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                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dis Chest"
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                        "paginaInicial" => "39"
                        "paginaFinal" => "44"
                        "link" => array:1 [
                          0 => array:2 [
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                            3 => "J Grigg"
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                          "autores" => array:3 [
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                            3 => "FF Meller"
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                            5 => "AM Keane"
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                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1995"
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                        "paginaInicial" => "1461"
                        "paginaFinal" => "1466"
                        "link" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7582277"
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                            2 => "J Law"
                            3 => "W MacLaren"
                            4 => "A Seaton"
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                        ]
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                  "host" => array:1 [
                    0 => array:1 [
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                        "tituloSerie" => "Thorax"
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                        "paginaFinal" => "845"
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                          "etal" => false
                          "autores" => array:5 [
                            0 => "A Ten Brinke"
                            1 => "AH Zwinderman"
                            2 => "PJ Sterk"
                            3 => "KF Rabe"
                            4 => "EH Bel"
                          ]
                        ]
                      ]
                    ]
                  ]
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                      "Revista" => array:5 [
                        "tituloSerie" => "Am J Respir Cir Care Med"
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                    0 => array:2 [
                      "titulo" => "Intramuscular high-dose triamcinolone acetonide in the treatment of severe chronic asthma"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
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                            2 => "OP Sharma"
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                      ]
                    ]
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                        "paginaInicial" => "322"
                        "paginaFinal" => "329"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9392980"
                            "web" => "Medline"
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                    0 => array:2 [
                      "titulo" => "High-dose intramuscular triamcinolone in severe&#44; chronic&#44; life-threatening asthma"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "RG Ogirala"
                            1 => "TK Aldrich"
                            2 => "DJ Prezant"
                            3 => "MJ Sinnett"
                            4 => "JB Enden"
                            5 => "MH Williams Jr"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199102283240903"
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                        "tituloSerie" => "N Engl J Med"
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                        "paginaInicial" => "585"
                        "paginaFinal" => "589"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2021388"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Oral versus intravenous corticosteroids in adults hospitalised with acute asthma"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "D Cunnington"
                            1 => "N Smith"
                            2 => "K Steed"
                            3 => "P Rosengarten"
                            4 => "AM Kelly"
                            5 => "H Teichtahl"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.1016/j.pupt.2004.12.003"
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                        "tituloSerie" => "Pulm Pharmacol Ther"
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                        "link" => array:1 [
                          0 => array:2 [
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Oral versus intravenous corticosteroids in children hospitalized with asthma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "JM Becker"
                            1 => "A Arora"
                            2 => "RJ Scarfone"
                            3 => "ND Spector"
                            4 => "ME Fontana-Penn"
                            5 => "E Gracely"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Allergy Clin Immunol"
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                        "paginaFinal" => "590"
                        "link" => array:1 [
                          0 => array:2 [
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                            "web" => "Medline"
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                  ]
                ]
              ]
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              "etiqueta" => "17"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Studies of plasma levels and urinary excretion after intramuscular injection of triamcinolone acetonide"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
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                            1 => "N Sakauchi"
                            2 => "S Kumaoka"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Metabolism"
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                        "paginaInicial" => "590"
                        "paginaFinal" => "596"
                        "link" => array:1 [
                          0 => array:2 [
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                            "web" => "Medline"
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                ]
              ]
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                    0 => array:1 [
                      "titulo" => "Prednisone metabolism"
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                    0 => array:1 [
                      "LibroEditado" => array:3 [
                        "titulo" => "Goodman and Gilman&#39;s&#46; The pharmacological basis of therapeutics"
