array:23 [
  "pii" => "S1579212908600713"
  "issn" => "15792129"
  "doi" => "10.1016/S1579-2129(08)60071-3"
  "estado" => "S300"
  "fechaPublicacion" => "2008-01-01"
  "aid" => "60071"
  "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)"
  "copyrightAnyo" => "2008"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "fla"
  "cita" => "Arch Bronconeumol. 2008;44:402-7"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 2426
    "formatos" => array:3 [
      "EPUB" => 119
      "HTML" => 1650
      "PDF" => 657
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1579212908600725"
    "issn" => "15792129"
    "doi" => "10.1016/S1579-2129(08)60072-5"
    "estado" => "S300"
    "fechaPublicacion" => "2008-01-01"
    "aid" => "60072"
    "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Arch Bronconeumol. 2008;44:408-12"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 3007
      "formatos" => array:3 [
        "EPUB" => 109
        "HTML" => 2174
        "PDF" => 724
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>"
      "titulo" => "Assessment of Differential Lung Function by Electrical Impedance Tomography"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "408"
          "paginaFinal" => "412"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J&#46; Bruno de Lema, Ernesto Serrano, Teresa Feixas, N&#250;ria Calaf, Mar&#237;a del Valle Camacho, Pere J&#46; Riu, Pere Casan"
          "autores" => array:7 [
            0 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Bruno de Lema"
            ]
            1 => array:2 [
              "nombre" => "Ernesto"
              "apellidos" => "Serrano"
            ]
            2 => array:2 [
              "nombre" => "Teresa"
              "apellidos" => "Feixas"
            ]
            3 => array:2 [
              "nombre" => "N&#250;ria"
              "apellidos" => "Calaf"
            ]
            4 => array:2 [
              "nombre" => "Mar&#237;a"
              "apellidos" => "del Valle Camacho"
            ]
            5 => array:2 [
              "nombre" => "Pere J&#46;"
              "apellidos" => "Riu"
            ]
            6 => array:2 [
              "nombre" => "Pere"
              "apellidos" => "Casan"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212908600725?idApp=UINPBA00003Z"
    "url" => "/15792129/0000004400000008/v1_201305150357/S1579212908600725/v1_201305150357/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S1579212908600701"
    "issn" => "15792129"
    "doi" => "10.1016/S1579-2129(08)60070-1"
    "estado" => "S300"
    "fechaPublicacion" => "2008-01-01"
    "aid" => "60070"
    "copyright" => "Sociedad Espa&#241;ola de Neumolog&#237;a y Cirug&#237;a Tor&#225;cica &#40;SEPAR&#41;"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "edi"
    "cita" => "Arch Bronconeumol. 2008;44:399-401"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 2287
      "formatos" => array:3 [
        "EPUB" => 97
        "HTML" => 1518
        "PDF" => 672
      ]
    ]
    "en" => array:8 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Editorial</span>"
      "titulo" => "Chronic Obstructive Pulmonary Disease and Lung Cancer"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "399"
          "paginaFinal" => "401"
        ]
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Esther Barreiro"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "Esther"
              "apellidos" => "Barreiro"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212908600701?idApp=UINPBA00003Z"
    "url" => "/15792129/0000004400000008/v1_201305150357/S1579212908600701/v1_201305150357/en/main.assets"
  ]
  "en" => array:13 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>"
    "titulo" => "Contribution of Exhaled Nitric Oxide Measurements to Abbreviated Bronchial Challenge Test Protocols"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "402"
        "paginaFinal" => "407"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Amparo Lloris Bayo, Miguel Perpi&#241;&#225; Tordera, Encarnaci&#243;n Mart&#237;nez P&#233;rez, Vicente Maci&#225;n Gisbert"
        "autores" => array:4 [
          0 => array:3 [
            "nombre" => "Amparo"
            "apellidos" => "Lloris Bayo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor1"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "Miguel"
            "apellidos" => "Perpi&#241;&#225; Tordera"
          ]
          2 => array:2 [
            "nombre" => "Encarnaci&#243;n"
            "apellidos" => "Mart&#237;nez P&#233;rez"
          ]
          3 => array:2 [
            "nombre" => "Vicente"
            "apellidos" => "Maci&#225;n Gisbert"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:1 [
            "entidad" => "Servicio de Neumolog&#237;a&#44; Hospital Universitario La Fe&#44; Valencia&#44; Spain E-mail&#58; amparolloris&#64;yaho"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor1"
            "etiqueta" => "&#42;"
            "correspondencia" => "Correspondence&#58; Dr A&#46; Lloris Bayo Servicio de Neumolog&#237;a&#44; Hospital Universitario La Fe Avda&#46; Campanar&#44; 21 46009 Valencia&#44; Spain"
          ]
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec155338"
          "palabras" => array:4 [
            0 => "Exhaled nitric oxide"
            1 => "Bronchial challenge test"
            2 => "Receiver operating characteristic &#40;ROC&#41; curves"
            3 => "Exaggerated bronchoconstriction"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec155337"
          "palabras" => array:4 [
            0 => "&#211;xido n&#237;trico exhalado"
            1 => "Prueba de provocaci&#243;n bronquial"
            2 => "Curvas de eficacia diagn&#243;stica"
            3 => "Broncoconstricci&#243;n excesiva"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:1 [
