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array:23 [ "pii" => "S0300289623002880" "issn" => "03002896" "doi" => "10.1016/j.arbres.2023.08.014" "estado" => "S300" "fechaPublicacion" => "2023-12-01" "aid" => "3395" "copyright" => "SEPAR" "copyrightAnyo" => "2023" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Arch Bronconeumol. 2023;59:829-30" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:18 [ "pii" => "S0300289623002818" "issn" => "03002896" "doi" => "10.1016/j.arbres.2023.08.008" "estado" => "S300" "fechaPublicacion" => "2023-12-01" "aid" => "3388" "copyright" => "The Author(s)" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Arch Bronconeumol. 2023;59:831-2" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case Report</span>" "titulo" => "Bardet–Biedl Syndrome: An Uncommon Cause of Bronchiectasis" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "831" "paginaFinal" => "832" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 701 "Ancho" => 1340 "Tamanyo" => 145886 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A, B) Computed tomography images showing bilateral bronchiectasis and bronchiolectasis predominantly in the middle fields and lower lobes of both hemithoraces. Other findings included distal branched images and centriacinar nodules measuring around 1<span class="elsevierStyleHsp" style=""></span>mm, associated with distal airway involvement.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Beatriz Raboso Moreno, Sara Calero Pardo, Araceli Abad Fernández" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Beatriz" "apellidos" => "Raboso Moreno" ] 1 => array:2 [ "nombre" => "Sara" "apellidos" => "Calero Pardo" ] 2 => array:2 [ "nombre" => "Araceli" "apellidos" => "Abad Fernández" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289623002818?idApp=UINPBA00003Z" "url" => "/03002896/0000005900000012/v3_202402290651/S0300289623002818/v3_202402290651/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0300289623003058" "issn" => "03002896" "doi" => "10.1016/j.arbres.2023.09.009" "estado" => "S300" "fechaPublicacion" => "2023-12-01" "aid" => "3405" "copyright" => "The Authors" "documento" => "article" "crossmark" => 1 "subdocumento" => "rev" "cita" => "Arch Bronconeumol. 2023;59:821-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review Article</span>" "titulo" => "MTBVAC: A Tuberculosis Vaccine Candidate Advancing Towards Clinical Efficacy Trials in TB Prevention" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "821" "paginaFinal" => "828" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 1 "multimedia" => array:5 [ "identificador" => "fig0015" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => false "mostrarDisplay" => true "figura" => array:1 [ 0 => array:4 [ "imagen" => "fx1.jpeg" "Alto" => 762 "Ancho" => 1333 "Tamanyo" => 132853 ] ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Sergio Lacámara, Carlos Martin" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Sergio" "apellidos" => "Lacámara" ] 1 => array:2 [ "nombre" => "Carlos" "apellidos" => "Martin" ] ] ] ] "resumen" => array:1 [ 0 => array:3 [ "titulo" => "Graphical abstract" "clase" => "graphical" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><elsevierMultimedia ident="fig0015"></elsevierMultimedia></p></span>" ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289623003058?idApp=UINPBA00003Z" "url" => "/03002896/0000005900000012/v3_202402290651/S0300289623003058/v3_202402290651/en/main.assets" ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case Report</span>" "titulo" => "Refractory Inflammatory Plastic Bronchitis in Children and the Use of Mepolizumab as a Treatment" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "829" "paginaFinal" => "830" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Gina V. Bustamante-Guevara, Ignacio Iglesias-Serrano, Jessica Camacho Soriano" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Gina V." "apellidos" => "Bustamante-Guevara" "email" => array:1 [ 0 => "ginabustamanteg@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Ignacio" "apellidos" => "Iglesias-Serrano" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Jessica" "apellidos" => "Camacho Soriano" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Unidad de Neumología Pediátrica y Fibrosis Quística, Hospital Universitario Vall d’Hebron, Barcelona, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Unidad de Anatomía Patológica, Hospital Universitario Vall d’Hebron, Barcelona, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2380 "Ancho" => 2007 "Tamanyo" => 340690 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Chest X-ray in 2017 showing left lower lobe opacity (prior to the first bronchoscopy). (B) Bronchial cast occluding left lower lobe visualized with the flexible bronchoscope. (C and D) Bronchial cast extracted with forceps. (E) Many inflammatory cells, predominantly eosinophils with Charcot-Leyden crystals (arrows). (F) Chest X-ray in 2023 showing small retrocardiac opacity.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A previously healthy boy was referred when he was 8 years old due to non-resolving left lower lobe (LLL) pneumonia (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A), after experiencing five episodes requiring antibiotics in the previous 8 months, showing only temporary clinical improvement.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">A chest computed tomography (CT) exhibited left hilar, subcarinal and bilateral axillary adenopathies with opacification of the LLL. Following a positive interferon-gamma release assay, anti-tuberculosis drugs were started, reaching 6 months of treatment, along with systemic steroids (based on the clinical suspicion of endobronchial tuberculosis).</p><p id="par0015" class="elsevierStylePara elsevierViewall">Three weeks after the CT, a bronchoscopy was performed (July 2017), finding a whitish solid material occluding the LLL bronchus that required forceps and rigid bronchoscopy to be partially removed (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>B–D). The initial report of the endobronchial plug described it as a compound of fibrinopurulent debris, without evidence of pathogenic microorganisms. Mild blood eosinophilia (1200/μL) was observed.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Concerns arose regarding tuberculosis as the cause of recurrent bronchial casts (BC), so a thorough review of the plugs was done, reporting some fibrino-mucoid material with many inflammatory cells, predominantly eosinophils, along with Charcot-Leyden crystals (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>E).