Editorial
Macrolides: Not Just Antibiotics
Rosa María Girón
, Julio Ancochea
Corresponding author
med002861@nacom.es
Correspondence: Dr R.M. Girón Servicio de Neumología, Hospital Universitario de la Princesa Diego de León, 62 28006 Madrid, Spain
Correspondence: Dr R.M. Girón Servicio de Neumología, Hospital Universitario de la Princesa Diego de León, 62 28006 Madrid, Spain
Servicio de Neumología, Hospital Universitario de la Princesa, Madrid, Spain
Read
6372
Timeswas read the article
3870
Total PDF
2502
Total HTML
Share statistics
array:22 [ "pii" => "S1579212908600361" "issn" => "15792129" "doi" => "10.1016/S1579-2129(08)60036-1" "estado" => "S300" "fechaPublicacion" => "2008-01-01" "aid" => "60036" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)" "copyrightAnyo" => "2008" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "edi" "cita" => "Arch Bronconeumol. 2008;44:229-32" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2242 "formatos" => array:3 [ "EPUB" => 99 "HTML" => 1429 "PDF" => 714 ] ] "itemSiguiente" => array:18 [ "pii" => "S1579212908600373" "issn" => "15792129" "doi" => "10.1016/S1579-2129(08)60037-3" "estado" => "S300" "fechaPublicacion" => "2008-01-01" "aid" => "60037" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 2008;44:233-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2947 "formatos" => array:3 [ "EPUB" => 103 "HTML" => 2004 "PDF" => 840 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>" "titulo" => "Cardiovascular Risk Factors in Chronic Obstructive Pulmonary Disease: Results of the ARCE Study" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "233" "paginaFinal" => "238" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Pilar de Lucas-Ramos, José Luis Izquierdo-Alonso, José Miguel Rodríguez-González Moro, José María Bellón-Cano, Julio Ancochea-Bermúdez, Myrian Calle-Rubio, Eduardo Calvo-Corbella, Jesús Molina-París, Esteban Pérez-Rodríguez, Sonia Pons" "autores" => array:10 [ 0 => array:2 [ "nombre" => "Pilar" "apellidos" => "de Lucas-Ramos" ] 1 => array:2 [ "nombre" => "José Luis" "apellidos" => "Izquierdo-Alonso" ] 2 => array:2 [ "nombre" => "José Miguel Rodríguez-González" "apellidos" => "Moro" ] 3 => array:2 [ "nombre" => "José María" "apellidos" => "Bellón-Cano" ] 4 => array:2 [ "nombre" => "Julio" "apellidos" => "Ancochea-Bermúdez" ] 5 => array:2 [ "nombre" => "Myrian" "apellidos" => "Calle-Rubio" ] 6 => array:2 [ "nombre" => "Eduardo" "apellidos" => "Calvo-Corbella" ] 7 => array:2 [ "nombre" => "Jesús" "apellidos" => "Molina-París" ] 8 => array:2 [ "nombre" => "Esteban" "apellidos" => "Pérez-Rodríguez" ] 9 => array:2 [ "nombre" => "Sonia" "apellidos" => "Pons" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212908600373?idApp=UINPBA00003Z" "url" => "/15792129/0000004400000005/v1_201305150349/S1579212908600373/v1_201305150349/en/main.assets" ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Editorial</span>" "titulo" => "Macrolides: Not Just Antibiotics" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "229" "paginaFinal" => "232" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Rosa María Girón, Julio Ancochea" "autores" => array:2 [ 0 => array:4 [ "nombre" => "Rosa María" "apellidos" => "Girón" "email" => array:1 [ 0 => "med002861@nacom.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:2 [ "nombre" => "Julio" "apellidos" => "Ancochea" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Neumología, Hospital Universitario de la Princesa, Madrid, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dr R.M. Girón Servicio de Neumología, Hospital Universitario de la Princesa Diego de León, 62 28006 Madrid, Spain" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2007-07-16" "fechaAceptado" => "2007-09-26" "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:48 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Macrolide immunomodulation of chronic respiratory diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "DP Healy" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Curr Infect Dis Rep" "fecha" => "2007" "volumen" => "9" "paginaInicial" => "7" "paginaFinal" => "13" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17254499" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anti-inflammatory effects of macrolides in lung diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A Jaffe" 1 => "A Bush" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatr Pulmonol" "fecha" => "2001" "volumen" => "31" "paginaInicial" => "464" "paginaFinal" => "473" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11389580" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Macrólidos, cetólidos y