Original Articles
Overall Long-Term Survival in Lung Cancer Analyzed in 610 Unselected Patients
J. Sánchez de Cos Escuín
, C. Disdier Vicente, J. Corral Peñafiel, J.A. Riesco Miranda, M.A. Sojo González, J.F. Masa Jiménez
Corresponding author
juli1949@separ.es
Correspondence: Dr. J. Sánchez de Cos Escuín. Isla de Hierro, 2, 3.°C. 10001 Cáceres. España
Correspondence: Dr. J. Sánchez de Cos Escuín. Isla de Hierro, 2, 3.°C. 10001 Cáceres. España
Hospital San Pedro de Alcántara, Cáceres, Spain
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Durán-Cantolla, J. Mar, G. de la Torre Muñecas, R. Rubio Aramendi, L. Guerra" "autores" => array:5 [ 0 => array:3 [ "preGrado" => "Dr" "nombre" => "J." "apellidos" => "Durán-Cantolla" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Mar" ] 2 => array:2 [ "nombre" => "G." "apellidos" => "de la Torre Muñecas" ] 3 => array:2 [ "nombre" => "R." "apellidos" => "Rubio Aramendi" ] 4 => array:2 [ "nombre" => "L." 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"apellidos" => "Sánchez de Cos Escuín" "email" => array:1 [ 0 => "juli1949@separ.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Disdier Vicente" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Corral Peñafiel" ] 3 => array:2 [ "nombre" => "J.A." "apellidos" => "Riesco Miranda" ] 4 => array:2 [ "nombre" => "M.A." "apellidos" => "Sojo González" ] 5 => array:2 [ "nombre" => "J.F." "apellidos" => "Masa Jiménez" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Hospital San Pedro de Alcántara, Cáceres, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dr. J. Sánchez de Cos Escuín. Isla de Hierro, 2, 3.°C. 10001 Cáceres. España" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2003-09-04" "fechaAceptado" => "2003-12-03" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec153436" "palabras" => array:3 [ 0 => "Lung cancer" 1 => "Overall survival" 2 => "Unselected patients" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec153435" "palabras" => array:3 [ 0 => "Cáncer de pulmón" 1 => "Supervivencia global" 2 => "Pacientes no seleccionados" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Introduction and Objectives</span><p class="elsevierStyleSimplePara elsevierViewall">Many studies of lung cancer survival are carried out in patients selected for certain features that usually influence prognosis favorably. The objective of this study was to assess the overall survival of unselected patients with a diagnosis of lung cancer in our practice.</p> <span class="elsevierStyleSectionTitle">Patients and Methods</span><p class="elsevierStyleSimplePara elsevierViewall">We studied 610 patients for whom survival information was available, a population comprising 88% of the 694 with lung cancer diagnosed in our hospital from 1991 through 1998. The variables analyzed for their correlation with survival were age, sex, histology, tumor-node-metastasis (TNM) stage, treatment, and time of diagnosis (with patients grouped by 2-year periods).</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The cases of 596 men and 14 women with a mean age of approximately 67 years were studied. Small cell tumors were found in 141, non-small cell tumors in 447, and other tissue types in 22. Surgical excision was carried out on 118 (19.3%), and treatment was confined to control of symptoms for 6.4% of the patients with small cell tumors and 40.5% of those with non-small cell cancer. Symptomatic treatment alone was more common for patients older than 70 years (52.5%) and less common during the last 2 years of the study period (1997-1998: 19%). Overall 5-year survival was 7.9% (2.8% in small cell cancer and 9.4% in non-small cell cancer). Survival rates were lower in patients over 70 years of age. Significant differences in survival were seen for successive TNM stages, with the exception of IIIA and IIIB. The 1997-1998 period saw better survival rates, at 40.8% after 1 year and 11.2% after 5 years.