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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Venous thromboembolism &#40;VTE&#41; can have long-term consequences&#44; such as post-thrombotic syndrome &#40;PTS&#41; or chronic thromboembolic pulmonary hypertension &#40;CTPH&#41;&#46; Recurrent thrombosis or bleeding can occur during follow-up&#46; These post-VTE complications can have adverse effects on quality of life &#40;QoL&#41;&#46; Previous research on QoL after VTE included only middle-aged subjects&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">1</span></a> Although the elderly are more prone to VTE<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">2</span></a> and the proportion of aged individuals is increasing worldwide&#44;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">3</span></a> there are no data on QoL in this population&#46; We investigated the QoL of a cohort of patients older than 75 y after VTE and analyzed the determinants 18 mo post-VTE&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">This was a prospective observational study of consecutive patients older than 75 y with acute VTE &#40;pulmonary embolism &#91;PE&#93; and&#47;or deep vein thrombosis &#91;DVT&#93;&#41; who presented to Hospital Universitario 12 de Octubre&#44; Spain between 2015 and 2017&#46; Comorbidity was measured using the non-age-adjusted Charlson index&#44;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">4</span></a> and the functional status of the patients in terms of basic activities of daily living was assessed using the Barthel index &#40;BI&#41; &#40;score range&#58; 0-100&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">5</span></a> Depression was established based on a review of the patient&#39;s history&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Clinical practitioners registered VTE recurrence and major bleeding&#46; A diagnosis of CTPH required documented pulmonary hypertension &#40;echocardiography or right catheterization&#41; and evidence of chronic thrombosis on ventilation-perfusion scintigraphy or computed tomography at least 3 mo post-PE&#46; The Ginsberg clinical scale was used to diagnose PTS 18 mo after DVT&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">6</span></a> To assess QoL&#44; we administered the Short Form 36 &#40;SF-36&#41; survey 18 mo after VTE and calculated the mean and its 95&#37; confidence interval &#40;95&#37;CI&#41; for each SF-36 subscale and two summary measures &#40;physical summary measure &#91;PSM&#93; and mental summary measure &#91;MSM&#93;&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">7&#44;8</span></a> The subscale values ranged from 0 to 100&#44; with higher scores corresponding to better health status&#46; The summary measures were &#8220;norm-based&#46;&#8221; Thus&#44; scores above or below 50 were considered above or below the mean of the reference population&#46; We compared the results with those previously published in a Spanish population of the same age&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">9</span></a> A difference of 5 points or more in any subscale was accepted as clinically and socially relevant&#44;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">7</span></a> and a <span class="elsevierStyleItalic">p</span>-value lower than 0&#46;0005 was considered statistically significant&#44; according to a Bonferroni correction for multiple comparisons&#46; Finally&#44; we pre-selected variables related to QoL in older and VTE patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">1&#44;10&#8211;12</span></a> We analyzed their impact on the summary measures using multivariable linear regression&#46; The variables included in the multivariable models for PSM were age&#44; sex&#44; Charlson index&#44; BI&#44; recurrent VTE&#44; bleeding&#44; CTPH&#44; and PTS&#46; Depression was included in the multivariable models for MSM&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The local ethics committee approved this study&#46; Prior to enrollment&#44; the subjects were informed about the study&#44; and provided written or verbal informed consent&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">In total&#44; 101 of 151 &#40;67&#37;&#41; patients completed the SF-36 questionnaire 18 mo post-VTE&#46; The median age was 81 y &#40;interquartile range &#91;IQR&#93;&#58; 79&#44; 86&#41;&#44; 61&#37; were females&#44; and 19&#37; had cancer&#46; The median BI was 100 &#40;IQR&#58; 85&#44; 100&#41;&#44; and the Charlson index was 1 &#40;IQR&#58; 0&#44; 2&#41;&#46; Eighty-two&#37; of patients had experienced a PE&#44; with or without DVT&#46; VTE recurrence&#44; major bleeding&#44; CPTH&#44; and PTS occurred in 8&#37;&#44; 5&#37;&#44; 3&#37;&#44; and 10&#37; of patients&#44; respectively&#46; The means for the two summary measures were lower than the values for the Spanish population older than 60 y &#40;PSM&#44; 45&#46;51 &#91;95&#37;CI&#58; 43&#46;68&#44; 47&#46;35&#93;&#59; MSM&#44; 47&#46;30 &#91;95&#37;CI&#58; 44&#46;95&#44; 49&#46;65&#93;&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; After the multivariable analysis&#44; the BI was the only determinant related&#44; clinically and statistically&#44; to PSM at the 18-mo follow-up &#40;<span