        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">The bronchial challenge test is commonly used to diagnose asthma but it is a tedious&#44; time-consuming procedure&#46; Although in recent years&#44; several shortened methods have been proposed&#44; it has been shown that they can give rise to exaggerated bronchoconstriction&#46; The aims of the present study were <span class="elsevierStyleItalic">a&#41;</span> to determine the frequency of exaggerated bronchoconstriction in patients with asthma following the application of a shortened bronchial challenge test&#44; and <span class="elsevierStyleItalic">b&#41;</span> to determine if the fraction of exhaled nitric oxide &#40;FE<span class="elsevierStyleInf">NO</span>&#41; can be used to predict the onset of exaggerated bronchoconstriction&#46;</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">We performed a prospective study of 210 patients with asthma in whom FE<span class="elsevierStyleInf">NO</span> levels were measured in accordance with the abbreviated protocol recommended by the European Respiratory Society &#40;ERS&#41;&#46; Exaggerated bronchoconstriction was defined as a decrease of more than 20&#37; in forced expiratory volume in 1 second after the first challenge&#44; after a skipped dose&#44; or after administration of saline&#46; A receiver operating characteristic &#40;ROC&#41; curve was generated to determine the best FE<span class="elsevierStyleInf">NO</span> cutoff value for predicting exaggerated bronchoconstriction&#46; The pretest probability of developing exaggerated bronchoconstriction was also calculated using Bayes&#39; theorem&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The frequency of exaggerated bronchoconstriction in our series was 30&#37;&#46; Patients who developed exaggerated bronchoconstriction had significantly higher FE<span class="elsevierStyleInf">NO</span> levels than those who did not &#40;32&#46;6 vs 16&#46;2 parts per billion &#91;ppb&#93;&#41;&#46; The chosen FE<span class="elsevierStyleInf">NO</span> cutoff of 19&#46;5 ppb had a sensitivity of 80&#37;&#44; a specificity of 77&#37;&#44; and a negative predictive value of 88&#37;&#46; The area under the ROC curve was 0&#46;83 &#40;95&#37; confidence interval&#44; 0&#46;77&#8211;0&#46;89&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The abbreviated bronchial challenge test recommended by the ERS led to exaggerated bronchoconstriction in 30&#37; of the patients studied&#46; FE<span class="elsevierStyleInf">NO</span> measurements could possibly be used to identify patients at increased risk of exaggerated bronchoconstriction&#46; The shortened challenge test can be performed safely in individuals with a FE<span class="elsevierStyleInf">NO</span> of &#60;19&#46;5 ppb&#46;</p>"
      ]
      "es" => array:1 [
        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">La prueba de provocaci&#243;n bronquial es un procedimiento habitual en el diagn&#243;stico del asma&#44; pero su realizaci&#243;n resulta larga y tediosa&#46; Por ello se han propuesto m&#233;todos que acortan su duraci&#243;n&#46; Sin embargo&#44; en los &#250;ltimos a&#241;os se ha se&#241;alado que dichos m&#233;todos pueden dar lugar a broncoconstricciones excesivas &#40;BE&#41;&#46; Los objetivos del presente estudio han sido&#58; a&#41; determinar la frecuencia de BE en pacientes con asma tras la aplicaci&#243;n del m&#233;todo abreviado de la prueba de provocaci&#243;n bronquial&#44; y b&#41; cuantificar si la determinaci&#243;n de &#243;xido n&#237;trico en aire exhalado &#40;ONE&#41; puede predecir la aparici&#243;n de BE&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha realizado un estudio prospectivo sobre 210 asm&#225;ticos a quienes se determin&#243; el ONE y se realiz&#243; una prueba de provocaci&#243;n bronquial siguiendo el protocolo abreviado de la European Respiratory Society &#40;ERS&#41;&#46; Se defini&#243; BE como una ca&#237;da superior al 20&#37; del volumen espiratorio forzado en el primer segundo tras la primera dosis&#44; despu&#233;s de suprimir una dosis o tras el diluyente&#46; Se construy&#243; una curva de eficacia diagn&#243;stica para determinar el mejor punto de corte del ONE para predecir BE y se calcul&#243; la probabilidad preprueba de presentar BE&#44; siguiendo el teorema de Bayes&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">La frecuencia de BE en nuestra serie fue del 30&#37;&#46; Hubo diferencias significativas en el ONE&#44; siendo la concentraci&#243;n m&#225;s elevada en el grupo que present&#243; BE &#40;32&#44;6 frente a 16&#44;2 ppb&#41;&#46; El punto de corte de ONE elegido fue 19&#44;5 ppb&#44; con una sensibilidad del 80&#37;&#44; especificidad del 77&#37; y valor predictivo negativo del 88&#37;&#46; El &#225;rea bajo la curva de eficacia diagn&#243;stica fue de 0&#44;83 &#40;intervalo de confianza del 95&#37;&#44; 0&#44;77&#8211;0&#44;89&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">La prueba de provocaci&#243;n bronquial abreviada que recomienda la ERS da lugar a un 30&#37; de BE&#46; La determinaci&#243;n de ONE podr&#237;a identificar a los pacientes con mayor probabilidad de presentar BE&#46; Una concentraci&#243;n de ONE inferior a 19&#44;5 ppb permite realizar la prueba de provocaci&#243;n bronquial abreviada con seguridad&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:1 [
        "nota" => "<p class="elsevierStyleNotepara">This study was partly funded by a grant from the Instituto de Salud Carlos III &#40;PI05&#47;0583&#41;&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:21 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Standardization of bronchial inhalation challenge procedures"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "H Chai"
                            1 => "RS Farr"
                            2 => "LA Froeligh"
                            3 => "DA Mathison"
                            4 => "JA McLean"
                            5 => "RR Rosenthal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Allergy Clin Immunol"
                        "fecha" => "1975"
                        "volumen" => "56"
                        "paginaInicial" => "323"
                        "paginaFinal" => "327"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1176724"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bronchial reactivity to inhaled histamine&#58; a method and clinical survey"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "DW Cockcroft"
                            1 => "DN Killian"
                            2 => "JJA Mellon"
                            3 => "FE Hargreave"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Allergy"
                        "fecha" => "1977"
                        "volumen" => "7"
                        "paginaInicial" => "235"
                        "paginaFinal" => "243"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/908121"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Airway responsiveness&#58; standardized challenge testing with pharmacological&#44; physical and sensitizing stimuli in adults&#46; Report Working Party Standardization of Lung Function Tests&#46; European Community for Steel and Coal&#46; Official Statement of the European Respiratory Society"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "PJ Sterk"
