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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Thoracic scan showing a pulmonary mass in the right upper lobe&#44; measuring 90<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>87<span class="elsevierStyleHsp" style=""></span>mm&#46; &#40;B&#41; Abdominal and pelvic CT scan showing a mass on the left flank with 103<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>83<span class="elsevierStyleHsp" style=""></span>mm&#46; &#40;C and D&#41; The tumor cells express both TTF-1 and cytokeratin 7&#44; which is compatible with pulmonary origin&#46; &#40;E&#41; H&#38;E staining&#58; poorly differentiated adenocarcinoma&#46;</p>"
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intermittent abdominal pain and asthenia&#46; No fever associated and no history of cancer or smoking habits&#46; Her medical history included hypertension&#44; dyslipidemia&#44; renal lithiasis and total hysterectomy&#46; She had been followed up in stomatology in the previous month&#44; for the recent appearance of an exophytic lesion in the lower right gingival&#46; On emergency admission&#44; physical examination revealed a palpable&#44; bulky abdominal mass on the left flank and umbilical region&#46; Blood tests revealed anemia &#40;9&#46;1<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#41;&#44; leukocytosis &#40;20&#46;55<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">9</span>&#47;L&#41;&#44; neutrophilia &#40;17&#46;3<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">9</span>&#47;L&#41; and high C reactive protein &#40;27<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41;&#46; Thoracic and abdominal computed tomography scan showed two masses&#44; one in the pulmonary right upper lobe&#44; measuring 90<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>87<span class="elsevierStyleHsp" style=""></span>mm&#44; and the second on the left flank with 103<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>83<span class="elsevierStyleHsp" style=""></span>mm &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A and B&#41;&#46; Abdominal&#44; lung and gingival lesions histopathology revealed poorly differentiated pulmonary adenocarcinoma&#46; Immunohistochemistry was negative for CDX2&#44; cytokeratin20&#44; GATA-3 and reactive for CK7 and TTF-1 &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>C&#8211;E&#41;&#46; These findings support that the metastatic lesions were from a primary lung carcinoma&#46; Unfortunately&#44; the patient died two months after the diagnosis due to an infectious complication&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The case we report is an exceptionally rare presentation of synchronous colonic and gum metastasis of primary lung adenocarcinoma&#46; The exact incidence of lung adenocarcinoma metastases to the colon is unknown because most of them are from squamous and large cell carcinomas&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> Metastasis in the oral mucosa are also very rare&#44; with a poor prognosis&#46; These metastasis may be the initial manifestation of neoplasia in about a quarter of cases&#44; although they are frequently confused with benign lesions of the oral soft tissues&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">This report emphasizes that exophytic gingival lesions of recent appearance&#44; 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Case Report
Lung Cancer: A Frequent Tumor With a Rare Synchronous Metastasis
Ana Castro Barbosaa,1,
Corresponding author
anabarbosa.med@gmail.com

Corresponding author.
, Augusto Silvab,1, Alexandra Pignatellic
a Serviço de Medicina Interna, Centro Hospitalar Universitário Lisboa Norte, Portugal
b Serviço de Reumatologia e Doenças Ósseas e Metabólicas, Centro Hospitalar Universitário Lisboa Norte, Portugal
c Serviço de Anatomia Patológica, Centro Hospitalar Universitário Lisboa Norte, Portugal
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intermittent abdominal pain and asthenia&#46; No fever associated and no history of cancer or smoking habits&#46; Her medical history included hypertension&#44; dyslipidemia&#44; renal lithiasis and total hysterectomy&#46; She had been followed up in stomatology in the previous month&#44; for the recent appearance of an exophytic lesion in the lower right gingival&#46; On emergency admission&#44; physical examination revealed a palpable&#44; bulky abdominal mass on the left flank and umbilical region&#46; Blood tests revealed anemia &#40;9&#46;1<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#41;&#44; leukocytosis &#40;20&#46;55<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">9</span>&#47;L&#41;&#44; neutrophilia &#40;17&#46;3<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">9</span>&#47;L&#41; and high C reactive protein &#40;27<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41;&#46; Thoracic and abdominal computed tomography scan showed two masses&#44; one in the pulmonary right upper lobe&#44; measuring 90<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>87<span class="elsevierStyleHsp" style=""></span>mm&#44; and the second on the left flank with 103<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>83<span class="elsevierStyleHsp" style=""></span>mm &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A and B&#41;&#46; Abdominal&#44; lung and gingival lesions histopathology revealed poorly differentiated pulmonary adenocarcinoma&#46; Immunohistochemistry was negative for CDX2&#44; cytokeratin20&#44; GATA-3 and reactive for CK7 and TTF-1 &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>C&#8211;E&#41;&#46; These findings support that the metastatic lesions were from a primary lung carcinoma&#46; Unfortunately&#44; the patient died two months after the diagnosis due to an infectious complication&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The case we report is an exceptionally rare presentation of synchronous colonic and gum metastasis of primary lung adenocarcinoma&#46; The exact incidence of lung adenocarcinoma metastases to the colon is unknown because most of them are from squamous and large cell carcinomas&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> Metastasis in the oral mucosa are also very rare&#44; with a poor prognosis&#46; These metastasis may be the initial manifestation of neoplasia in about a quarter of cases&#44; although they are frequently confused with benign lesions of the oral soft tissues&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">This report emphasizes that exophytic gingival lesions of recent appearance&#44; 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Article information
ISSN: 03002896
Original language: English
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