Original Articles
Factors Affecting Drug Prescription in Patients With Stable COPD: Results From a Multicenter Spanish Study
J. de Miguel Díeza, J.L. Izquierdo Alonsob,
, J. Molina Parísc, J.M. Bellón Canod, J.M. Rodríguez González-Moroa, P. de Lucas Ramosa
Corresponding author
jlizquierdo@sescam.org
Correspondence: Dr. J.L. Izquierdo Alonso. Sección de Neumología. Hospital General Universitario de Guadalajara. Donantes de Sangre, s/n. 19002 Guadalajara. España
Correspondence: Dr. J.L. Izquierdo Alonso. Sección de Neumología. Hospital General Universitario de Guadalajara. Donantes de Sangre, s/n. 19002 Guadalajara. España
a Servicio de Neumología, Hospital General Universitario Gregorio Marañón, Madrid, Spain
b Servicio de Neumología, Hospital General Universitario de Guadalajara, Guadalajara, Spain
c Centro de Salud Francia, Fuenlabrada, Madrid, Spain
d Unidad de Investigación, Hospital General Universitario Gregorio Marañón, Madrid, Spain
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Rodríguez González-Moro, P. de Lucas Ramos" "autores" => array:6 [ 0 => array:3 [ "nombre" => "J." "apellidos" => "de Miguel Díez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 1 => array:5 [ "preGrado" => "Dr." "nombre" => "J.L." "apellidos" => "Izquierdo Alonso" "email" => array:1 [ 0 => "jlizquierdo@sescam.org" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 2 => array:3 [ "nombre" => "J." "apellidos" => "Molina París" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] 3 => array:3 [ "nombre" => "J.M." "apellidos" => "Bellón Cano" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff4" ] ] ] 4 => array:3 [ "nombre" => "J.M." "apellidos" => "Rodríguez González-Moro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 5 => array:3 [ "nombre" => "P." "apellidos" => "de Lucas Ramos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Servicio de Neumología, Hospital General Universitario Gregorio Marañón, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Neumología, Hospital General Universitario de Guadalajara, Guadalajara, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Centro de Salud Francia, Fuenlabrada, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] 3 => array:3 [ "entidad" => "Unidad de Investigación, Hospital General Universitario Gregorio Marañón, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff4" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dr. J.L. Izquierdo Alonso. Sección de Neumología. Hospital General Universitario de Guadalajara. Donantes de Sangre, s/n. 19002 Guadalajara. España" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2004-01-01" "fechaAceptado" => "2004-06-23" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key Words" "identificador" => "xpalclavsec153910" "palabras" => array:5 [ 0 => "COPD" 1 => "FEV<span class="elsevierStyleInf">1</span>" 2 => "Health-related quality of life" 3 => "Dyspnea" 4 => "Treatment" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec153911" "palabras" => array:5 [ 0 => "EPOC" 1 => "FEV<span class="elsevierStyleInf">1</span>" 2 => "Calidad de vida relacionada con la salud" 3 => "Disnea" 4 => "Tratamiento" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">TO determine what factors are associated with prescription of drugs to patients with stable chronic obstructive pulmonary disease (COPD).</p> <span class="elsevierStyleSectionTitle">Material and Methods</span><p class="elsevierStyleSimplePara elsevierViewall">We studied 568 patients with stable COPD. Assessments included determination of the severity of dyspnea, body mass index, health-related quality of life, and spirometry testing.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The forced expiratory volume in 1 second was significantly associated with prescription of long-acting β<span class="elsevierStyleInf">2</span>-adrenergic agonists (odds ratio [OR]=0.98; 95% confidence interval [CI], 0.96-1) and inhaled corticosteroids (OR=0.98; 95% CI, 0.96-1). Quality of life was related to administration of short-acting β<span class="elsevierStyleInf">2</span>-adrenergic agonists (OR=1.02; 95% CI, 1-1.03), long-acting β<span class="elsevierStyleInf">2</span>-adrenergic agonists (OR=1.02; 95% CI, 1-1.03), ipratropium bromide (OR=1.03; 95% CI, 1-1.04), theophylline drugs (OR=1.02; 95% CI, 1-1.03), and inhaled corticosteroids (OR=1.02; 95% CI, 1-1.03). The severity of dyspnea was significantly associated with prescription of oral corticosteroids (for grade IV dyspnea, OR=15.25; 95% CI, 2.40-97.02). Body mass index was not related to drug administration.