Case Reports
Early Pleuropulmonary Toxicity Associated With Cabergoline, an Antiparkinsonian Drug
Christian Villavicencioa, Alba Ramírez-Sarmientob, Ángel Gayetec, Santiago Graud, Mauricio Orozco-Levib,
Corresponding author
morozco@IMIM.es
Correspondence: Dr. M. Orozco-Levi. Servicio de Neumología. Hospital del Mar. Pg. Marítim, 25. 08003 Barcelona. España
Correspondence: Dr. M. Orozco-Levi. Servicio de Neumología. Hospital del Mar. Pg. Marítim, 25. 08003 Barcelona. España
a Servicio de Geriatría, Hospital del Mar, Hospital de la Esperanza, Centro Fórum, Instituto de Atención Geriátrica y Sociosanitaria (IAGS), Barcelona, Spain
b Servicio de Neumología, Hospital del Mar, Unidad de Investigación Muscular y del Sistema Respiratorio (URMAR), IMIM, CEXSUniversidad Pompeu Fabra, Barcelona, Spain
c Servicio de Radiología, CRC-Mar, Hospital del Mar, Barcelona, Spain
d Servicio de Farmacia, Hospital del Mar, Barcelona, Spain
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Geriátrica y Sociosanitaria (IAGS), Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Neumología, Hospital del Mar, Unidad de Investigación Muscular y del Sistema Respiratorio (URMAR), IMIM, CEXSUniversidad Pompeu Fabra, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Servicio de Radiología, CRC-Mar, Hospital del Mar, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] 3 => array:3 [ "entidad" => "Servicio de Farmacia, Hospital del Mar, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff4" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dr. M. Orozco-Levi. Servicio de Neumología. Hospital del Mar. Pg. Marítim, 25. 08003 Barcelona. España" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2006-07-20" "fechaAceptado" => "2006-08-30" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec155005" "palabras" => array:3 [ 0 => "Pleural effusion" 1 => "Pulmonary toxicity" 2 => "Cabergoline" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec155006" "palabras" => array:3 [ 0 => "Derrame pleural" 1 => "Toxicidad pulmonar" 2 => "Cabergolina" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">We report a case of pleural effusion, pericardial thickening, and pulmonary involvement in a patient with dry cough, dyspnea, edema, and changes in the skin of the lower limbs. Treatment with cabergoline (Sogilen) had been started 4 months earlier. Pleural effusion, pericardial thickening, and impaired pulmonary function (airflow obstruction, increased airway resistance, and reduced carbon monoxide diffusing capacity) were observed. The Naranjo scale pointed to a probable relationship between cabergoline and these adverse effects. We report on outcome after 2 months of follow-up, during which time there was a slow and incomplete improvement in respiratory function. This is the first case in our practice setting of early pleuropulmonary toxicity associated with cabergoline.</p>" ] "es" => array:1 [ "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Describimos un caso de derrame pleural, engrosamiento pericárdico y afectación pulmonar en un paciente con síntomas de tos seca, disnea, edemas y afectación cutánea de extremidades inferiores. Cuatro meses antes había iniciado tratamiento con cabergolina (Sogilen®). Se demostró la existencia de derrame pleural, engrosamiento pericárdico y alteración de las pruebas funcionales respiratorias (obstrucción del flujo aéreo, incremento de la resistencia de las vías aéreas y disminución de la capacidad de transferencia de monóxido de carbono). La escala de Naranjo imputó una relación “probable” entre el fármaco y los efectos adversos detectados. Incluimos la evaluación evolutiva tras 2 meses de seguimiento, durante el cual se documentó una mejoría lenta e incompleta de las alteraciones funcionales respiratorias. En el ámbito de nuestra práctica neumológica, este caso constituye la primera descripción clínica de toxicidad pleuropulmonar precoz asociada al tratamiento con cabergolina.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:11 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "AF Fishman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "paginaInicial" => "798" "edicion" => "2nd ed." 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