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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The special article &#8220;Multidisciplinary Management of Patients with Chronic Obstructive Pulmonary Disease and Cardiovascular Disease&#8221; represents an interesting and much-needed effort to create a comprehensive guideline on an important yet somewhat neglected topic&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> However&#44; we would like to make some considerations regarding the manuscript&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The authors have discussed the potential risks of pulmonary toxicity associated with commonly used cardiovascular drugs such as amiodarone and beta-blockers&#44; as well as the cardiovascular risks of respiratory medications like bronchodilators&#46; Long-term use of azithromycin is recommended for COPD patients with chronic bronchial infection and frequent exacerbations<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a>&#59; however&#44; there are concerns about serious adverse cardiovascular effects due to its potential proarrhythmic effects&#44; especially in patients with a high baseline risk of cardiovascular disease&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> Therefore&#44; it is advisable to use this antibiotic with caution in patients with cardiovascular disease&#44; avoiding its use in those with a prolonged QT interval in their electrocardiogram&#44; and to monitor the QT interval after initiating treatment&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Furthermore&#44; theophylline is recommended as a third-line therapy for COPD patients with uncontrolled dyspnea&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> As theophylline has a narrow therapeutic window and can cause cardiac arrhythmias&#44; it should be avoided or closely monitored in patients with cardiovascular disease&#44; especially those who are taking multiple medications due to potential interactions&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Regarding the recommendation stated in Table 3 of prescribing triple therapy for COPD exacerbators to reduce exacerbations and mortality&#44; we believe that it should be somewhat tempered&#46; We agree with the authors comment that the benefits of triple therapy over double bronchodilation &#40;LABA plus LAMA&#41; in COPD are mostly seen in exacerbator patients with a baseline blood eosinophil count of 100<span class="elsevierStyleHsp" style=""></span>cells&#47;mm<span class="elsevierStyleSup">3</span> or higher&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> Taking into account the broad audience of the manuscript beyond the pulmonology field&#44; it may be advisable to explicitly state caution in using triple therapy in patients with low eosinophil counts&#46; These patients are unlikely to benefit from inhaled corticosteroids &#40;ICS&#41;&#44; which may have significant adverse effects&#44; particularly in patients with cardiovascular disease&#46; There is controversy surrounding the potential impact of prolonged use of inhaled ICS on worsening diabetes mellitus &#40;DM&#41; control or increasing the incidence of DM&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> DM is both a cardiovascular risk factor and a risk factor for exacerbation and death in COPD&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> Therefore&#44; caution should be exercised when considering long-term use of ICS&#44; especially in those patients with poor glycemic control since this could promote respiratory infection or chronic bronchial colonization&#44; including those caused by potentially pathogenic microorganisms &#40;i&#46;e&#46; <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span>&#41;&#44; which has been associated with an increased risk of cardiovascular events&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Artificial intelligence involvement</span><p id="par0025" class="elsevierStylePara elsevierViewall">No AI tool or software has been used to produce this manuscript&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Funding</span><p id="par0030" class="elsevierStylePara elsevierViewall">This manuscript has received no funding&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0035" class="elsevierStylePara elsevierViewall">Rafael Golpe declares that he has received speaking or advisory fees&#44; or economic aid to attend congresses from Astra-Zeneca&#44; GSK&#44; Novartis&#44; FAES&#44; Chiesi&#44; Mundipharma&#44; Menarini&#44; TEVA&#44; Grifols&#44; Ferrer&#44; Boehringer-Ingelheim&#44; Rovi&#44; and Gebro&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Juan Marco Figueira-Gon&#231;alves has received speaking or advisory fees&#44; or economic aid to attend congresses from Laboratorio Esteve&#44; Mundipharma&#44; Astra-Zeneca&#44; Boehringer-Ingelheim&#44; Ferrer&#44; Menarini&#44; Rovi&#44; GlaxoSmithKline&#44; Chiesi&#44; Novartis y GebroPharma&#46;</p></span></span>"
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Discussion Letter
Comment on “Multidisciplinary Management of Patients With Chronic Obstructive Pulmonary Disease and Cardiovascular Disease”
Rafael Golpea,
Corresponding author
, Juan Marco Figueira-Gonçalvesb,c
a Servicio de Neumología, Hospital Universitario Lucus Augusti, Lugo, Spain