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Drug prescription in patients with stable COPD correlates not only with forced expiratory volume in 1 second but also with other parameters such as health-related quality of life and dyspnea.</p><p class="elsevierStyleSimplePara elsevierViewall">Factores determinantes de la prescripción farmacológica en los pacientes con EPOC estable. Resultados de un estudio multicéntrico español (IDENTEPOC)</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Determinar qué factores se relacionan con la prescripción de fármacos en los pacientes con enfermedad pulmonar obstructiva crónica (EPOC) estable.</p> <span class="elsevierStyleSectionTitle">Material Y Métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se estudió a 568 pacientes con EPOC estable. La evaluación realizada incluyó la medición del grado de disnea, la determinación del índice de masa corporal, el estudio de la calidad de vida relacionada con la salud y la realización de una espirometría.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">El volumen espiratorio forzado en el primer segundo se asoció significativamente con la prescripción de β<span class="elsevierStyleInf">2</span>-adrenérgicos de acción larga (<span class="elsevierStyleItalic">odds ratio</span> [OR] = 0,98; in-tervalo de confianza [IC] del 95%, 0,96-1) y corticoides in-halados (OR = 0,98; IC del 95%, 0,96-1). La calidad de vida se relacionó con la administración de β<span class="elsevierStyleInf">2</span>-adrenérgicos de acción corta (OR = 1,02; IC del 95%, 1-1,03), β<span class="elsevierStyleInf">2</span>-adrenérgicos de acción larga (OR = 1,02; IC del 95%, 1-1,03), bromuro de ipratropio (OR = 1,03; IC del 95%, 1-1,04), teofilinas (OR = 1,02; IC del 95%, 1-1,03) y corticoides inhalados (OR = 1,02; IC del 95%, 1-1,03). El grado de disnea mostró una asociación significativa con la prescripción de corticoides orales (para disnea grado IV, OR = 15,25; IC del 95%, 2,40-97,02). No se encontró ninguna relación entre la administración de fármacos y el índice de masa corporal.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">La prescripción farmacológica de los pacientes con EPOC estable viene determinada no sólo por el volumen espiratorio forzado en el primer segundo, sino tam-bién por otros parámetros, entre los que se incluyen la calidad de vida relacionada con la salud y la disnea.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:36 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Guía clínica para el diagnóstico y el tratamiento de la enfermedad pulmonar obstructiva crónica" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "JA Barberà" 1 => "G Peces-Barba" 2 => "AGN Agustí" 3 => "JL Izquierdo" 4 => "E Monsó" 5 => "T Montemayor" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol." "fecha" => "2001" "volumen" => "37" "paginaInicial" => "297" "paginaFinal" => "316" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11412529" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "BTS guidelines for the management of chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "The COPD guidelines group of the standards of care committee of the BTS" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Thorax" "fecha" => "1997" "volumen" => "52" "numero" => "Suppl 5" "paginaInicial" => "1" "paginaFinal" => "28" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9039230" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Optimal assessment and management of chronic obstructive pulmonary disease (COPD). A consensus statement of the European Respiratory Society" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "NM Siafakas" 1 => "P Vermeire" 2 => "NB Pride" 3 => "P Paoletti" 4 => "J Gibson" 5 => "P Howard" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J." "fecha" => "1995" "volumen" => "8" "paginaInicial" => "1398" "paginaFinal" => "1420" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7489808" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "American Thoracic Society" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med." "fecha" => "1995" "volumen" => "152" "paginaInicial" => "S77" "paginaFinal" => "S120" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7582322" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) workshop summary" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "RA Pauwels" 1 => "AS Buist" 2 => "PMA Calverley" 3 => "CR Jenkins" 4 => "SS Hurd" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.163.5.2101039" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med." "fecha" => "2001" "volumen" => "163" "paginaInicial" => "1256" "paginaFinal" => "1276" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11316667" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The importance of spirometry in COPD and asthma: effect on approach to management" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "BR Celli" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Chest" "fecha" => "2000" "volumen" => "117" "paginaInicial" => "S15" "paginaFinal" => "SS9" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Is lung function really a good parameter in evaluating the long-term effects of inhaled corticosteroids in COPD?