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The survival rates in lung cancer patients in our hospital practice are low because the rate of surgical resections is low owing to the high percentage of cases found in advanced stages. Our observations are similar to those reported from other European countries.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Introducción y Objetivos</span><p class="elsevierStyleSimplePara elsevierViewall">Muchos estudios sobre la supervivencia en el cáncer de pulmón se refieren a subgrupos de pacientes seleccionados por diferentes criterios que suelen influir favorablemente en la estimación del pronóstico. El objetivo de este trabajo es conocer la supervivencia global de los pacientes diagnosticados en nuestro medio.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">De 694 pacientes diagnosticados de cáncer de pulmón en nuestro centro en el período 1991-1998, se incluyó en el estudio a 610 (88%) con datos de supervivencia. Se analizaron la edad, el sexo, la estirpe histológica, esta-dios, tumor, nódulos, metástasis (TNM), tratamiento aplicado bienio diagnóstico y su relación con la supervivencia.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Se incluyó en el estudio a 596 varones y a 14 mujeres, con una mediana de edad de 67 años. En cuanto a la estirpe del cáncer de pulmón, 141 eran microcíticos, 447 no microcíticos y 22 de otra estirpe. Se operó a 118 pacientes (19,3%). El 6,4% de los casos de cáncer de pulmón microcí-tico y el 40,5% de los no microcíticos recibieron sólo tratamiento sintomático. Éste fue más frecuente en mayores de 70 años (52,5%) y menos habitual durante el último bienio (1997-1998; 19%). La supervivencia a los 5 años del grupo total fue del 7,9% (del 2,8% para los microcíticos y del 9,4% para los no microcíticos). Los mayores de 70 años tuvieron peor supervivencia. Hubo diferencias significativas entre los sucesivos estadios TNM clínico, salvo entre IIIA y IIIB. Los diagnosticados en el período 1997-1998 tuvieron mejor supervivencia (un 40,8% al año y un 11,2% a los 5 años).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">La supervivencia observada, similar a la de otros países europeos, es pobre porque la tasa de resec-ciones quirúrgicas es baja dado el alto porcentaje de estadios avanzados.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:19 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fallecimientos en España por todas las causas (año 2003)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Instituto Nacional de Estadística" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "WWW" => array:1 [ "link" => "Available from: www.ine.es" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mortalidad según la causa en ocho regiones del mundo. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 4 | 9 | 13 |
| 2024 October | 34 | 35 | 69 |
| 2024 September | 30 | 33 | 63 |
| 2024 August | 46 | 42 | 88 |
| 2024 July | 28 | 26 | 54 |
| 2024 June | 37 | 30 | 67 |
| 2024 May | 32 | 27 | 59 |
| 2024 April | 15 | 20 | 35 |
