. Godie" 1 => "A.J. Coldman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Res" "fecha" => "1984" "volumen" => "44" "paginaInicial" => "3.643" "paginaFinal" => "3.653" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6594192" "web" => "Medline" ] ] ] ] ] ] ] ] 57 => array:3 [ "identificador" => "bib0290" "etiqueta" => "58." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A mathematical model for relatin drug sensivity of tumours to their spontaneous mutation rate" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.H. Goldie" 1 => "A.J. Coldman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Treat Rep" "fecha" => "1979" "volumen" => "63" "paginaInicial" => "1.727" "paginaFinal" => "1.733" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/526938" "web" => "Medline" ] ] ] ] ] ] ] ] 58 => array:3 [ "identificador" => "bib0295" "etiqueta" => "59." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical implications of tumor cell heterogeneity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "L.E. Schnipper" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "N Eng J Med" "fecha" => "1986" "volumen" => "314" "paginaInicial" => "1.423" "paginaFinal" => "1.431" ] ] ] ] ] ] 59 => array:3 [ "identificador" => "bib0300" "etiqueta" => "60." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rationale for the use of alternating non-cross-resistant chemotherapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.H. Goldie" 1 => "A.J. Coldman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Treat Rep" "fecha" => "1982" "volumen" => "66" "paginaInicial" => "439" "paginaFinal" => "449" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7060033" "web" => "Medline" ] ] ] ] ] ] ] ] 60 => array:3 [ "identificador" => "bib0305" "etiqueta" => "61." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of small cell lung cancer by different chemotherapy regimens" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C. Gropp" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Treat Rev" "fecha" => "1983" "volumen" => "10" "paginaInicial" => "111" "paginaFinal" => "120" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6313190" "web" => "Medline" ] ] ] ] ] ] ] ] 61 => array:3 [ "identificador" => "bib0310" "etiqueta" => "62." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cyclic alternating chemotherapy for small cell carcinoma of the lung" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "N. Murray" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Treat Rep" "fecha" => "1985" "volumen" => "69" "paginaInicial" => "1.241" "paginaFinal" => "1.242" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4075316" "web" => "Medline" ] ] ] ] ] ] ] ] 62 => array:3 [ "identificador" => "bib0315" "etiqueta" => "63." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Canadian multicentre randomized trial comparing sequential and alternating administration of two non-cross limited small cell carcinoma of the lung" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "W.K. Evans" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Proc ASCO" "fecha" => "1985" "volumen" => "4" "paginaInicial" => "177" ] ] ] ] ] ] 63 => array:3 [ "identificador" => "bib0320" "etiqueta" => "64." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Phase III study of CCNU, cyclophosphamide, adriamycin, vincristine and VP-16 in small cell carcinoma of the lung" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D. Ettinger" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1982" "volumen" => "49" "paginaInicial" => "1.544" "paginaFinal" => "1.554" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7074579" "web" => "Medline" ] ] ] ] ] ] ] ] 64 => array:3 [ "identificador" => "bib0325" "etiqueta" => "65." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Concurrent chemotherapy with VP-16-vincristine-adriamycin-cyclophosphamide (EVAC) versus alternating chemotherapy with VP-16-cisplatine and vincristine-adriamycin-cyclophosphamide (VPP/VAC) in limited small cell cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G.E. Goddman" 1 => "J. Blasko" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Proc ASCO" "fecha" => "1986" "volumen" => "5" "paginaInicial" => "169" ] ] ] ] ] ] 65 => array:3 [ "identificador" => "bib0330" "etiqueta" => "66." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A randomized comparison of conventional chemotherapy with inmediate alternation of non-cross-resistant chemotherapy in extensivo disease small cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D. Ettinger" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Proc ASCO" "fecha" => "1986" "volumen" => "5" "paginaInicial" => "169" ] ] ] ] ] ] 66 => array:3 [ "identificador" => "bib0335" "etiqueta" => "67." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Alternating non-cross-resistant combination chemotherapy for small cell anaplastic carcinoma of the lung" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R.S. Aroney" 1 => "D.R. Bell" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1982" "volumen" => "49" "paginaInicial" => "2.449" "paginaFinal" => "2.456" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7074579" "web" => "Medline" ] ] ] ] ] ] ] ] 67 => array:3 [ "identificador" => "bib0340" "etiqueta" => "68." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chemotherapy of small cell carcinoma of the lung. A randomized comparison of alternating and sequential combination chemotherapy programs" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.R. Daniels" 1 => "L.Y. Chalk" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/jco.1984.2.12.1366" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "1984" "volumen" => "2" "paginaInicial" => "1.192" "paginaFinal" => "1.198" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6439835" "web" => "Medline" ] ] ] ] ] ] ] ] 68 => array:3 [ "identificador" => "bib0345" "etiqueta" => "69." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognostic factors in small cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "K. Osterlind" 1 => "P. Kragh" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Res" "fecha" => "1986" "volumen" => "46" "paginaInicial" => "4.189" "paginaFinal" => "4.194" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3779657" "web" => "Medline" ] ] ] ] ] ] ] ] 69 => array:3 [ "identificador" => "bib0350" "etiqueta" => "70." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Continous versus alternating combination chemotherapy for advanced small cell carcinoma of the lung" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "K. Osterlind" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Res" "fecha" => "1983" "volumen" => "43" "paginaInicial" => "6.085" "paginaFinal" => "6.089" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6640549" "web" => "Medline" ] ] ] ] ] ] ] ] 70 => array:3 [ "identificador" => "bib0355" "etiqueta" => "71." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cyclic alternating combination chemotherapy for small cell bronchogenic carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.H. Cohen" 1 => "D.C. Ihde" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Treat Rep" "fecha" => "1979" "volumen" => "63" "paginaInicial" => "163" "paginaFinal" => "170" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/221114" "web" => "Medline" ] ] ] ] ] ] ] ] 71 => array:3 [ "identificador" => "bib0360" "etiqueta" => "72." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Alternating non-cross-resistant drug combinations in the treatment of metastatic small cell carcinoma of the lung" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S. Krauss" 1 => "S. Lowenbraum" 2 => "A. Bartolucci" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Clin Trials" "fecha" => "1981" "volumen" => "4" "paginaInicial" => "147" "paginaFinal" => "156" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6265109" "web" => "Medline" ] ] ] ] ] ] ] ] 72 => array:3 [ "identificador" => "bib0365" "etiqueta" => "73." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Alternating non-cross resistant chemotherapy of small cell lung cancer." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "B.I. Sikic" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Current status and new developments. Orlando, Fla, Academia Press" "fecha" => "1984" "paginaInicial" => "191" "paginaFinal" => "198" ] ] ] ] ] ] 73 => array:3 [ "identificador" => "bib0370" "etiqueta" => "74." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cyclic alternating «non-cross-resistant» chemotherapy in the management of small cell anaplastic carcinoma of the lung" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.A. Elliot" 1 => "K. Osteling" 2 => "H.H. Hansen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Treat Rev" "fecha" => "1984" "volumen" => "11" "paginaInicial" => "1" "paginaFinal" => "4" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6733712" "web" => "Medline" ] ] ] ] ] ] ] ] 74 => array:3 [ "identificador" => "bib0375" "etiqueta" => "75." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Current status of research into small cell carcinoma of the lung" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.F. Smyth" 1 => "H.H. Hansen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Cancer Clin Oncol" "fecha" => "1985" "volumen" => "21" "paginaInicial" => "1.295" "paginaFinal" => "1.298" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3938397" "web" => "Medline" ] ] ] ] ] ] ] ] 75 => array:3 [ "identificador" => "bib0380" "etiqueta" => "76." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Principles for the comprehensive management of small cell lung cancer. Lung cancer: current trends and future prospects" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "H.H. Hansen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "1984" "editorial" => "Lung Cancer Working Party" "editorialLocalizacion" => "Bruselas" ] ] ] ] ] ] 76 => array:3 [ "identificador" => "bib0385" "etiqueta" => "77." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cisplatinum plus VP16 chemotherapy as a frontline treatment in small cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C. Boni" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Proc ASCO" "fecha" => "1985" "volumen" => "4" "paginaInicial" => "196" ] ] ] ] ] ] 77 => array:3 [ "identificador" => "bib0390" "etiqueta" => "78." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Small cell lung cancer is still a problem" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D. Bergsagel" 1 => "R. Feld" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/jco.1984.2.12.1366" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "1984" "volumen" => "2" "paginaInicial" => "1.189" "paginaFinal" => "1.195" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6439835" "web" => "Medline" ] ] ] ] ] ] ] ] 78 => array:3 [ "identificador" => "bib0395" "etiqueta" => "79." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Combination cyclophosphamide, adrimycin and vincristine repidly alternating with combination cisplatin and VP-16 in treatment of small cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R.B. Natale" 1 => "B. Shank" 2 => "B.S. Hilaris" 3 => "R.E. Wittes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Med" "fecha" => "1985" "volumen" => "79" "paginaInicial" => "303" "paginaFinal" => "308" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2994472" "web" => "Medline" ] ] ] ] ] ] ] ] 79 => array:3 [ "identificador" => "bib0400" "etiqueta" => "80." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of adjuvant central iv. hyperalimentation on the normal and response to treatment of patients with small cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G.H. Clamon" 1 => "R. Feld" 2 => "W.A.K. Evans" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Treat Rep" "fecha" => "1984" "volumen" => "69" "paginaInicial" => "167" "paginaFinal" => "171" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2982491" "web" => "Medline" ] ] ] ] ] ] ] ] 80 => array:3 [ "identificador" => "bib0405" "etiqueta" => "81." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of warfarin anticoagulation in survival in carcinoma of the lung, colon, head and neck and prostate" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L.R. Zacharski" 1 => "W.G. Henderson" 2 => "F.R. Rickles" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1984" "volumen" => "53" "paginaInicial" => "2.046" "paginaFinal" => "2.053" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6722735" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/03002896/0000002400000001/v1_201509151059/S0300289615318846/v1_201509151059/es/main.assets" "Apartado" => array:4 [ "identificador" => "43810" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Actualización de diagnóstico y tratamiento" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/03002896/0000002400000001/v1_201509151059/S0300289615318846/v1_201509151059/es/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615318846?idApp=UINPBA00003Z" ]
Journal Information
Vol. 24. Issue 1.
Pages 15-20 (January - February 1988)
Vol. 24. Issue 1.
Pages 15-20 (January - February 1988)
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Estado actual en el tratamiento del carcinoma broncopulmonar de celulas pequeñas
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A. Ordoñez gallego, C. Garcia giron, J. Feliu batlle
Servicio de Oncología Médica. Hospital La Paz. Madrid
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Bibliografía
[1.]
D. Anthoine, X. Feintrenie.
El cáncer bronquial microcelular.
Press Méd (ed. esp.), 4 (1985), pp. 230-235
[2.]
J. Craig.
Segundo carcinoma pulmonar broncógeno después de un carcinoma de células pequeñas.
Am J Med (ed. esp.), 76 (1984), pp. 1.013-1.020
[3.]
M.D. Abeloff, J. Eggleston, G. Mendelsohn.
Cambios en las características morfológicas y bioquímicas del carcinoma de células pequeñas de pulmón.
Am J Med (ed. esp.), 66 (1979), pp. 351-364
[4.]
R. Yesner.
A unified concept of lung cancer histopathology.
Am Soc Clin Onc Proc, 1 (1977), pp. 271-275
[5.]
D.N. Carney, A.F. Gazdar, M. Nau, J.D. Minna.
Biológica! heterogeneity of small cell lung cancer.