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "CP van Schayck" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J." "fecha" => "2000" "volumen" => "15" "paginaInicial" => "238" "paginaFinal" => "239" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10706484" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "EPOC: desde el nihilismo no justificado a un optimismo razonable" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "B Celli" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol." "fecha" => "2002" "volumen" => "38" "paginaInicial" => "585" "paginaFinal" => "588" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12568704" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A comparison of the level of dyspnea vs disease severity in indicating the health-related quality of life of patients with COPD" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "T Hajiro" 1 => "K Nishimura" 2 => "M Tsukino" 3 => "A Ikeda" 4 => "T Oga" 5 => "T Izumi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1999" "volumen" => "116" "paginaInicial" => "1632" "paginaFinal" => "1637" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10593787" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Weight loss is a reversible factor in the prognosis of chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "AM Schols" 1 => "J Slangen" 2 => "L Volovics" 3 => "EF Wouters" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.157.6.9705017" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med." "fecha" => "1998" "volumen" => "157" "paginaInicial" => "1791" "paginaFinal" => "1797" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9620907" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Variables related to increased mortality following outpatient pulmonary rehabilitation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "DA Gerardi" 1 => "L Lovett" 2 => "ML Benoit-Connors" 3 => "JC Reardon" 4 => "RL ZuWallack" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J." "fecha" => "1996" "volumen" => "9" "paginaInicial" => "431" "paginaFinal" => "435" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8730000" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fiabilidad del diagnóstico de la EPOC en atención primaria y neumología en España. Factores predictivos" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J de Miguel Díez" 1 => "JL Izquierdo Alonso" 2 => "J Molina París" 3 => "JM Rodríguez González-Moro" 4 => "P de Lucas Ramos" 5 => "G Gaspar Alonso-Vega" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol." "fecha" => "2003" "volumen" => "39" "paginaInicial" => "203" "paginaFinal" => "208" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12749802" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tratamiento farmacológico de la EPOC en dos niveles asistenciales. Grado de adecuación a las normativas recomendadas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Díez de Miguel" 1 => "JL Izquierdo Alonso" 2 => "JM Rodríguez González-Moro" 3 => "P de Lucas Ramos" 4 => "J Molina París" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol." "fecha" => "2003" "volumen" => "39" "paginaInicial" => "195" "paginaFinal" => "202" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12749801" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Usefulness of the Medical Research Council (MRC) dyspnoea scale as a measure of disability in patients with chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "JC Bestall" 1 => "EA Paul" 2 => "R Garrod" 3 => "R Garnham" 4 => "PW Jones" 5 => "JA Wedzicha" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "1999" "volumen" => "54" "paginaInicial" => "581" "paginaFinal" => "586" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10377201" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A self-complete measure of health status for chronic airflow limitation. The St George's Respiratory Questionnaire" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "PW Jones" 1 => "FH Quirk" 2 => "CM Baveystock" 3 => "P Littlejohns" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm/145.6.1321" "Revista" => array:6 [ "tituloSerie" => "Am Rev Respir Dis." "fecha" => "1992" "volumen" => "145" "paginaInicial" => "1321" "paginaFinal" => "1327" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1595997" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Validity and reliability of the St George's Respiratory Questionnaire after adaptation to a different language and culture: the Spanish example" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M Ferrer" 1 => "J Alonso" 2 => "L Prieto" 3 => "V Plaza" 4 => "E Monsó" 5 => "R Marrades" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J." "fecha" => "1996" "volumen" => "9" "paginaInicial" => "1160" "paginaFinal" => "1166" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8804932" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Standardization of spirometry and PEF: 1994 update" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "American Thoracic Society" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am J Respir Crit Care Med." "fecha" => "1995" "volumen" => "152" "paginaInicial" => "1007" "paginaFinal" => "1136" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Standard lung function testing" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "European Community for Coal and Steel" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:9 [ "titulo" => "Report of working party on standardization of lung function test" "tituloSerie" => "Bull Eur Physiopathol Respir." "fecha" => "1983" "volumen" => "19" "numero" => "Suppl 5" "paginaInicial" => "1" "paginaFinal" => "95" "editores" => "PHQuanjer" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6616097" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "BR Celli" 1 => "CG Cote" 2 => "JM Marín" 3 => "C Casanova" 4 => "M Montes de Oca" 5 => "RA Méndez" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa021322" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med." "fecha" => "2004" "volumen" => "350" "paginaInicial" => "1005" "paginaFinal" => "1012" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14999112" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efficacy of salmeterol xinafoate in the treatment of COPD" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "DA Mahler" 1 => "JF Donohue" 2 => "RA Barbee" 3 => "MD Goldman" 4 => "NJ Gross" 5 => "ME Wisniewski" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1999" "volumen" => "115" "paginaInicial" => "957" "paginaFinal" => "965" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10208192" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long term effects of inhaled corticosteroids in chronic obstructive pulmonary disease: a meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "PM van Grunsven" 1 => "CP van Schayck" 2 => "JP Derenne" 3 => "HAM Kerstjens" 4 => "TEJ Renkema" 5 => "DS Postma" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "1999" "volumen" => "54" "paginaInicial" => "7" "paginaFinal" => "14" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10343624" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Manifestaciones clínicas: la disnea y su importancia en el paciente con EPOC" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "JM Marín Trigo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol." "fecha" => "2001" "volumen" => "37" "numero" => "Suppl 2" "paginaInicial" => "8" "paginaFinal" => "13" ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inspiratory capacity, dynamic hyperinflation, breathlessness and exercise performance during the 6-minute walk test in chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "JM Marín" 1 => "SJ Carrizo" 2 => "M Gascón" 3 => "A Sánchez" 4 => "B Gallego" 5 => "BR Celli" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.163.6.2003172" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med." "fecha" => "2001" "volumen" => "163" "paginaInicial" => "1395" "paginaFinal" => "1399" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11371407" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inhaled bronchodilators reduce dynamic hyperinflation during exercise in patients with chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "MJ Belman" 1 => "WC Botnick" 2 => "JW Shin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.153.3.8630581" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med." "fecha" => "1996" "volumen" => "153" "paginaInicial" => "967" "paginaFinal" => "975" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8630581" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of chronic obstructive pulmonary disease and its exacerbations in general practice" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "Segú