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    "titulo" => "Lung Transplantation and the Development of Diabetes Mellitus in Adult Patients With Cystic Fibrosis"
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            0 => "Cystic-fibrosis-related diabetes"
            1 => "Diabetes and cystic fibrosis"
            2 => "Post-transplantation diabetes mellitus"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">The prevalence of diabetes mellitus is higher in patients with cystic fibrosis than in the general population&#46; Solid organ transplantation is a significant risk factor for diabetes mellitus&#44; which has been linked to type of immunosuppression&#46; The aim of this study was to analyze whether lung transplantation represents a significant risk factor for the onset of abnormal carbohydrate metabolism in cystic fibrosis&#44; whether it affects severity of alterations&#44; and whether there is a relation to type of immunosuppression&#46;</p> <span class="elsevierStyleSectionTitle">Patients and Methods</span><p class="elsevierStyleSimplePara elsevierViewall">The following data were extracted retrospectively for 54 patients with cystic fibrosis&#58; type of carbohydrate metabolism alteration and treatment received&#44; whether or not transplantation took place&#44; and type of immunosuppression used&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Twenty of the 54 patients &#40;37&#37;&#41; underwent lung transplantation&#59; 18 of them &#40;89&#37;&#41; developed diabetes mellitus&#46; Eight of the patients &#40;24&#37;&#41; who did not receive a lung developed diabetes and 10 &#40;29&#37;&#41; displayed carbohydrate intolerance &#40;P&#60;&#46;01&#44; &#967;<span class="elsevierStyleSup">2</span> test&#41;&#46; Insulin was administered to 36&#46;3&#37; of nontransplanted patients and 78&#46;6&#37; of transplanted patients&#46; The influence of immunosuppressant used was analyzed in 15 patients&#46; Nine out of 10 patients &#40;90&#37;&#41; treated with cyclosporine and 4 out of 5 &#40;80&#37;&#41; of those treated with tacrolimus developed diabetes mellitus&#46; All received the same regimen of corticosteroid therapy&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">For cystic fibrosis patients&#44; lung transplantation is a significant risk factor for developing abnormal carbohydrate metabolism and it influences severity and treatment&#46; No significant differences in the frequency of development of diabetes mellitus were found in relation to type of immunosuppression&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">La prevalencia de diabetes mellitus &#40;DM&#41; en pacientes con fibrosis quistica &#40;FQ&#41; es mayor que en la poblacion general&#46;</p><p class="elsevierStyleSimplePara elsevierViewall">El trasplante de organos solidos es un factor de riesgo importante para el desarrollo de DM y se ha relacionado con el tipo de inmunodepresion&#46; El objetivo del estudio ha sido analizar si el trasplante pulmonar &#40;TP&#41; es un factor de riesgo importante para desarrollar alteracion hidrocarbonada en la FQ&#44; si influye en su gravedad y tratamiento&#44; y si existe relacion con el tipo de inmunodepresion&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y M&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se estudio retrospectivamente a 54 pacientes adultos con FQ&#44; sobre los que se recogieron los siguientes datos&#58; tipo de alteracion hidrocarbonada y su tratamiento&#44; existencia o no de TP y tipo de inmunodepresion&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">De los 54 pacientes&#44; 20 recibieron TP &#40;37&#37;&#41;&#46; De estos&#44; el 89&#37; &#40;n &#61; 18&#41; presento DM&#46; Entre aquellos que no recibieron TP&#44; el 24&#37; &#40;n &#61; 8&#41; presento DM y el 29&#37; &#40;n &#61; 10&#41; intolerancia hidrocarbonada &#40;p &#60; 0&#44;01&#59; prueba de &#967;<span class="elsevierStyleSup">2</span>&#41;&#46; Se pauto insulina al 36&#44;3&#37; de los pacientes sin TP y al 78&#44;6&#37; de los trasplantados&#46; La influencia de la inmunodepresion se analizo en 15 pacientes&#46; Desarrollaron DM el 90&#37; &#40;9&#47;10&#41; de los tratados con ciclosporina y el 80&#37; &#40;4&#47;5&#41; de los tratados con tacrolimus&#46; Todos llevaban la misma pauta de corticoterapia&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">El TP es un factor de riesgo importante para el desarrollo de alteracion hidrocarbonada en pacientes con FQ e influye en su gravedad y tratamiento&#46; No hemos encontrado diferencia significativa entre el tipo de inmunodepresion y la aparicion de DM&#46;</p>"
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                          "autores" => array:3 [
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                        "paginaInicial" => "1992"
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                0 => array:2 [
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "R Barrio Castellanos"
                            1 => "A Cos Blanco"
                            2 => "E Garcia Garcia"
                            3 => "M Gussinye Canadell"
                            4 => "JF Merino Torres"
                            5 => "MT Munoz Calvo"
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                        ]
                      ]
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                            0 => "S Tofe"
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                          "autores" => array:6 [
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                            1 => "J Madill"
                            2 => "C Chaparro"
                            3 => "A Tsang"
                            4 => "TK Waddell"
                            5 => "LG Singer"
                          ]
                        ]
                      ]
                    ]
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                        "paginaInicial" => "773"
                        "paginaFinal" => "778"
                        "link" => array:1 [
                          0 => array:2 [
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                      "titulo" => "Assessment of insulin sensitivity and beta-cell function from measurements in the fasting state and during an oral glucose tolerance test"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M Albareda"
                            1 => "J Rodriguez-Espinosa"
                            2 => "M Murugo"
                            3 => "A de Leiva"
                            4 => "R Corcoy"
                          ]
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                        "paginaFinal" => "1511"