Semin Oncol, 12 (1985), pp. 289-303
[6.]
D.C. Ihde.
Current status of therapy for small cell carcinoma of the lung.
Cancer, 54 (1984), pp. 2.722-2.728
[7.]
M.J. Straus.
Lung cancer..
GruneStratton, (1983), pp. 21-35
[8.]
T.W. Shields.
Surgical resection in the management of small cell carcinoma of the lung.
J Thorac Cardiovasc Surg, 83 (1982), pp. 12-19
[9.]
Editorial.
Small-cell carcinoma of the broncus.
Lancet, 1 (1980), pp. 77
[10.]
M. Irisson, C. Boutin.
Revue de l’état actuel du traitment des cancer anaplasiques bronchiques à petites cellules.
Poumon Coeur, 36 (1980), pp. 197-204
[11.]
H.H. Hansen, M. Rorth.
Lung cancer. En: Cancer chemotherapy.
Ed. Pinedo, Chabner-Elsevier, (1985),
[12.]
H.H. Hansen.
Chemotherapy of advanced small cell anaplastic carcinoma: supperiority of a four-drug combination to a three-drug combination.
Ann Int Med, 89 (1978), pp. 177-181
[13.]
R.K. Oldham, F.A. Greco.
El cáncer pulmonar microcelular, enfermedad curable.
Cancer chemother. Pharmacol, 4 (1980), pp. 173-177
[14.]
R.T. Eagan, L.H. Maurier, R.J. Forcier, M. Tulloh.
Small cell carcinoma of the lung: staging, paraneoplastic syndromes, treatment and survival.
Cancer, 33 (1974), pp. 527-541
[15.]
J. Aisner, M. Whitacre, D.A. Vanecho, P.H. Wienik.
Combination chemotherapy for small cell carcinoma of the lung.
Cancer Treat Rep, 66 (1982), pp. 221-230
[16.]
J. Klastersky.
Combination chemotherapy with cisplatin, adriamycin, etoposide and cyclophosphamide in small cell lung carcinoma.
Proc ASCO, 4 (1985), pp. 78
[17.]
J. Aisner.
Platinum, doxorrubicin, cyclophosphamide and etoposide, PACE, for small cell lung cancer.
Proc ASCO, 4 (1985), pp. 181
[18.]
J. Klastersky.
Combination chemotherapy with adriamycin, etoposide and cyclophosphamide for small cell carcinoma of the lung.
Cancer, 56 (1985), pp. 71-75
[19.]
B.E. Johnson, D.C. Ihde, P.A. Bunn.
Patients with small cell lung cancer treated with combination chemotherapy with or without irradiation.
Ann Int Med, 103 (1985), pp. 430-438
[20.]
R.B. Weiss.
Small cell carcinoma of the lung: therapeutic management.
Ann Int Med, 88 (1978), pp. 522-531
[21.]
R.W. Byhard, J.D. Cox.
Is chest radiotherapy necessary in any of all patients with small cell carcinoma of the lung?.
Yes. Cancer Treat Rep, 67 (1983), pp. 209-215
[22.]
M.H. Cohen.
Is thoracic radition therapy necessary for patients with limited-stage small cell lung cancer?.
No. Cancer Treat Rep, 67 (1983), pp. 217-221
[23.]
H.H. Hansen, P. Dombernowsky, H.S. Hansen.
Chemotherapy versus chemotherapy plus radiotherapy in regional small cell carcinoma of the lung: a randomized trial.
Proc Am Assoc Cancer Res, 20 (1979), pp. 277
[24.]
E. Stevens, L. Einhorn, R. Rohn.
Treatment of limited small cell lung cancer.
Proc Am Soc Clin Oncol, 20 (1979), pp. 435
[25.]
P. Bunn, M. Cohen.
Randomized trial of chemotherapy versus chemotherapy plus radiotherapy in limited stage small cell lung cancer.
Proc Am Soc Clin Oncol, 2 (1983), pp. 200
[26.]