JL on behalf of the EOLO Group" "etal" => false "autores" => array:5 [ 0 => "M Miravitlles" 1 => "C Mayordomo" 2 => "M Artés" 3 => "L Sánchez Agudo" 4 => "F Nicolau" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Respir Med." "fecha" => "1999" "volumen" => "93" "paginaInicial" => "173" "paginaFinal" => "179" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10464874" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Guidelines versus clinical practice in the treatment of chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "N Roche" 1 => "T Legape" 2 => "J Bourcereau" 3 => "P Terrioux" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J." "fecha" => "2001" "volumen" => "18" "paginaInicial" => "903" "paginaFinal" => "908" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11829094" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Steroids in COPD. The nearly eternal question" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "NR Anthonisen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1999" "volumen" => "115" "paginaInicial" => "3" "paginaFinal" => "4" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9925052" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Health status measurement in chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "PW Jones" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2001" "volumen" => "56" "paginaInicial" => "880" "paginaFinal" => "887" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11641515" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Quality of life changes in COPD patients treated with salmeterol" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "PW Jones" 1 => "TK Bosh" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am J Respir Crit Care Med." "fecha" => "1997" "volumen" => "155" "paginaInicial" => "1238" "paginaFinal" => "1239" ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inhaled formoterol dry powder versus ipratropium bromide in chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R Dahl" 1 => "LAPM Greefhorst" 2 => "D Nowak" 3 => "V Nonikov" 4 => "AM Byrne" 5 => "MH Thomson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.164.5.2007006" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med." "fecha" => "2001" "volumen" => "164" "paginaInicial" => "778" "paginaFinal" => "784" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11549532" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment and quality of life in patients with chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M Miravitlles" 1 => "JL álvarez-Sala" 2 => "R Lamarca" 3 => "M Ferrer" 4 => "F Masa" 5 => "H Verea" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Qual Life Res." "fecha" => "2002" "volumen" => "11" "paginaInicial" => "329" "paginaFinal" => "338" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12086118" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effect of supplementary oral nutrition in poorly nourished patients with chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J Efthimiou" 1 => "J Fleming" 2 => "C Gomes" 3 => "SG Spiro" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm/137.5.1075" "Revista" => array:6 [ "tituloSerie" => "Am Rev Respir Dis." "fecha" => "1998" "volumen" => "137" "paginaInicial" => "1075" "paginaFinal" => "1082" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3057956" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib33" "etiqueta" => "33" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anthropometric and pulmonary function test profile of outpatients with stable chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "H Sahebjami" 1 => "JT Doers" 2 => "ML Render" 3 => "TL Bond" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Med." "fecha" => "1993" "volumen" => "94" "paginaInicial" => "469" "paginaFinal" => "474" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8498391" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib34" "etiqueta" => "34" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Influence of body weight on the severity of dyspnea in chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "H Sahebjami" 1 => "E Sathianpitayakul" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.161.3.9905023" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med." "fecha" => "2000" "volumen" => "161" "paginaInicial" => "886" "paginaFinal" => "890" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10712338" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib35" "etiqueta" => "35" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M Figueras" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "titulo" => "Estimación