estreptograminas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J Mensa" 1 => "E García-Vazquez" 2 => "J Vila" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Enferm Infecc Microbiol Clin" "fecha" => "2003" "volumen" => "21" "paginaInicial" => "200" "paginaFinal" => "208" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12681133" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Macrolides in cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J McArdle" 1 => "J Talwalkar" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Cystic fibrosis" "paginaInicial" => "347" "paginaFinal" => "360" "serieFecha" => "2007" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Azithromycin inhibits quorum sensing in <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span>" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "K Tateda" 1 => "R Comte" 2 => "JC Pechere" 3 => "T Köhler" 4 => "K Yamaguchi" 5 => "C Van Delden" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/AAC.45.6.1930-1933.2001" "Revista" => array:6 [ "tituloSerie" => "Antimicrob Agents Chemother" "fecha" => "2001" "volumen" => "45" "paginaInicial" => "1930" "paginaFinal" => "1933" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11353657" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Buccal adherence of <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> in patients with cystic fibrosis and long-term therapy with azithromycin" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "U Baumann" 1 => "J Fischer" 2 => "P Gudowius" 3 => "M Lingner" 4 => "S Herrmann" 5 => "B Tümmler" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Infection" "fecha" => "2001" "volumen" => "29" "paginaInicial" => "7" "paginaFinal" => "11" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11261763" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical response to azithromycin in cystic fibrosis correlates with in vitro effects on <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> phenotypes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "D Nguyen" 1 => "M Emond" 2 => "N Mayer-Hamblett" 3 => "L Saiman" 4 => "B Marshall" 5 => "J Burns" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ppul.20620" "Revista" => array:6 [ "tituloSerie" => "Pediatr Pulmonol" "fecha" => "2007" "volumen" => "42" "paginaInicial" => "533" "paginaFinal" => "541" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17469154" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Azithromycin inhibits MUC5AC production induced by the <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> autoinducer N-(3-oxodode-canoyl) homoserine lactone in NCL-H292 cells" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Y Imamura" 1 => "K Yanagihara" 2 => "Y Mizuta" 3 => "M Seki" 4 => "H Ohno" 5 => "Y Higashiyama" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/AAC.48.9.3457-3461.2004" "Revista" => array:6 [ "tituloSerie" => "Antimicrob Agents Chemother" "fecha" => "2004" "volumen" => "48" "paginaInicial" => "3457" "paginaFinal" => "3461" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15328111" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of clarithromycin on sputum production and its rheological properties in chronic respiratory tract infections" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J Tamaoki" 1 => "K Takeyama" 2 => "E Tagaya" 3 => "K Cono" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Antimicrob Agents Chemother" "fecha" => "1995" "volumen" => "39" "paginaInicial" => "1688" "paginaFinal" => "1690" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7486901" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-term azithromycin in cystic fibrosis: another possible mechanism of action?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "U Pradal" 1 => "A Delmarco" 2 => "M Morganti" 3 => "M Cipolli" 4 => "E Mini" 5 => "G Cazzola" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1179/joc.2005.17.4.393" "Revista" => array:6 [ "tituloSerie" => "J Chemother" "fecha" => "2005" "volumen" => "17" "paginaInicial" => "393" "paginaFinal" => "400" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16167518" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anti-inflammatory properties of macrolides" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "T Wagner" 1 => "J Burns" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.inf.0000253037.90204.9f" "Revista" => array:6 [ "tituloSerie" => "Pediatr Infect Dis J" "fecha" => "2007" "volumen" => "26" "paginaInicial" => "75" "paginaFinal" => "76" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17195710" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Azithromycin selectively reduces tumor necrosis factor alpha