                            1 => "LM Fabbri"
                            2 => "PH Quanjer"
                            3 => "DW Cockcroft"
                            4 => "PM O&#39;Byrne"
                            5 => "SD Anderson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "1993"
                        "volumen" => "16"
                        "paginaInicial" => "53"
                        "paginaFinal" => "83"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "EF Juniper"
                            1 => "DW Cockcroft"
                            2 => "FE Hargreave"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:5 [
                        "edicion" => "2nd ed&#46;"
                        "titulo" => "Histamine and methacholine inhalation tests&#58; tidal breathing method-laboratory procedure and standardization"
                        "fecha" => "1994"
                        "editorial" => "AB Draco"
                        "editorialLocalizacion" => "Lund"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Methacholine challenge testing&#58; safety of low starting FEV1"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "RJ Martin"
                            1 => "JS Wanger"
                            2 => "CG Irvin"
                            3 => "BB Bartelson"
                            4 => "RM Cherniak"
                            5 => "the Asthma Clinical Research Network &#40;ACRN&#41;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1997"
                        "volumen" => "112"
                        "paginaInicial" => "53"
                        "paginaFinal" => "56"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9228357"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A survey of the current use and methods of analysis of bronchoprovocational challenges"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "GC Scott"
                            1 => "SR Braun"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1991"
                        "volumen" => "100"
                        "paginaInicial" => "322"
                        "paginaFinal" => "328"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1864101"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Use and safety of a shortened histamine challenge test in an occupational study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "AM Kremer"
                            1 => "TM Pal"
                            2 => "M Oldenziel"
                            3 => "M Kerkof"
                            4 => "JGR De Monchy"
                            5 => "B Rijken"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "1995"
                        "volumen" => "8"
                        "paginaInicial" => "737"
                        "paginaFinal" => "741"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7656944"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Frequency and determinants of exaggerated bronchoconstriction during shortened methacholine challenge tests in epidemiological and clinical set-ups"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S Troyanov"
                            1 => "JL Malo"
                            2 => "A Cartier"
                            3 => "D Gautrin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2000"
                        "volumen" => "16"
                        "paginaInicial" => "9"
                        "paginaFinal" => "14"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10933078"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Methacholine inhalation challenge&#58; a shorter&#44; cheaper and safe approach"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "G Izbicki"
                            1 => "E Bar-Yishay"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2001"
                        "volumen" => "17"
                        "paginaInicial" => "46"
                        "paginaFinal" => "51"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11307754"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Guidelines for methacholine and exercise challenge testing-1999"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "American Thoracic Society"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.161.1.ats11-99"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2000"
                        "volumen" => "161"
                        "paginaInicial" => "309"
                        "paginaFinal" => "329"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10619836"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Airway hyperresponsiveness"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "PM O&#39;Byrne"
                            1 => "MD Inman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2003"
                        "volumen" => "123"
                        "paginaInicial" => "411S"
                        "paginaFinal" => "416S"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12629006"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Exhaled nitric oxide in asthma&#58; from bench to bedside"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "CA Bates"
                            1 => "PE Silkoff"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Allergy Clin Immunol"
                        "fecha" => "2003"
                        "volumen" => "111"
                        "paginaInicial" => "256"
                        "paginaFinal" => "262"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12589342"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "titulo" => "ATS&#47;ERS Recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide&#44; 2005"
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.200406-710ST"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2005"
                        "volumen" => "171"
                        "paginaInicial" => "912"
                        "paginaFinal" => "930"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15817806"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Las curvas ROC en la evaluaci&#243;n de las pruebas diagn&#243;sticas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "MJ Burge&#241;o"
                            1 => "JL Garc&#237;a Bastos"
                            2 => "JM Gonz&#225;lez Buitrago"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;"
                        "fecha" => "1995"
