Original Articles
Analysis of Energy Expenditure in Adults With Cystic Fibrosis: Comparison of Indirect Calorimetry and Prediction Equations
Casilda Olveira Fustera,
, Gabriel Olveira Fusterb, Antonio Dorado Galindoc, Alicia Padilla Galoc, Julio Merino Verdugoc, Francisco Miralles Lozanoc
Corresponding author
gabrielm.olveira.sspa@juntadeandalucia.es
Correspondence: Dr. G. Olveira Fuster. Servicio de Endocrinología y Nutrición. Hospital Universitario Carlos Haya. Avda. Carlos Haya, s/n. 29010 Málaga. España
Correspondence: Dr. G. Olveira Fuster. Servicio de Endocrinología y Nutrición. Hospital Universitario Carlos Haya. Avda. Carlos Haya, s/n. 29010 Málaga. España
a Unidad de Fibrosis Quística de Adultos, Servicio de Neumología, Hospital Universitario Carlos Haya, Málaga, Spain
b Unidad de Fibrosis Quística de Adultos, Servicio de Endocrinología y Nutrición, Hospital Universitario Carlos Haya, Málaga, Spain
c Servicio de Neumología, Hospital Universitario Carlos Haya, Málaga, Spain
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Antonio Riesco" "apellidos" => "Miranda" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157921290760086X?idApp=UINPBA00003Z" "url" => "/15792129/0000004300000007/v1_201305150322/S157921290760086X/v1_201305150322/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>" "titulo" => "Analysis of Energy Expenditure in Adults With Cystic Fibrosis: Comparison of Indirect Calorimetry and Prediction Equations" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "366" "paginaFinal" => "372" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Casilda Olveira Fuster, Gabriel Olveira Fuster, Antonio Dorado Galindo, Alicia Padilla Galo, Julio Merino Verdugo, Francisco Miralles Lozano" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Casilda Olveira" "apellidos" => "Fuster" "email" => array:1 [ 0 => "gabrielm.olveira.sspa@juntadeandalucia.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "Gabriel Olveira" "apellidos" => "Fuster" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 2 => array:3 [ "nombre" => "Antonio Dorado" "apellidos" => "Galindo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] 3 => array:3 [ "nombre" => "Alicia Padilla" "apellidos" => "Galo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] 4 => array:3 [ "nombre" => "Julio Merino" "apellidos" => "Verdugo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] 5 => array:3 [ "nombre" => "Francisco Miralles" "apellidos" => "Lozano" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Unidad de Fibrosis Quística de Adultos, Servicio de Neumología, Hospital Universitario Carlos Haya, Málaga, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Unidad de Fibrosis Quística de Adultos, Servicio de Endocrinología y Nutrición, Hospital Universitario Carlos Haya, Málaga, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Servicio de Neumología, Hospital Universitario Carlos Haya, Málaga, Spain" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dr. G. Olveira Fuster. Servicio de Endocrinología y Nutrición. Hospital Universitario Carlos Haya. Avda. Carlos Haya, s/n. 29010 Málaga. España" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2006-04-19" "fechaAceptado" => "2006-10-03" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec154923" "palabras" => array:4 [ 0 => "Cystic fibrosis" 1 => "Energy expenditure" 2 => "Indirect calorimetry" 3 => "Nutrition" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec154924" "palabras" => array:4 [ 0 => "Fibrosis quística" 1 => "Gasto energético" 2 => "Calorimetría indirecta" 3 => "Nutrición" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">OBJECTIVE</span><p class="elsevierStyleSimplePara elsevierViewall">Undernutrition, which implies an imbalance between energy intake and energy requirements, is common in patients with cystic fibrosis. The aim of this study was to compare resting energy expenditure determined by indirect calorimetry with that obtained with commonly used predictive equations in adults with cystic fibrosis and to assess the influence of clinical variables on the values obtained.