class="elsevierStyleItalic">B</span>-coefficient&#58; 0&#46;119 &#91;95&#37;CI&#58; 0&#46;043&#44; 0&#46;195&#93;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;002&#41;&#46; Neither the Charlson index nor VTE-related factors were related to PSM &#40;Charlson <span class="elsevierStyleItalic">B</span>-coefficient&#58; &#8722;0&#46;126 &#91;95&#37;CI&#58; &#8722;1&#46;238&#44; 0&#46;986&#93;&#44; recurrence <span class="elsevierStyleItalic">B</span>-coefficient&#58; &#8722;3&#46;650 &#91;95&#37;CI&#58; &#8722;11&#46;051&#44; 3&#46;751&#93;&#59; bleeding <span class="elsevierStyleItalic">B</span>-coefficient&#58; 1&#46;846 &#91;95&#37;CI&#58; &#8722;2&#46;934&#44; 6&#46;625&#93;&#59; CTPH <span class="elsevierStyleItalic">B</span>-coefficient&#58; 2&#46;182 &#91;95CI&#37;&#58; &#8722;6&#46;659&#44; 11&#46;022&#93;&#59; PTS <span class="elsevierStyleItalic">B</span>-coefficient&#58; &#8722;5&#46;212 &#91;95&#37;CI&#58; &#8722;10&#46;980&#44; 0&#46;557&#93;&#41;&#46; No factors were related to MSM after the multivariable analysis&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">This study showed that older VTE patients reported worse QoL than that of older patients in the general Spanish population&#44; with mainly physical function affected&#46; Although several studies concluded that VTE had a negative impact on the QoL of middle-aged people&#44;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">1</span></a> a recent study<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">13</span></a> reported that QoL 1 y after VTE improved to a level similar to that of a healthy population&#46; This finding differs from that found in our study&#44; in which both summary measures were below the population norms after 18 mo&#46; We ascribe this disparity to the age difference of the study populations&#46; The disability prevalence increases among the aged&#44;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">14</span></a> and it have been linked to a reduced QoL in several disorders&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">12&#44;14&#44;15</span></a> In the present study&#44; the BI was the only independent determinant of a low PSM score&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Our study had some limitations&#46; First&#44; the small sample size limited the power to detect an association between QoL and long-term complications&#46; Thus&#44; no conclusions can be drawn about the impact of recurrence&#44; bleeding&#44; CTPH or PTS on QoL&#46; In addition&#44; this was a monocentric study&#44; which limits its external validity&#46; Finally&#44; we did not use a disease-specific QoL questionnaire&#44; which could have been more sensitive than the SF-36 survey in detecting differences in QoL&#46; However&#44; previous studies on VTE and QoL employed the SF-36 survey and demonstrated good reliability and validity&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">1&#44;13</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Despite the aforementioned limitations&#44; to our knowledge&#44; this is the first study to examine QoL in aged VTE patients&#46; The response rate in the present study was similar to that of earlier research<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">1</span></a> and can be attributed to the challenging nature of follow-ups of elderly populations&#46; Given that VTE-related complications usually occur within the first 2 y&#44;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">1</span></a> we estimate that an average follow-up of 1&#46;5 y should be sufficient to identify the impact of most of these complications on QoL&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">In our cohort&#44; older VTE patients reported worse QoL than that of the general population of the same age&#44; and the BI was the only independent determinant of QoL&#46; Although our study cannot lead to firm conclusions&#44; the results may be relevant for future research on the influence of VTE-related complications or treatment on the QoL of patients&#46;</p></span>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">SF-36 subscales&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Cohort results &#40;mean &#40;95&#37;CI&#41;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="3" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Comparison with Spanish population over 60-year-old</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="3" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Comparison with Spanish population from 80 to 85-year-old</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Reference values &#40;mean&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mean difference&#40;95&#37;CI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Reference values &#40;mean&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mean difference&#40;95&#37;CI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Physical functioning&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44&#46;66 &#40;38&#46;30&#44; 51&#46;02&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">65&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;21&#46;04 &#40;&#8722;27&#46;40&#44; &#8722;14&#46;68&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">68&#46;93&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;24&#46;27 &#40;&#8722;30&#46;63&#44; &#8722;17&#46;91&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Physical role&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60&#46;19 &#40;50&#46;15&#44; 70&#46;24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">73&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;13&#46;11 &#40;&#8722;23&#46;15&#44; 3&#46;06&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;100&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">63&#46;18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;2&#46;99 &#40;&#8722;13&#46;03&#44; 7&#46;06&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;100&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Bodily pain&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">57&#46;40 &#40;50&#46;51&#44; 64&#46;28&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">68&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;11&#46;00 &#40;&#8722;17&#46;89&#44; &#8722;4&#46;12&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;011&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">64&#46;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;7&#46;04 &#40;&#8722;13&#46;92&#44; &#8722;0&#46;16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;096&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">General health&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">48&#46;27 &#40;43&#46;91&#44; 52&#46;63&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">55&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;7&#46;63 &#40;&#8722;11&#46;99&#44; &#8722;3&#46;27&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">52&#46;51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;4&#46;24 &#40;&#8722;8&#46;60&#44; 0&#46;12&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;063&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vitality&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">52&#46;14 &#40;46&#46;12&#44; 58&#46;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;8&#46;36 &#40;&#8722;14&#46;38&#44; &#8722;2&#46;35&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54&#46;39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;2&#46;25 &#40;&#8722;8&#46;27&#44; 3&#46;76&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;705&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Social functioning&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75&#46;24 &#40;69&#46;05&#44; 81&#46;44&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">79&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;3&#46;96 &#40;&#8722;10&#46;15&#44; 2&#46;24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;645&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">72&#46;79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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Scientific letter
Quality of Life After a Venous Thrombosis in Elderly Patients: Results From a Prospective Spanish Cohort
Calidad de vida tras una trombosis venosa en pacientes mayores: resultados de una cohorte prospecpectiva española
Covadonga Gómez-Cuervo
Corresponding author
, Carmen Díaz-Pedroche, Asunción Pérez-Jacoiste Asín, Antonio Lalueza, Raquel Díaz-Simón, Carlos Lumbreras
Servicio de Medicina Interna, Hospital Universitario 12 de Octubre, Madrid, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Venous thromboembolism &#40;VTE&#41; can have long-term consequences&#44; such as post-thrombotic syndrome &#40;PTS&#41; or chronic thromboembolic pulmonary hypertension &#40;CTPH&#41;&#46; Recurrent thrombosis or bleeding can occur during follow-up&#46; These post-VTE complications can have adverse effects on quality of life &#40;QoL&#41;&#46; Previous research on QoL after VTE included only middle-aged subjects&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">1</span></a> Although the elderly are more prone to VTE<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">2</span></a> and the proportion of aged individuals is increasing worldwide&#44;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">3</span></a> there are no data on QoL in this population&#46; We investigated the QoL of a cohort of patients older than 75 y after VTE and analyzed the determinants 18 mo post-VTE&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">This was a prospective observational study of consecutive patients older than 75 y with acute VTE &#40;pulmonary embolism &#91;PE&#93; and&#47;or deep vein thrombosis &#91;DVT&#93;&#41; who presented to Hospital Universitario 12 de Octubre&#44; Spain between 2015 and 2017&#46; Comorbidity was measured using the non-age-adjusted Charlson index&#44;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">4</span></a> and the functional status of the patients in terms of basic activities of daily living was assessed using the Barthel index &#40;BI&#41; &#40;score range&#58; 0-100&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">5</span></a> Depression was established based on a review of the patient&#39;s history&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Clinical practitioners registered VTE recurrence and major bleeding&#46; A diagnosis of CTPH required documented pulmonary hypertension &#40;echocardiography