C.A. Pérez, L. Einhorn, R.K. Oldham.
Preliminary report of a randomized trial of radiotherapy to the torax in limited small cell carcinoma of the lung treated with multiagent chemotherapy.
Proc Am Soc Clin Oncol, 2 (1983), pp. 190
[27.]
R.L. Souhami, D.M. Geddes, S.G. Spiro.
Radiotherapy in small cell cancer of the lung treated with combination chemotherapy.
Br Med J, 288 (1984), pp. 1.643-1.644
[28.]
C.A. Pérez.
Randomized trial of radiotherapy to the thorax in limited small-cell carcinoma of the lung treated with multiagent chemotherapy and elective brain irradiation.
J Clin Oncol, 2 (1984), pp. 1.200-1.206
[29.]
C.F. Lucas.
Morbidity of cranial relapse in small cell lung cancer and the impact of radiation therapy.
Cancer Treat Rep, 70 (1986), pp. 565-570
[30.]
J.T.W. Licciardelli.
Disturbing central nervous system complications following combination chemotherapy and prophylactic whole-brain irradiation in patients with small cell lung cáncer.
Cancer Treat Rep, 69 (1985), pp. 1.429-1.434
[31.]
B.E. Johnson, D.C. Ihde.
Neurologic, neuropsychologic and computed cranial tomography scan abnormalities in 2 to 10 years survivors of small-cell lung cancer.
J Clin Oncol, 3 (1985), pp. 1.669-1.676
[32.]
S.G. Spiro.
La quimioterapia en el cáncer pulmonar de células pequeñas.
Br Med J (ed. esp.), 1 (1986), pp. 17-20
[33.]
R. Feld, G.H. Clamon.
Short course prophylactic cranial irradiation for small cell lung cancer.
Am J Clin Oncol, 8 (1985), pp. 371-376
[34.]
N. Thatcher.
Three month's treatment with chemotherapy and radiotherapy for small cell lung cancer.
Br J Cancer, 52 (1985), pp. 327-332
[35.]
N. Thatcher, R.D. James.
Three month's treatment with cyclophosphamide VP16213 followed by methotrexate and thoracic radiotherapy for small cell lung cancer.
Cancer, 56 (1985), pp. 1.332-1.336
[36.]
R. Feld, W.K. Evans.
Combined modality induction therapy without maintenance chemotherapy for small cell carcinoma of the lung.
J Clin Oncol, 2 (1984), pp. 294-298
[37.]
F.A. Greco, D.H. Johnson.
Chemotherapy of small cell lung cancer.
Sem Oncol, 4 (1985), pp. 31-37
[38.]
M.H. Cohen, P.J. Creaven, B.E. Fossieck.
Intensive chemo-therapy of small cell bronchogenic carcinoma.
Cancer Treat Rep, 61 (1977), pp. 349-354
[39.]
D.H. Johnson, F.A. Greco.
Extensivo stage small bronchogenic carcinoma intensive induction chemotherapy with highdose cyclophosphamide plus high dose etoposide.
J Clin Oncol, 3 (1985), pp. 170-178
[40.]
M. Markman, M.D. Abelof.
Intensive alternating chemotherapy regimen in small cell carcinoma of the lung.
Cancer Treat Rep, 69 (1985), pp. 161-166
[41.]
S. Lowenbraun.
Combination chemotherapy in small cell lung carcinoma.
Cancer, 54 (1984), pp. 2.344-2.400
[42.]
J. Klastersky.
Active combinations of SCLC. Discussion of the importance of dosage and scheduling.
Lung Cancer Working Party, (1984),
[43.]
M. Valdivieso, F. Cabanillas.
Effects of intensive induction chemotherapy for extensive disease small cell bronchogenic carcinoma.
Am J Med, 76 (1984), pp. 405-410
[44.]
M.R. O’Donnell.
Intensive induction chemotherapy for small cell anaplastia carcinoma of the lung.