level in cystic fibrosis airway epithelial cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C Cigana" 1 => "B Asale" 2 => "P Melotti" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/AAC.01142-06" "Revista" => array:6 [ "tituloSerie" => "Antimicrob Agents Chemother" "fecha" => "2007" "volumen" => "51" "paginaInicial" => "975" "paginaFinal" => "981" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17210769" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Azithromycin modulates neutrophil function and circulating inflammatory mediators in healthy human subjects" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "O Culic" 1 => "V Erakovic" 2 => "I Cepelak" 3 => "K Barisic" 4 => "K Brajsa" 5 => "Z Ferencic" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Pharmacol" "fecha" => "2002" "volumen" => "450" "paginaInicial" => "277" "paginaFinal" => "289" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12208321" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Azithromycin blocks neutrophil recruitment in <span class="elsevierStyleItalic">Pseudomonas</span> endobronchial infection" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "W Tsai" 1 => "M Rodríguez" 2 => "K Young" 3 => "JC Deng" 4 => "VJ Thannickal" 5 => "K Tateda" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am J Respir Care Med" "fecha" => "2004" "volumen" => "170" "paginaInicial" => "1331" "paginaFinal" => "1339" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Macrolides in the treatment of asthma and cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "G Ferrara" 1 => "M Losi" 2 => "F Franco" 3 => "L Corbetta" 4 => "L Fabbri" 5 => "L Richeldi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Respir Med" "fecha" => "2005" "volumen" => "99" "paginaInicial" => "1" "paginaFinal" => "10" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15672842" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Macrolide antibiotics and asthma treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "S Johnston" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaci.2006.03.035" "Revista" => array:6 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "2006" "volumen" => "117" "paginaInicial" => "1233" "paginaFinal" => "1236" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16750980" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Macrolides for chronic asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "L Richeldi" 1 => "G Ferrara" 2 => "LM Fabbri" 3 => "TJ Lasserson" 4 => "PG Gibson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Cochrane Database Syst Rev" "fecha" => "2005" "numero" => "3" "paginaInicial" => "CD002997" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anti-inflammtory effect of roxithromycin in patients with aspirin-intolerant asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "T Shoji" 1 => "S Yoshida" 2 => "H Sakamoto" 3 => "H Hasegawa" 4 => "H Nakagawa" 5 => "H Amayasu" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Exp Allergy" "fecha" => "1999" "volumen" => "29" "paginaInicial" => "950" "paginaFinal" => "956" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10383596" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efficacy and safety of low-dose troleandomycin therapy in children with severe steroid-requiring asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "AK Kamada" 1 => "M Hill" 2 => "D Ikle" 3 => "A Brenner" 4 => "S Szefler" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "1993" "volumen" => "91" "paginaInicial" => "873" "paginaFinal" => "882" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8473676" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A double-blind study of troleandomycin and methylprednisolone in asthmatic subjects who require daily corticosteroids" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "H Nelson" 1 => "D Camilos" 2 => "P Corsello" 3 => "N Levesque" 4 => "A Buchmeier" 5 => "B Bucher" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm/147.2.398" "Revista" => array:6 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1993" "volumen" => "147" "paginaInicial" => "398" "paginaFinal" => "404" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8430965" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "<span class="elsevierStyleItalic">Mycoplasma pneumoniae</span> and <span class="elsevierStyleItalic">Chlamydia pneumoniae</span> in asthma: effect of clarithromycin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M Kraft" 1 => "G Cassell" 2 => "J Pak" 3 => "R Martin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2002" "volumen" => "121" "paginaInicial" => "1782" "paginaFinal" => "1788" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12065339" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Trial