                        "volumen" => "104"
                        "paginaInicial" => "661"
                        "paginaFinal" => "670"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Gu&#237;a espa&#241;ola para el manejo del asma &#40;GEMA&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "V Plaza Moral"
                            1 => "FJ &#193;lvarez Guti&#233;rrez"
                            2 => "P Cas&#225;n Clar&#224;"
                            3 => "N Cobos Barroso"
                            4 => "A L&#243;pez Vi&#241;a"
                            5 => "MA Llauger Rossell&#243;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2003"
                        "volumen" => "39"
                        "numero" => "Supl 5"
                        "paginaInicial" => "3"
                        "paginaFinal" => "42"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Methacholine challenge&#58; test-shortening procedures"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "DW Cockcroft"
                            1 => "DD Marciniuk"
                            2 => "TS Hurst"
                            3 => "DJ Cotton"
                            4 => "KF Laframboise"
                            5 => "BD McNab"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2001"
                        "volumen" => "120"
                        "paginaInicial" => "1857"
                        "paginaFinal" => "1860"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11742913"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Correlation between exhaled nitric oxide&#44; sputum eosinophils&#44; and methacholine responsiveness in patients with mild asthma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A Jatakanon"
                            1 => "S Lim"
                            2 => "SA Kharitonov"
                            3 => "KF Chung"
                            4 => "PJ Barnes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "1998"
                        "volumen" => "53"
                        "paginaInicial" => "91"
                        "paginaFinal" => "95"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9624291"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Combined use of exhaled nitric oxide and airway hyperresponsiveness in characterizing asthma in a large population study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "AH Henriksen"
                            1 => "T Lingaas Holmen"
                            2 => "M Sue Chu"
                            3 => "L Bjermer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2002"
                        "volumen" => "15"
                        "paginaInicial" => "849"
                        "paginaFinal" => "855"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10853848"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Exhaled nitric oxide measurements&#58; clinical application and interpretation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "DR Taylor"
                            1 => "MW Pijnenburg"
                            2 => "AD Smith"
                            3 => "JC De Jongste"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/thx.2005.056093"
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "2006"
                        "volumen" => "61"
                        "paginaInicial" => "817"
                        "paginaFinal" => "827"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16936238"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hiperrespuesta bronquial en el asma&#46; Patogenia y medici&#243;n"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M Perpi&#241;&#225; Tordera"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2004"
                        "volumen" => "40"
                        "numero" => "Supl 5"
                        "paginaInicial" => "8"
                        "paginaFinal" => "13"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16137451"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Asthma&#58; defining of the persistent adult phenotypes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "SE Wenzel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(06)69290-8"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2006"
                        "volumen" => "368"
                        "paginaInicial" => "804"
                        "paginaFinal" => "813"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16935691"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15792129/0000004400000008/v1_201305150357/S1579212908600713/v1_201305150357/en/main.assets"
  "Apartado" => null
  "PDF" => "https://static.elsevier.es/multimedia/15792129/0000004400000008/v1_201305150357/S1579212908600713/v1_201305150357/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212908600713?idApp=UINPBA00003Z"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Original Articles
Contribution of Exhaled Nitric Oxide Measurements to Abbreviated Bronchial Challenge Test Protocols
Amparo Lloris Bayo*, Miguel Perpiñá Tordera, Encarnación Martínez Pérez, Vicente Macián Gisbert
Servicio de Neumología, Hospital Universitario La Fe, Valencia, Spain E-mail: amparolloris@yaho
Read
4408
Times
was read the article
1935
Total PDF
2473
Total HTML
Share statistics
 array:23 [
  "pii" => "S1579212908600713"
  "issn" => "15792129"
  "doi" => "10.1016/S1579-2129(08)60071-3"
  "estado" => "S300"
  "fechaPublicacion" => "2008-01-01"
  "aid" => "60071"
  "copyright" => "Sociedad Espa&#241;ola de Neumolog&#237;a y Cirug&#237;a Tor&#225;cica &#40;SEPAR&#41;"
  "copyrightAnyo" => "2008"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "fla"
  "cita" => "Arch Bronconeumol. 2008;44:402-7"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 2426
    "formatos" => array:3 [
      "EPUB" => 119
      "HTML" => 1650
      "PDF" => 657
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1579212908600725"
    "issn" => "15792129"
    "doi" => "10.1016/S1579-2129(08)60072-5"
    "estado" => "S300"
    "fechaPublicacion" => "2008-01-01"
    "aid" => "60072"
    "copyright" => "Sociedad Espa&#241;ola de Neumolog&#237;a y Cirug&#237;a Tor&#225;cica &#40;SEPAR&#41;"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Arch Bronconeumol. 2008;44:408-12"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 3007
      "formatos" => array:3 [
        "EPUB" => 109
        "HTML" => 2174
        "PDF" => 724
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>"
