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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">The aim of this study was to determine the impact of chronic obstructive pulmonary disease &#40;COPD&#41; on activities of daily living in a large group of patients in Spain who responded to a specific questionnaire&#46; A second aim was to explore the practical utility of the questionnaire and determine which variables could be used to identify &#8220;fragile&#8221; patients or patients in greater need of attention&#46; To do this&#44; we examined the relationship between questionnaire results and clinical variables&#44; lung function measurements&#44; socioeconomic status&#44; and validated quality of life questionnaires&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p class="elsevierStyleSimplePara elsevierViewall">We conducted an observational&#44; descriptive&#44; multicenter&#44; cross-sectional study in which 227 respiratory specialists from all over Spain collected data from 1057 patients with COPD&#46; Each patient was given a specific questionnaire containing 7 items that measured the extent to which COPD affected different aspects of their lives&#46; The patients rated each item on a scale of 0 to 2&#44; depending on the level of impact&#46; Total possible scores&#44; thus&#44; ranged from 0 to 14&#44; and patients with a score of 9 or higher were classified as fragile&#46; We then explored the relationship between questionnaire results and clinical variables&#44; socioeconomic status&#44; spirometric values&#44; and quality of life as measured by the St George&#39;s Respiratory Questionnaire &#40;SGRQ&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">We studied 1057 patients &#40;95&#46;2&#37; male&#41; with a mean &#40;SD&#41; age of 67 &#40;9&#41; years and a mean predicted forced expiratory volume in 1 second &#40;FEV<span class="elsevierStyleInf">1</span>&#41; of 41&#46;8&#37; &#40;13&#46;3&#37;&#41;&#46; The mean questionnaire score was 6&#46;3 &#40;3&#46;1&#41;&#46; The activities that were affected most were sport and leisure&#44; habitual physical activity&#44; and sex life &#40;major impact reported by 52&#46;5&#37;&#44; 30&#46;3&#37;&#44; and 20&#46;2&#37; of patients&#44; respectively&#41;&#46; We found a correlation between questionnaire scores and known disease severity markers such as SGRQ scores&#44; dyspnea&#44; number of exacerbations&#44; and FEV<span class="elsevierStyleInf">1</span> in liters&#46; Patients included in the fragile category were older and had a lower socioeconomic status&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">COPD impact questionnaire scores correlated well with SGRQ scores and the usual clinical variables and lung function measurements for evaluating disease severity &#40;dyspnea&#44; FEV<span class="elsevierStyleInf">1</span>&#44; and exacerbations&#41;&#46; The questionnaire could&#44; therefore&#44; be a useful tool for identifying fragile patients who&#44; in addition to having poorer clinical status and lung function measurements&#44; have a lower socioeconomic status&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Realizamos el estudio con el prop&#243;sito de conocer&#44; a trav&#233;s de un cuestionario espec&#237;fico&#44; el impacto de la enfermedad pulmonar obstructiva cr&#243;nica &#40;EPOC&#41; sobre las actividades de la vida diaria en un grupo amplio de pacientes en Espa&#241;a&#46; Asimismo estudiamos su relaci&#243;n con par&#225;metros cl&#237;nicos&#44; funcionales y socioecon&#243;micos&#44; y con escalas validadas de calidad de vida&#44; para evaluar su utilidad en la pr&#225;ctica habitual y determinar qu&#233; variables pueden definir a los pacientes &#8220;fr&#225;giles&#8221; o que requieren una mayor atenci&#243;n&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha realizado un estudio observacional&#44; descriptivo&#44; multic&#233;ntrico y transversal&#44; con la participaci&#243;n de 227 neum&#243;logos de toda Espa&#241;a&#44; que incluy&#243; a pacientes con el diagn&#243;stico de EPOC&#46; A todos &#233;stos se les pas&#243; un cuestionario espec&#237;fico con 7 preguntas que med&#237;an el impacto de la enfermedad sobre aspectos de la vida diaria Las respuestas se valoraron de 0 a 2&#44; seg&#250;n el grado de afectaci&#243;n&#44; lo que supone un intervalo entre 0 y 14 unidades&#46; Definimos al paciente como &#8220;fr&#225;gil&#8221; si presentaba valores iguales o mayores de 9 en el cuestionario de impacto&#46; Se evalu&#243; la relaci&#243;n entre la escala de impacto y variables cl&#237;nicas&#44; situaci&#243;n socioecon&#243;mica&#44; espirometr&#237;a y