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(B) Chest CT axial image showing a collection in the thickness of the right pectoralis major muscle (arrows). (C) Anteroposterior chest X-ray identifying a new extraparenchymal lesion. (D) Chest CT axial image showing a focal lytic lesion in the left fourth costal arch (arrow) surrounded by an extrapleural fluid collection (asterisk). (E) Chest CT axial image (maximum intensity projection) showing the percutaneous drainage procedure of the left hemithorax collection. (F) Follow-up anteroposterior chest X-ray showing radiological improvement of the collection. (G) MRI sagittal image (inversion-recovery sequence with fat suppression) identifying typical signs of acute spondylodiscitis: increased signal intensity in the L5-S1 intervertebral disc (arrow) and altered signal of the vertebral endplates adjacent to the disc (asterisks). (H) MRI axial image (T1-weighted sequence after intravenous gadolinium administration) showing a ring-enhancing collection in the thickness of the left pyramidal muscle (arrow).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Luis Gorospe Sarasúa, Jesús Javier Martín-Pinacho, Ana María Ayala-Carbonero, Esther Gambí-Pisonero, Pilar Martín-Dávila, Rosa Mariela Mirambeaux-Villalona, Gemma María Muñoz-Molina" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Luis" "apellidos" => "Gorospe Sarasúa" ] 1 => array:2 [ "nombre" => "Jesús Javier" "apellidos" => "Martín-Pinacho" ] 2 => array:2 [ "nombre" => "Ana María" "apellidos" => "Ayala-Carbonero" ] 3 => array:2 [ "nombre" => "Esther" "apellidos" => "Gambí-Pisonero" ] 4 => array:2 [ "nombre" => "Pilar" "apellidos" => "Martín-Dávila" ] 5 => array:2 [ "nombre" => "Rosa Mariela" "apellidos" => "Mirambeaux-Villalona" ] 6 => array:2 [ "nombre" => "Gemma María" "apellidos" => "Muñoz-Molina" ] ] ] ] ] "idiomaDefecto" => "en" 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false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>" "titulo" => "Bronchial Infection due to <span class="elsevierStyleItalic">Pseudomonas Aeruginosa</span> in Patients with Cystic Fibrosis Diagnosed in Neonatal Screening" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "532" "paginaFinal" => "534" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Infección bronquial por <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> en los pacientes con fibrosis quística diagnosticados por cribado neonatal" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Roser Ayats Vidal, Montserrat Bosque García, Miguel García González, Óscar Asensio de la Cruz" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Roser" "apellidos" => "Ayats Vidal" ] 1 => array:2 [ "nombre" => "Montserrat" "apellidos" => "Bosque García" ] 2 => array:2 [ "nombre" => "Miguel" "apellidos" => "García González" ] 3 => array:2 [ "nombre" => "Óscar" "apellidos" => "Asensio de la Cruz" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0300289620301058" "doi" => "10.1016/j.arbres.2020.03.024" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289620301058?idApp=UINPBA00003Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212920301592?idApp=UINPBA00003Z" "url" => "/15792129/0000005600000008/v2_202008090657/S1579212920301592/v2_202008090657/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>" "titulo" => "Acute Respiratory Failure Caused by Pulmonary Lymphangitic Carcinomatosis in a Patient With Lung Adenocarcinoma at Initial Diagnosis" "tieneTextoCompleto" => true "saludo" => "Dear Editor:" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "534" "paginaFinal" => "535" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Akihito Okazaki, Kazuhiko Shibata, Yasuhiko Matsuda, Yasutaka Shiba, Keiichi Iwasa, Kazuo Kasahara" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Akihito" "apellidos" => "Okazaki" "email" => array:1 [ 0 => "akihitookazaki1017@gmail.com" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Kazuhiko" "apellidos" => "Shibata" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Yasuhiko" "apellidos" => "Matsuda" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Yasutaka" "apellidos" => "Shiba" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "Keiichi" "apellidos" => "Iwasa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 5 => array:3 [ "nombre" => "Kazuo" "apellidos" => "Kasahara" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Department of Respiratory Medicine, Koseiren Takaoka Hospital, 5-10, Eiraku-machi, Takaoka 933-8555, Japan" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Department of Medical Oncology, Koseiren Takaoka Hospital, 5-10, Eiraku-machi, Takaoka 933-8555, Japan" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Department of Respiratory Medicine, Kanazawa University Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, 13-1, Takara-machi, Kanazawa 920-8641, Japan" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Insuficiencia respiratoria aguda causada por linfangitis carcinomatosa pulmonar en un paciente con adenocarcinoma de pulmón desde el diagnóstico inicial" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 577 "Ancho" => 1500 "Tamanyo" => 93250 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Chest X-ray showing a mass shadow in the left hilar region and bilateral diffuse interstitial opacities (A). Computed tomography revealing a mass in the left upper pulmonary lobe (B), pulmonary carcinomatosis lymphangitis, and minor bilateral pleural effusions (C). Chest X-ray showing marked improvement after four weeks of treatment (D).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Pulmonary lymphangitic carcinomatosis is associated with poor prognosis and tissue collection is difficult depending on the respiratory condition in such patients.