of roxithromycin in subjects with asthma and serological evidence of infection with <span class="elsevierStyleItalic">Chlamydia pneumoniae</span>" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P Black" 1 => "C Jenkins" 2 => "R Scicchitano" 3 => "F Blasi" 4 => "L Allegar" 5 => "G Mills" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.164.4.2011040" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2001" "volumen" => "164" "paginaInicial" => "536" "paginaFinal" => "541" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11520711" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clarithromycin reduces the severity of bronchial hyperresponsiveness in patients with asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E Kostadima" 1 => "S Tsiodras" 2 => "E Alexopoulos" 3 => "A Kaditis" 4 => "I Mavrou" 5 => "N Georgatou" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2004" "volumen" => "23" "paginaInicial" => "714" "paginaFinal" => "717" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15176685" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clarithromycin suppresses bronchial hyperresponsiveness associated with eosinophilic inflammation in patients with asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H Amayasu" 1 => "S Yacida" 2 => "S Ebana" 3 => "Y Yamamoto" 4 => "T Nishikawa" 5 => "T Shoji" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S1081-1206(10)62409-X" "Revista" => array:6 [ "tituloSerie" => "Ann Allergy Asthma Immunol" "fecha" => "2000" "volumen" => "84" "paginaInicial" => "594" "paginaFinal" => "598" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10875487" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Macrolide activities beyond their antimicrobial effects: macrolides in diffuse panbronchiolitis and cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M Schultz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/jac/dkh309" "Revista" => array:6 [ "tituloSerie" => "J Antimicrob Chemother" "fecha" => "2004" "volumen" => "54" "paginaInicial" => "21" "paginaFinal" => "28" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15190022" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Improvement of survival in patients with diffuse panbronchiolitis treated with low-dose erythromycin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S Kudoh" 1 => "A Azuma" 2 => "M Yamamoto" 3 => "T Izumi" 4 => "M Ando" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.157.6.9710075" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "1998" "volumen" => "157" "paginaInicial" => "1829" "paginaFinal" => "1832" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9620913" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-term efficacy and safety of clarithromycin treatment in patients with diffuse panbronchiolitis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J Kadota" 1 => "H Mukae" 2 => "H Ishii" 3 => "T Nagata" 4 => "H Kaida" 5 => "K Tomono" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Respir Med" "fecha" => "2003" "volumen" => "97" "paginaInicial" => "844" "paginaFinal" => "850" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12854636" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Macrolide antibiotics for cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "K Southern" 1 => "P Barrer" 2 => "A Solis" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/14651858.CD002203.pub4" "Revista" => array:5 [ "tituloSerie" => "Cochrane Database Syst Rev" "fecha" => "2004" "numero" => "2" "paginaInicial" => "CD002203" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23152214" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long term azithromycin in children with cystic fibrosis: a randomised, placebo-controlled crossover trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A Equi" 1 => "I Balfour-Lynn" 2 => "A Bush" 3 => "M Rosenthal" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Lancet" "fecha" => "2002" "volumen" => "28" "paginaInicial" => "978" "paginaFinal" => "984" ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of long term treatment with azithromycin on disease parameters in cystic fibrosis: a randomised trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J Wolter" 1 => "S Seeney" 2 => "S Bell" 3 => "S Bowler" 4 => "P Mases" 5 => "J McCormack" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2002" "volumen" => "57" "paginaInicial" => "212" "paginaFinal" => "216" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11867823" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The use of macrolide antibiotics