Cancer Treat Rep, 69 (1985), pp. 571-575
[45.]
J.P. Sculier, J. Klastersky, P. Stryckmans.
Late intensification in small cell lung cancer a phase I study of high doses of cyclophosphamide and etoposide with autologous bone marrow transplantation.
J Clin Oncol, 3 (1985), pp. 184-191
[46.]
G. Spitzer.
High-dose intensification therapy with autologous bone marrow support for limited small cell bronchogenic carcinoma.
J Clin Oncol, 4 (1986), pp. 4-10
[47.]
S. Harland, D. Pérez, J. Millar, I. Smith.
A randomized trial of cyclophosphamide pretreatment («priming») before short-duration chemotherapy for small cell lung carcinoma.
Eur J Cancer Clin Oncol, 21 (1985), pp. 61-66
[48.]
S.N. Wolff, F.A. Greco.
Randomized dose-response evaluation of etoposide in small cell carcinoma of the lung.
Cancer Treat Rep, 70 (1986), pp. 583-587
[49.]
G. Dangaard, H.H. Hansen, M. Rorth.
Phase II study of vindesine, cisplatin and hexamethylmelamine in small cell carcinoma of the lung.
Cancer Treat Rep, 68 (1984), pp. 1.179-1.185
[50.]
N. Niederle, J. Schutte.
Treatment of recurrent small cell lung carcinoma with vindesine and cisplatin.
Cancer Treat Rep, 68 (1984), pp. 791-795
[51.]
D.F. Chiuten, M. Valdivieso.
Combination chemotherapy with vindesine and cisplatin for refractory small cell bronchogenic carcinoma.
Cancer Treat Rep, 70 (1986),
[52.]
W.K. Evans, D. Osoba, R. Feld.
VP-16 alone and in combination with cisplatin for relapse in small cell lung cancer.
Cancer, 53 (1984), pp. 1.461-1.466
[53.]
W.K. Evans, D. Osoba, R. Feld.
Etoposide and cisplatin. An effective treatment for relapse in small cell lung cancer.
J Clin Oncol, 3 (1985), pp. 65-71
[54.]
L.L. Porter, F.A. Greco.
Cisplatin and etoposide combination chemotherapy for refractary small cell carcinoma of the lung.
Cancer Treat Rep, 69 (1985), pp. 479-484
[55.]
A. Ordónez, J. Vicente, G. Martín.
Tratamiento quimioterápico del carcinoma broncopulmonar microcelular.
Comunicación al I Congreso Conjunto de las Sociedades Oncológicas Españolas, (1986),
[56.]
J.H. Goldie, A.J. Coldman.
Genetic instability in the development of drug resistance.
Sem in Oncology, 3 (1985), pp. 222-230
[57.]
J.H. Godie, A.J. Coldman.
The genetic origin of drug resistance in neoplasms: implications for systemic therapy.
Cancer Res, 44 (1984), pp. 3.643-3.653
[58.]
J.H. Goldie, A.J. Coldman.
A mathematical model for relatin drug sensivity of tumours to their spontaneous mutation rate.
Cancer Treat Rep, 63 (1979), pp. 1.727-1.733
[59.]
L.E. Schnipper.
Clinical implications of tumor cell heterogeneity.
N Eng J Med, 314 (1986), pp. 1.423-1.431
[60.]
J.H. Goldie, A.J. Coldman.
Rationale for the use of alternating non-cross-resistant chemotherapy.
Cancer Treat Rep, 66 (1982), pp. 439-449
[61.]
C. Gropp.
Treatment of small cell lung cancer by different chemotherapy regimens.
Cancer Treat Rev, 10 (1983), pp. 111-120
[62.]
N. Murray.
Cyclic alternating chemotherapy for small cell carcinoma of the lung.
Cancer Treat Rep, 69 (1985), pp. 1.241-1.242
[63.]
W.K. Evans.
Canadian multicentre randomized trial comparing sequential and alternating administration of two non-cross limited small cell carcinoma of the lung.