                        "link" => array:1 [
                          0 => array:2 [
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                      "titulo" => "HbAlc is not recommended as a screening test for diabetes in cystic fibrosis"
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                          "autores" => array:5 [
                            0 => "RW Holl"
                            1 => "C Buck"
                            2 => "C Babka"
                            3 => "A Wolf"
                            4 => "A Thon"
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                      "Revista" => array:5 [
                        "tituloSerie" => "Diabetes Care"
                        "fecha" => "2000"
                        "volumen" => "23"
                        "paginaInicial" => "126"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10857984"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diagnosis&#44; screening and management of cystic fibrosis related diabetes mellitus&#46; A consensus conference report"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A Moran"
                            1 => "D Hardin"
                            2 => "D Rodman"
                            3 => "HF Allen"
                            4 => "RJ Beall"
                            5 => "D Borowitz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Diabetes Res Clin Pract"
                        "fecha" => "1999"
                        "volumen" => "45"
                        "paginaInicial" => "61"
                        "paginaFinal" => "73"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10499886"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "On behalf of the International Expert Panel on New-Onset Diabetes After Transplantation&#46; New-onset diabetes after transplantation 2003 International Consensus Guidelines&#58; an endocrinologist&#39;s view"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "JA Davidson"
                            1 => "A Wilkinson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Diabetes Care"
                        "fecha" => "2004"
                        "volumen" => "27"
                        "paginaInicial" => "805"
                        "paginaFinal" => "812"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14988309"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "New-onset diabetes after transplantation&#58; 2003 International Consensus Guidelines"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J Davidson"
                            1 => "A Wilkinson"
                            2 => "J Dantal"
                            3 => "F Dotta"
                            4 => "H Haller"
                            5 => "D Hernandez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.TP.0000043982.08656.81"
                      "Revista" => array:7 [
                        "tituloSerie" => "Transplantation"
                        "fecha" => "2003"
                        "volumen" => "75"
                        "numero" => "Suppl"
                        "paginaInicial" => "3"
                        "paginaFinal" => "24"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12544863"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Glucose intolerance in children with cystic fibrosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "MP Solomon"
                            1 => "DC Wilson"
                            2 => "M Corey"
                            3 => "D Kalnins"
                            4 => "J Zielenski"
                            5 => "LC Tsui"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1067/mpd.2003.5"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pediatr"
                        "fecha" => "2003"
                        "volumen" => "142"
                        "paginaInicial" => "128"
                        "paginaFinal" => "132"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12584532"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cystic fibrosis-related diabetes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "AD Mackie"
                            1 => "SJ Thornton"
                            2 => "FP Edenborough"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Diabet Med"
                        "fecha" => "2003"
                        "volumen" => "20"
                        "paginaInicial" => "425"
                        "paginaFinal" => "436"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12786675"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Trastomos en el metabolismo hidrocarbonado en la fibrosis quistica"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R Barrio Castellanos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Hormona y Factores de Crecimiento"
                        "fecha" => "2005"
                        "volumen" => "8"
                        "numero" => "1"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lung transplantation for cystic fibrosis&#58; 6-year follow-up"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S Quattmcci"
                            1 => "M Rolla"
                            2 => "G Cimino"
                            3 => "S Bertasi"
                            4 => "S Cingolani"
                            5 => "F Scalercio"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Cys Fibres"
                        "fecha" => "2005"
                        "volumen" => "4"
                        "paginaInicial" => "107"
                        "paginaFinal" => "114"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cystic fibrosis-related diabetes&#58; the role of peripheral insulin resistance and beta-cell dysfunction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "B Yung"
                            1 => "FH Noormohamed"
                            2 => "M Kemp"
                            3 => "J Hooper"
                            4 => "AF Iant"
                            5 => "ME Hodson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Diabet Med"
                        "fecha" => "2002"
                        "volumen" => "19"
                        "paginaInicial" => "221"
                        "paginaFinal" => "226"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11963922"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mechanisms of insulin resistance in cystic fibrosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "DS Hardin"
                            1 => "A Ieblanc"
                            2 => "G Marshall"
                            3 => "DK Seilheimer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Physiol Endocrinol Metab"