del impacto de las prácticas asistenciales no recomendadas en el abordaje de la EPOC" "fecha" => "1999" "editorial" => "Romargaf" "editorialLocalizacion" => "Barcelona" ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib36" "etiqueta" => "36" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "Pharmacoeconomic evaluation of acute exacerbations of chronic bronchitis and COPD" ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2002" "volumen" => "121" "paginaInicial" => "1449" "paginaFinal" => "1455" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12006427" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15792129/0000004100000002/v1_201305150204/S1579212906603996/v1_201305150204/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/15792129/0000004100000002/v1_201305150204/S1579212906603996/v1_201305150204/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212906603996?idApp=UINPBA00003Z" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 3 | 6 | 9 |
| 2024 October | 33 | 13 | 46 |
| 2024 September | 24 | 15 | 39 |
| 2024 August | 37 | 33 | 70 |
| 2024 July | 24 | 22 | 46 |
| 2024 June | 28 | 19 | 47 |
| 2024 May | 23 | 33 | 56 |
| 2024 April | 18 | 21 | 39 |
| 2024 March | 16 | 12 | 28 |
| 2024 February | 15 | 23 | 38 |
| 2023 March | 2 | 2 | 4 |
| 2023 February | 14 | 26 | 40 |
| 2023 January | 17 | 35 | 52 |
| 2022 December | 19 | 27 | 46 |
| 2022 November | 21 | 25 | 46 |
| 2022 October | 22 | 30 | 52 |
| 2022 September | 12 | 18 | 30 |
| 2022 August | 15 | 30 | 45 |
| 2022 July | 15 | 44 | 59 |
| 2022 June | 11 | 25 | 36 |
| 2022 May | 10 | 23 | 33 |
| 2022 April | 14 | 29 | 43 |
| 2022 March | 14 | 37 | 51 |
| 2022 February | 16 | 42 | 58 |
| 2022 January | 11 | 27 | 38 |
| 2021 December | 8 | 33 | 41 |
| 2021 November | 14 | 39 | 53 |
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| 2021 September | 13 | 35 | 48 |
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| 2021 April | 34 | 45 | 79 |
| 2021 March | 21 | 17 | 38 |
| 2021 February | 13 | 22 | 35 |
| 2021 January | 17 | 14 | 31 |
| 2020 December | 11 | 16 | 27 |
| 2020 November | 10 | 17 | 27 |
| 2020 October | 15 | 9 | 24 |
| 2020 September | 15 | 2 | 17 |
| 2020 August | 52 | 8 | 60 |
| 2020 July | 41 | 12 | 53 |
| 2020 June | 1 | 8 | 9 |
| 2020 May | 25 | 14 | 39 |
| 2020 April | 37 | 8 | 45 |
| 2020 March | 13 | 15 | 28 |
| 2020 February | 7 | 13 | 20 |
| 2020 January | 13 | 13 | 26 |
| 2019 December | 10 | 10 | 20 |
| 2019 November | 18 | 10 | 28 |
| 2019 October | 6 | 4 | 10 |
| 2019 September | 12 | 11 | 23 |
| 2019 August | 9 | 5 | 14 |
| 2019 July | 7 | 17 | 24 |
| 2019 June | 6 | 11 | 17 |
| 2019 May | 11 | 10 | 21 |
| 2019 April | 14 | 19 | 33 |
| 2019 March | 15 | 16 | 31 |
| 2019 February | 12 | 15 | 27 |
| 2019 January | 7 | 13 | 20 |
| 2018 December | 6 | 22 | 28 |
| 2018 November | 16 | 8 | 24 |
| 2018 October | 26 | 15 | 41 |
| 2018 September | 12 | 14 | 26 |
| 2018 May | 5 | 0 | 5 |
| 2018 April | 4 | 8 | 12 |
| 2018 March | 7 | 1 | 8 |
| 2018 February | 2 | 11 | 13 |
| 2018 January | 5 | 7 | 12 |
| 2017 December | 4 | 6 | 10 |
| 2017 November | 2 | 4 | 6 |
| 2017 October | 10 | 20 | 30 |
| 2017 September | 4 | 3 | 7 |
| 2017 August | 10 | 13 | 23 |
| 2017 July | 2 | 3 | 5 |
| 2017 June | 9 | 7 | 16 |
| 2017 May | 10 | 11 | 21 |
| 2017 April | 8 | 1 | 9 |
| 2017 March | 25 | 7 | 32 |
| 2017 February | 2 | 3 | 5 |
| 2017 January | 2 | 2 | 4 |
| 2016 December | 14 | 8 | 22 |
| 2016 November | 19 | 11 | 30 |
| 2016 October | 23 | 9 | 32 |
| 2016 September | 15 | 2 | 17 |
| 2016 August | 16 | 4 | 20 |
| 2016 July | 3 | 0 | 3 |
| 2016 March | 3 | 0 | 3 |
| 2015 December | 2 | 0 | 2 |
| 2015 October | 35 | 1 | 36 |
| 2015 September | 30 | 5 | 35 |
| 2015 August | 34 | 9 | 43 |
| 2015 July | 37 | 6 | 43 |
| 2015 June | 36 | 2 | 38 |
| 2015 May | 44 | 12 | 56 |
| 2015 April | 41 | 6 | 47 |
| 2015 March | 37 | 6 | 43 |
| 2015 February | 42 | 3 | 45 |
| 2015 January | 38 | 5 | 43 |
| 2014 December | 28 | 6 | 34 |
| 2014 November | 25 | 4 | 29 |
| 2014 October | 40 | 7 | 47 |
| 2014 September | 39 | 8 | 47 |
| 2014 August | 25 | 9 | 34 |
| 2014 July | 25 | 8 | 33 |
| 2014 June | 35 | 8 | 43 |
| 2014 May | 45 | 13 | 58 |
| 2014 April | 47 | 8 | 55 |
| 2014 March | 62 | 12 | 74 |
| 2014 February | 47 | 7 | 54 |
| 2014 January | 39 | 6 | 45 |
| 2013 December | 54 | 8 | 62 |
| 2013 November | 27 | 7 | 34 |
| 2013 October | 43 | 5 | 48 |
| 2013 September | 35 | 11 | 46 |
| 2013 August | 39 | 6 | 45 |
| 2013 July | 52 | 8 | 60 |
| 2013 June | 34 | 3 | 37 |
| 2013 May | 34 | 8 | 42 |
| 2013 April | 20 | 4 | 24 |
| 2013 March | 4 | 1 | 5 |
Show all