in patients with cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "L Saiman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Curr Opin Pulm Med" "fecha" => "2004" "volumen" => "10" "paginaInicial" => "515" "paginaFinal" => "523" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15510060" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Azithromycin concentration in serum and bronchial secretions of patients with cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M Cipolli" 1 => "G Cazzola" 2 => "A Novelli" 3 => "M Caseta" 4 => "S Fallani" 5 => "T Mazzei" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clin Drug Invest" "fecha" => "2001" "volumen" => "21" "paginaInicial" => "353" "paginaFinal" => "360" ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib33" "etiqueta" => "33" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Heterogeneity of treatment response to azithromycin in patients with cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "L Saiman" 1 => "N Mayer-Hamblett" 2 => "P Campbell" 3 => "B Marshall" 4 => "Group Macrolide Study" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200502-218OC" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2005" "volumen" => "172" "paginaInicial" => "1008" "paginaFinal" => "1012" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16040785" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib34" "etiqueta" => "34" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long term effects of azithromycin in patients with cystic fibrosis: a double-blind, placebo-controlled trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A Clement" 1 => "A Tamalet" 2 => "E Leroux" 3 => "S Ravilly" 4 => "B Fauroux" 5 => "J Jais" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/thx.2005.057950" "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2006" "volumen" => "61" "paginaInicial" => "895" "paginaFinal" => "902" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16809416" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib35" "etiqueta" => "35" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A pilot study of low-dose erythromycin in bronchiectasis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K Tsang" 1 => "P Ho" 2 => "K Chan" 3 => "M Ip" 4 => "W Lam" 5 => "C Ho" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "1999" "volumen" => "13" "paginaInicial" => "361" "paginaFinal" => "364" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10065682" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib36" "etiqueta" => "36" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of roxithromycin on airway responsiveness in children with bronchiectasis: a double-blind, placebo-controlled study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Y Koh" 1 => "M Lee" 2 => "Y Sun" 3 => "K Sung" 4 => "J Chae" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Eur Respir J" "fecha" => "1997" "volumen" => "10" "paginaInicial" => "994" "paginaFinal" => "999" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9163637" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673607613828" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib37" "etiqueta" => "37" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prophylactic antibiotic treatment of bronchiectasis with azithromycin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G Davies" 1 => "R Wilson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2004" "volumen" => "59" "paginaInicial" => "540" "paginaFinal" => "541" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15170048" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib38" "etiqueta" => "38" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Azithromycin reverses airflow obstruction in established bronchiolitis obliterans syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B Yates" 1 => "DM Murphy" 2 => "IA Forrest" 3 => "C Ward" 4 => "RM Rutherford" 5 => "AJ Fisher" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200411-1537OC" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2005" "volumen" => "172" "paginaInicial" => "772" "paginaFinal" => "775" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15976371" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib39" "etiqueta" => "39" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Maintenance azithromycin therapy for bronchiolitis obliterans syndrome: results of a pilot study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S Gerhardt" 1 => "J McDyer" 2 => "R Girgis" 3 => "J Conte" 4 => "S Yang" 5 => "J Orens" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200212-1424BC" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2003" "volumen" => "168" "paginaInicial" => "121" "paginaFinal" => "125" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12672648" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib40" "etiqueta" => "40" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Is it bronchiolitis obliterans syndrome or is it chronic rejection: a reappraisal?