Proc ASCO, 4 (1985), pp. 177
[64.]
D. Ettinger.
Phase III study of CCNU, cyclophosphamide, adriamycin, vincristine and VP-16 in small cell carcinoma of the lung.
Cancer, 49 (1982), pp. 1.544-1.554
[65.]
G.E. Goddman, J. Blasko.
Concurrent chemotherapy with VP-16-vincristine-adriamycin-cyclophosphamide (EVAC) versus alternating chemotherapy with VP-16-cisplatine and vincristine-adriamycin-cyclophosphamide (VPP/VAC) in limited small cell cancer.
Proc ASCO, 5 (1986), pp. 169
[66.]
D. Ettinger.
A randomized comparison of conventional chemotherapy with inmediate alternation of non-cross-resistant chemotherapy in extensivo disease small cell lung cancer.
Proc ASCO, 5 (1986), pp. 169
[67.]
R.S. Aroney, D.R. Bell.
Alternating non-cross-resistant combination chemotherapy for small cell anaplastic carcinoma of the lung.
Cancer, 49 (1982), pp. 2.449-2.456
[68.]
J.R. Daniels, L.Y. Chalk.
Chemotherapy of small cell carcinoma of the lung. A randomized comparison of alternating and sequential combination chemotherapy programs.
J Clin Oncol, 2 (1984), pp. 1.192-1.198
[69.]
K. Osterlind, P. Kragh.
Prognostic factors in small cell lung cancer.
Cancer Res, 46 (1986), pp. 4.189-4.194
[70.]
K. Osterlind.
Continous versus alternating combination chemotherapy for advanced small cell carcinoma of the lung.
Cancer Res, 43 (1983), pp. 6.085-6.089
[71.]
M.H. Cohen, D.C. Ihde.
Cyclic alternating combination chemotherapy for small cell bronchogenic carcinoma.
Cancer Treat Rep, 63 (1979), pp. 163-170
[72.]
S. Krauss, S. Lowenbraum, A. Bartolucci.
Alternating non-cross-resistant drug combinations in the treatment of metastatic small cell carcinoma of the lung.
Cancer Clin Trials, 4 (1981), pp. 147-156
[73.]
B.I. Sikic.
Alternating non-cross resistant chemotherapy of small cell lung cancer..
Current status and new developments. Orlando, Fla, Academia Press, (1984), pp. 191-198
[74.]
J.A. Elliot, K. Osteling, H.H. Hansen.
Cyclic alternating «non-cross-resistant» chemotherapy in the management of small cell anaplastic carcinoma of the lung.
Cancer Treat Rev, 11 (1984), pp. 1-4
[75.]
J.F. Smyth, H.H. Hansen.
Current status of research into small cell carcinoma of the lung.
Eur J Cancer Clin Oncol, 21 (1985), pp. 1.295-1.298
[76.]
H.H. Hansen.
Principles for the comprehensive management of small cell lung cancer. Lung cancer: current trends and future prospects.
Lung Cancer Working Party, (1984),
[77.]
C. Boni.
Cisplatinum plus VP16 chemotherapy as a frontline treatment in small cell lung cancer.
Proc ASCO, 4 (1985), pp. 196
[78.]
D. Bergsagel, R. Feld.
Small cell lung cancer is still a problem.
J Clin Oncol, 2 (1984), pp. 1.189-1.195
[79.]
R.B. Natale, B. Shank, B.S. Hilaris, R.E. Wittes.
Combination cyclophosphamide, adrimycin and vincristine repidly alternating with combination cisplatin and VP-16 in treatment of small cell lung cancer.
Am J Med, 79 (1985), pp. 303-308
[80.]
G.H. Clamon, R. Feld, W.A.K. Evans.
Effect of adjuvant central iv. hyperalimentation on the normal and response to treatment of patients with small cell lung cancer.
Cancer Treat Rep, 69 (1984), pp. 167-171
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