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                        "serieFecha" => "2001"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treatment of chronic severe asthma"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "HA Boushey"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "West J Med"
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                        "paginaFinal" => "360"
                      ]
                    ]
                  ]
                ]
              ]
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                0 => array:2 [
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                      "titulo" => "Glucocorticoid therapy-induced skin atrophy"
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                          "autores" => array:4 [
                            0 => "S Schoepe"
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                            2 => "E May"
                            3 => "K Asadullah"
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                        ]
                      ]
                    ]
                  ]
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                        "tituloSerie" => "Exp Dermatol"
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                        "link" => array:1 [
                          0 => array:2 [
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                            "web" => "Medline"
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                  ]
                ]
              ]
            ]
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                    0 => array:2 [
                      "titulo" => "Short-term growth and collagen turnover in asthmatic adolescents treated with the inhaled glucocorticoid budesonide"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
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                            3 => "G Kollerup"
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                        ]
                      ]
                    ]
                  ]
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                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Steroids"
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                        "paginaFinal" => "664"
                        "link" => array:1 [
                          0 => array:2 [
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Panretinal photocoagulation and intravitreal triamcinolone acetonide for the management of proliferative diabetic retinopathy with macular edema"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
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                            3 => "A Schakal"
                            4 => "ZF Bashshur"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Retina"
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                        "paginaFinal" => "142"
                        "link" => array:1 [
                          0 => array:2 [
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Review Articles
Triamcinolone Acetonide in the Treatment of Corticosteroid-Resistant Asthma: Risks and Benefits
César Picado
Corresponding author
cpicado@ub.edu

Correspondence: Dr C. Picado Servei de Pneumologia, Hospital Clínic Villarroel, 17008036 Barcelona, Spain
, María del Carmen Vennera
Servei de Pneumologia, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain
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          "clase" => "keyword"
          "titulo" => "Palabras clave"
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          "palabras" => array:4 [
            0 => "Asma grave"
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            2 => "Prednisona"
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        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Few therapeutic alternatives to prednisone are available forsevere&#44; corticosteroid-resistant asthma&#46; Injectable triamcinoloneacetonide &#40;TA&#41; has been used in this type of asthma&#44; althoughits use is controversial&#46; TA shows considerable efficacy whencompared with prednisone according to nearly all studies&#44; although the majority do not provide a high level of evidence&#46; The use of TA has been questioned&#44; with claims put forwardthat it is equivalent to increasing the corticosteroid dose&#44; thusleading to a higher risk of adverse effects&#46; This would meanthat TA would not represent an improvement over prednisonebecause of the trade-offs between risks and benefits&#46; Thisinterpretation is questionable&#44; however&#44; because the data showthat TA causes fewer adverse effects than prednisone&#44; meaningthat the balance of risks and benefits does favor TA&#46; Therefore&#44; TA can be considered a useful option for the treatment ofpatients with severe prednisone-resistant asthma&#46;</p>"
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      "es" => array:1 [
        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Las alternativas terap&#233;uticas a la prednisona en el asmagrave que no responde a los corticoides son escasas&#46; Elacet&#243;nido de triamcinolona &#40;AT&#41; de administraci&#243;ninyectada se ha utilizado en esta asma&#44; aunque su empleo esmotivo de controversia&#46; Casi todos los estudios realizados&#44; aunque en su mayor&#237;a son de escasa calidad&#44; muestran unaeficacia sustancial del AT comparado con la prednisona&#46; Seha cuestionado el uso del AT aduci&#233;ndose que equivale aaumentar la dosis del glucocorticoide&#44; lo que comportar&#225; unmayor riesgo de efectos secundarios&#44; de modo que el balancefinal de riesgos y beneficios del AT no mejorar&#237;a el de laprednisona&#46; Los datos publicados permiten dudar de esainterpretaci&#243;n&#44; ya que muestran que el AT ocasiona menosefectos secundarios que la prednisona&#44; por lo que el balancede riesgos y beneficios es superior al de esta &#250;ltima&#46; Por ellopuede considerarse el AT una opci&#243;n v&#225;lida para tratar alos pacientes con asma grave que no responde a laprednisona&#46;</p>"
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      "titulo" => "References"
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          "bibliografiaReferencia" => array:22 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Difficult&#47;therapy-resistant asthma&#58; the need for an integrated approach to define clinical phenotypes&#44; evaluate risk factors&#44; understand pathophysiology and find novel therapies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "ERS Task Force on Difficult&#47;Therapy-Resistant Asthma"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "1999"
                        "volumen" => "13"
                        "paginaInicial" => "1198"
                        "paginaFinal" => "1208"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10414427"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mecanismos moleculares de los glucocorticoides"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "BG Cos&#237;o"