</p> <span class="elsevierStyleSectionTitle">PATIENTS AND METHODS</span><p class="elsevierStyleSimplePara elsevierViewall">We studied 21 patients with clinically stable cystic fibrosis, obtaining data on anthropometric variables, hand grip dynamometry, electrical bioimpedance, and resting energy expenditure by indirect calorimetry. We used the intraclass correlation coefficient (ICC) and the Bland–Altman method to assess agreement between the values obtained for resting energy expenditure measured by indirect calorimetry and those obtained with the World Health Organization (WHO) and Harris–Benedict prediction equations.</p> <span class="elsevierStyleSectionTitle">RESULTS</span><p class="elsevierStyleSimplePara elsevierViewall">The prediction equations underestimated resting energy expenditure in more than 90% of cases. The agreement between the value obtained by indirect calorimetry and that calculated with the prediction equations was poor (ICC for comparisons with the WHO and Harris–Benedict equations, −; 0.47 and 0.41, respectively). Bland–Altman analysis revealed a variable bias between the results of indirect calorimetry and those obtained with prediction equations, irrespective of the resting energy expenditure. The difference between the values measured by indirect calorimetry and those obtained with the WHO equation was significantly larger in patients homozygous for the ΔF508 mutation and in those with exocrine pancreatic insufficiency.</p> <span class="elsevierStyleSectionTitle">CONCLUSIONS</span><p class="elsevierStyleSimplePara elsevierViewall">The WHO and Harris–Benedict prediction equations underestimate resting energy expenditure in adults with cystic fibrosis. There is poor agreement between the values for resting energy expenditure determined by indirect calorimetry and those estimated with prediction equations. Underestimation was greater in patients with exocrine pancreatic insufficiency and patients who were homozygous for Δ F508.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">OBJETIVO</span><p class="elsevierStyleSimplePara elsevierViewall">La desnutrición es frecuente en pacientes con fibrosis quística (FQ) e implica un desequilibrio entre la ingesta y los requerimientos. Nuestro objetivo ha sido calcular el gasto energético en reposo (GER) mediante calorimetría indirecta en adultos con FQ, compararlo con las fórmulas estimativas habitualmente empleadas y valorar la influencia de parámetros clínicos sobre el GER.</p> <span class="elsevierStyleSectionTitle">PACIENTES Y MÉTODOS</span><p class="elsevierStyleSimplePara elsevierViewall">Estudiamos a 21 pacientes con FQ que se encontraban estables clínicamente. Se efectuaron medidas de parámetros antropométricos, dinamometría de mano, impedanciometría bioeléctrica y del GER medido por calorimetría indirecta (CI). Estudiamos la concordancia entre los valores del GER medidos y estimados por las fórmulas de la Organización Mundial de la Salud (OMS) y de Harris-Benedict (HB) mediante el coeficiente de correlación intraclase y el método de Bland-Altman.</p> <span class="elsevierStyleSectionTitle">RESULTADOS</span><p class="elsevierStyleSimplePara elsevierViewall">Las ecuaciones infraestimaron el GER en más del 90% de los casos. La concordancia entre la CI y la estimada por las fórmulas fue escasa (para OMS, 0,47, y para HB, 0,41). Mediante el método de Bland-Altman observamos un sesgo variable entre la CI y las fórmulas, independiente de los valores del GER. La diferencia entre la CI respecto de la estimada por la fórmula de la OMS fue significativamente mayor en homocigóticos ΔF508 y en los pacientes con insuficiencia pancreática exocrina frente al resto.</p> <span class="elsevierStyleSectionTitle">CONCLUSIONES</span><p class="elsevierStyleSimplePara elsevierViewall">En adultos con FQ, las fórmulas de la OMS y de HB infraestiman el GER. Hay una baja concordancia entre los valores del GER medidos y estimados. La infraestimación fue mayor en pacientes con insuficiencia pancreática exocrina y en homocigóticos ΔF508.</p>" ] ] "NotaPie" => array:1 [ 0 => array:1 [ "nota" => "<p class="elsevierStyleNotepara">This study was partially funded by a grant from the Andalusian public health service (Consejería de Salud de la Junta de Andalucía, grant 02/150) and by Instituto de Salud Carlos III, Red de Centros de Metabolismo y Nutrición (C03/08).</p>" ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:44 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Standards of care for patients with cystic fibrosis: a European consensus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "E Kerem" 1 => "S Conway" 2 => "S Elborn" 3 => "H Heijerman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Cystic Fibrosis" "fecha" => "2005" "volumen" => "4" "paginaInicial" => "7" "paginaFinal" => "26" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nutrition in patients with cystic fibrosis: a European Consensus" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M Sinaasappel" 1 => "M Stern" 2 => "J Littlewood" 3 => "S Wolfe" 4 => "G Steinkamp" 5 => "HGM Heijerman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 5 | 6 | 11 |