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "GM Verleden" 1 => "LJ Dupont" 2 => "DE Van Raemdonck" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1183/09031936.05.00057404" "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2005" "volumen" => "25" "paginaInicial" => "221" "paginaFinal" => "224" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15684284" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib41" "etiqueta" => "41" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-term azithromycin use for treatment of bronchiolitis obliterans syndrome in lung transplant recipients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "D Shitrit" 1 => "D Bendayan" 2 => "S Gidon" 3 => "M Saute" 4 => "I Bakal" 5 => "MR Kramer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.healun.2004.08.006" "Revista" => array:6 [ "tituloSerie" => "J Heart Lung Transplant" "fecha" => "2005" "volumen" => "24" "paginaInicial" => "1440" "paginaFinal" => "1443" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16143268" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib42" "etiqueta" => "42" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effect of oral clarithromycin on health status and sputum bacteriology in stable COPD" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D Banerjee" 1 => "OA Khair" 2 => "D Honeybourne" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Respir Med" "fecha" => "2005" "volumen" => "99" "paginaInicial" => "208" "paginaFinal" => "215" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15715188" "web" => "Medline" ] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib43" "etiqueta" => "43" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Macrolides for the treatment of chronic sinusitis, asthma, and COPD" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M Gotfried" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2004" "volumen" => "125" "paginaInicial" => "52S" "paginaFinal" => "61S" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14872001" "web" => "Medline" ] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib44" "etiqueta" => "44" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community–acquired pneumonia in adults" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "American Thoracic Society" "etal" => true "autores" => array:6 [ 0 => "LA Mandell" 1 => "RG Wunderink" 2 => "A Anzueto" 3 => "JG Bartlett" 4 => "GD Campbell" 5 => "NC Dean" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1086/511159" "Revista" => array:6 [ "tituloSerie" => "Clin Infect Dis" "fecha" => "2007" "volumen" => "44" "paginaInicial" => "S27" "paginaFinal" => "S72" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17278083" "web" => "Medline" ] ] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib45" "etiqueta" => "45" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Normativas para el diagnóstico y el tratamiento de la neumonía adquirida en la comunidad. Sociedad Española de Neumología y Cirugía Torácica (SEPAR)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "I Alfageme" 1 => "J Aspa" 2 => "S Bello" 3 => "J Blanquer" 4 => "R Blanquer" 5 => "L Borderías" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2005" "volumen" => "41" "paginaInicial" => "272" "paginaFinal" => "289" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15919009" "web" => "Medline" ] ] ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib46" "etiqueta" => "46" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Azithromycin for acute lower respiratory tract infections" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R Panpanich" 1 => "P Lerttrakarnnon" 2 => "M Laopaiboon" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Cochrane Database Syst Rev" "fecha" => "2004" "numero" => "4" "paginaInicial" => "CD001954" ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib47" "etiqueta" => "47" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anti-inflammatory effect of macrolidesan underappreciated benefit in the treatment of community-acquired respiratory tract infections and chronic inflammatory pulmonary conditions?