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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">Mucociliary transport is an important defense mechanism for the airways&#46; The aim of this study was to establish reference values for nasal mucociliary clearance time &#40;MCT&#41; by means of the saccharin test&#46;</p> <span class="elsevierStyleSectionTitle">Subjects and Methods</span><p class="elsevierStyleSimplePara elsevierViewall">A cross-sectional&#44; descriptive&#44; observational study was performed&#46; The variables studied were nasal MCT&#44; age&#44; and sex&#46; We included 249 healthy nonsmokers &#40;134 male and 115 female subjects&#41; aged over 10 years and stratified the sample by age&#46; To establish reference values&#44; percentiles were calculated and lower and upper limits of normal were established at the 2&#46;5 and 97&#46;5 percentiles&#44; respectively&#46; The association between nasal MCT and the main study variables was then investigated along with the reproducibility of the test&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The following values for nasal MCT were obtained for the sample as a whole&#58; mean &#40;SD&#41;&#44; 17&#46;17 &#40;8&#46;43&#41; minutes&#59; median &#40;interquartile range&#41;&#44; 16 minutes &#40;12-20 minutes&#41;&#44; indicating that the central 50&#37; of the sample fell within this 8-minute range&#59; and maximum and minimum values of 4 to 54 minutes &#40;range&#44; 50 minutes&#41;&#46; The upper and lower limits of normal were 6 and 36 minutes&#44; respectively&#46; In addition&#44; it is noteworthy that only 6 subjects had a nasal MCT longer than 36 minutes&#46; No significant differences between male and female subjects were found&#46; Nasal MCT showed a positive correlation with age &#40;&#961;&#61;0&#46;324&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;0001&#41;&#46; No significant differences were observed in the reproducibility test &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;208&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">In addition to facilitating reliable data on mucociliary function&#44; the saccharin test is easy to do&#44; inexpensive&#44; and reproducible&#46; The data obtained from this study should allow the results of this test to be correctly interpreted for a given subject&#39;s age and so facilitate its use in clinical practice&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">El transporte mucociliar es un importante mecanismo de defensa de las v&#237;as respiratorias&#46; El objetivo de este estudio ha sido obtener los valores de referencia del tiempo de transporte mucociliar nasal &#40;TTMCN&#41; mediante el test de la sacarina&#46;</p> <span class="elsevierStyleSectionTitle">Sujetos Y M&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha realizado un estudio observacional&#44; transversal y descriptivo&#46; Las variables estudiadas fueron el TTMCN&#44; la edad y el sexo&#46; Se incluy&#243; a 249 sujetos &#40;134 varones y 115 mujeres&#41; mayores de 10 a&#241;os&#44; sanos y no fumadores&#44; que se asignaron a grupos seg&#250;n su edad&#46; Para el an&#225;lisis predictivo de los valores de normalidad se obtuvieron los percentiles&#44; estableciendo los l&#237;mites de referencia por los percentiles 2&#44;5 y 97&#44;5&#46; Se analiz&#243; la asociaci&#243;n entre el TTMCN y las variables principales&#46; Se estudi&#243; asimismo la reproducibilidad del test&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Del an&#225;lisis global de la muestra destacan los siguientes datos&#58; mediana de 16 min&#59; media &#177; desviaci&#243;n est&#225;ndar de 17&#44;17 &#177; 8&#44;43 min&#59; rango de 50 min &#40;4-54&#41;&#59; l&#237;mites de referencia de 6-36 min&#44; y amplitud intercuart&#237;lica de 8 min &#40;un 50&#37; central de la muestra entre 12 y 20 min&#41;&#46; Es asimismo rese&#241;able que s&#243;lo 6 sujetos tuvieron un TTMCN superior a 36 min&#46; No se encontraron diferencias significativas entre varones y mujeres&#46; El TTMCN mostr&#243; una correlaci&#243;n positiva con la edad &#40;r<span class="elsevierStyleInf">s</span> &#61; 0&#44;324&#59; p &#61; 0&#44;0001&#41;&#46; No se observaron diferencias significativas &#40;p &#61; 0&#44;208&#41; en la prueba de reproducibilidad&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">El test de la sacarina es f&#225;cil de realizar&#44; econ&#243;mico y reproducible&#44; y facilita datos fiables de la funci&#243;n mucociliar&#46; Los datos obtenidos en este trabajo permiten la correcta interpretaci&#243;n de los resultados de esta prueba seg&#250;n la edad del sujeto&#44; lo que facilitar&#225; su uso&#46;</p>"
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Original Articles
Saccharin Test for the Study of Mucociliary Clearance: Reference Values for a Spanish Population
Pedro Plaza Valíaa,
Corresponding author
ppv01v@saludalia.com

Correspondence: Dr P. Plaza Valía Servicio de Neumología, Hospital Universitario Dr. Peset Gaspar Aguilar, 90 46017 Valencia, Spain
, Francisco Carrión Valerob, Julio Marín Pardob, Daniel Bautista Renteroc, Carmen González Monted
