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Bronchogenic Carcinoma 2000-2001: Characteristics and Overall Survival
Graciliano Estrada Triguerosa,
, Lorena Comechea, Ángel López Encuentraa, Javier Montoro Zuluetaa, Fulgencio González Garridoa, Francisco Colinab
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graciestrada@hotmail.com
Correspondence: Dr. G. Estrada Trigueros. Servicio de Neumología. Hospital Universitario 12 de Octubre. Avda. de Córdoba, s/n. 28047 Madrid. España
Correspondence: Dr. G. Estrada Trigueros. Servicio de Neumología. Hospital Universitario 12 de Octubre. Avda. de Córdoba, s/n. 28047 Madrid. España
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Estrada Trigueros. Servicio de Neumología. Hospital Universitario 12 de Octubre. Avda. de Córdoba, s/n. 28047 Madrid. España" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2006-09-19" "fechaAceptado" => "2007-03-27" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec154654" "palabras" => array:5 [ 0 => "Carcinoma" 1 => "bronchogenic" 2 => "Survival" 3 => "Staging" 4 => "Prognosis" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec154655" "palabras" => array:4 [ 0 => "Carcinoma broncogénico" 1 => "Supervivencia" 2 => "Estadificación" 3 => "Pronóstico" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetive</span><p class="elsevierStyleSimplePara elsevierViewall">To describe the clinical characteristics and survival of patients diagnosed with bronchogenic carcinoma during the years 2000 and 2001 in a tertiary level hospital.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Data were collected from our hospital's tumor registry and validated with independent sources. Of all the patients diagnosed with or treated for bronchogenic carcinoma in our hospital, only those from our health care area were selected.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">During the 2-year study period, 482 patients were diagnosed. Of those, 90% were men. The mean (SD) age was 66.6 (9.65) years. Large cell carcinomas accounted for 29.4% of cases. Of all the cases of bronchogenic carcinoma, 41.3% were diagnosed in stage IV. Thirty percent of non-small cell carcinomas were classified as stage I, compared to 6% of small cell carcinomas (<span class="elsevierStyleItalic">P</span><.001). The most frequent treatment was chemotherapy (42.1%) and 20% of patients underwent surgery. The overall 5-year survival rate was 13% (95% confidence interval [CI], 10%–16%), while survival was significantly lower in patients aged 68 years or older (95% CI, 3%–15%; <span class="elsevierStyleItalic">P</span><.001) and in patients with small cell carcinoma (0%, <span class="elsevierStyleItalic">P</span><.01).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Our recent experience (2000-2001) confirmed the advanced age of patients with bronchogenic carcinoma, the frequency of diagnosis in advanced stages of the disease (41% in stage IV), and the low overall 5-year survival rate (13%).</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Describir las características clínicas y la super-vivencia de los carcinomas broncogénicos (CB) diagnosticados durante los años 2000 y 2001 en un hospital terciario.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">La información se recogió de la base de datos del Registro de Tumores del hospital y se validó con fuentes independientes. De todos los pacientes con CB diagnosticados o tratados en nuestro centro, se seleccionó a los que provenían exclusivamente del área de salud correspondiente.