      "titulo" => "Assessment of Differential Lung Function by Electrical Impedance Tomography"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "408"
          "paginaFinal" => "412"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J&#46; Bruno de Lema, Ernesto Serrano, Teresa Feixas, N&#250;ria Calaf, Mar&#237;a del Valle Camacho, Pere J&#46; Riu, Pere Casan"
          "autores" => array:7 [
            0 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Bruno de Lema"
            ]
            1 => array:2 [
              "nombre" => "Ernesto"
              "apellidos" => "Serrano"
            ]
            2 => array:2 [
              "nombre" => "Teresa"
              "apellidos" => "Feixas"
            ]
            3 => array:2 [
              "nombre" => "N&#250;ria"
              "apellidos" => "Calaf"
            ]
            4 => array:2 [
              "nombre" => "Mar&#237;a"
              "apellidos" => "del Valle Camacho"
            ]
            5 => array:2 [
              "nombre" => "Pere J&#46;"
              "apellidos" => "Riu"
            ]
            6 => array:2 [
              "nombre" => "Pere"
              "apellidos" => "Casan"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212908600725?idApp=UINPBA00003Z"
    "url" => "/15792129/0000004400000008/v1_201305150357/S1579212908600725/v1_201305150357/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S1579212908600701"
    "issn" => "15792129"
    "doi" => "10.1016/S1579-2129(08)60070-1"
    "estado" => "S300"
    "fechaPublicacion" => "2008-01-01"
    "aid" => "60070"
    "copyright" => "Sociedad Espa&#241;ola de Neumolog&#237;a y Cirug&#237;a Tor&#225;cica &#40;SEPAR&#41;"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "edi"
    "cita" => "Arch Bronconeumol. 2008;44:399-401"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 2287
      "formatos" => array:3 [
        "EPUB" => 97
        "HTML" => 1518
        "PDF" => 672
      ]
    ]
    "en" => array:8 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Editorial</span>"
      "titulo" => "Chronic Obstructive Pulmonary Disease and Lung Cancer"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "399"
          "paginaFinal" => "401"
        ]
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Esther Barreiro"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "Esther"
              "apellidos" => "Barreiro"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212908600701?idApp=UINPBA00003Z"
    "url" => "/15792129/0000004400000008/v1_201305150357/S1579212908600701/v1_201305150357/en/main.assets"
  ]
  "en" => array:13 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>"
    "titulo" => "Contribution of Exhaled Nitric Oxide Measurements to Abbreviated Bronchial Challenge Test Protocols"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "402"
        "paginaFinal" => "407"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Amparo Lloris Bayo, Miguel Perpi&#241;&#225; Tordera, Encarnaci&#243;n Mart&#237;nez P&#233;rez, Vicente Maci&#225;n Gisbert"
        "autores" => array:4 [
          0 => array:3 [
            "nombre" => "Amparo"
            "apellidos" => "Lloris Bayo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor1"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "Miguel"
            "apellidos" => "Perpi&#241;&#225; Tordera"
          ]
          2 => array:2 [
            "nombre" => "Encarnaci&#243;n"
            "apellidos" => "Mart&#237;nez P&#233;rez"
          ]
          3 => array:2 [
            "nombre" => "Vicente"
            "apellidos" => "Maci&#225;n Gisbert"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:1 [
            "entidad" => "Servicio de Neumolog&#237;a&#44; Hospital Universitario La Fe&#44; Valencia&#44; Spain E-mail&#58; amparolloris&#64;yaho"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor1"
            "etiqueta" => "&#42;"
            "correspondencia" => "Correspondence&#58; Dr A&#46; Lloris Bayo Servicio de Neumolog&#237;a&#44; Hospital Universitario La Fe Avda&#46; Campanar&#44; 21 46009 Valencia&#44; Spain"
          ]
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec155338"
          "palabras" => array:4 [
            0 => "Exhaled nitric oxide"
            1 => "Bronchial challenge test"
            2 => "Receiver operating characteristic &#40;ROC&#41; curves"
            3 => "Exaggerated bronchoconstriction"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec155337"
          "palabras" => array:4 [
            0 => "&#211;xido n&#237;trico exhalado"
            1 => "Prueba de provocaci&#243;n bronquial"
            2 => "Curvas de eficacia diagn&#243;stica"
            3 => "Broncoconstricci&#243;n excesiva"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:1 [
        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">The bronchial challenge test is commonly used to diagnose asthma but it is a tedious&#44; time-consuming procedure&#46; Although in recent years&#44; several shortened methods have been proposed&#44; it has been shown that they can give rise to exaggerated bronchoconstriction&#46; The aims of the present study were <span class="elsevierStyleItalic">a&#41;</span> to determine the frequency of exaggerated bronchoconstriction in patients with asthma following the application of a shortened bronchial challenge test&#44; and <span class="elsevierStyleItalic">b&#41;</span> to determine if the fraction of exhaled nitric oxide &#40;FE<span class="elsevierStyleInf">NO</span>&#41; can be used to predict the onset of exaggerated bronchoconstriction&#46;</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">We performed a prospective study of 210 patients with asthma in whom FE<span class="elsevierStyleInf">NO</span> levels were measured in accordance with the abbreviated protocol recommended by the European Respiratory Society &#40;ERS&#41;&#46; Exaggerated bronchoconstriction was defined as a decrease of more than 20&#37; in forced expiratory volume in 1 second after the first challenge&#44; after a skipped dose&#44; or after administration of saline&#46; A receiver operating characteristic &#40;ROC&#41; curve was generated to determine the best FE<span class="elsevierStyleInf">NO</span> cutoff value for predicting exaggerated bronchoconstriction&#46; The pretest probability of developing exaggerated bronchoconstriction was also calculated using Bayes&#39; theorem&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The frequency of exaggerated bronchoconstriction in our series was 30&#37;&#46; Patients who developed