Update on the Mechanisms of Muscle Dysfunction in COPD

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Enfermedades Respiratorias, Barcelona, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dr J. Gea Servicio de Neumología Hospital Mar Pg Marítim, 2708003 Barcelona, Spain" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2007-06-22" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec155283" "palabras" => array:4 [ 0 => "Respiratory muscles" 1 => "Peripheral muscles" 2 => "Muscledysfunction" 3 => "Lung disease" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec155282" "palabras" => array:3 [ 0 => "Músculos respiratorios" 1 => "Músculos periféricos. Disfunción muscular" 2 => "Enfermedad pulmonar" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "Muscle function is essential for both ventilation (respiratorymuscles) and interacting with the environment (peripheralmuscles). One of the systemic manifestations of chronicobstructive pulmonary disease (COPD) is skeletal muscledysfunction. While the causes of this dysfunction are poorlyunderstood, various local and systemic factors appear to playa role. Among the systemic factors are those arising from thelung disease itself, which increases respiratory muscle activity, leads to unfavorable geometric relationships, and results in areduction in the patient's use of the peripheral musculature. Other systemic factors include inflammation and oxidativestress, malnutrition, impaired gas exchange, comorbidity, andcertain myotoxic drugs. Local factors include muscleinflammation and oxidative stress, apoptosis, injury, andimpaired regenerative capacity. All of these factors interactin different ways in each muscle group, giving rise to variousphenotypes and specific contractile capacities." ] "es" => array:1 [ "resumen" => "La función muscular es esencial tanto para la ventilación(músculos respiratorios) como para la vida de relación(músculos periféricos). Los pacientes con enfermedad pul-monar obstructiva crónica (EPOC), en el contexto de suafectación sistémica, presentan disfunción muscular. Lascausas de ésta no están totalmente definidas, aunque pare-cen intervenir diferentes factores tanto sistémicos como lo-cales. Entre los primeros figuran los derivados de la propiaenfermedad pulmonar: aumento de la actividad y geometríadesfavorable para los músculos respiratorios, y disminuciónde la actividad para los periféricos. También son factoresgenerales la inflamación-estrés oxidativo, las alteracionesnutricionales y del intercambio de gases, la comorbilidad ylos fármacos miotóxicos. En cuanto a los locales, incluyeninflamación-estrés oxidativo en los músculos, apoptosis ydaño con baja capacidad regenerativa. Estos factores inter-accionarían de forma diferenciada en cada grupo musculary darían lugar a fenotipos y capacidad contráctil específicos." ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:114 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Pulmonary Disease. National Heart, Lung and Blood Institute. 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Update on the Mechanisms of Muscle Dysfunction in COPD

Joaquim Gea

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jgea@imim.es

Correspondence: Dr J. Gea Servicio de Neumología Hospital Mar Pg Marítim, 2708003 Barcelona, Spain

, Esther Barreiro

Servicio de Neumología, Hospital del Mar, Unidad de Investigación en Músculo y Aparato Respiratorio (URMAR), IMIM, Departamentode Ciencias Experimentales y de la Salud (CEXS), Universidad Pompeu Fabra, CIBER en Enfermedades Respiratorias, Barcelona, Spain

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    "titulo" => "Update on the Mechanisms of Muscle Dysfunction in COPD"
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        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Muscle function is essential for both ventilation &#40;respiratorymuscles&#41; and interacting with the environment &#40;peripheralmuscles&#41;&#46; One of the systemic manifestations of chronicobstructive pulmonary disease &#40;COPD&#41; is skeletal muscledysfunction&#46; While the causes of this dysfunction are poorlyunderstood&#44; various local and systemic factors appear to playa role&#46; Among the systemic factors are those arising from thelung disease itself&#44; which increases respiratory muscle activity&#44; leads to unfavorable geometric relationships&#44; and results in areduction in the patient&#39;s use of the peripheral musculature&#46; Other systemic factors include inflammation and oxidativestress&#44; malnutrition&#44; impaired gas exchange&#44; comorbidity&#44; andcertain myotoxic drugs&#46; Local factors include muscleinflammation and oxidative stress&#44; apoptosis&#44; injury&#44; andimpaired regenerative capacity&#46; All of these factors interactin different ways in each muscle group&#44; giving rise to variousphenotypes and specific contractile capacities&#46;</p>"
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Article information