calidad de vida medida con el cuestionario espec&#237;fico St&#46; George&#39;s Respiratory Questionnaire &#40;SGRQ&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Estudiamos a 1&#46;057 pacientes &#40;un 95&#44;2&#37; varones&#41;&#44; con una edad media &#40;&#177; desviaci&#243;n est&#225;ndar&#41; de 67 &#177; 9 a&#241;os y volumen espiratorio forzado en el primer segundo &#40;FEV<span class="elsevierStyleInf">1</span>&#41;&#44; expresado en porcentaje&#44; del 41&#44;8 &#177; 13&#44;3&#37;&#46; La puntuaci&#243;n media del cuestionario de impacto fue de 6&#44;3 &#177; 3&#44;1&#46; Las actividades con mayor afectaci&#243;n fueron deporte y ocio&#44; actividad f&#237;sica habitual y vida sexual &#40;mucha afectaci&#243;n en el 52&#44;5&#44; el 30&#44;3 y el 20&#44;2&#37; de los pacientes&#44; respectivamente&#41;&#46; Encontramos relaci&#243;n entre la puntuaci&#243;n del cuestionario y par&#225;metros conocidos de gravedad &#40;SGRQ&#44; disnea&#44; n&#250;mero de agudizaciones y FEV<span class="elsevierStyleInf">1</span> expresado en litros&#41;&#46; Los pacientes definidos como fr&#225;giles ten&#237;an mayor edad y menor nivel tanto cultural como econ&#243;mico&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">El cuestionario de impacto de la EPOC se correlaciona bien con los cl&#225;sicos par&#225;metros cl&#237;nicos y funcionales de valoraci&#243;n de la gravedad de la enfermedad &#40;disnea&#44; FEV<span class="elsevierStyleInf">1</span> y exacerbaciones&#41; y con el cuestionario de calidad de vida relacionada con la salud SGRQ&#46; As&#237; pues&#44; podr&#237;a ser un instrumento &#250;til para identificar un perfil de paciente fr&#225;gil&#44; que presenta&#44; adem&#225;s de una peor situaci&#243;n cl&#237;nica y funcional&#44; una situaci&#243;n socioecon&#243;mica m&#225;s desfavorecida&#46;</p>"
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Original Article
Impact of Chronic Obstructive Pulmonary Disease on Activities of Daily Living: Results of the Multicenter EIME Study
Francisco Javier Álvarez-Gutiérreza,
Corresponding author
fag01se@saludalia.com

Correspondence: Dr. F.J. Álvarez-Gutiérrez. Alcalde Manuel del Valle, Edificio Cónsul, portal 6, 1.°, A. 41008 Sevilla. España
, Marc Miravitllesb, Miriam Callec, Elena Gobarttd, Francisco Lópeze, Antonio Martínf, the EIME Study Group *
a Servicio de Neumología, Red Respira RTIC 03/11 ISCIII, Hospital Virgen del Rocío, Sevilla. Spain
b Servei de Pneumologia, Institut Clínic del Tòrax (IDIBAPS), Red Respira RTIC 03/11 ISCIII, Hospital Clínic, Barcelona, Spain
c Servicio de Neumología. Red Respira RTIC 03/11 ISCIII, Hospital Clínico San Carlos, Madrid, Spain
d R&D Department, Boehringer Ingelheim, Barcelona, Spain
e Nufarm 21, Madrid, Spain
f R&D Department, Pfizer, Madrid, Spain
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">The aim of this study was to determine the impact of chronic obstructive pulmonary disease &#40;COPD&#41; on activities of daily living in a large group of patients in Spain who responded to a specific questionnaire&#46; A second aim was to explore the practical utility of the questionnaire and determine which variables could be used to identify &#8220;fragile&#8221; patients or patients in greater need of attention&#46; To do this&#44; we examined the relationship between questionnaire results and clinical variables&#44; lung function measurements&#44; socioeconomic status&#44; and validated quality of life questionnaires&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p class="elsevierStyleSimplePara elsevierViewall">We conducted an observational&#44; descriptive&#44; multicenter&#44; cross-sectional study in which 227 respiratory specialists from all over Spain collected data from 1057 patients with COPD&#46; Each patient was given a specific questionnaire containing 7 items that measured the extent to which COPD affected different aspects of their lives&#46; The patients rated each item on a scale of 0 to 2&#44; depending on the level of impact&#46; Total possible scores&#44; thus&#44; ranged from 0 to 14&#44; and patients with a score of 9 or higher were classified as fragile&#46; We then explored the relationship between questionnaire results and clinical variables&#44; socioeconomic status&#44; spirometric values&#44; and quality of life as measured by the St George&#39;s Respiratory Questionnaire &#40;SGRQ&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">We studied 1057 patients &#40;95&#46;2&#37; male&#41; with a mean &#40;SD&#41; age of 67 &#40;9&#41; years and a mean predicted forced expiratory volume in 1 second &#40;FEV<span class="elsevierStyleInf">1</span>&#41; of 