Correspondence: Dr C. Picado Servei de Pneumologia, Hospital Clínic Villarroel, 17008036 Barcelona, Spain
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array:2 [ "nombre" => "Rafael" "apellidos" => "Pelayo" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157921290860052X?idApp=UINPBA00003Z" "url" => "/15792129/0000004400000006/v1_201305150352/S157921290860052X/v1_201305150352/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review Articles</span>" "titulo" => "Triamcinolone Acetonide in the Treatment of Corticosteroid-Resistant Asthma: Risks and Benefits" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "324" "paginaFinal" => "327" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "César Picado, María del Carmen Vennera" "autores" => array:2 [ 0 => array:4 [ "nombre" => "César" "apellidos" => "Picado" "email" => array:1 [ 0 => "cpicado@ub.edu" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:2 [ "nombre" => "María" "apellidos" => "del Carmen Vennera" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servei de Pneumologia, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dr C. Picado Servei de Pneumologia, Hospital Clínic Villarroel, 17008036 Barcelona, Spain" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2007-08-23" "fechaAceptado" => "2007-09-18" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec155280" "palabras" => array:4 [ 0 => "Severe asthma" 1 => "Corticosteroid-resistant asthma" 2 => "Prednisone" 3 => "Triamcinolone acetonide" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec155279" "palabras" => array:4 [ 0 => "Asma grave" 1 => "Asma corticorresistente" 2 => "Prednisona" 3 => "Acetónido de triamcinolona" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Few therapeutic alternatives to prednisone are available forsevere, corticosteroid-resistant asthma. Injectable triamcinoloneacetonide (TA) has been used in this type of asthma, althoughits use is controversial. TA shows considerable efficacy whencompared with prednisone according to nearly all studies, although the majority do not provide a high level of evidence. The use of TA has been questioned, with claims put forwardthat it is equivalent to increasing the corticosteroid dose, thusleading to a higher risk of adverse effects. This would meanthat TA would not represent an improvement over prednisonebecause of the trade-offs between risks and benefits. Thisinterpretation is questionable, however, because the data showthat TA causes fewer adverse effects than prednisone, meaningthat the balance of risks and benefits does favor TA. Therefore, TA can be considered a useful option for the treatment ofpatients with severe prednisone-resistant asthma.</p>" ] "es" => array:1 [ "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Las alternativas terapéuticas a la prednisona en el asmagrave que no responde a los corticoides son escasas. Elacetónido de triamcinolona (AT) de administracióninyectada se ha utilizado en esta asma, aunque su empleo esmotivo de controversia. Casi todos los estudios realizados, aunque en su mayoría son de escasa calidad, muestran unaeficacia sustancial del AT comparado con la prednisona. Seha cuestionado el uso del AT aduciéndose que equivale aaumentar la dosis del glucocorticoide, lo que comportará unmayor riesgo de efectos secundarios, de modo que el balancefinal de riesgos y beneficios del AT no mejoraría el de laprednisona. Los datos publicados permiten dudar de esainterpretación, ya que muestran que el AT ocasiona menosefectos secundarios que la prednisona, por lo que el balancede riesgos y beneficios es superior al de esta última. Por ellopuede considerarse el AT una opción válida para tratar alos pacientes con asma grave que no responde a laprednisona.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:22 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Difficult/therapy-resistant asthma: the need for an integrated approach to define clinical phenotypes, evaluate risk factors, understand pathophysiology and find novel therapies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "ERS Task Force on Difficult/Therapy-Resistant Asthma" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "1999" "volumen" => "13" "paginaInicial" => "1198" "paginaFinal" => "1208" "link" => array:1 [ 0 => array:2 [ "url" => 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Year/Month | Html | Total | |