or right catheterization&#41; and evidence of chronic thrombosis on ventilation-perfusion scintigraphy or computed tomography at least 3 mo post-PE&#46; The Ginsberg clinical scale was used to diagnose PTS 18 mo after DVT&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">6</span></a> To assess QoL&#44; we administered the Short Form 36 &#40;SF-36&#41; survey 18 mo after VTE and calculated the mean and its 95&#37; confidence interval &#40;95&#37;CI&#41; for each SF-36 subscale and two summary measures &#40;physical summary measure &#91;PSM&#93; and mental summary measure &#91;MSM&#93;&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">7&#44;8</span></a> The subscale values ranged from 0 to 100&#44; with higher scores corresponding to better health status&#46; The summary measures were &#8220;norm-based&#46;&#8221; Thus&#44; scores above or below 50 were considered above or below the mean of the reference population&#46; We compared the results with those previously published in a Spanish population of the same age&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">9</span></a> A difference of 5 points or more in any subscale was accepted as clinically and socially relevant&#44;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">7</span></a> and a <span class="elsevierStyleItalic">p</span>-value lower than 0&#46;0005 was considered statistically significant&#44; according to a Bonferroni correction for multiple comparisons&#46; Finally&#44; we pre-selected variables related to QoL in older and VTE patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">1&#44;10&#8211;12</span></a> We analyzed their impact on the summary measures using multivariable linear regression&#46; The variables included in the multivariable models for PSM were age&#44; sex&#44; Charlson index&#44; BI&#44; recurrent VTE&#44; bleeding&#44; CTPH&#44; and PTS&#46; Depression was included in the multivariable models for MSM&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The local ethics committee approved this study&#46; Prior to enrollment&#44; the subjects were informed about the study&#44; and provided written or verbal informed consent&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">In total&#44; 101 of 151 &#40;67&#37;&#41; patients completed the SF-36 questionnaire 18 mo post-VTE&#46; The median age was 81 y &#40;interquartile range &#91;IQR&#93;&#58; 79&#44; 86&#41;&#44; 61&#37; were females&#44; and 19&#37; had cancer&#46; The median BI was 100 &#40;IQR&#58; 85&#44; 100&#41;&#44; and the Charlson index was 1 &#40;IQR&#58; 0&#44; 2&#41;&#46; Eighty-two&#37; of patients had experienced a PE&#44; with or without DVT&#46; VTE recurrence&#44; major bleeding&#44; CPTH&#44; and PTS occurred in 8&#37;&#44; 5&#37;&#44; 3&#37;&#44; and 10&#37; of patients&#44; respectively&#46; The means for the two summary measures were lower than the values for the Spanish population older than 60 y &#40;PSM&#44; 45&#46;51 &#91;95&#37;CI&#58; 43&#46;68&#44; 47&#46;35&#93;&#59; MSM&#44; 47&#46;30 &#91;95&#37;CI&#58; 44&#46;95&#44; 49&#46;65&#93;&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; After the multivariable analysis&#44; the BI was the only determinant related&#44; clinically and statistically&#44; to PSM at the 18-mo follow-up &#40;<span class="elsevierStyleItalic">B</span>-coefficient&#58; 0&#46;119 &#91;95&#37;CI&#58; 0&#46;043&#44; 0&#46;195&#93;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;002&#41;&#46; Neither the Charlson index nor VTE-related factors were related to PSM &#40;Charlson <span class="elsevierStyleItalic">B</span>-coefficient&#58; &#8722;0&#46;126 &#91;95&#37;CI&#58; &#8722;1&#46;238&#44; 0&#46;986&#93;&#44; recurrence <span class="elsevierStyleItalic">B</span>-coefficient&#58; &#8722;3&#46;650 &#91;95&#37;CI&#58; &#8722;11&#46;051&#44; 3&#46;751&#93;&#59; bleeding <span class="elsevierStyleItalic">B</span>-coefficient&#58; 1&#46;846 &#91;95&#37;CI&#58; &#8722;2&#46;934&#44; 6&#46;625&#93;&#59; CTPH <span class="elsevierStyleItalic">B</span>-coefficient&#58; 2&#46;182 &#91;95CI&#37;&#58; &#8722;6&#46;659&#44; 11&#46;022&#93;&#59; PTS <span class="elsevierStyleItalic">B</span>-coefficient&#58; &#8722;5&#46;212 &#91;95&#37;CI&#58; &#8722;10&#46;980&#44; 0&#46;557&#93;&#41;&#46; No factors were related to MSM after the multivariable analysis&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">This study showed that older VTE patients reported worse QoL than that of older patients in the general Spanish population&#44; with mainly physical function affected&#46; Although several studies concluded that VTE had a negative impact on the QoL of middle-aged people&#44;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">1</span></a> a recent study<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">13</span></a> reported that QoL 1 y after VTE improved to a level similar to that of a healthy population&#46; This finding differs from that found in our study&#44; in which both summary measures were below the population norms after 18 mo&#46; We ascribe this disparity to the age difference of the study populations&#46; The disability prevalence increases among the aged&#44;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">14</span></a> and it have been linked to a reduced QoL