a Servicio de Neumología, Hospital Universitario Dr. Peset, Valencia, Spain
b Servicio de Neumología, Hospital Clínico Universitario, Valencia, Spain
c Servicio de Medicina Preventiva, Hospital Dr. Peset, Valencia, Spain
d Servicio de Medicina Preventiva, Hospital de Sagunto, Sagunto, Valencia, Spain
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">Mucociliary transport is an important defense mechanism for the airways&#46; The aim of this study was to establish reference values for nasal mucociliary clearance time &#40;MCT&#41; by means of the saccharin test&#46;</p> <span class="elsevierStyleSectionTitle">Subjects and Methods</span><p class="elsevierStyleSimplePara elsevierViewall">A cross-sectional&#44; descriptive&#44; observational study was performed&#46; The variables studied were nasal MCT&#44; age&#44; and sex&#46; We included 249 healthy nonsmokers &#40;134 male and 115 female subjects&#41; aged over 10 years and stratified the sample by age&#46; To establish reference values&#44; percentiles were calculated and lower and upper limits of normal were established at the 2&#46;5 and 97&#46;5 percentiles&#44; respectively&#46; The association between nasal MCT and the main study variables was then investigated along with the reproducibility of the test&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The following values for nasal MCT were obtained for the sample as a whole&#58; mean &#40;SD&#41;&#44; 17&#46;17 &#40;8&#46;43&#41; minutes&#59; median &#40;interquartile range&#41;&#44; 16 minutes &#40;12-20 minutes&#41;&#44; indicating that the central 50&#37; of the sample fell within this 8-minute range&#59; and maximum and minimum values of 4 to 54 minutes &#40;range&#44; 50 minutes&#41;&#46; The upper and lower limits of normal were 6 and 36 minutes&#44; respectively&#46; In addition&#44; it is noteworthy that only 6 subjects had a nasal MCT longer than 36 minutes&#46; No significant differences between male and female subjects were found&#46; Nasal MCT showed a positive correlation with age &#40;&#961;&#61;0&#46;324&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;0001&#41;&#46; No significant differences were observed in the reproducibility test &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;208&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">In addition to facilitating reliable data on mucociliary function&#44; the saccharin test is easy to do&#44; inexpensive&#44; and reproducible&#46; The data obtained from this study should allow the results of this test to be correctly interpreted for a given subject&#39;s age and so facilitate its use in clinical practice&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">El transporte mucociliar es un importante mecanismo de defensa de las v&#237;as respiratorias&#46; El objetivo de este estudio ha sido obtener los valores de referencia del tiempo de transporte mucociliar nasal &#40;TTMCN&#41; mediante el test de la sacarina&#46;</p> <span class="elsevierStyleSectionTitle">Sujetos Y M&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha realizado un estudio observacional&#44; transversal y descriptivo&#46; Las variables estudiadas fueron el TTMCN&#44; la edad y el sexo&#46; Se incluy&#243; a 249 sujetos &#40;134 varones y 115 mujeres&#41; mayores de 10 a&#241;os&#44; sanos y no fumadores&#44; que se asignaron a grupos seg&#250;n su edad&#46; Para el an&#225;lisis predictivo de los valores de normalidad se obtuvieron los percentiles&#44; estableciendo los l&#237;mites de referencia por los percentiles 2&#44;5 y 97&#44;5&#46; Se analiz&#243; la asociaci&#243;n entre el TTMCN y las variables principales&#46; Se estudi&#243; asimismo la reproducibilidad del test&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Del an&#225;lisis global de la muestra destacan los siguientes datos&#58; mediana de 16 min&#59; media &#177; desviaci&#243;n est&#225;ndar de 17&#44;17 &#177; 8&#44;43 min&#59; rango de 50 min &#40;4-54&#41;&#59; l&#237;mites de referencia de 6-36 min&#44; y amplitud intercuart&#237;lica de 8 min &#40;un 50&#37; central de la muestra entre 12 y 20 min&#41;&#46; Es asimismo rese&#241;able que s&#243;lo 6 sujetos tuvieron un TTMCN superior a 36 min&#46; No se encontraron diferencias significativas entre varones y mujeres&#46; El TTMCN mostr&#243; una correlaci&#243;n positiva con la edad &#40;r<span class="elsevierStyleInf">s</span> &#61; 0&#44;324&#59; p &#61; 0&#44;0001&#41;&#46; No se observaron diferencias significativas &#40;p &#61; 0&#44;208&#41; en la prueba de reproducibilidad&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">El test de la sacarina es f&#225;cil de realizar&#44; econ&#243;mico y reproducible&#44; y facilita datos fiables de la funci&#243;n mucociliar&#46; Los datos obtenidos en este trabajo permiten la correcta interpretaci&#243;n de los resultados de esta prueba seg&#250;n la edad del sujeto&#44; lo que facilitar&#225; su uso&#46;</p>"
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Article information
ISSN: 15792129
Original language: English
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