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Aspergillus fumigatus and Candida albicans in Cystic Fibrosis: Clinical Significance and Specific Immune Response Involving Serum Immunoglobulins G, A, and M
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"https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212908600282?idApp=UINPBA00003Z" "url" => "/15792129/0000004400000003/v1_201305150345/S1579212908600282/v1_201305150345/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>" "titulo" => "<span class="elsevierStyleItalic">Aspergillus fumigatus</span> and <span class="elsevierStyleItalic">Candida albicans</span> in Cystic Fibrosis: Clinical Significance and Specific Immune Response Involving Serum Immunoglobulins G, A, and M" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "146" "paginaFinal" => "151" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Luis Máiz, Manuela Cuevas, Adelaida Lamas, Aurora Sousa, Santiago Quirce, Lucrecia Suárez" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Luis" "apellidos" => "Máiz" "email" => array:1 [ 0 => "lmaiz.hrc@salud.madrid.org" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "Manuela" "apellidos" => "Cuevas" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 2 => array:3 [ "nombre" => "Adelaida" "apellidos" => "Lamas" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 3 => array:3 [ "nombre" => "Aurora" "apellidos" => "Sousa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] 4 => array:3 [ "nombre" => "Santiago" "apellidos" => "Quirce" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff4" ] ] ] 5 => array:3 [ "nombre" => "Lucrecia" "apellidos" => "Suárez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Unidad de Fibrosis Quística, Hospital Ramón y Cajal, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Inmunología, Hospital Ramón y Cajal, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Servicio de Microbiología, Hospital Ramón y Cajal, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] 3 => array:3 [ "entidad" => "Servicio de Alergia, Hospital Universitario La Paz, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff4" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dr L. Máiz Unidad de Fibrosis Quística, Hospital Ramón y Cajal Ctra Colmenar, km 9.128034 Madrid, Spain" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2006-12-18" "fechaAceptado" => "2007-07-24" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec155191" "palabras" => array:4 [ 0 => "Aspergillus fumigatus" 1 => "<span class="elsevierStyleItalic">Candida albicans</span>" 2 => "Cystic fibrosis" 3 => "Fungal colonization" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec155192" "palabras" => array:4 [ 0 => "Aspergillus fumigatus" 1 => "<span class="elsevierStyleItalic">Candida albicans</span>" 2 => "Fibrosis quística" 3 => "Colonización fúngica" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">The aim of this study was to analyze the clinical significance of <span class="elsevierStyleItalic">Aspergillus fumigatus</span> and <span class="elsevierStyleItalic">Candida albicans</span> in respiratory secretions from patients with cystic fibrosis and to assess the immune response to these fungi in serum.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">The study included 66 patients with cystic fibrosis (34 men; mean age, 16.2 years). Sera from 15 healthy individuals were used as controls.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The serum concentrations of immunoglobulin (Ig) G, IgA, and IgM against <span class="elsevierStyleItalic">A fumigatus</span> and <span class="elsevierStyleItalic">C albicans</span> were higher in patients than in the control group. There was no correlation between the presence of <span class="elsevierStyleItalic">A fumigatus</span> in respiratory secretions and the immune response to the fungus measured in serum. In contrast, the presence of <span class="elsevierStyleItalic">C albicans</span> in respiratory secretions was correlated with the immune response to that fungus. The likelihood of obtaining <span class="elsevierStyleItalic">A fumigatus</span> cultures from respiratory secretions increased with age. The presence of these fungi in respiratory samples was not a risk factor for greater respiratory impairment.