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Se diagnosticaron 482 casos en los 2 años del estudio; un 90% de los pacientes eran varones. La edad media ± desviación estándar fue de 66,6 ± 9,65 años. El 29,4% eran CB de células grandes. El 41,3% de todos los CB se diagnosticaron en estadio IV. El 30% de los CB no microcíticos se clasificaron en estadio I, en comparación con el 6% de los CB microcíticos (p < 0,001). El tratamiento más frecuente fue la quimioterapia (42,1%); la cirugía se efectuó en el 20% de los casos. La supervivencia global a los 5 años fue de 13% (intervalo de confianza del 95%, 10–16%), y fue significativamente inferior (p < 0,001) en los pacientes con mayor edad (≥ 68 años), en quienes se cifró en un 9% (intervalo de confianza del 95%, 3–15), y en el CB microcítico (0%; p < 0,01).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Se confirma en nuestra reciente experiencia (2000-2001) la elevada edad de los pacientes con CB, el frecuente diagnóstico en estadios avanzados (estadio IV: 41%) y la deficiente supervivencia global a los 5 años (el 13% del global).</p>" ] ] "NotaPie" => array:1 [ 0 => array:1 [ "nota" => "<p class="elsevierStyleNotepara">This study was partially funded by RTIC-03/11-ISCIII-Red-Respira and by FIS grant 03/0046 from the Spanish Ministry of Health.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:26 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fallecimientos en España por todas las causas (año 2003)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Instituto Nacional de Estadística" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "WWW" => array:1 [ "link" => "Available from: www.ine.es" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ten year survey of lung cancer treatment and survival in hospital in the United States" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "WA Fry" 1 => "JL Phillips" 2 => "HR Menck" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1999" "volumen" => "86" "paginaInicial" => "1867" "paginaFinal" => "1876" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10547562" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lung cancer mortality in European Regions (1995-1997)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "JM Borrás" 1 => "E Fernández" 2 => "JR González" 3 => "E Negri" 4 => "F Lucchini" 5 => "C la Vecchia" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Oncol" "fecha" => "2003" "volumen" => "14" "paginaInicial" => "159" "paginaFinal" => "161" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12488308" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "El pronóstico tras la resección del carcinoma broncogénico no células pequeñas según la nueva norma de estadificación: un análisis de 1.433 pacientes" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J Padilla" 1 => "JC Peñalver" 2 => "A García Zarza" 3 => "J Pastor" 4 => "F Blasco" 5 => "F Paris" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "1999" "volumen" => "35" "paginaInicial" => "483" "paginaFinal" => "487" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10618748" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Carcinoma broncogénico no anaplásico de células pequeñas T2N1M0. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 2 | 2 | 4 |
| 2024 October | 27 | 13 | 40 |
| 2024 September | 24 | 10 | 34 |
| 2024 August | 43 | 33 | 76 |
| 2024 July | 24 | 16 | 40 |
| 2024 June | 25 | 18 | 43 |
| 2024 May | 35 | 27 | 62 |