exaggerated bronchoconstriction had significantly higher FE<span class="elsevierStyleInf">NO</span> levels than those who did not &#40;32&#46;6 vs 16&#46;2 parts per billion &#91;ppb&#93;&#41;&#46; The chosen FE<span class="elsevierStyleInf">NO</span> cutoff of 19&#46;5 ppb had a sensitivity of 80&#37;&#44; a specificity of 77&#37;&#44; and a negative predictive value of 88&#37;&#46; The area under the ROC curve was 0&#46;83 &#40;95&#37; confidence interval&#44; 0&#46;77&#8211;0&#46;89&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The abbreviated bronchial challenge test recommended by the ERS led to exaggerated bronchoconstriction in 30&#37; of the patients studied&#46; FE<span class="elsevierStyleInf">NO</span> measurements could possibly be used to identify patients at increased risk of exaggerated bronchoconstriction&#46; The shortened challenge test can be performed safely in individuals with a FE<span class="elsevierStyleInf">NO</span> of &#60;19&#46;5 ppb&#46;</p>"
      ]
      "es" => array:1 [
        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">La prueba de provocaci&#243;n bronquial es un procedimiento habitual en el diagn&#243;stico del asma&#44; pero su realizaci&#243;n resulta larga y tediosa&#46; Por ello se han propuesto m&#233;todos que acortan su duraci&#243;n&#46; Sin embargo&#44; en los &#250;ltimos a&#241;os se ha se&#241;alado que dichos m&#233;todos pueden dar lugar a broncoconstricciones excesivas &#40;BE&#41;&#46; Los objetivos del presente estudio han sido&#58; a&#41; determinar la frecuencia de BE en pacientes con asma tras la aplicaci&#243;n del m&#233;todo abreviado de la prueba de provocaci&#243;n bronquial&#44; y b&#41; cuantificar si la determinaci&#243;n de &#243;xido n&#237;trico en aire exhalado &#40;ONE&#41; puede predecir la aparici&#243;n de BE&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha realizado un estudio prospectivo sobre 210 asm&#225;ticos a quienes se determin&#243; el ONE y se realiz&#243; una prueba de provocaci&#243;n bronquial siguiendo el protocolo abreviado de la European Respiratory Society &#40;ERS&#41;&#46; Se defini&#243; BE como una ca&#237;da superior al 20&#37; del volumen espiratorio forzado en el primer segundo tras la primera dosis&#44; despu&#233;s de suprimir una dosis o tras el diluyente&#46; Se construy&#243; una curva de eficacia diagn&#243;stica para determinar el mejor punto de corte del ONE para predecir BE y se calcul&#243; la probabilidad preprueba de presentar BE&#44; siguiendo el teorema de Bayes&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">La frecuencia de BE en nuestra serie fue del 30&#37;&#46; Hubo diferencias significativas en el ONE&#44; siendo la concentraci&#243;n m&#225;s elevada en el grupo que present&#243; BE &#40;32&#44;6 frente a 16&#44;2 ppb&#41;&#46; El punto de corte de ONE elegido fue 19&#44;5 ppb&#44; con una sensibilidad del 80&#37;&#44; especificidad del 77&#37; y valor predictivo negativo del 88&#37;&#46; El &#225;rea bajo la curva de eficacia diagn&#243;stica fue de 0&#44;83 &#40;intervalo de confianza del 95&#37;&#44; 0&#44;77&#8211;0&#44;89&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">La prueba de provocaci&#243;n bronquial abreviada que recomienda la ERS da lugar a un 30&#37; de BE&#46; La determinaci&#243;n de ONE podr&#237;a identificar a los pacientes con mayor probabilidad de presentar BE&#46; Una concentraci&#243;n de ONE inferior a 19&#44;5 ppb permite realizar la prueba de provocaci&#243;n bronquial abreviada con seguridad&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:1 [
        "nota" => "<p class="elsevierStyleNotepara">This study was partly funded by a grant from the Instituto de Salud Carlos III &#40;PI05&#47;0583&#41;&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:21 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Standardization of bronchial inhalation challenge procedures"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "H Chai"
                            1 => "RS Farr"
                            2 => "LA Froeligh"
                            3 => "DA Mathison"
                            4 => "JA McLean"
                            5 => "RR Rosenthal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Allergy Clin Immunol"
                        "fecha" => "1975"
                        "volumen" => "56"
                        "paginaInicial" => "323"
                        "paginaFinal" => "327"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1176724"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bronchial reactivity to inhaled histamine&#58; a method and clinical survey"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "DW Cockcroft"
                            1 => "DN Killian"
                            2 => "JJA Mellon"
                            3 => "FE Hargreave"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Allergy"
                        "fecha" => "1977"
                        "volumen" => "7"
                        "paginaInicial" => "235"
                        "paginaFinal" => "243"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/908121"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Airway responsiveness&#58; standardized challenge testing with pharmacological&#44; physical and sensitizing stimuli in adults&#46; Report Working Party Standardization of Lung Function Tests&#46; European Community for Steel and Coal&#46; Official Statement of the European Respiratory Society"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "PJ Sterk"
                            1 => "LM Fabbri"
                            2 => "PH Quanjer"
                            3 => "DW Cockcroft"
                            4 => "PM O&#39;Byrne"
                            5 => "SD Anderson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "1993"
                        "volumen" => "16"
                        "paginaInicial" => "53"
                        "paginaFinal" => "83"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "EF Juniper"
                            1 => "DW Cockcroft"
                            2 => "FE Hargreave"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:5 [
                        "edicion" => "2nd ed&#46;"
                        "titulo" => "Histamine and methacholine inhalation tests&#58; tidal breathing method-laboratory procedure and standardization"
                        "fecha" => "1994"
                        "editorial" => "AB Draco"