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G Amsted" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Antimicrobiol Chemother" "fecha" => "2005" "volumen" => "55" "paginaInicial" => "10" "paginaFinal" => "21" ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib48" "etiqueta" => "48" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Approaches to the synthesis of immunolides: selective immunomodulatory macrolides for cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "RA Fecik" 1 => "PL Nguyen" 2 => "L Venkatraman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Curr Opin Drug Discov Devel" "fecha" => "2005" "volumen" => "8" "paginaInicial" => "741" "paginaFinal" => "747" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16312149" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15792129/0000004400000005/v1_201305150349/S1579212908600361/v1_201305150349/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/15792129/0000004400000005/v1_201305150349/S1579212908600361/v1_201305150349/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212908600361?idApp=UINPBA00003Z" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 4 | 22 | 26 |
| 2024 October | 35 | 94 | 129 |
| 2024 September | 36 | 125 | 161 |
| 2024 August | 37 | 150 | 187 |
| 2024 July | 32 | 132 | 164 |
| 2024 June | 31 | 136 | 167 |
| 2024 May | 36 | 132 | 168 |
| 2024 April | 22 | 131 | 153 |
| 2024 March | 20 | 122 | 142 |
| 2024 February | 24 | 113 | 137 |
| 2023 March | 8 | 27 | 35 |
| 2023 February | 48 | 130 | 178 |
| 2023 January | 21 | 156 | 177 |
| 2022 December | 31 | 152 | 183 |
| 2022 November | 23 | 120 | 143 |
| 2022 October | 24 | 55 | 79 |
| 2022 September | 23 | 54 | 77 |
| 2022 August | 23 | 72 | 95 |
| 2022 July | 20 | 59 | 79 |
| 2022 June | 24 | 59 | 83 |
| 2022 May | 14 | 52 | 66 |
| 2022 April | 20 | 64 | 84 |
| 2022 March | 18 | 79 | 97 |
| 2022 February | 22 | 63 | 85 |
| 2022 January | 12 | 53 | 65 |
| 2021 December | 17 | 67 | 84 |
| 2021 November | 21 | 57 | 78 |
| 2021 October | 28 | 67 | 95 |
| 2021 September | 21 | 74 | 95 |
| 2021 August | 15 | 41 | 56 |
| 2021 July | 18 | 41 | 59 |
| 2021 June | 13 | 32 | 45 |
| 2021 May | 21 | 32 | 53 |
| 2021 April | 56 | 57 | 113 |
| 2021 March | 37 | 44 | 81 |
| 2021 February | 25 | 41 | 66 |
| 2021 January | 17 | 30 | 47 |
| 2020 December | 19 | 20 | 39 |
| 2020 November | 17 | 37 | 54 |
| 2020 October | 21 | 21 | 42 |
| 2020 September | 4 | 15 | 19 |
| 2020 August | 20 | 16 | 36 |
| 2020 July | 19 | 26 | 45 |
| 2020 June | 5 | 19 | 24 |
| 2020 May | 25 | 23 | 48 |
| 2020 April | 24 | 24 | 48 |
| 2020 March | 19 | 14 | 33 |
| 2020 February | 23 | 19 | 42 |
| 2020 January | 40 | 22 | 62 |
| 2019 December | 17 | 18 | 35 |
| 2019 November | 22 | 15 | 37 |
| 2019 October | 13 | 8 | 21 |
| 2019 September | 14 | 16 | 30 |
| 2019 August | 15 | 16 | 31 |
| 2019 July | 22 | 14 | 36 |
| 2019 June | 20 | 19 | 39 |
| 2019 May | 22 | 22 | 44 |
| 2019 April | 25 | 38 | 63 |
| 2019 March | 21 | 24 | 45 |
| 2019 February | 15 | 15 | 30 |
| 2019 January | 5 | 5 | 10 |
| 2018 December | 10 | 12 | 22 |
| 2018 November | 37 | 13 | 50 |
| 2018 October | 22 | 24 | 46 |
| 2018 September | 13 | 6 | 19 |
| 2018 May | 3 | 0 | 3 |
| 2018 April | 11 | 7 | 18 |
| 2018 March | 2 | 5 | 7 |
| 2018 February | 7 | 10 | 17 |
| 2018 January | 11 | 7 | 18 |
| 2017 December | 8 | 11 | 19 |
| 2017 November | 5 | 6 | 11 |
| 2017 October | 9 | 13 | 22 |
| 2017 September | 3 | 11 | 14 |
| 2017 August | 12 | 17 | 29 |
| 2017 July | 11 | 11 | 22 |
| 2017 June | 23 | 15 | 38 |
| 2017 May | 13 | 5 | 18 |
| 2017 April | 9 | 3 | 12 |
| 2017 March | 14 | 4 | 18 |
| 2017 February | 7 | 4 | 11 |
| 2017 January | 4 | 3 | 7 |
| 2016 December | 10 | 5 | 15 |
| 2016 November | 14 | 8 | 22 |
| 2016 October | 15 | 7 | 22 |
| 2016 September | 8 | 11 | 19 |
| 2016 August | 9 | 6 | 15 |
| 2016 July | 10 | 6 | 16 |
| 2016 March | 2 | 0 | 2 |
| 2015 December | 2 | 0 | 2 |
| 2015 October | 30 | 6 | 36 |
| 2015 September | 36 | 7 | 43 |
| 2015 August | 22 | 9 | 31 |
| 2015 July | 34 | 8 | 42 |
| 2015 June | 27 | 11 | 38 |
| 2015 May | 44 | 12 | 56 |
| 2015 April | 23 | 14 | 37 |
| 2015 March | 27 | 6 | 33 |
| 2015 February | 13 | 3 | 16 |
| 2015 January | 20 | 4 | 24 |
| 2014 December | 22 | 6 | 28 |
| 2014 November | 18 | 6 | 24 |
| 2014 October | 34 | 8 | 42 |
| 2014 September | 22 | 8 | 30 |
| 2014 August | 21 | 4 | 25 |
| 2014 July | 21 | 9 | 30 |
| 2014 June | 28 | 7 | 35 |
| 2014 May | 26 | 14 | 40 |
| 2014 April | 36 | 6 | 42 |
| 2014 March | 43 | 8 | 51 |
| 2014 February | 35 | 10 | 45 |
| 2014 January | 19 | 5 | 24 |
| 2013 December | 26 | 9 | 35 |
| 2013 November | 21 | 8 | 29 |
| 2013 October | 26 | 6 | 32 |
| 2013 September | 33 | 9 | 42 |
| 2013 August | 30 | 4 | 34 |
| 2013 July | 39 | 11 | 50 |
| 2013 June | 29 | 9 | 38 |
| 2013 May | 26 | 7 | 33 |
| 2013 April | 16 | 3 | 19 |
| 2013 March | 7 | 2 | 9 |
Show all
