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array:23 [ "pii" => "S1579212921003165" "issn" => "15792129" "doi" => "10.1016/j.arbr.2020.03.034" "estado" => "S300" "fechaPublicacion" => "2021-10-01" "aid" => "2465" "copyright" => "SEPAR" "copyrightAnyo" => "2020" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Arch Bronconeumol. 2021;57:651" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:18 [ "pii" => "S1579212921003177" "issn" => "15792129" "doi" => "10.1016/j.arbr.2020.04.017" "estado" => "S300" "fechaPublicacion" => "2021-10-01" "aid" => "2469" "copyright" => "SEPAR" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Arch Bronconeumol. 2021;57:652" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Clinical Image</span>" "titulo" => "Right Lung Middle Lobe Agenesis and Multiple Bone Anomalies" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "652" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Agenesia del lóbulo medio del pulmón derecho y anomalías óseas múltiples" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1338 "Ancho" => 3810 "Tamanyo" => 364779 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Coronal anterior projection air specific volume rendering 3D CT image shows a normal right upper lobe bronchus (arrow) and narrowed lower lobe bronchus (dashed arrow), but there is not middle lobe bronchus. (B) Posterior view 3D volume rendered CT image reveals fusion anomalies (frames) in multiple segment between fifth and sixth ribs. (C) Anterior view 3D volume rendered CT image shows a giant forked shaped xiphoid of the sternum.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Veysel Ayyildiz, Yener Aydin, Hayri Ogul" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Veysel" "apellidos" => "Ayyildiz" ] 1 => array:2 [ "nombre" => "Yener" "apellidos" => "Aydin" ] 2 => array:2 [ "nombre" => "Hayri" "apellidos" => "Ogul" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212921003177?idApp=UINPBA00003Z" "url" => "/15792129/0000005700000010/v1_202110020725/S1579212921003177/v1_202110020725/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1579212921003153" "issn" => "15792129" "doi" => "10.1016/j.arbr.2020.04.016" "estado" => "S300" "fechaPublicacion" => "2021-10-01" "aid" => "2461" "copyright" => "SEPAR" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Arch Bronconeumol. 2021;57:650" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Clinical Image</span>" "titulo" => "Atypical Metastasis of Lung Adenocarcinoma" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "650" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Metástasis atípicas de adenocarcinoma de pulmón" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 616 "Ancho" => 1500 "Tamanyo" => 212138 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) On the posterior side of the gastric lower body, a deep ulcer with elevated edges was observed, with an extension of about 5<span class="elsevierStyleHsp" style=""></span>cm – biopsies of the edges were performed. (B) and (C) Hematoxylin-and-eosin staining of the gastric lesion showed a papillary pattern and cohesive neoplastic cells forming irregular gland-like tubular structures, findings compatible with poorly differentiated adenocarcinoma. The positivity of (D) thyroid transcription factor 1 (TTF-1) and (E) cytokeratin 7 (CK-7) stained in brown was determined by immunohistochemistry.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Ângela Dias Cunha, Marta Sousa, Paula Sousa" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Ângela" "apellidos" => "Dias Cunha" ] 1 => array:2 [ "nombre" => "Marta" "apellidos" => "Sousa" ] 2 => array:2 [ "nombre" => "Paula" "apellidos" => "Sousa" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212921003153?idApp=UINPBA00003Z" "url" => "/15792129/0000005700000010/v1_202110020725/S1579212921003153/v1_202110020725/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Clinical Image</span>" "titulo" => "88-Year-Old Woman With an Incidental Lung Mass" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "651" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Oriana Salamo, Sujith V. Cherian, Rosa M. Estrada-Y-Martin" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Oriana" "apellidos" => "Salamo" "email" => array:1 [ 0 => "oriana.k.salamocolletti@uth.tmc.edu" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Sujith V." "apellidos" => "Cherian" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Rosa M." "apellidos" => "Estrada-Y-Martin" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "University of Texas Health Science Center at Houston, Department of Internal Medicine, Houston, TX, USA" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "University of Texas Health Science Center at Houston, Department of Pulmonary, Critical Care and Sleep Medicine, Houston, TX, USA" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Mujer de 88 años con una masa pulmonar incidental" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 866 "Ancho" => 1750 "Tamanyo" => 384647 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A, B) 6.4<span class="elsevierStyleHsp" style=""></span>cm heterogenous mass replacing the lingula with large endobronchial component. (C) Hematoxylin and eosin-stained section of lung (400×). (D) Tumor cells with positive CK5/6 staining (100×). (E) Neoplastic cells with positive staining for pancytokeratin AE1/AE3 (100×). (F) Neoplastic cells P40 positive (100×).