| 2024 October | 28 | 17 | 45 |
| 2024 September | 34 | 19 | 53 |
| 2024 August | 41 | 33 | 74 |
| 2024 July | 26 | 23 | 49 |
| 2024 June | 40 | 18 | 58 |
| 2024 May | 40 | 28 | 68 |
| 2024 April | 21 | 23 | 44 |
| 2024 March | 29 | 13 | 42 |
| 2024 February | 31 | 22 | 53 |
| 2023 March | 6 | 3 | 9 |
| 2023 February | 18 | 24 | 42 |
| 2023 January | 18 | 39 | 57 |
| 2022 December | 25 | 38 | 63 |
| 2022 November | 24 | 23 | 47 |
| 2022 October | 25 | 29 | 54 |
| 2022 September | 18 | 32 | 50 |
| 2022 August | 21 | 37 | 58 |
| 2022 July | 19 | 38 | 57 |
| 2022 June | 20 | 33 | 53 |
| 2022 May | 17 | 41 | 58 |
| 2022 April | 22 | 38 | 60 |
| 2022 March | 18 | 43 | 61 |
| 2022 February | 18 | 36 | 54 |
| 2022 January | 14 | 42 | 56 |
| 2021 December | 16 | 45 | 61 |
| 2021 November | 14 | 60 | 74 |
| 2021 October | 46 | 46 | 92 |
| 2021 September | 31 | 71 | 102 |
| 2021 August | 11 | 36 | 47 |
| 2021 July | 14 | 38 | 52 |
| 2021 June | 16 | 41 | 57 |
| 2021 May | 15 | 29 | 44 |
| 2021 April | 24 | 88 | 112 |
| 2021 March | 22 | 18 | 40 |
| 2021 February | 19 | 14 | 33 |
| 2021 January | 12 | 19 | 31 |
| 2020 December | 11 | 22 | 33 |
| 2020 November | 11 | 16 | 27 |
| 2020 October | 9 | 10 | 19 |
| 2020 September | 7 | 3 | 10 |
| 2020 August | 11 | 11 | 22 |
| 2020 July | 16 | 14 | 30 |
| 2020 June | 12 | 5 | 17 |
| 2020 May | 9 | 11 | 20 |
| 2020 April | 23 | 24 | 47 |
| 2020 March | 17 | 12 | 29 |
| 2020 February | 23 | 11 | 34 |
| 2020 January | 26 | 21 | 47 |
| 2019 December | 12 | 10 | 22 |
| 2019 November | 6 | 14 | 20 |
| 2019 October | 7 | 9 | 16 |
| 2019 September | 2 | 13 | 15 |
| 2019 August | 10 | 10 | 20 |
| 2019 July | 11 | 16 | 27 |
| 2019 June | 6 | 8 | 14 |
| 2019 May | 14 | 10 | 24 |
| 2019 April | 8 | 32 | 40 |
| 2019 March | 5 | 18 | 23 |
| 2019 February | 8 | 12 | 20 |
| 2019 January | 2 | 14 | 16 |
| 2018 December | 7 | 17 | 24 |
| 2018 November | 18 | 9 | 27 |
| 2018 October | 40 | 19 | 59 |
| 2018 September | 11 | 15 | 26 |
| 2018 May | 6 | 0 | 6 |
| 2018 April | 16 | 6 | 22 |
| 2018 March | 13 | 4 | 17 |
| 2018 February | 5 | 11 | 16 |
| 2018 January | 7 | 10 | 17 |
| 2017 December | 3 | 5 | 8 |
| 2017 November | 2 | 9 | 11 |
| 2017 October | 6 | 9 | 15 |
| 2017 September | 2 | 14 | 16 |
| 2017 August | 4 | 12 | 16 |
| 2017 July | 2 | 5 | 7 |
| 2017 June | 7 | 11 | 18 |
| 2017 May | 4 | 10 | 14 |
| 2017 April | 2 | 3 | 5 |
| 2017 March | 4 | 22 | 26 |
| 2017 February | 3 | 3 | 6 |
| 2017 January | 4 | 7 | 11 |
| 2016 December | 10 | 6 | 16 |
| 2016 November | 12 | 10 | 22 |
| 2016 October | 8 | 12 | 20 |
| 2016 September | 7 | 12 | 19 |
| 2016 August | 10 | 6 | 16 |
| 2016 July | 4 | 5 | 9 |
| 2016 March | 1 | 0 | 1 |
| 2016 February | 1 | 0 | 1 |
| 2015 December | 2 | 0 | 2 |
| 2015 October | 60 | 20 | 80 |
| 2015 September | 72 | 21 | 93 |
| 2015 August | 50 | 9 | 59 |
| 2015 July | 90 | 15 | 105 |
| 2015 June | 48 | 12 | 60 |
| 2015 May | 75 | 15 | 90 |
| 2015 April | 64 | 13 | 77 |
| 2015 March | 65 | 11 | 76 |
| 2015 February | 49 | 12 | 61 |
| 2015 January | 65 | 11 | 76 |
| 2014 December | 74 | 14 | 88 |
| 2014 November | 67 | 14 | 81 |
| 2014 October | 63 | 18 | 81 |
| 2014 September | 76 | 10 | 86 |
| 2014 August | 59 | 13 | 72 |
| 2014 July | 50 | 20 | 70 |
| 2014 June | 66 | 15 | 81 |
| 2014 May | 75 | 14 | 89 |
| 2014 April | 73 | 6 | 79 |
| 2014 March | 78 | 11 | 89 |
| 2014 February | 87 | 9 | 96 |
| 2014 January | 71 | 9 | 80 |
| 2013 December | 61 | 8 | 69 |
| 2013 November | 53 | 11 | 64 |
| 2013 October | 50 | 18 | 68 |
| 2013 September | 51 | 12 | 63 |
| 2013 August | 54 | 20 | 74 |
| 2013 July | 63 | 12 | 75 |
| 2013 June | 43 | 11 | 54 |
| 2013 May | 46 | 7 | 53 |
| 2013 April | 28 | 10 | 38 |
| 2013 March | 18 | 1 | 19 |
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