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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Axial image of chest CT &#40;pulmonary parenchymal window&#41; showing linear thickening of the subpleural lung interstitium &#40;arrows&#41;&#46; &#40;B&#41; Maximum intensity projection &#40;MIP&#41; axial reconstruction &#40;pulmonary parenchymal window&#41; of left lung&#44; showing a peripheral &#8220;tree-in-bud&#8221; pattern consisting of linear opacities forming predominantly subpleural branches &#40;circled&#41;&#46; See also the presence of small centrilobular nodules &#40;arrow&#41;&#46; &#40;C&#41; MIP coronal reconstruction &#40;pulmonary parenchymal window&#41; of the left lung&#44; also showing the &#8220;tree-in-bud&#8221; pattern &#40;circled&#41;&#46; &#40;D&#41; Chest CT sagittal image &#40;bone window&#41; revealing multiple focal bone lesions &#40;arrows&#41; in the sternum and several vertebrae&#44; consistent with bone metastases&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Pulmonary tumor thrombotic microangiopathy &#40;PTTM&#41; is a rare and generally fatal form of pulmonary tumor embolism that generally presents with rapidly progressing dyspnea in patients with disseminated malignant disease&#46; Clinical diagnosis is difficult&#44; and unfortunately PTTM is generally only confirmed <span class="elsevierStyleItalic">post mortem&#46;</span><a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We report the case of a 58-year-old man&#44; former smoker &#40;20 pack-years&#41;&#44; who presented with a 2-week history of progressive dyspnea and dry cough&#46; Significant clinical history included prostate adenocarcinoma &#40;Gleason score 6&#41;&#44; treated with radiation therapy with curative intent 6 years previously&#44; with no biochemical evidence of tumor relapse&#46; Clinical examination revealed tachypnea and fine crackles on auscultation&#46; Basal oxygen saturation was 88&#37; and laboratory test findings did not suggest infection&#44; although D-dimer levels were elevated&#46; A chest radiograph showed bilateral diffuse interstitial involvement and prominent lung hila&#46; Chest CT angiogram ruled out embolism on the main pulmonary&#44; lobar or segmentary arteries&#44; although multiple mediastinal and hilar lymphadenopathies were detected&#44; along with severe interstitial involvement consistent with thickening of the subpleural pulmonary interstitium &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41; and the presence of numerous centrilobular nodules and &#8220;tree-in-bud&#8221; images &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B and <span class="elsevierStyleSmallCaps">C</span>&#41;&#46; Multiple focal bone lesions&#44; predominantly sclerotic&#44; were also observed in the vertebrae and sternum&#44; consistent with metastasis &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>D&#41;&#46; Given these radiological findings&#44; PTTM secondary to prostate adenocarcinoma was suggested as an initial diagnosis&#44; although other possibilities such as sarcoidosis or infection with an unusual pathogen were not ruled out&#46; Four days after admission&#44; the patient developed rapidly progressing respiratory failure that required urgent intubation&#46; A few hours later&#44; he suffered an episode of cardiorespiratory arrest with asystole and died despite prolonged attempts at cardiopulmonary resuscitation&#46; The diagnosis of PTTM was confirmed on autopsy&#44; which revealed an unsuspected undifferentiated occult gastric &#8220;signet ring&#8221; adenocarcinoma&#44; with extensive metastases and multiple tumor embolisms in the small-caliber peripheral pulmonary arteries&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">PTTM is a rare form of pulmonary arterial tumor embolism&#44; in which small tumor cell embolisms cause fibrocellular proliferation in the intima of small-caliber pulmonary arteries&#46; These changes lead to stenosis&#47;occlusion of the pulmonary arteries and a subsequent rise in pulmonary vascular resistance&#44; which in turn leads to rapidly progressing precapillary pulmonary hypertension&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> Clinically&#44; patients tend to develop acute&#47;subacute <span class="elsevierStyleItalic">cor pulmonale</span> and respiratory failure&#46; Most patients who develop PTTM have documented metastatic cancer&#44; the most common tumor being gastric adenocarcinoma followed by lung cancer&#44; but on occasions &#40;as in our case&#41; it can occur in patients with no diagnosis of metastatic disease&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> In a recent review&#44; none of the 30 cases scrutinized was due to disseminated prostate cancer&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> Unfortunately&#44; most PTTMs are diagnosed <span class="elsevierStyleItalic">post mortem</span> on autopsy&#44; and only some isolated cases have been described in surgical biopsies <span class="elsevierStyleItalic">ante mortem&#46;</span> Only a high clinical suspicion and consistent radiological findings will prompt the physician to make a clinical diagnosis of PTTM and to plan the appropriate treatment&#44; which is generally based on a combination of chemotherapy&#44; anti-coagulants and corticosteroids&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> Significant radiological signs of PTTM described on CT include the &#8220;tree-in-bud&#8221; pattern&#46; This is practically the only vascular cause of this radiological pattern&#44; and should be distinguished from the bronchial presentation that is generally observed in patients with infectious bronchiolitis&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">PTTM should be suspected in oncological patients with worsening respiratory function and&#47;or who develop acute&#47;subacute <span class="elsevierStyleItalic">cor pulmonale</span>&#44; particularly in the absence of pulmonary artery embolisms on chest CT angiogram&#46; Detection of a &#8220;tree-in-bud&#8221; pattern without clinical signs of respiratory infection should also alert to this diagnosis&#46;</p></span>"
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Scientific Letter
Radiological Diagnosis of Pulmonary Tumor Thrombotic Microangiopathy: A Non-bronchial Cause of «Tree-in-Bud» Pattern on Computed Tomography
Diagnóstico radiológico de microangiopatía trombótica tumoral pulmonar: una causa no bronquial de patrón de «árbol en brote» en tomografía computarizada
Luis Gorospe Sarasúa
Corresponding author
luisgorospe@yahoo.com

Corresponding author.
, Almudena Ureña-Vacas, Ernesto García-Santana
Servicio de Radiodiagnóstico, Hospital Universitario Ramón y Cajal, Madrid, Spain
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        "titulo" => "Diagn&#243;stico radiol&#243;gico de microangiopat&#237;a tromb&#243;tica tumoral pulmonar&#58; una causa no bronquial de patr&#243;n de &#171;&#225;rbol en brote&#187; en tomograf&#237;a computarizada"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Axial image of chest CT &#40;pulmonary parenchymal window&#41; showing linear thickening of the subpleural lung interstitium &#40;arrows&#41;&#46; &#40;B&#41; Maximum intensity projection &#40;MIP&#41; axial reconstruction &#40;pulmonary parenchymal window&#41; of left lung&#44; showing a peripheral &#8220;tree-in-bud&#8221; pattern consisting of linear opacities forming predominantly subpleural branches &#40;circled&#41;&#46; See also the presence of small centrilobular nodules &#40;arrow&#41;&#46; &#40;C&#41; MIP coronal reconstruction &#40;pulmonary parenchymal window&#41; of the left lung&#44; also showing the &#8220;tree-in-bud&#8221; pattern &#40;circled&#41;&#46; &#40;D&#41; Chest CT sagittal image &#40;bone window&#41; revealing multiple focal bone lesions &#40;arrows&#41; in the sternum and several vertebrae&#44; consistent with bone metastases&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Pulmonary tumor thrombotic microangiopathy &#40;PTTM&#41; is a rare and generally fatal form of pulmonary tumor embolism that generally presents with rapidly progressing dyspnea in patients with disseminated malignant disease&#46; Clinical diagnosis is difficult&#44; and unfortunately PTTM is generally only confirmed <span class="elsevierStyleItalic">post mortem&#46;</span><a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We report the case of a 58-year-old man&#44; former smoker &#40;20 pack-years&#41;&#44; who presented with a 2-week history of progressive dyspnea and dry cough&#46; Significant clinical history included prostate adenocarcinoma &#40;Gleason score 6&#41;&#44; treated with radiation therapy with curative intent 6 years previously&#44; with no biochemical evidence of tumor relapse&#46; Clinical examination revealed tachypnea and fine crackles on auscultation&#46; Basal oxygen saturation was 88&#37; and laboratory test findings did not suggest infection&#44; although D-dimer levels were elevated&#46; A chest radiograph showed bilateral diffuse interstitial involvement and prominent lung hila&#46; Chest CT angiogram ruled out embolism on the main pulmonary&#44; lobar or segmentary arteries&#44; although multiple mediastinal and hilar lymphadenopathies were detected&#44; along with severe interstitial involvement consistent with thickening of the subpleural pulmonary interstitium &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41; and the presence of numerous centrilobular nodules and &#8220;tree-in-bud&#8221; images &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B and <span class="elsevierStyleSmallCaps">C</span>&#41;&#46; Multiple focal bone lesions&#44; predominantly