---|---|---|---|
2024 November | 2 | 3 | 5 |
2024 October | 31 | 21 | 52 |
2024 September | 30 | 12 | 42 |
2024 August | 39 | 33 | 72 |
2024 July | 25 | 22 | 47 |
2024 June | 42 | 29 | 71 |
2024 May | 35 | 21 | 56 |
2024 April | 20 | 20 | 40 |
2024 March | 19 | 24 | 43 |
2024 February | 33 | 20 | 53 |
2023 June | 0 | 1 | 1 |
2023 March | 2 | 3 | 5 |
2023 February | 14 | 23 | 37 |
2023 January | 22 | 31 | 53 |
2022 December | 27 | 23 | 50 |
2022 November | 26 | 18 | 44 |
2022 October | 38 | 34 | 72 |
2022 September | 26 | 23 | 49 |
2022 August | 26 | 39 | 65 |
2022 July | 28 | 47 | 75 |
2022 June | 19 | 30 | 49 |
2022 May | 23 | 32 | 55 |
2022 April | 47 | 35 | 82 |
2022 March | 46 | 40 | 86 |
2022 February | 23 | 29 | 52 |
2022 January | 25 | 43 | 68 |
2021 December | 23 | 46 | 69 |
2021 November | 24 | 47 | 71 |
2021 October | 29 | 42 | 71 |
2021 September | 21 | 53 | 74 |
2021 August | 24 | 32 | 56 |
2021 July | 17 | 27 | 44 |
2021 June | 20 | 25 | 45 |
2021 May | 29 | 35 | 64 |
2021 April | 45 | 65 | 110 |
2021 March | 25 | 19 | 44 |
2021 February | 22 | 19 | 41 |
2021 January | 14 | 8 | 22 |
2020 December | 28 | 17 | 45 |
2020 November | 23 | 15 | 38 |
2020 October | 24 | 9 | 33 |
2020 September | 13 | 4 | 17 |
2020 August | 22 | 12 | 34 |
2020 July | 17 | 17 | 34 |
2020 June | 18 | 4 | 22 |
2020 May | 10 | 12 | 22 |
2020 April | 28 | 16 | 44 |
2020 March | 20 | 11 | 31 |
2020 February | 22 | 13 | 35 |
2020 January | 30 | 15 | 45 |
2019 December | 22 | 16 | 38 |
2019 November | 19 | 10 | 29 |
2019 October | 18 | 7 | 25 |
2019 September | 12 | 9 | 21 |
2019 August | 19 | 12 | 31 |
2019 July | 28 | 19 | 47 |
2019 June | 9 | 10 | 19 |
2019 May | 14 | 18 | 32 |
2019 April | 23 | 65 | 88 |
2019 March | 20 | 42 | 62 |
2019 February | 14 | 34 | 48 |
2019 January | 5 | 11 | 16 |
2018 December | 12 | 21 | 33 |
2018 November | 11 | 16 | 27 |
2018 October | 17 | 18 | 35 |
2018 September | 16 | 20 | 36 |
2018 May | 7 | 0 | 7 |
2018 April | 12 | 12 | 24 |
2018 March | 4 | 9 | 13 |
2018 February | 5 | 13 | 18 |
2018 January | 8 | 8 | 16 |
2017 December | 7 | 9 | 16 |
2017 November | 5 | 7 | 12 |
2017 October | 7 | 11 | 18 |
2017 September | 6 | 14 | 20 |
2017 August | 10 | 16 | 26 |
2017 July | 14 | 19 | 33 |
2017 June | 12 | 12 | 24 |
2017 May | 7 | 12 | 19 |
2017 April | 2 | 4 | 6 |
2017 March | 3 | 22 | 25 |
2017 February | 4 | 6 | 10 |
2017 January | 2 | 6 | 8 |
2016 December | 5 | 11 | 16 |
2016 November | 11 | 12 | 23 |
2016 October | 10 | 14 | 24 |
2016 September | 7 | 11 | 18 |
2016 August | 5 | 2 | 7 |
2016 July | 6 | 4 | 10 |
2016 March | 2 | 0 | 2 |
2015 December | 2 | 0 | 2 |
2015 October | 104 | 9 | 113 |
2015 September | 74 | 7 | 81 |
2015 August | 66 | 6 | 72 |
2015 July | 66 | 9 | 75 |
2015 June | 65 | 7 | 72 |
2015 May | 69 | 7 | 76 |
2015 April | 63 | 9 | 72 |
2015 March | 55 | 9 | 64 |
2015 February | 35 | 1 | 36 |
2015 January | 51 | 8 | 59 |
2014 December | 75 | 6 | 81 |
2014 November | 99 | 8 | 107 |
2014 October | 70 | 9 | 79 |
2014 September | 54 | 6 | 60 |
2014 August | 54 | 11 | 65 |
2014 July | 55 | 10 | 65 |
2014 June | 76 | 8 | 84 |
2014 May | 81 | 12 | 93 |
2014 April | 78 | 10 | 88 |
2014 March | 68 | 8 | 76 |
2014 February | 67 | 13 | 80 |
2014 January | 62 | 10 | 72 |
2013 December | 48 | 14 | 62 |
2013 November | 48 | 7 | 55 |
2013 October | 51 | 11 | 62 |
2013 September | 54 | 11 | 65 |
2013 August | 43 | 11 | 54 |
2013 July | 56 | 11 | 67 |
2013 June | 44 | 6 | 50 |
2013 May | 33 | 6 | 39 |
2013 April | 40 | 4 | 44 |
2013 March | 6 | 2 | 8 |