| 2024 April | 16 | 23 | 39 |
| 2024 March | 17 | 9 | 26 |
| 2024 February | 14 | 21 | 35 |
| 2023 March | 3 | 2 | 5 |
| 2023 February | 15 | 15 | 30 |
| 2023 January | 16 | 24 | 40 |
| 2022 December | 21 | 19 | 40 |
| 2022 November | 15 | 15 | 30 |
| 2022 October | 20 | 24 | 44 |
| 2022 September | 14 | 20 | 34 |
| 2022 August | 19 | 31 | 50 |
| 2022 July | 15 | 34 | 49 |
| 2022 June | 12 | 28 | 40 |
| 2022 May | 15 | 27 | 42 |
| 2022 April | 10 | 24 | 34 |
| 2022 March | 18 | 32 | 50 |
| 2022 February | 17 | 29 | 46 |
| 2022 January | 12 | 24 | 36 |
| 2021 December | 14 | 37 | 51 |
| 2021 November | 17 | 43 | 60 |
| 2021 October | 13 | 39 | 52 |
| 2021 September | 17 | 68 | 85 |
| 2021 August | 18 | 24 | 42 |
| 2021 July | 13 | 23 | 36 |
| 2021 June | 22 | 27 | 49 |
| 2021 May | 13 | 21 | 34 |
| 2021 April | 19 | 52 | 71 |
| 2021 March | 14 | 8 | 22 |
| 2021 February | 11 | 11 | 22 |
| 2021 January | 9 | 9 | 18 |
| 2020 December | 8 | 10 | 18 |
| 2020 November | 6 | 10 | 16 |
| 2020 October | 11 | 6 | 17 |
| 2020 September | 6 | 5 | 11 |
| 2020 August | 11 | 4 | 15 |
| 2020 July | 5 | 14 | 19 |
| 2020 June | 4 | 3 | 7 |
| 2020 May | 9 | 13 | 22 |
| 2020 April | 11 | 15 | 26 |
| 2020 March | 11 | 7 | 18 |
| 2020 February | 9 | 13 | 22 |
| 2020 January | 11 | 11 | 22 |
| 2019 December | 9 | 9 | 18 |
| 2019 November | 5 | 8 | 13 |
| 2019 October | 4 | 4 | 8 |
| 2019 September | 4 | 14 | 18 |
| 2019 August | 10 | 3 | 13 |
| 2019 July | 9 | 18 | 27 |
| 2019 June | 30 | 1 | 31 |
| 2019 May | 44 | 8 | 52 |
| 2019 April | 12 | 21 | 33 |
| 2019 March | 12 | 9 | 21 |
| 2019 February | 8 | 12 | 20 |
| 2019 January | 5 | 7 | 12 |
| 2018 December | 11 | 10 | 21 |
| 2018 November | 39 | 13 | 52 |
| 2018 October | 33 | 13 | 46 |
| 2018 September | 12 | 17 | 29 |
| 2018 May | 1 | 0 | 1 |
| 2018 April | 4 | 4 | 8 |
| 2018 March | 3 | 3 | 6 |
| 2018 February | 2 | 9 | 11 |
| 2018 January | 3 | 7 | 10 |
| 2017 December | 8 | 7 | 15 |
| 2017 November | 1 | 5 | 6 |
| 2017 October | 6 | 15 | 21 |
| 2017 September | 5 | 18 | 23 |
| 2017 August | 4 | 10 | 14 |
| 2017 July | 3 | 6 | 9 |
| 2017 June | 8 | 10 | 18 |
| 2017 May | 6 | 3 | 9 |
| 2017 April | 3 | 6 | 9 |
| 2017 March | 1 | 40 | 41 |
| 2017 February | 3 | 1 | 4 |
| 2017 January | 1 | 0 | 1 |
| 2016 December | 2 | 3 | 5 |
| 2016 November | 7 | 4 | 11 |
| 2016 October | 10 | 16 | 26 |
| 2016 September | 6 | 3 | 9 |
| 2016 August | 6 | 3 | 9 |
| 2016 July | 1 | 8 | 9 |
| 2016 March | 2 | 0 | 2 |
| 2015 December | 3 | 0 | 3 |
| 2015 October | 39 | 5 | 44 |
| 2015 September | 30 | 6 | 36 |
| 2015 August | 29 | 6 | 35 |
| 2015 July | 34 | 6 | 40 |
| 2015 June | 27 | 2 | 29 |
| 2015 May | 37 | 8 | 45 |
| 2015 April | 23 | 10 | 33 |
| 2015 March | 37 | 4 | 41 |
| 2015 February | 20 | 5 | 25 |
| 2015 January | 24 | 2 | 26 |
| 2014 December | 15 | 4 | 19 |
| 2014 November | 22 | 9 | 31 |
| 2014 October | 29 | 9 | 38 |
| 2014 September | 25 | 5 | 30 |
| 2014 August | 28 | 6 | 34 |
| 2014 July | 26 | 7 | 33 |
| 2014 June | 38 | 5 | 43 |
| 2014 May | 35 | 11 | 46 |
| 2014 April | 29 | 7 | 36 |
| 2014 March | 42 | 9 | 51 |
| 2014 February | 48 | 9 | 57 |
| 2014 January | 27 | 8 | 35 |
| 2013 December | 27 | 12 | 39 |
| 2013 November | 34 | 9 | 43 |
| 2013 October | 35 | 6 | 41 |
| 2013 September | 38 | 8 | 46 |
| 2013 August | 36 | 7 | 43 |
| 2013 July | 39 | 18 | 57 |
| 2013 June | 32 | 7 | 39 |
| 2013 May | 35 | 5 | 40 |
| 2013 April | 17 | 3 | 20 |
| 2013 March | 5 | 1 | 6 |
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