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">In response to increased colonization of the lower respiratory tract by <span class="elsevierStyleItalic">A fumigatus</span> and <span class="elsevierStyleItalic">C albicans</span>, patients with cystic fibrosis have elevated serum levels of IgG, IgA, and IgM against those fungi. In patients with cystic fibrosis, culture of sputum and oropharyngeal secretions is adequate for the assessment of lower respiratory tract colonization by <span class="elsevierStyleItalic">C albicans</span> but not <span class="elsevierStyleItalic">A fumigatus</span>. Fungal colonization of the lower respiratory tract is not a risk factor for greater respiratory impairment in patients with cystic fibrosis.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Estudiar el significado clínico de <span class="elsevierStyleItalic">Aspergillus fumigatus</span> y <span class="elsevierStyleItalic">Candida albicans</span> en las secreciones respirato-rias de los pacientes con fibrosis quística (FQ) y las inmuno-rrespuestas séricas frente a estos hongos.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se estudió a 66 pacientes con FQ (34 varones; edad media: 16,2 años). Como grupo control se utilizaron los sueros de 15 individuos sanos.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Las concentraciones de inmunoglobulina (Ig) G, IgA e IgM frente a <span class="elsevierStyleItalic">A. fumigatus</span> y <span class="elsevierStyleItalic">C. albicans</span> estuvieron más elevadas en los pacientes con FQ que en el grupo control. No hubo correlación entre el hallazgo de <span class="elsevierStyleItalic">A. fumigatus</span> en las secreciones respiratorias y las inmunorrespuestas séricas frente al hongo. Sí hubo correlación entre la presencia de <span class="elsevierStyleItalic">C. albicans</span> en las secreciones respiratorias y las inmunorrespuestas frente a <span class="elsevierStyleItalic">C. albicans</span>. A medida que aumentaba la edad de los pacientes, aumentaba la probabilidad de cultivar <span class="elsevierStyleItalic">A. fumigatus</span> en las secreciones respiratorias. La presencia de estos hongos en muestras respiratorias no fue un factor de riesgo para un mayor deterioro respiratorio.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Como respuesta a la elevada colonización del aparato respiratorio inferior por <span class="elsevierStyleItalic">A. fumigatus</span> y <span class="elsevierStyleItalic">C. albicans</span>, los pacientes con FQ presentan respuestas séricas elevadas de IgG, IgA e IgM frente a estos hongos. En los pacientes con FQ el cultivo de esputos y aspirados orofaríngeos no sirve para evaluar la colonización del aparato respiratorio inferior por <span class="elsevierStyleItalic">A. fumigatus</span>, pero sí por <span class="elsevierStyleItalic">C. albicans</span>. En estos pacientes, la colonización fúngica del aparato respiratorio inferior no es un factor de riesgo para el deterioro respiratorio.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:24 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mycological surveillance of children with cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R Blaschke-Hellmessen" 1 => "H Spitzer" 2 => "KD Paul" 3 => "C Hoffmann" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Mycoses" "fecha" => "1991" "volumen" => "34" "numero" => "Suppl 1" "paginaInicial" => "43" "paginaFinal" => "47" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1818262" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of chronic intermittent administration of inhaled tobramycin on respiratory microbial flora in patients with cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "JL Burns" 1 => "JM van Dalfsen" 2 => "RM Shawar" 3 => "KL Otto" 4 => "RL Garber" 5 => "JM Quan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1086/314727" "Revista" => array:6 [ "tituloSerie" => "J Infect Dis" "fecha" => "1999" "volumen" => "179" "paginaInicial" => "1190" "paginaFinal" => "1196" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10191222" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical significance of the recovery of Aspergillus species from the respiratory secretions of cystic fibrosis patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "CE Milla" 1 => "CL Wielinsky" 2 => "WE Regelmann" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/(SICI)1099-0496(199601)21:1<6::AID-PPUL1>3.0.CO;2-R" "Revista" => array:6 [ "tituloSerie" => "Pediatr Pulmonol" "fecha" => "1996" "volumen" => "21" "paginaInicial" => "6" "paginaFinal" => "10" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8776259" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence of Aspergillus fumigatus and other fungal species in the sputum of adult