                            1 => "A Torrego"
                            2 => "IM Adcock"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2005"
                        "volumen" => "41"
                        "paginaInicial" => "34"
                        "paginaFinal" => "41"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15676134"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Glucocorticoid receptors in human airways"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "L Pujols"
                            1 => "J Mullol"
                            2 => "A Torrego"
                            3 => "C Picado"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1398-9995.2004.00635.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Allergy"
                        "fecha" => "2004"
                        "volumen" => "59"
                        "paginaInicial" => "1042"
                        "paginaFinal" => "1052"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15355461"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Normativa para el asma de dif&#237;cil control"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A L&#243;pez-Vi&#241;a"
                            1 => "R Ag&#252;ero-Balb&#237;n"
                            2 => "JL Aller-&#193;lvarez"
                            3 => "T Baz&#250;s-Gonz&#225;lez"
                            4 => "BG Cos&#237;o"
                            5 => "A de Diego-Dami&#225;n"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2005"
                        "volumen" => "41"
                        "paginaInicial" => "513"
                        "paginaFinal" => "523"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16194515"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Antiinmunoglobulina E&#44; un anticuerpo monoclonal&#44; en el tratamiento de las enfermedades respiratorias"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P Cabrera-Navarro"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2006"
                        "volumen" => "42"
                        "paginaInicial" => "241"
                        "paginaFinal" => "245"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16740240"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Triamcinolone in corticosteroid-resistant asthma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "MD Peake"
                            1 => "RM Cayton"
                            2 => "P Howard"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dis Chest"
                        "fecha" => "1979"
                        "volumen" => "73"
                        "paginaInicial" => "39"
                        "paginaFinal" => "44"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/435372"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intramuscular triamcinolone for difficult asthma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "JR Panickar"
                            1 => "P Kenia"
                            2 => "M Silverman"
                            3 => "J Grigg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Pediatric Pulmonol"
                        "fecha" => "2005"
                        "volumen" => "39"
                        "paginaInicial" => "421"
                        "paginaFinal" => "425"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Exhaled nitric oxide after a single dose of intramuscular triamcinolone in children with difficult to control asthma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "JR Panickar"
                            1 => "N Bhatnagar"
                            2 => "J Grigg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Pediatric Pulmonol"
                        "fecha" => "2007"
                        "volumen" => "42"
                        "paginaInicial" => "573"
                        "paginaFinal" => "578"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Single&#44; high-dose intramuscular triamcinolone acetonide versus weekly oral methotrexate in life-threatening asthma&#58; a double-blind study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "RG Ogirala"
                            1 => "TM Sturm"
                            2 => "TK Aldrich"
                            3 => "FF Meller"
                            4 => "EB Pacia"
                            5 => "AM Keane"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.152.5.7582277"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1995"
                        "volumen" => "152"
                        "paginaInicial" => "1461"
                        "paginaFinal" => "1466"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7582277"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intramuscular triamcinolone acetonide in chronic severe asthma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "DT McLeod"
                            1 => "SJ Capewell"
                            2 => "J Law"
                            3 => "W MacLaren"
                            4 => "A Seaton"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "1985"
                        "volumen" => "40"
                        "paginaInicial" => "840"
                        "paginaFinal" => "845"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3906999"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparison of oral prednisolone and intramuscular depot triamcinolone in patients with severe chronic asthma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "RF Willey"
                            1 => "RJ Fergusson"
                            2 => "DJ Godden"
                            3 => "GK Crompton"
                            4 => "IW Grant"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "1984"
                        "volumen" => "39"
                        "paginaInicial" => "340"
                        "paginaFinal" => "344"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6377562"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#8220;Refractory&#8221; eosinophilic airway inflammation in severe asthma&#58; effect of parenteral corticosteroids"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A Ten Brinke"
                            1 => "AH Zwinderman"
                            2 => "PJ Sterk"
                            3 => "KF Rabe"
                            4 => "EH Bel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am J Respir Cir Care Med"
                        "fecha" => "2004"
                        "volumen" => "170"
                        "paginaInicial" => "601"
                        "paginaFinal" => "605"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intramuscular high-dose triamcinolone acetonide in the treatment of severe chronic asthma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "L Mancinelli"
                            1 => "L Navarro"