| 2024 March | 20 | 12 | 32 |
| 2024 February | 15 | 19 | 34 |
| 2023 March | 1 | 2 | 3 |
| 2023 February | 22 | 15 | 37 |
| 2023 January | 17 | 23 | 40 |
| 2022 December | 19 | 22 | 41 |
| 2022 November | 21 | 21 | 42 |
| 2022 October | 15 | 27 | 42 |
| 2022 September | 20 | 25 | 45 |
| 2022 August | 17 | 32 | 49 |
| 2022 July | 14 | 39 | 53 |
| 2022 June | 24 | 29 | 53 |
| 2022 May | 14 | 27 | 41 |
| 2022 April | 19 | 23 | 42 |
| 2022 March | 25 | 27 | 52 |
| 2022 February | 15 | 25 | 40 |
| 2022 January | 19 | 30 | 49 |
| 2021 December | 15 | 39 | 54 |
| 2021 November | 15 | 31 | 46 |
| 2021 October | 23 | 44 | 67 |
| 2021 September | 17 | 42 | 59 |
| 2021 August | 13 | 23 | 36 |
| 2021 July | 19 | 25 | 44 |
| 2021 June | 18 | 32 | 50 |
| 2021 May | 12 | 18 | 30 |
| 2021 April | 15 | 49 | 64 |
| 2021 March | 30 | 26 | 56 |
| 2021 February | 9 | 10 | 19 |
| 2021 January | 9 | 13 | 22 |
| 2020 December | 14 | 16 | 30 |
| 2020 November | 6 | 10 | 16 |
| 2020 October | 9 | 5 | 14 |
| 2020 September | 7 | 2 | 9 |
| 2020 August | 29 | 11 | 40 |
| 2020 July | 32 | 12 | 44 |
| 2020 June | 13 | 4 | 17 |
| 2020 May | 29 | 13 | 42 |
| 2020 April | 38 | 6 | 44 |
| 2020 March | 50 | 10 | 60 |
| 2020 February | 68 | 11 | 79 |
| 2020 January | 50 | 8 | 58 |
| 2019 December | 21 | 5 | 26 |
| 2019 November | 14 | 9 | 23 |
| 2019 October | 3 | 5 | 8 |
| 2019 September | 9 | 15 | 24 |
| 2019 August | 18 | 17 | 35 |
| 2019 July | 12 | 14 | 26 |
| 2019 June | 8 | 5 | 13 |
| 2019 May | 8 | 15 | 23 |
| 2019 April | 30 | 36 | 66 |
| 2019 March | 7 | 16 | 23 |
| 2019 February | 10 | 14 | 24 |
| 2019 January | 6 | 4 | 10 |
| 2018 December | 11 | 12 | 23 |
| 2018 November | 9 | 6 | 15 |
| 2018 October | 16 | 9 | 25 |
| 2018 September | 6 | 8 | 14 |
| 2018 May | 5 | 2 | 7 |
| 2018 April | 6 | 3 | 9 |
| 2018 March | 4 | 6 | 10 |
| 2018 February | 4 | 8 | 12 |
| 2018 January | 5 | 10 | 15 |
| 2017 December | 6 | 9 | 15 |
| 2017 November | 6 | 6 | 12 |
| 2017 October | 4 | 4 | 8 |
| 2017 September | 6 | 8 | 14 |
| 2017 August | 7 | 9 | 16 |
| 2017 July | 6 | 5 | 11 |
| 2017 June | 8 | 17 | 25 |
| 2017 May | 7 | 7 | 14 |
| 2017 April | 3 | 1 | 4 |
| 2017 March | 2 | 10 | 12 |
| 2017 February | 0 | 1 | 1 |
| 2017 January | 3 | 3 | 6 |
| 2016 December | 5 | 5 | 10 |
| 2016 November | 15 | 6 | 21 |
| 2016 October | 17 | 8 | 25 |
| 2016 September | 7 | 8 | 15 |
| 2016 August | 4 | 2 | 6 |
| 2016 July | 1 | 0 | 1 |
| 2016 March | 3 | 0 | 3 |
| 2015 December | 2 | 0 | 2 |
| 2015 October | 49 | 1 | 50 |
| 2015 September | 42 | 12 | 54 |
| 2015 August | 38 | 8 | 46 |
| 2015 July | 29 | 3 | 32 |
| 2015 June | 35 | 10 | 45 |
| 2015 May | 37 | 12 | 49 |
| 2015 April | 32 | 10 | 42 |
| 2015 March | 34 | 6 | 40 |
| 2015 February | 35 | 4 | 39 |
| 2015 January | 24 | 5 | 29 |
| 2014 December | 25 | 6 | 31 |
| 2014 November | 29 | 7 | 36 |
| 2014 October | 53 | 8 | 61 |
| 2014 September | 47 | 8 | 55 |
| 2014 August | 32 | 8 | 40 |
| 2014 July | 38 | 5 | 43 |
| 2014 June | 41 | 6 | 47 |
| 2014 May | 42 | 9 | 51 |
| 2014 April | 44 | 7 | 51 |
| 2014 March | 53 | 8 | 61 |
| 2014 February | 46 | 12 | 58 |
| 2014 January | 38 | 4 | 42 |
| 2013 December | 39 | 10 | 49 |
| 2013 November | 31 | 5 | 36 |
| 2013 October | 32 | 5 | 37 |
| 2013 September | 37 | 11 | 48 |
| 2013 August | 37 | 7 | 44 |
| 2013 July | 45 | 26 | 71 |
| 2013 June | 33 | 7 | 40 |
| 2013 May | 41 | 5 | 46 |
| 2013 April | 12 | 7 | 19 |
| 2013 March | 8 | 2 | 10 |
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