patients with cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "N Bakare" 1 => "V Rickerts" 2 => "J Bargon" 3 => "G Just-Nubling" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Mycoses" "fecha" => "2003" "volumen" => "46" "paginaInicial" => "19" "paginaFinal" => "23" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12955848" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Qualitative and quantitative microbiological analysis of sputa of 102 patients with cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A Bauernfeind" 1 => "R Bertele" 2 => "K Harms" 3 => "G Horl" 4 => "R Jungwirth" 5 => "C Petermuller" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Infection" "fecha" => "1987" "volumen" => "4" "paginaInicial" => "270" "paginaFinal" => "277" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Serologic IgE immune responses against Aspergillus fumigatus and Candida albicans in patients with cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L Máiz" 1 => "M Cuevas" 2 => "S Quirce" 3 => "JF Cañón" 4 => "A Pacheco" 5 => "A Sousa" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2002" "volumen" => "121" "paginaInicial" => "782" "paginaFinal" => "788" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11888960" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Development of immune responses to Aspergillus at an early age in children with cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "JM el-Dahr" 1 => "R Fink" 2 => "R Selden" 3 => "LK Arruda" 4 => "TA Platts-Mills" 5 => "PW Heymann" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.150.6.7952609" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "1994" "volumen" => "150" "paginaInicial" => "1513" "paginaFinal" => "1518" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7952609" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathophysiology and management of pulmonary infections in cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "RL Gibson" 1 => "JL Burns" 2 => "BW Ramsey" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200304-505SO" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2003" "volumen" => "168" "paginaInicial" => "918" "paginaFinal" => "951" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14555458" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fatal invasive aspergillosis in an adolescent with cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "K Brown" 1 => "M Rosenthal" 2 => "A Bush" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatr Pulmonol" "fecha" => "1999" "volumen" => "27" "paginaInicial" => "130" "paginaFinal" => "133" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10088937" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Allergic bronchopulmonary aspergillosis in cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P Laufer" 1 => "JN Fink" 2 => "WT Bruns" 3 => "GF Unger" 4 => "JH Kalbfleisch" 5 => "PA Greenberger" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "1984" "volumen" => "73" "paginaInicial" => "44" "paginaFinal" => "48" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6693666" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immune responses to Aspergillus in cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R Zeaske" 1 => "WT Bruns" 2 => "JN Fink" 3 => "PA Greenberger" 4 => "H Colby" 5 => "JL Liotta" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "1988" "volumen" => "82" "paginaInicial" => "73" "paginaFinal" => "77" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3392373" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Selective expression of a major allergen and cytotoxin, Asp fI, in Aspergillus fumigatus. Implications for the immunopathogenesis of Aspergillus-related diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "LK Arruda" 1 => "BJ Mann" 2 => "MD Chapman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Immunol" "fecha" => "1992" "volumen" => "149" "paginaInicial" => "3354" "paginaFinal" => "3359" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1431110" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Normativa del diagnóstico y el tratamiento de la afección respiratoria en la fibrosis quística" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L Máiz" 1 => "F Baranda" 2 => "R Coll" 3 => "C Prados" 4 => "M Vendrell" 5 => "A Escribano" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2001" "volumen" => "37" "paginaInicial" => "316" "paginaFinal" => "324" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11562317" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fibrosis