in several disorders&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">12&#44;14&#44;15</span></a> In the present study&#44; the BI was the only independent determinant of a low PSM score&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Our study had some limitations&#46; First&#44; the small sample size limited the power to detect an association between QoL and long-term complications&#46; Thus&#44; no conclusions can be drawn about the impact of recurrence&#44; bleeding&#44; CTPH or PTS on QoL&#46; In addition&#44; this was a monocentric study&#44; which limits its external validity&#46; Finally&#44; we did not use a disease-specific QoL questionnaire&#44; which could have been more sensitive than the SF-36 survey in detecting differences in QoL&#46; However&#44; previous studies on VTE and QoL employed the SF-36 survey and demonstrated good reliability and validity&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">1&#44;13</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Despite the aforementioned limitations&#44; to our knowledge&#44; this is the first study to examine QoL in aged VTE patients&#46; The response rate in the present study was similar to that of earlier research<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">1</span></a> and can be attributed to the challenging nature of follow-ups of elderly populations&#46; Given that VTE-related complications usually occur within the first 2 y&#44;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">1</span></a> we estimate that an average follow-up of 1&#46;5 y should be sufficient to identify the impact of most of these complications on QoL&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">In our cohort&#44; older VTE patients reported worse QoL than that of the general population of the same age&#44; and the BI was the only independent determinant of QoL&#46; Although our study cannot lead to firm conclusions&#44; the results may be relevant for future research on the influence of VTE-related complications or treatment on the QoL of patients&#46;</p></span>"
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">SF-36 subscales&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Cohort results &#40;mean &#40;95&#37;CI&#41;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="3" align="center" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Comparison with Spanish population over 60-year-old</th><th class="td" title="\n
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                  \t\t\t\t  " colspan="3" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Comparison with Spanish population from 80 to 85-year-old</th></tr><tr title="table-row"><th class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Reference values &#40;mean&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mean difference&#40;95&#37;CI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Reference values &#40;mean&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mean difference&#40;95&#37;CI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Physical functioning&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44&#46;66 &#40;38&#46;30&#44; 51&#46;02&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">65&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;21&#46;04 &#40;&#8722;27&#46;40&#44; &#8722;14&#46;68&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">68&#46;93&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">&#8722;24&#46;27 &#40;&#8722;30&#46;63&#44; &#8722;17&#46;91&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Physical role&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">60&#46;19 &#40;50&#46;15&#44; 70&#46;24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">73&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;13&#46;11 &#40;&#8722;23&#46;15&#44; 3&#46;06&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;100&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">63&#46;18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;2&#46;99 &#40;&#8722;13&#46;03&#44; 7&#46;06&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;100&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Bodily pain&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">57&#46;40 &#40;50&#46;51&#44; 64&#46;28&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">68&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;11&#46;00 &#40;&#8722;17&#46;89&#44; &#8722;4&#46;12&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;011&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">64&#46;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;7&#46;04 &#40;&#8722;13&#46;92&#44; &#8722;0&#46;16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;096&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">General health&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">48&#46;27 &#40;43&#46;91&#44; 52&#46;63&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">55&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;7&#46;63 &#40;&#8722;11&#46;99&#44; &#8722;3&#46;27&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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Article information
ISSN: 15792129
Original language: English
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