b Servicio de Neumología y Cirugía Torácica, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain
c University Institute of Tropical Disease and Public Health of the Canary Islands, University of La Laguna, Santa Cruz de Tenerife, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The special article &#8220;Multidisciplinary Management of Patients with Chronic Obstructive Pulmonary Disease and Cardiovascular Disease&#8221; represents an interesting and much-needed effort to create a comprehensive guideline on an important yet somewhat neglected topic&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> However&#44; we would like to make some considerations regarding the manuscript&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The authors have discussed the potential risks of pulmonary toxicity associated with commonly used cardiovascular drugs such as amiodarone and beta-blockers&#44; as well as the cardiovascular risks of respiratory medications like bronchodilators&#46; Long-term use of azithromycin is recommended for COPD patients with chronic bronchial infection and frequent exacerbations<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a>&#59; however&#44; there are concerns about serious adverse cardiovascular effects due to its potential proarrhythmic effects&#44; especially in patients with a high baseline risk of cardiovascular disease&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> Therefore&#44; it is advisable to use this antibiotic with caution in patients with cardiovascular disease&#44; avoiding its use in those with a prolonged QT interval in their electrocardiogram&#44; and to monitor the QT interval after initiating treatment&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Furthermore&#44; theophylline is recommended as a third-line therapy for COPD patients with uncontrolled dyspnea&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> As theophylline has a narrow therapeutic window and can cause cardiac arrhythmias&#44; it should be avoided or closely monitored in patients with cardiovascular disease&#44; especially those who are taking multiple medications due to potential interactions&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Regarding the recommendation stated in Table 3 of prescribing triple therapy for COPD exacerbators to reduce exacerbations and mortality&#44; we believe that it should be somewhat tempered&#46; We agree with the authors comment that the benefits of triple therapy over double bronchodilation &#40;LABA plus LAMA&#41; in COPD are mostly seen in exacerbator patients with a baseline blood eosinophil count of 100<span class="elsevierStyleHsp" style=""></span>cells&#47;mm<span class="elsevierStyleSup">3</span> or higher&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> Taking into account the broad audience of the manuscript beyond the pulmonology field&#44; it may be advisable to explicitly state caution in using triple therapy in patients with low eosinophil counts&#46; These patients are unlikely to benefit from inhaled corticosteroids &#40;ICS&#41;&#44; which may have significant adverse effects&#44; particularly in patients with cardiovascular disease&#46; There is controversy surrounding the potential impact of prolonged use of inhaled ICS on worsening diabetes mellitus &#40;DM&#41; control or increasing the incidence of DM&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> DM is both a cardiovascular risk factor and a risk factor for exacerbation and death in COPD&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> Therefore&#44; caution should be exercised when considering long-term use of ICS&#44; especially in those patients with poor glycemic control since this could promote respiratory infection or chronic bronchial colonization&#44; including those caused by potentially pathogenic microorganisms &#40;i&#46;e&#46; <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span>&#41;&#44; which has been associated with an increased risk of cardiovascular events&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Artificial intelligence involvement</span><p id="par0025" class="elsevierStylePara elsevierViewall">No AI tool or software has been used to produce this manuscript&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Funding</span><p id="par0030" class="elsevierStylePara elsevierViewall">This manuscript has received no funding&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0035" class="elsevierStylePara elsevierViewall">Rafael Golpe declares that he has received speaking or advisory fees&#44; or economic aid to attend congresses from Astra-Zeneca&#44; GSK&#44; Novartis&#44; FAES&#44; Chiesi&#44; Mundipharma&#44; Menarini&#44; TEVA&#44; Grifols&#44; Ferrer&#44; Boehringer-Ingelheim&#44; Rovi&#44; and Gebro&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Juan Marco Figueira-Gon&#231;alves has received speaking or advisory fees&#44; or economic aid to attend congresses from Laboratorio Esteve&#44; Mundipharma&#44; Astra-Zeneca&#44; Boehringer-Ingelheim&#44; Ferrer&#44; Menarini&#44; Rovi&#44; GlaxoSmithKline&#44; Chiesi&#44; Novartis y GebroPharma&#46;</p></span></span>"
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Article information
ISSN: 03002896
Original language: English
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