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 88-year-old woman was referred to the pulmonary clinic for evaluation of a asymptomatic left lung mass which was incidentally found on chest radiographs. CT scan of the thorax showed a 6.4<span class="elsevierStyleHsp" style=""></span>cm mass, and additional PET scan failed to reveal metastatic disease. An endobronchial ultrasound guided-biopsy was performed, and pathology showed neoplastic cells with large nuclei arranged in nests, with positive staining for pancytokeratin AE1/AE3, CK5/6, P40 and EBER-in situ hybridization, ultimately favoring the diagnosis of <span class="elsevierStyleItalic">Epstein–Barr virus positive lymphoepithelioma-like carcinoma</span> (PLELC) instead of squamous cell carcinoma of the lung (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Further tests revealed a low pulmonary reserve, and given her age, lack of symptoms and the size of the primary lesion, a decision for “watchful waiting” with frequent surveillance imaging was made.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">PLELC is a rare type of non-small cell lung cancer associated with Epstein–Barr; has been mostly described in young non-smoker Asians accounting for only 0.9% of primary lung malignancies.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">1</span></a> Noticeably, 35% of the patients are asymptomatic when the tumor is incidentally found. Unfortunately, there is no standard treatment for PLELC at this time due to its rarity, but overall, patients have a significantly better prognosis when compared to other lung malignancies.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">2</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of Interests</span><p id="par0015" class="elsevierStylePara elsevierViewall">The authors declare no actual or potential conflict of interests.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflict of Interests" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 866 "Ancho" => 1750 "Tamanyo" => 384647 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A, B) 6.4<span class="elsevierStyleHsp" style=""></span>cm heterogenous mass replacing the lingula with large endobronchial component. (C) Hematoxylin and eosin-stained section of lung (400×). (D) Tumor cells with positive CK5/6 staining (100×). (E) Neoplastic cells with positive staining for pancytokeratin AE1/AE3 (100×). (F) Neoplastic cells P40 positive (100×).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:2 [ 0 => array:3 [ "identificador" => "bib0015" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary pulmonary lymphoepithelioma-like carcinoma: a rare type of lung cancer with a favorable outcome in comparison to squamous carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B. Chen" 1 => "X. Chen" 2 => "P. Zhou" 3 => "L. Yang" 4 => "J. Ren" 5 => "X. Yang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/s12931-019-1236-2" "Revista" => array:5 [ "tituloSerie" => "Respir Res" "fecha" => "2019" "volumen" => "20" "paginaInicial" => "262" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31752892" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0020" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical features and prognosis of pulmonary lymphoepithelioma-like carcinoma: summary of eighty-five cases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Y. Qin" 1 => "G. Gao" 2 => "X. Xie" 3 => "Z. Zhu" 4 => "W. Guan" 5 => "X. Lin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.cllc.2018.12.014" "Revista" => array:6 [ "tituloSerie" => "Clin Lung Cancer" "fecha" => "2019" "volumen" => "20" "paginaInicial" => "e329" "paginaFinal" => "e337" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30683631" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15792129/0000005700000010/v1_202110020725/S1579212921003165/v1_202110020725/en/main.assets" "Apartado" => array:4 [ "identificador" => "60604" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Clinical Images" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15792129/0000005700000010/v1_202110020725/S1579212921003165/v1_202110020725/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212921003165?idApp=UINPBA00003Z" ]
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