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    "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
    "titulo" => "Lung Transplantation and the Development of Diabetes Mellitus in Adult Patients With Cystic Fibrosis"
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        "autoresLista" => "Mar&#237;a Soledad Navas de Sol&#237;s, Juan Francisco Merino Torres, Isabel Mascarell Mart&#237;nez, Francisco Pi&#241;&#243;n Sell&#233;s"
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            "nombre" => "Mar&#237;a Soledad Navas"
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          3 => array:2 [
            "nombre" => "Francisco Pi&#241;&#243;n"
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            "entidad" => "Servicio de Endocrinolog&#237;a y Nutrici&#243;n&#44; Hospital Universitario La Fe&#44; Valencia&#44; Spain"
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            "correspondencia" => "Correspondence&#58; Dr&#46; J&#46;F&#46; Merino Torres&#46; Servicio de Endocrinolog&#237;a y Nutrici&#243;n&#46; Hospital Universitario La Fe&#46; Avda&#46; Campanar&#44; 21&#46; 46009 Valencia&#46; Espa&#241;a"
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    "fechaRecibido" => "2005-12-20"
    "fechaAceptado" => "2006-05-16"
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          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec154784"
          "palabras" => array:3 [
            0 => "Cystic-fibrosis-related diabetes"
            1 => "Diabetes and cystic fibrosis"
            2 => "Post-transplantation diabetes mellitus"
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            0 => "Fibrosis qu&#237;stica"
            1 => "Diabetes relacionada con fibrosis qu&#237;stica"
            2 => "Diabetes mellitus postrasplante"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">The prevalence of diabetes mellitus is higher in patients with cystic fibrosis than in the general population&#46;</p><p class="elsevierStyleSimplePara elsevierViewall">Solid organ transplantation is a significant risk factor for diabetes mellitus&#44; which has been linked to type of immunosuppression&#46; The aim of this study was to analyze whether lung transplantation represents a significant risk factor for the onset of abnormal carbohydrate metabolism in cystic fibrosis&#44; whether it affects severity of alterations&#44; and whether there is a relation to type of immunosuppression&#46;</p> <span class="elsevierStyleSectionTitle">Patients and Methods</span><p class="elsevierStyleSimplePara elsevierViewall">The following data were extracted retrospectively for 54 patients with cystic fibrosis&#58; type of carbohydrate metabolism alteration and treatment received&#44; whether or not transplantation took place&#44; and type of immunosuppression used&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Twenty of the 54 patients &#40;37&#37;&#41; underwent lung transplantation&#59; 18 of them &#40;89&#37;&#41; developed diabetes mellitus&#46; Eight of the patients &#40;24&#37;&#41; who did not receive a lung developed diabetes and 10 &#40;29&#37;&#41; displayed carbohydrate intolerance &#40;P&#60;&#46;01&#44; &#967;<span class="elsevierStyleSup">2</span> test&#41;&#46; Insulin was administered to 36&#46;3&#37; of nontransplanted patients and 78&#46;6&#37; of transplanted patients&#46; The influence of immunosuppressant used was analyzed in 15 patients&#46; Nine out of 10 patients &#40;90&#37;&#41; treated with cyclosporine and 4 out of 5 &#40;80&#37;&#41; of those treated with tacrolimus developed diabetes mellitus&#46; All received the same regimen of corticosteroid therapy&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">For cystic fibrosis patients&#44; lung transplantation is a significant risk factor for developing abnormal carbohydrate metabolism and it influences severity and treatment&#46; No significant differences in the frequency of development of diabetes mellitus were found in relation to type of immunosuppression&#46;</p>"
      ]
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">La prevalencia de diabetes mellitus &#40;DM&#41; en pacientes con fibrosis qu&#237;stica &#40;FQ&#41; es mayor que en la poblaci&#243;n general&#46;</p><p class="elsevierStyleSimplePara elsevierViewall">El trasplante de &#243;rganos s&#243;lidos es un factor de riesgo importante para el desarrollo de DM y se ha relacionado con el tipo de inmunodepresi&#243;n&#46; El objetivo del estudio ha sido analizar si el trasplante pulmonar &#40;TP&#41; es un factor de riesgo importante para desarrollar alteraci&#243;n hidrocarbonada en la FQ&#44; si influye en su gravedad y tratamiento&#44; y si existe relaci&#243;n con el tipo de inmunodepresi&#243;n&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y M&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se estudi&#243; retrospectivamente a 54 pacientes adultos con FQ&#44; sobre los que se recogieron los siguientes datos&#58; tipo de alteraci&#243;n hidrocarbonada y su tratamiento&#44; existencia o no de TP y tipo de inmunodepresi&#243;n&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">De los 54 pacientes&#44; 20 recibieron TP &#40;37&#37;&#41;&#46; De &#233;stos&#44; el 89&#37; &#40;n &#61; 18&#41; present&#243; DM&#46; Entre aquellos que no recibieron TP&#44; el 24&#37; &#40;n &#61; 8&#41; present&#243; DM y el 29&#37; &#40;n &#61; 10&#41; intolerancia hidrocarbonada &#40;p &#60; 0&#44;01&#59; prueba de &#967;<span class="elsevierStyleSup">2</span>&#41;&#46; Se paut&#243; insulina al 36&#44;3&#37; de los pacientes sin TP y al 78&#44;6&#37; de los trasplantados&#46; La influencia de la inmunodepresi&#243;n se analiz&#243; en 15 pacientes&#46; Desarrollaron DM el 90&#37; &#40;9&#47;10&#41; de los tratados con ciclosporina y el 80&#37; &#40;4&#47;5&#41; de los tratados con tacrolimus&#46; Todos llevaban la misma pauta de corticoterapia&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">El TP es un factor de riesgo importante para el desarrollo de alteraci&#243;n hidrocarbonada en pacientes con FQ e influye en su gravedad y tratamiento&#46; No hemos encontrado diferencia significativa entre el tipo de inmunodepresi&#243;n y la aparici&#243;n de DM&#46;</p>"
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                      "titulo" => "New-onset diabetes after transplantation&#58; 2003 International Consensus Guidelines"
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