quística en adultos: acuerdos inter e intraobservador para las escalas de puntuación de Brasfield y Chrispin-Norman en la radiografía de tórax y relación con datos clínicos y espirométricos" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "V Gutiérrez" 1 => "MJ Olivera" 2 => "RM Girón" 3 => "F Rodríguez-Salvanés" 4 => "P Caballero" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2005" "volumen" => "41" "paginaInicial" => "553" "paginaFinal" => "559" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16266668" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Normativa para la práctica de la espirometría forzada" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J Sanchis" 1 => "P Casán" 2 => "J Castillo" 3 => "N González" 4 => "R Palenciano" 5 => "J Roca" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "1989" "volumen" => "25" "paginaInicial" => "132" "paginaFinal" => "134" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lung volumes and forced ventilatory flows. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "PH Quanjer" 1 => "GJ Tammeling" 2 => "JE Cotes" 3 => "OF Pedersen" 4 => "R Peslin" 5 => "JC Yernault" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Eur Respir J Supl" "fecha" => "1993" "volumen" => "16" "paginaInicial" => "5" "paginaFinal" => "40" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Serologic response to Candida albicans and Aspergillus fumigatus in cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "B Przyklenk" 1 => "A Bauernfeind" 2 => "G Horl" 3 => "G Emminger" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Infection" "fecha" => "1987" "volumen" => "15" "paginaInicial" => "308" "paginaFinal" => "310" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3312024" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sensitization to Aspergillus fumigatus and lung function in children with cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C Wojnarowski" 1 => "I Eichler" 2 => "C Gartner" 3 => "M Gotz" 4 => "S Renner" 5 => "DY Koller" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.155.6.9196093" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "1997" "volumen" => "155" "paginaInicial" => "1902" "paginaFinal" => "1907" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9196093" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A critical review of the role of precipitins in hypersensitivity pneumonitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R Burrel" 1 => "R Rylander" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Respir Dis" "fecha" => "1981" "volumen" => "62" "paginaInicial" => "332" "paginaFinal" => "343" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7047184" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Antibody responses to Aspergillus fumigatus allergens in patients with cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "LK Arruda" 1 => "A Muir" 2 => "LD Vailes" 3 => "RF Selden" 4 => "TA Platts-Mills" 5 => "MD Chapman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int Arch Allergy Immunol" "fecha" => "1995" "volumen" => "107" "paginaInicial" => "410" "paginaFinal" => "411" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7613194" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Allergic bronchopulmonary aspergillosis with low serum IgE levels in a child with cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "L Máiz" 1 => "M Cuevas" 2 => "S Quirce" 3 => "A Pacheco" 4 => "H Escobar" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "1997" "volumen" => "100" "paginaInicial" => "431" "paginaFinal" => "432" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9314361" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fungal spores in lung and sputum" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J Mullins" 1 => "A Seaton" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Allergy" "fecha" => "1978" "volumen" => "8" "paginaInicial" => "525" "paginaFinal" => "533" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/361283" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Variability in parameters of allergic bronchopulmonary aspergillosis in patients with cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "PS Hutcheson" 1 => "AJ Rejent" 2 => "RG Slavin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "1991" "volumen" => "88" "paginaInicial" => "390" "paginaFinal" => "394" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1890268" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Serological diagnosis