                        "editorialLocalizacion" => "Lund"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Methacholine challenge testing&#58; safety of low starting FEV1"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "RJ Martin"
                            1 => "JS Wanger"
                            2 => "CG Irvin"
                            3 => "BB Bartelson"
                            4 => "RM Cherniak"
                            5 => "the Asthma Clinical Research Network &#40;ACRN&#41;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1997"
                        "volumen" => "112"
                        "paginaInicial" => "53"
                        "paginaFinal" => "56"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9228357"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A survey of the current use and methods of analysis of bronchoprovocational challenges"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "GC Scott"
                            1 => "SR Braun"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1991"
                        "volumen" => "100"
                        "paginaInicial" => "322"
                        "paginaFinal" => "328"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1864101"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Use and safety of a shortened histamine challenge test in an occupational study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "AM Kremer"
                            1 => "TM Pal"
                            2 => "M Oldenziel"
                            3 => "M Kerkof"
                            4 => "JGR De Monchy"
                            5 => "B Rijken"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "1995"
                        "volumen" => "8"
                        "paginaInicial" => "737"
                        "paginaFinal" => "741"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7656944"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Frequency and determinants of exaggerated bronchoconstriction during shortened methacholine challenge tests in epidemiological and clinical set-ups"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S Troyanov"
                            1 => "JL Malo"
                            2 => "A Cartier"
                            3 => "D Gautrin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2000"
                        "volumen" => "16"
                        "paginaInicial" => "9"
                        "paginaFinal" => "14"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10933078"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Methacholine inhalation challenge&#58; a shorter&#44; cheaper and safe approach"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "G Izbicki"
                            1 => "E Bar-Yishay"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2001"
                        "volumen" => "17"
                        "paginaInicial" => "46"
                        "paginaFinal" => "51"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11307754"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Guidelines for methacholine and exercise challenge testing-1999"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "American Thoracic Society"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.161.1.ats11-99"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2000"
                        "volumen" => "161"
                        "paginaInicial" => "309"
                        "paginaFinal" => "329"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10619836"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Airway hyperresponsiveness"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "PM O&#39;Byrne"
                            1 => "MD Inman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2003"
                        "volumen" => "123"
                        "paginaInicial" => "411S"
                        "paginaFinal" => "416S"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12629006"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Exhaled nitric oxide in asthma&#58; from bench to bedside"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "CA Bates"
                            1 => "PE Silkoff"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Allergy Clin Immunol"
                        "fecha" => "2003"
                        "volumen" => "111"
                        "paginaInicial" => "256"
                        "paginaFinal" => "262"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12589342"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "titulo" => "ATS&#47;ERS Recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide&#44; 2005"
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.200406-710ST"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2005"
                        "volumen" => "171"
                        "paginaInicial" => "912"
                        "paginaFinal" => "930"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15817806"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Las curvas ROC en la evaluaci&#243;n de las pruebas diagn&#243;sticas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "MJ Burge&#241;o"
                            1 => "JL Garc&#237;a Bastos"
                            2 => "JM Gonz&#225;lez Buitrago"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;"
                        "fecha" => "1995"
                        "volumen" => "104"
                        "paginaInicial" => "661"
                        "paginaFinal" => "670"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Gu&#237;a espa&#241;ola para el manejo del asma &#40;GEMA&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "V Plaza Moral"
                            1 => "FJ &#193;lvarez Guti&#233;rrez"
                            2 => "P Cas&#225;n Clar&#224;"
                            3 => "N Cobos Barroso"
                            4 => "A L&#243;pez Vi&#241;a"
                            5 => "MA Llauger Rossell&#243;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2003"
                        "volumen" => "39"
                        "numero" => "Supl 5"
                        "paginaInicial" => "3"
                        "paginaFinal" => "42"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Methacholine challenge&#58; test-shortening procedures"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "DW Cockcroft"
                            1 => "DD Marciniuk"
                            2 => "TS Hurst"