                        "fecha" => "2001"
                        "volumen" => "281"
                        "paginaInicial" => "E1022"
                        "paginaFinal" => "E1028"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11595659"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hepatic insulin resistance and defects in substrate utilization in cystic fibrosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "DS Hardin"
                            1 => "A Ieblanc"
                            2 => "L Para"
                            3 => "DK Seilheimer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Diabetes"
                        "fecha" => "1999"
                        "volumen" => "48"
                        "paginaInicial" => "1082"
                        "paginaFinal" => "1087"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10331413"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "New-onset diabetes after transplantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "MD Piero Marchetti"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.healun.2004.03.007"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Heart Lung Transplant"
                        "fecha" => "2004"
                        "volumen" => "23"
                        "paginaInicial" => "S194"
                        "paginaFinal" => "S201"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15093805"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Posttransplant diabetes mellitus in pediatric thoracic organ recipients receiving tacrolimus-based immunosuppression"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "JA Paolillo"
                            1 => "G Boyle"
                            2 => "Y Iaw"
                            3 => "S Miller"
                            4 => "K Iawrence"
                            5 => "K Wagner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Transplantation"
                        "fecha" => "2001"
                        "volumen" => "71"
                        "paginaInicial" => "252"
                        "paginaFinal" => "256"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11213069"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diabetes mellitus after kidney transplantation in the United States"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "BL Kasiske"
                            1 => "JJ Zinder"
                            2 => "D Gilbertson"
                            3 => "AJ Matas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Transplant"
                        "fecha" => "2003"
                        "volumen" => "3"
                        "paginaInicial" => "178"
                        "paginaFinal" => "185"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12603213"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "New onset diabetes mellitus in patients receiving calcineurin inhibitors&#58; a systematic review and meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "O Heisel"
                            1 => "R Heisel"
                            2 => "R Balshaw"
                            3 => "P Keown"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1046/j.1600-6143.2003.00372.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Transplant"
                        "fecha" => "2004"
                        "volumen" => "4"
                        "paginaInicial" => "583"
                        "paginaFinal" => "595"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15023151"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tacrolimus &#40;FK506&#41; as primary immunosuppressant after lung transplantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F Kur"
                            1 => "H Reichenspumer"
                            2 => "BM Meiser"
                            3 => "A Welz"
                            4 => "H Fiirst"
                            5 => "C Miiller"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1055/s-2007-1013136"
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorac Cardiovasc Surg"
                        "fecha" => "1999"
                        "volumen" => "47"
                        "paginaInicial" => "174"
                        "paginaFinal" => "178"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10443520"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "High incidence of tacrolimus-associated posttransplantation diabetes in the Korean renal allograft recipients according to American Diabetes Association criteria"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "YM Cho"
                            1 => "KS Park"
                            2 => "HS Jung"
                            3 => "HJ Jean"
                            4 => "C Ahn"
                            5 => "J Ha"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Diabetes Care"
                        "fecha" => "2003"
                        "volumen" => "26"
                        "paginaInicial" => "1123"
                        "paginaFinal" => "1128"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12663584"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Immediate conversion from tacrolimus to cyclosporine in the treatment of posttransplantation diabetes mellitus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J Oberholzer"
                            1 => "J Thielke"
                            2 => "B Hatipoglu"
                            3 => "G Testa"
                            4 => "HN Sankary"
                            5 => "E Benedetti"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.transproceed.2004.12.085"
                      "Revista" => array:6 [
                        "tituloSerie" => "Transplant Proc"
                        "fecha" => "2005"
                        "volumen" => "37"
                        "paginaInicial" => "999"
                        "paginaFinal" => "1000"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15848603"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tacrolimus based immunosuppression"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M Roy First"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "J Nephrol"
                        "fecha" => "2004"
                        "volumen" => "17"
                        "numero" => "Suppl 8"
                        "paginaInicial" => "25"
                        "paginaFinal" => "31"
                        "itemHostRev" => array:3 [
                          "pii" => "S1529943009000084"
                          "estado" => "S300"
                          "issn" => "15299430"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
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