of infection of the urinary tract by yeast" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "DW Warnock" 1 => "DC Speller" 2 => "JA Morris" 3 => "PH Mackie" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Clin Pathol" "fecha" => "1976" "volumen" => "29" "paginaInicial" => "836" "paginaFinal" => "840" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/824329" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15792129/0000004400000003/v1_201305150345/S1579212908600294/v1_201305150345/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/15792129/0000004400000003/v1_201305150345/S1579212908600294/v1_201305150345/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212908600294?idApp=UINPBA00003Z" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 4 | 3 | 7 |
| 2024 October | 35 | 19 | 54 |
| 2024 September | 35 | 12 | 47 |
| 2024 August | 49 | 34 | 83 |
| 2024 July | 39 | 21 | 60 |
| 2024 June | 47 | 23 | 70 |
| 2024 May | 45 | 30 | 75 |
| 2024 April | 40 | 25 | 65 |
| 2024 March | 32 | 14 | 46 |
| 2024 February | 24 | 23 | 47 |
| 2023 March | 6 | 4 | 10 |
| 2023 February | 56 | 14 | 70 |
| 2023 January | 33 | 34 | 67 |
| 2022 December | 30 | 23 | 53 |
| 2022 November | 39 | 28 | 67 |
| 2022 October | 57 | 25 | 82 |
| 2022 September | 18 | 18 | 36 |
| 2022 August | 48 | 35 | 83 |
| 2022 July | 54 | 32 | 86 |
| 2022 June | 23 | 33 | 56 |
| 2022 May | 26 | 26 | 52 |
| 2022 April | 15 | 26 | 41 |
| 2022 March | 20 | 34 | 54 |
| 2022 February | 25 | 23 | 48 |
| 2022 January | 14 | 29 | 43 |
| 2021 December | 19 | 41 | 60 |
| 2021 November | 18 | 50 | 68 |
| 2021 October | 26 | 53 | 79 |
| 2021 September | 19 | 56 | 75 |
| 2021 August | 14 | 41 | 55 |
| 2021 July | 15 | 24 | 39 |
| 2021 June | 11 | 28 | 39 |
| 2021 May | 19 | 24 | 43 |
| 2021 April | 33 | 58 | 91 |
| 2021 March | 44 | 23 | 67 |
| 2021 February | 12 | 22 | 34 |
| 2021 January | 23 | 13 | 36 |
| 2020 December | 11 | 7 | 18 |
| 2020 November | 13 | 18 | 31 |
| 2020 October | 5 | 3 | 8 |
| 2020 September | 12 | 2 | 14 |
| 2020 August | 15 | 12 | 27 |
| 2020 July | 22 | 15 | 37 |
| 2020 June | 4 | 6 | 10 |
| 2020 May | 18 | 15 | 33 |
| 2020 April | 14 | 21 | 35 |
| 2020 March | 17 | 11 | 28 |
| 2020 February | 24 | 16 | 40 |
| 2020 January | 13 | 15 | 28 |
| 2019 December | 14 | 15 | 29 |
| 2019 November | 21 | 12 | 33 |
| 2019 October | 5 | 4 | 9 |
| 2019 September | 13 | 20 | 33 |
| 2019 August | 17 | 6 | 23 |
| 2019 July | 11 | 20 | 31 |
| 2019 June | 14 | 8 | 22 |
| 2019 May | 24 | 7 | 31 |
| 2019 April | 30 | 41 | 71 |
| 2019 March | 14 | 13 | 27 |
| 2019 February | 12 | 15 | 27 |
| 2019 January | 7 | 10 | 17 |
| 2018 December | 13 | 14 | 27 |
| 2018 November | 41 | 12 | 53 |
| 2018 October | 33 | 15 | 48 |
| 2018 September | 9 | 10 | 19 |
| 2018 May | 4 | 0 | 4 |
| 2018 April | 8 | 6 | 14 |
| 2018 March | 3 | 5 | 8 |
| 2018 February | 8 | 4 | 12 |
| 2018 January | 3 | 9 | 12 |
| 2017 December | 8 | 10 | 18 |
| 2017 November | 5 | 6 | 11 |
| 2017 October | 6 | 10 | 16 |
| 2017 September | 4 | 4 | 8 |
| 2017 August | 10 | 9 | 19 |
| 2017 July | 15 | 11 | 26 |
| 2017 June | 10 | 15 | 25 |
| 2017 May | 7 | 7 | 14 |
| 2017 April | 6 | 6 | 12 |
| 2017 March | 4 | 13 | 17 |
| 2017 February | 5 | 2 | 7 |
| 2017 January | 2 | 5 | 7 |
| 2016 December | 10 | 4 | 14 |
| 2016 November | 11 | 6 | 17 |
| 2016 October | 11 | 9 | 20 |
| 2016 September | 9 | 8 | 17 |
| 2016 August | 6 | 3 | 9 |
| 2016 July | 6 | 2 | 8 |
| 2016 March | 1 | 0 | 1 |
| 2016 February | 2 | 0 | 2 |
| 2015 December | 2 | 0 | 2 |
| 2015 October | 72 | 6 | 78 |
| 2015 September | 71 | 6 | 77 |
| 2015 August | 61 | 5 | 66 |
| 2015 July | 68 | 9 | 77 |
| 2015 June | 62 | 5 | 67 |
| 2015 May | 88 | 7 | 95 |
| 2015 April | 51 | 16 | 67 |
| 2015 March | 60 | 2 | 62 |
| 2015 February | 54 | 2 | 56 |
| 2015 January | 53 | 5 | 58 |
| 2014 December | 52 | 5 | 57 |
| 2014 November | 64 | 4 | 68 |
| 2014 October | 67 | 11 | 78 |
| 2014 September | 48 | 9 | 57 |
| 2014 August | 67 | 9 | 76 |
| 2014 July | 68 | 14 | 82 |
| 2014 June | 84 | 6 | 90 |
| 2014 May | 84 | 71 | 155 |
| 2014 April | 83 | 12 | 95 |
| 2014 March | 141 | 7 | 148 |
| 2014 February | 70 | 12 | 82 |
| 2014 January | 60 | 6 | 66 |
| 2013 December | 45 | 7 | 52 |
| 2013 November | 35 | 13 | 48 |
| 2013 October | 40 | 11 | 51 |
| 2013 September | 43 | 10 | 53 |
| 2013 August | 48 | 6 | 54 |
| 2013 July | 49 | 12 | 61 |
| 2013 June | 30 | 6 | 36 |
| 2013 May | 41 | 5 | 46 |
| 2013 April | 20 | 1 | 21 |
| 2013 March | 9 | 2 | 11 |
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