ISSN: 15792129
Original language: English

DOI:10.1016/S1579-2129(08)60054-3

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Year/Month	Html	Pdf	Total

2024 November	6	6	12
2024 October	29	15	44
2024 September	31	14	45
2024 August	40	33	73
2024 July	28	21	49
2024 June	32	21	53
2024 May	42	24	66
2024 April	25	25	50
2024 March	25	15	40
2024 February	17	21	38
2023 March	1	2	3
2023 February	17	23	40
2023 January	20	27	47
2022 December	21	27	48
2022 November	25	18	43
2022 October	20	31	51
2022 September	15	16	31
2022 August	20	29	49
2022 July	23	38	61
2022 June	18	26	44
2022 May	25	34	59
2022 April	16	40	56
2022 March	23	41	64
2022 February	18	23	41
2022 January	17	39	56
2021 December	15	47	62
2021 November	18	46	64
2021 October	28	41	69
2021 September	20	58	78
2021 August	13	34	47
2021 July	16	27	43
2021 June	42	35	77
2021 May	20	30	50
2021 April	49	56	105
2021 March	45	26	71
2021 February	27	22	49
2021 January	7	11	18
2020 December	20	16	36
2020 November	19	17	36
2020 October	17	6	23
2020 September	9	6	15
2020 August	16	13	29
2020 July	14	16	30
2020 June	18	2	20
2020 May	15	14	29
2020 April	21	30	51
2020 March	21	11	32
2020 February	17	16	33
2020 January	18	17	35
2019 December	28	16	44
2019 November	13	12	25
2019 October	7	8	15
2019 September	5	12	17
2019 August	22	10	32
2019 July	15	14	29
2019 June	13	7	20
2019 May	13	14	27
2019 April	18	15	33
2019 March	14	15	29
2019 February	16	7	23
2019 January	8	8	16
2018 December	12	11	23
2018 November	18	14	32
2018 October	16	14	30
2018 September	13	11	24
2018 May	5	0	5
2018 April	8	5	13
2018 March	7	4	11
2018 February	5	4	9
2018 January	8	7	15
2017 December	8	2	10
2017 November	2	4	6
2017 October	8	6	14
2017 September	7	7	14
2017 August	9	11	20
2017 July	12	12	24
2017 June	38	14	52
2017 May	4	4	8
2017 April	5	2	7
2017 March	8	5	13
2017 February	7	4	11
2017 January	2	3	5
2016 December	5	4	9
2016 November	11	6	17
2016 October	11	6	17
2016 September	8	4	12
2016 August	5	4	9
2016 July	6	4	10
2016 March	1	0	1
2016 February	1	0	1
2015 December	3	0	3
2015 October	97	9	106
2015 September	79	7	86
2015 August	81	9	90
2015 July	76	8	84
2015 June	52	4	56
2015 May	78	11	89
2015 April	63	12	75
2015 March	44	4	48
2015 February	58	6	64
2015 January	61	14	75
2014 December	47	12	59
2014 November	57	7	64
2014 October	77	9	86
2014 September	47	3	50
2014 August	51	14	65
2014 July	73	5	78
2014 June	60	8	68
2014 May	74	12	86
2014 April	56	7	63
2014 March	68	13	81
2014 February	75	8	83
2014 January	63	10	73
2013 December	69	13	82
2013 November	47	9	56
2013 October	58	8	66
2013 September	54	5	59
2013 August	52	11	63
2013 July	59	12	71
2013 June	47	12	59
2013 May	51	11	62
2013 April	31	4	35
2013 March	6	2	8

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