41&#46;8&#37; &#40;13&#46;3&#37;&#41;&#46; The mean questionnaire score was 6&#46;3 &#40;3&#46;1&#41;&#46; The activities that were affected most were sport and leisure&#44; habitual physical activity&#44; and sex life &#40;major impact reported by 52&#46;5&#37;&#44; 30&#46;3&#37;&#44; and 20&#46;2&#37; of patients&#44; respectively&#41;&#46; We found a correlation between questionnaire scores and known disease severity markers such as SGRQ scores&#44; dyspnea&#44; number of exacerbations&#44; and FEV<span class="elsevierStyleInf">1</span> in liters&#46; Patients included in the fragile category were older and had a lower socioeconomic status&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">COPD impact questionnaire scores correlated well with SGRQ scores and the usual clinical variables and lung function measurements for evaluating disease severity &#40;dyspnea&#44; FEV<span class="elsevierStyleInf">1</span>&#44; and exacerbations&#41;&#46; The questionnaire could&#44; therefore&#44; be a useful tool for identifying fragile patients who&#44; in addition to having poorer clinical status and lung function measurements&#44; have a lower socioeconomic status&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Realizamos el estudio con el prop&#243;sito de conocer&#44; a trav&#233;s de un cuestionario espec&#237;fico&#44; el impacto de la enfermedad pulmonar obstructiva cr&#243;nica &#40;EPOC&#41; sobre las actividades de la vida diaria en un grupo amplio de pacientes en Espa&#241;a&#46; Asimismo estudiamos su relaci&#243;n con par&#225;metros cl&#237;nicos&#44; funcionales y socioecon&#243;micos&#44; y con escalas validadas de calidad de vida&#44; para evaluar su utilidad en la pr&#225;ctica habitual y determinar qu&#233; variables pueden definir a los pacientes &#8220;fr&#225;giles&#8221; o que requieren una mayor atenci&#243;n&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha realizado un estudio observacional&#44; descriptivo&#44; multic&#233;ntrico y transversal&#44; con la participaci&#243;n de 227 neum&#243;logos de toda Espa&#241;a&#44; que incluy&#243; a pacientes con el diagn&#243;stico de EPOC&#46; A todos &#233;stos se les pas&#243; un cuestionario espec&#237;fico con 7 preguntas que med&#237;an el impacto de la enfermedad sobre aspectos de la vida diaria Las respuestas se valoraron de 0 a 2&#44; seg&#250;n el grado de afectaci&#243;n&#44; lo que supone un intervalo entre 0 y 14 unidades&#46; Definimos al paciente como &#8220;fr&#225;gil&#8221; si presentaba valores iguales o mayores de 9 en el cuestionario de impacto&#46; Se evalu&#243; la relaci&#243;n entre la escala de impacto y variables cl&#237;nicas&#44; situaci&#243;n socioecon&#243;mica&#44; espirometr&#237;a y calidad de vida medida con el cuestionario espec&#237;fico St&#46; George&#39;s Respiratory Questionnaire &#40;SGRQ&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Estudiamos a 1&#46;057 pacientes &#40;un 95&#44;2&#37; varones&#41;&#44; con una edad media &#40;&#177; desviaci&#243;n est&#225;ndar&#41; de 67 &#177; 9 a&#241;os y volumen espiratorio forzado en el primer segundo &#40;FEV<span class="elsevierStyleInf">1</span>&#41;&#44; expresado en porcentaje&#44; del 41&#44;8 &#177; 13&#44;3&#37;&#46; La puntuaci&#243;n media del cuestionario de impacto fue de 6&#44;3 &#177; 3&#44;1&#46; Las actividades con mayor afectaci&#243;n fueron deporte y ocio&#44; actividad f&#237;sica habitual y vida sexual &#40;mucha afectaci&#243;n en el 52&#44;5&#44; el 30&#44;3 y el 20&#44;2&#37; de los pacientes&#44; respectivamente&#41;&#46; Encontramos relaci&#243;n entre la puntuaci&#243;n del cuestionario y par&#225;metros conocidos de gravedad &#40;SGRQ&#44; disnea&#44; n&#250;mero de agudizaciones y FEV<span class="elsevierStyleInf">1</span> expresado en litros&#41;&#46; Los pacientes definidos como fr&#225;giles ten&#237;an mayor edad y menor nivel tanto cultural como econ&#243;mico&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">El cuestionario de impacto de la EPOC se correlaciona bien con los cl&#225;sicos par&#225;metros cl&#237;nicos y funcionales de valoraci&#243;n de la gravedad de la enfermedad &#40;disnea&#44; FEV<span class="elsevierStyleInf">1</span> y exacerbaciones&#41; y con el cuestionario de calidad de vida relacionada con la salud SGRQ&#46; As&#237; pues&#44; podr&#237;a ser un instrumento &#250;til para identificar un perfil de paciente fr&#225;gil&#44; que presenta&#44; adem&#225;s de una peor situaci&#243;n cl&#237;nica y funcional&#44; una situaci&#243;n socioecon&#243;mica m&#225;s desfavorecida&#46;</p>"
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