</p><p id="par0025" class="elsevierStylePara elsevierViewall">Because of reappearing consolidation in the LLL despite treatment with inhaled corticosteroids and azithromycin, serial bronchoscopies were required over 2 years (September 2017, four in 2018, three in 2019), to remove extensive BC. He received oral bursts of steroids (35–60 days/year) from 2017 to 2021.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Owing to the presence of persistent refractory inflammatory BC and blood eosinophilia (500–1300/μL) unrelated to other conditions, treatment with mepolizumab<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">1,2</span></a> was deemed suitable. Furthermore, the main components of the casts were eosinophils and bronchoalveolar lavage eosinophilia was present up to 51%.</p><p id="par0035" class="elsevierStylePara elsevierViewall">In May 2020 he needed another bronchoscopy, finding many BC filling all LLL segments. At that point, the patient had only received two doses of mepolizumab, due to poor treatment adherence. After an episode of pneumonia in February 2021, regular monthly treatment with mepolizumab was started. Since then, radiological and clinical improvements were observed.</p><p id="par0040" class="elsevierStylePara elsevierViewall">Some bronchoalveolar lavage and bronchial aspirate cultures were positive for <span class="elsevierStyleItalic">Haemophilus influenzae</span>, but the vast majority were negative. A few colonies of <span class="elsevierStyleItalic">Aspergillus fumigatus</span> were found once in the culture of the BC and bronchial aspirate; however, specific IgE and IgG serum levels were negative.</p><p id="par0045" class="elsevierStylePara elsevierViewall">A chest CT conducted in August 2021 revealed some residual bronchiectasis without significant bronchial occupation. The last bronchoscopy was performed in July 2022, undergone to discard disease progression and settle the therapeutic length with mepolizumab. The only finding was a small and thin cast in a subsegment of S6 in LLL.</p><p id="par0050" class="elsevierStylePara elsevierViewall">In August 2022, a spirometry demonstrates a positive bronchodilator response. A new chest X-ray in March 2023 showed radiological stability, with a small subsegmental retrocardiac opacity and bronchiectasis in LLL, suggesting residual changes (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>F).</p><p id="par0055" class="elsevierStylePara elsevierViewall">In conclusion, our patient with refractory inflammatory plastic bronchitis<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">3,4</span></a> has presented clinical improvement since the beginning of mepolizumab. This treatment with evidenced efficacy in other eosinophilic diseases,<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">1,2</span></a> might be helpful in inflammatory plastic bronchitis. Even so, before considering it a standardized treatment, prospective comparative studies are required.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0060" class="elsevierStylePara elsevierViewall">None declared.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflict of Interests</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors state that they have no conflict of interests.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Funding" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Conflict of Interests" ] 2 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2380 "Ancho" => 2007 "Tamanyo" => 340690 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Chest X-ray in 2017 showing left lower lobe opacity (prior to the first bronchoscopy). (B) Bronchial cast occluding left lower lobe visualized with the flexible bronchoscope. (C and D) Bronchial cast extracted with forceps. (E) Many inflammatory cells, predominantly eosinophils with Charcot-Leyden crystals (arrows). (F) Chest X-ray in 2023 showing small retrocardiac opacity.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:4 [ 0 => array:3 [ "identificador" => "bib0025" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mepolizumab in eosinophilic disorders" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.P. Abonia" 1 => "P.E. Putnam" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1586/eci.11.27" "Revista" => array:6 [ "tituloSerie" => "Expert Rev Clin Immunol" "fecha" => "2011" "volumen" => "7" "paginaInicial" => "411" "paginaFinal" => "417" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21790283" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0030" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Biologic agents for the treatment of hypereosinophilic syndromes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "F.L. Kuang" 1 => "A.D. Klion" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaip.2017.08.001" "Revista" => array:6 [ "tituloSerie" => "J Allergy Clin Immunol Pract" "fecha" => "2017" "volumen" => "5" "paginaInicial" => "1502" "paginaFinal" => "1509" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29122152" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0035" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Current evaluation and management of plastic bronchitis in the pediatric population" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Y. Li" 1 => "R.J. Williams" 2 => "N.D. Dombrowski" 3 => "K. Watters" 4 => "K.P. Daly" 5 => "A.L. Irace" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ijporl.2019.109799" "Revista" => array:5 [ "tituloSerie" => "Int J Pediatr Otorhinolaryngol" "fecha" => "2020" "volumen" => "130" "paginaInicial" => "109799" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31812839" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0040" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Plastic bronchitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "B.K. Rubin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ccm.2016.04.003" "Revista" => array:6 [ "tituloSerie" => "Clin Chest Med" "fecha" => "2016" "volumen" => "37" "paginaInicial" => "405" "paginaFinal" => "408" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27514587" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/03002896/0000005900000012/v3_202402290651/S0300289623002880/v3_202402290651/en/main.assets" "Apartado" => array:4 [ "identificador" => "93562" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Case Reports" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/03002896/0000005900000012/v3_202402290651/S0300289623002880/v3_202402290651/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289623002880?idApp=UINPBA00003Z" ]
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