sclerotic&#44; were also observed in the vertebrae and sternum&#44; consistent with metastasis &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>D&#41;&#46; Given these radiological findings&#44; PTTM secondary to prostate adenocarcinoma was suggested as an initial diagnosis&#44; although other possibilities such as sarcoidosis or infection with an unusual pathogen were not ruled out&#46; Four days after admission&#44; the patient developed rapidly progressing respiratory failure that required urgent intubation&#46; A few hours later&#44; he suffered an episode of cardiorespiratory arrest with asystole and died despite prolonged attempts at cardiopulmonary resuscitation&#46; The diagnosis of PTTM was confirmed on autopsy&#44; which revealed an unsuspected undifferentiated occult gastric &#8220;signet ring&#8221; adenocarcinoma&#44; with extensive metastases and multiple tumor embolisms in the small-caliber peripheral pulmonary arteries&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">PTTM is a rare form of pulmonary arterial tumor embolism&#44; in which small tumor cell embolisms cause fibrocellular proliferation in the intima of small-caliber pulmonary arteries&#46; These changes lead to stenosis&#47;occlusion of the pulmonary arteries and a subsequent rise in pulmonary vascular resistance&#44; which in turn leads to rapidly progressing precapillary pulmonary hypertension&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> Clinically&#44; patients tend to develop acute&#47;subacute <span class="elsevierStyleItalic">cor pulmonale</span> and respiratory failure&#46; Most patients who develop PTTM have documented metastatic cancer&#44; the most common tumor being gastric adenocarcinoma followed by lung cancer&#44; but on occasions &#40;as in our case&#41; it can occur in patients with no diagnosis of metastatic disease&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> In a recent review&#44; none of the 30 cases scrutinized was due to disseminated prostate cancer&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> Unfortunately&#44; most PTTMs are diagnosed <span class="elsevierStyleItalic">post mortem</span> on autopsy&#44; and only some isolated cases have been described in surgical biopsies <span class="elsevierStyleItalic">ante mortem&#46;</span> Only a high clinical suspicion and consistent radiological findings will prompt the physician to make a clinical diagnosis of PTTM and to plan the appropriate treatment&#44; which is generally based on a combination of chemotherapy&#44; anti-coagulants and corticosteroids&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> Significant radiological signs of PTTM described on CT include the &#8220;tree-in-bud&#8221; pattern&#46; This is practically the only vascular cause of this radiological pattern&#44; and should be distinguished from the bronchial presentation that is generally observed in patients with infectious bronchiolitis&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">PTTM should be suspected in oncological patients with worsening respiratory function and&#47;or who develop acute&#47;subacute <span class="elsevierStyleItalic">cor pulmonale</span>&#44; particularly in the absence of pulmonary artery embolisms on chest CT angiogram&#46; Detection of a &#8220;tree-in-bud&#8221; pattern without clinical signs of respiratory infection should also alert to this diagnosis&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Gorospe Saras&#250;a L&#44; Ure&#241;a-Vacas A&#44; Garc&#237;a-Santana E&#46; Diagn&#243;stico radiol&#243;gico de microangiopat&#237;a tromb&#243;tica tumoral pulmonar&#58; una causa no bronquial de patr&#243;n de &#171;&#225;rbol en brote&#187; en tomograf&#237;a computarizada&#46; Arch Bronconeumol&#46; 2016&#59;52&#58;621&#8211;622&#46;</p>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Axial image of chest CT &#40;pulmonary parenchymal window&#41; showing linear thickening of the subpleural lung interstitium &#40;arrows&#41;&#46; &#40;B&#41; Maximum intensity projection &#40;MIP&#41; axial reconstruction &#40;pulmonary parenchymal window&#41; of left lung&#44; showing a peripheral &#8220;tree-in-bud&#8221; pattern consisting of linear opacities forming predominantly subpleural branches &#40;circled&#41;&#46; See also the presence of small centrilobular nodules &#40;arrow&#41;&#46; &#40;C&#41; MIP coronal reconstruction &#40;pulmonary parenchymal window&#41; of the left lung&#44; also showing the &#8220;tree-in-bud&#8221; pattern &#40;circled&#41;&#46; &#40;D&#41; Chest CT sagittal image &#40;bone window&#41; revealing multiple focal bone lesions &#40;arrows&#41; in the sternum and several vertebrae&#44; consistent with bone metastases&#46;</p>"
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ISSN: 15792129
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