Case Reports
Accelerated Phase of Idiopathic Pulmonary Fibrosis
Lander Altube Urrengoetxea
, Carlos Salinas Solano, Myriam Aburto Barrenetxea, Francisco Javier Moraza Cortés, Aitor Ballaz Quincoces, Alberto Capelastegui Sainz
Corresponding author
lander.altubeurrengoetxea@osakidetza.net
Correspondence: Dr. L. Altube Urrengoetxea. Servicio de Neumología. Hospital de Galdakao. Labeaga Auzoa, s/n. 48960 Galdakao. Vizcaya. España
Correspondence: Dr. L. Altube Urrengoetxea. Servicio de Neumología. Hospital de Galdakao. Labeaga Auzoa, s/n. 48960 Galdakao. Vizcaya. España
Servicio de Neumología, Hospital de Galdakao, Galdakao, Vizcaya, Spain
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"/15792129/0000004300000009/v1_201305150327/S1579212907601165/v1_201305150327/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case Reports</span>" "titulo" => "Accelerated Phase of Idiopathic Pulmonary Fibrosis" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "516" "paginaFinal" => "518" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Lander Altube Urrengoetxea, Carlos Salinas Solano, Myriam Aburto Barrenetxea, Francisco Javier Moraza Cortés, Aitor Ballaz Quincoces, Alberto Capelastegui Sainz" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Lander Altube" "apellidos" => "Urrengoetxea" "email" => array:1 [ 0 => "lander.altubeurrengoetxea@osakidetza.net" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:2 [ "nombre" => "Carlos Salinas" "apellidos" => "Solano" ] 2 => array:2 [ "nombre" => "Myriam Aburto" "apellidos" => "Barrenetxea" ] 3 => array:2 [ "nombre" => "Francisco Javier Moraza" "apellidos" => "Cortés" ] 4 => array:2 [ "nombre" => "Aitor Ballaz" "apellidos" => "Quincoces" ] 5 => array:2 [ "nombre" => "Alberto Capelastegui" "apellidos" => "Sainz" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Neumología, Hospital de Galdakao, Galdakao, Vizcaya, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dr. L. Altube Urrengoetxea. Servicio de Neumología. Hospital de Galdakao. Labeaga Auzoa, s/n. 48960 Galdakao. Vizcaya. España" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2006-07-31" "fechaAceptado" => "2006-08-30" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec155003" "palabras" => array:3 [ 0 => "Accelerated phase" 1 => "Idiopathic pulmonary fibrosis" 2 => "Tumor markers" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec155004" "palabras" => array:3 [ 0 => "Fase acelerada" 1 => "Fibrosis pulmonar idiopática" 2 => "Marcadores tumorales" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">The natural history of idiopathic pulmonary fibrosis is characterized by a slow progression resulting in respiratory failure and death. The progression to the fulminant form is rapid in a small percentage of cases, however. Within weeks or months, patients develop respiratory distress, and extensive ground-glass patterns can be seen in computed tomography scans and hyaline membranes in biopsy samples. This is described as an accelerated phase of idiopathic pulmonary fibrosis, in which elevated levels of acute-phase reactants and tumor markers have been reported. To date, the monoclonal tumor marker, CA 15-3 has not been associated with the accelerated phase.</p>" ] "es" => array:1 [ "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">La historia natural de la fibrosis pulmonar idiopática es la lenta evolución hacia la insuficiencia respiratoria y la muerte. Sin embargo, un pequeño porcentaje de casos evoluciona en semanas o pocos meses de forma fulminante con insuficiencia respiratoria, imágenes extensas de vidrio esmerilado y formación de membranas hialinas en las muestras de biopsia; es lo que se denomina “fase acelerada” de la fibrosis pulmonar idiopática, durante la cual se describen incrementos de las cifras de reactantes de fase aguda y marcadores tumorales. Hasta la fecha no se ha relacionado el marcador tumoral monoclonal CA 15/3 con dicha fase acelerada.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:11 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "International multidisciplinary consensus classification of the idiopathic interstitial pneumonias" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "American Thoracic Society/European Respiratory Society" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.165.2.ats01" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2002" "volumen" => "165" "paginaInicial" => "277" "paginaFinal" => "304" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11790668" "web" => "Medline" ] ] ] ] ] ] ] ] 1 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