                            3 => "DJ Cotton"
                            4 => "KF Laframboise"
                            5 => "BD McNab"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2001"
                        "volumen" => "120"
                        "paginaInicial" => "1857"
                        "paginaFinal" => "1860"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11742913"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Correlation between exhaled nitric oxide&#44; sputum eosinophils&#44; and methacholine responsiveness in patients with mild asthma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A Jatakanon"
                            1 => "S Lim"
                            2 => "SA Kharitonov"
                            3 => "KF Chung"
                            4 => "PJ Barnes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "1998"
                        "volumen" => "53"
                        "paginaInicial" => "91"
                        "paginaFinal" => "95"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9624291"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Combined use of exhaled nitric oxide and airway hyperresponsiveness in characterizing asthma in a large population study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "AH Henriksen"
                            1 => "T Lingaas Holmen"
                            2 => "M Sue Chu"
                            3 => "L Bjermer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2002"
                        "volumen" => "15"
                        "paginaInicial" => "849"
                        "paginaFinal" => "855"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10853848"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Exhaled nitric oxide measurements&#58; clinical application and interpretation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "DR Taylor"
                            1 => "MW Pijnenburg"
                            2 => "AD Smith"
                            3 => "JC De Jongste"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/thx.2005.056093"
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "2006"
                        "volumen" => "61"
                        "paginaInicial" => "817"
                        "paginaFinal" => "827"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16936238"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hiperrespuesta bronquial en el asma&#46; Patogenia y medici&#243;n"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M Perpi&#241;&#225; Tordera"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2004"
                        "volumen" => "40"
                        "numero" => "Supl 5"
                        "paginaInicial" => "8"
                        "paginaFinal" => "13"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16137451"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Asthma&#58; defining of the persistent adult phenotypes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "SE Wenzel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(06)69290-8"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2006"
                        "volumen" => "368"
                        "paginaInicial" => "804"
                        "paginaFinal" => "813"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16935691"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15792129/0000004400000008/v1_201305150357/S1579212908600713/v1_201305150357/en/main.assets"
  "Apartado" => null
  "PDF" => "https://static.elsevier.es/multimedia/15792129/0000004400000008/v1_201305150357/S1579212908600713/v1_201305150357/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212908600713?idApp=UINPBA00003Z"
]
Article information
ISSN: 15792129
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 1 1 2
2024 October 31 19 50
2024 September 29 12 41
2024 August 38 26 64
2024 July 24 22 46
2024 June 34 19 53
2024 May 27 30 57
2024 April 21 22 43
2024 March 20 20 40
2024 February 15 27 42
2023 March 4 3 7
2023 February 15 24 39
2023 January 20 27 47
2022 December 19 21 40
2022 November 17 27 44
2022 October 20 30 50
2022 September 21 14 35
2022 August 19 38 57
2022 July 23 45 68
2022 June 22 37 59
2022 May 16 27 43
2022 April 23 30 53
2022 March 23 41 64
2022 February 16 36 52
2022 January 15 32 47
2021 December 18 44 62
2021 November 14 56 70
2021 October 17 58 75
2021 September 12 61 73
2021 August 14 35 49
2021 July 12 34 46
2021 June 10 33 43
2021 May 13 29 42
2021 April 39 104 143
2021 March 14 22 36
2021 February 14 23 37
2021 January 8 19 27
2020 December 13 15 28
2020 November 11 19 30
2020 October 12 14 26
2020 September 6 5 11
2020 August 12 9 21
2020 July 17 19 36
2020 June 5 3 8
2020 May 12 10 22
2020 April 17 22 39
2020 March 15 12 27
2020 February 17 11 28
2020 January 12 12 24
2019 December 11 16 27
2019 November 16 14 30
2019 October 10 10 20
2019 September 9 13 22
2019 August 39 11 50
2019 July 14 16 30
2019 June 9 7 16
2019 May 14 6 20
2019 April 38 11 49
2019 March 24 12 36
2019 February 11 14 25
2019 January 12 9 21
2018 December 13 9 22
2018 November 20 18 38
2018 October 25 24 49
2018 September 14 6 20
2018 May 9 0 9
2018 April 12 5 17
2018 March 11 4 15
2018 February 7 4 11
2018 January 11 8 19
2017 December 8 6 14
2017 November 2 0 2
2017 October 8 7 15
2017 September 3 9 12
2017 August 4 14 18
2017 July 14 19 33
2017 June 6 14 20
2017 May 6 9 15
2017 April 2 5 7
2017 March 7 13 20
2017 February 6 6 12
2017 January 3 1 4
2016 December 10 8 18
2016 November 9 4 13
2016 October 19 14 33
2016 September 11 9 20
2016 August 11 4 15
2016 July 5 3 8
2016 March 1 0 1
2016 February 1 0 1
2016 January 1 0 1
2015 December 2 0 2
2015 October 28 13 41
2015 September 34 10 44
2015 August 32 12 44
2015 July 33 4 37
2015 June 22 11 33
2015 May 42 16 58
2015 April 33 8 41
2015 March 29 6 35
2015 February 32 9 41
2015 January 43 7 50
2014 December 27 4 31
2014 November 37 6 43
2014 October 38 9 47
2014 September 26 7 33
2014 August 31 9 40
2014 July 30 8 38
2014 June 43 9 52
2014 May 43 12 55
2014 April 53 6 59
2014 March 54 6 60
2014 February 46 15 61
2014 January 37 7 44
2013 December 37 10 47
2013 November 37 7 44
2013 October 44 8 52
2013 September 33 10 43
2013 August 51 7 58
2013 July 51 10 61
2013 June 39 12 51
2013 May 40 8 48
2013 April 25 6 31
2013 March 8 2 10
Show all

Follow this link to access the full text of the article

Archivos de Bronconeumología

Are you a health professional able to prescribe or dispense drugs?