                            2 => "OP Sharma"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "West J Med"
                        "fecha" => "1997"
                        "volumen" => "167"
                        "paginaInicial" => "322"
                        "paginaFinal" => "329"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9392980"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "High-dose intramuscular triamcinolone in severe&#44; chronic&#44; life-threatening asthma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "RG Ogirala"
                            1 => "TK Aldrich"
                            2 => "DJ Prezant"
                            3 => "MJ Sinnett"
                            4 => "JB Enden"
                            5 => "MH Williams Jr"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199102283240903"
                      "Revista" => array:7 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1991"
                        "volumen" => "324"
                        "paginaInicial" => "585"
                        "paginaFinal" => "589"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2021388"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0212698211000413"
                          "estado" => "S300"
                          "issn" => "02126982"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib15"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oral versus intravenous corticosteroids in adults hospitalised with acute asthma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "D Cunnington"
                            1 => "N Smith"
                            2 => "K Steed"
                            3 => "P Rosengarten"
                            4 => "AM Kelly"
                            5 => "H Teichtahl"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.pupt.2004.12.003"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pulm Pharmacol Ther"
                        "fecha" => "2005"
                        "volumen" => "18"
                        "paginaInicial" => "207"
                        "paginaFinal" => "212"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15707855"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib16"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oral versus intravenous corticosteroids in children hospitalized with asthma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "JM Becker"
                            1 => "A Arora"
                            2 => "RJ Scarfone"
                            3 => "ND Spector"
                            4 => "ME Fontana-Penn"
                            5 => "E Gracely"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Allergy Clin Immunol"
                        "fecha" => "1999"
                        "volumen" => "103"
                        "paginaInicial" => "586"
                        "paginaFinal" => "590"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10200005"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib17"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Studies of plasma levels and urinary excretion after intramuscular injection of triamcinolone acetonide"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M Kusama"
                            1 => "N Sakauchi"
                            2 => "S Kumaoka"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Metabolism"
                        "fecha" => "1971"
                        "volumen" => "20"
                        "paginaInicial" => "590"
                        "paginaFinal" => "596"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4325410"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "titulo" => "Prednisone metabolism"
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:3 [
                        "titulo" => "Goodman and Gilman&#39;s&#46; The pharmacological basis of therapeutics"
                        "paginaInicial" => "1987"
                        "serieFecha" => "2001"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treatment of chronic severe asthma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "HA Boushey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "West J Med"
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                        "volumen" => "157"
                        "paginaInicial" => "359"
                        "paginaFinal" => "360"
                      ]
                    ]
                  ]
                ]
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            ]
            19 => array:3 [
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              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Glucocorticoid therapy-induced skin atrophy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S Schoepe"
                            1 => "H Sch&#228;cke"
                            2 => "E May"
                            3 => "K Asadullah"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.0906-6705.2006.00435.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Exp Dermatol"
                        "fecha" => "2006"
                        "volumen" => "15"
                        "paginaInicial" => "406"
                        "paginaFinal" => "420"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16689857"
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                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Short-term growth and collagen turnover in asthmatic adolescents treated with the inhaled glucocorticoid budesonide"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C Heuck"
                            1 => "OD Wolthers"
                            2 => "M Hansen"
                            3 => "G Kollerup"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Steroids"
                        "fecha" => "1997"
                        "volumen" => "62"
                        "paginaInicial" => "659"
                        "paginaFinal" => "664"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9381513"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Panretinal photocoagulation and intravitreal triamcinolone acetonide for the management of proliferative diabetic retinopathy with macular edema"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "WM Zein"
                            1 => "BN Noureddin"
                            2 => "FA Jurdi"
                            3 => "A Schakal"
                            4 => "ZF Bashshur"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Retina"
                        "fecha" => "2006"
                        "volumen" => "26"
                        "paginaInicial" => "137"
                        "paginaFinal" => "142"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16467667"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
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Article information
ISSN: 15792129
Original language: English
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