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> Liquid biopsy could be highly effective and help in addressing the problem of poor prognosis in lymphangitic carcinomatosis patients. Here, we report a case of lung adenocarcinoma with acute severe respiratory failure caused by pulmonary lymphangitic carcinomatosis at initial diagnosis, who could receive appropriate therapy by using liquid biopsy.</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 70-year-old man with a 30 pack-year history of smoking was referred to our hospital with a 1-month history of slight fever and dyspnea on exertion. Initial diagnosis at a previous hospital had indicated bacterial pneumonia accompanied by interstitial pneumonia, which had been treated with an antibacterial drug. Sputum cytology had revealed adenocarcinoma and the patient was referred to our hospital.</p><p id="par0015" class="elsevierStylePara elsevierViewall">On admission, the patient had bilateral inspiratory crackles on chest auscultation. Laboratory findings showed severe hypoxemia and elevated levels of Krebs von den Lungen-6 (KL-6, 2638<span class="elsevierStyleHsp" style=""></span>U/mL) and carcinoembryonic antigen (CEA, 6.9<span class="elsevierStyleHsp" style=""></span>ng/mL). Chest X-ray showed a mass shadow in the left hilar region and bilateral diffuse interstitial opacities (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A). Computed tomography (CT) imaging revealed a mass in the left upper pulmonary lobe, bilateral diffuse beaded thickening of the intralobular septum, and minor bilateral pleural effusions (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a> B and C). Performing bronchoscopy was considered difficult because high flow of oxygen (reservoir mask: 6<span class="elsevierStyleHsp" style=""></span>L/min) was required for severe respiratory failure.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Adenocarcinoma was confirmed by cytological examination of the pleural effusions obtained by left pleural puncture, and epidermal growth factor receptor (EGFR) exon 19 deletion was found in the plasma EGFR gene mutation test at the time of hospitalization. The patient was confirmed for EGFR mutation-positive lung adenocarcinoma accompanied by carcinomatosis lymphangitis and pleurisy, and treatment with osimertinib (80<span class="elsevierStyleHsp" style=""></span>mg/day) was initiated on the fourth day of admission.</p><p id="par0025" class="elsevierStylePara elsevierViewall">Although respiratory failure exacerbated and noninvasive positive pressure ventilation (NPPV) was required temporarily, respiratory failure resolved and NPPV treatment was withdrawn after two weeks. After four weeks of treatment, the patient experienced symptomatic relief as evidenced by marked improvement in the patient's X-ray (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>D). EGFR exon 19 deletion was also detected in the pleural effusion samples. The patient was returned to the previous hospital. Currently, the patient is in partial remission following 12 months of treatment with osimertinib.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Pulmonary lymphangitic carcinomatosis is mainly detected in patients with adenocarcinoma, especially those with lung, breast, and gastric cancers, and associated with poor prognosis.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> In advanced non-small cell lung cancer (NSCLC), identifying driver gene mutations is recommended, but tissue collection is difficult depending on the general condition of the patient, such as respiratory failure, which is often a time-limited situation in such patients. Liquid biopsy is useful when tissue sampling is difficult or inadequate.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> Although liquid biopsy can only currently be used in clinical practice for EGFR sensitizing and resistance mutations, various NSCLC driver genes have been detected successfully with the help of several plasma-based tests including molecular tests (such as detection of ROS-1) even before proceeding to tissue-based tests.<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">3–6</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">In the present case, the time gap between the plasma EGFR mutation test and result report was only three days. This case indicates that liquid biopsy for detecting other driver gene mutations in addition to the EGFR mutation are warranted, since a therapeutic effect can be expected in the patient with driver gene mutation-positive NSCLC; this is true even in cases where tissue tests are difficult, such as in patients with lymphangitic carcinomatosis, which generally have poor prognosis.</p><p id="par0040" class="elsevierStylePara elsevierViewall">In summary, we reported a case of EGFR mutation positive lung adenocarcinoma with acute severe respiratory failure caused by pulmonary lymphangitic carcinomatosis. Although tissue collection was difficult, the patient could receive appropriate therapy by using liquid biopsy. Liquid biopsy could help in addressing the problem of poor prognosis in lymphangitic carcinomatosis patients.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 577 "Ancho" => 1500 "Tamanyo" => 93250 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Chest X-ray showing a mass shadow in the left hilar region and bilateral diffuse interstitial opacities (A). Computed tomography revealing a mass in the left upper pulmonary lobe (B), pulmonary carcinomatosis lymphangitis, and minor bilateral pleural effusions (C). Chest X-ray showing marked improvement after four weeks of treatment (D).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:6 [ 0 => array:3 [ "identificador" => "bib0035" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary lymphangitis carcinomatosis: systematic review and meta-analysis of case reports, 1970–2018" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M. 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