Editorial
The Impact of Re-Admissions in COPD
El impacto de los reingresos en la EPOC
Jaber S. Alqahtani
, Swapna Mandal, John R. Hurst
Corresponding author
UCL Respiratory, University College London, London, UK
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Alqahtani, Swapna Mandal, John R. Hurst" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Jaber S." "apellidos" => "Alqahtani" "email" => array:1 [ 0 => "j.hurst@ucl.ac.uk" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Swapna" "apellidos" => "Mandal" ] 2 => array:2 [ "nombre" => "John R." "apellidos" => "Hurst" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "UCL Respiratory, University College London, London, UK" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "El impacto de los reingresos en la EPOC" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The respiratory community is failing people living with chronic obstructive pulmonary disease (COPD) by not addressing the problem of high re-admission rates following hospital treatment for exacerbations of COPD. This failure is not because of inadequate data describing the scale of the problem. In the UK national audit, 43% of 74,645 patients had been re-admitted by 90 days and this figure had increased over time.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">1</span></a> 35% of 15,191 patients in the European COPD Audit were re-admitted by 90 days.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">2</span></a> A US database of 1,055,830 index admissions had a re-admission rate of 19.2% at 30 days,<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">3</span></a> which compares to 24% at 30 days in the UK: remarkably similar re-admission rates are seen across diverse health settings.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Our failure to address re-admissions in COPD is also not due to a lack of evidence explaining their causes, and risk factors. The commonest cause of re-admissions are respiratory-related, COPD and pneumonia for example, accounting for 52% in the US study referred to above.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">3</span></a> A recent systematic review of risk-factors for all-cause readmissions highlighted co-morbidities, previous exacerbations and hospitalisation, and increased length of stay as significant risk factors for all-cause readmission. In particular, heart failure, renal failure, depression and alcohol use were all associated with an increased risk of 30-day re-admission.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">4</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The significant impact of re-admissions on patients is clear. In a systematic review of how people living with COPD value COPD outcomes, exacerbations and hospitalisations due to exacerbation were the outcomes rated most important.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">5</span></a> Moreover, patients with COPD and frequent hospital admissions are at significant risk of increased mortality with a survival rate of only 20% at five years.<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">6</span></a> Our failure to address re-admissions in COPD occurs despite evidence that exacerbations, particularly hospitalised exacerbations cause much of the health-care burden and costs associated with COPD: the cost of a severe (hospitalised) exacerbation being eight times the cost of a community treated event.<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">7</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Thus, hospitalised COPD exacerbations are important to payers and patients, there is abundant evidence from diverse health care systems highlights the scale of the problem, and the causes and risk-factors appear well understood. What has gone wrong? It must be time to think again about this problem.</p><p id="par0025" class="elsevierStylePara elsevierViewall">First, understanding risk-factors for, and causes of re-admission following hospital treatment for an exacerbation of COPD is not the same as having evidence-based interventions to mitigate this risk. The likely candidates of supported self-management and ‘Discharge Bundles’ have had disappointing results in clinical trials,<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">8</span></a> likely because they are complex interventions requiring input from several individuals thus making it difficult to implement them effectively. Although only applicable to a minority of the sickest patients with hypercapnoea, domiciliary NIV is an example of an intervention where there is high quality trial evidence of benefit in reducing the risk of re-admission (and death).<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">9</span></a> Evidence is emerging on the benefits of post-exacerbation pulmonary rehabilitation (PR),<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">10</span></a> but access to PR in general is limited<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">1</span></a> and implementation of post-exacerbation PR would require significant additional resource.</p><p id="par0030" class="elsevierStylePara elsevierViewall">There is clearly need for more work to understand the mechanisms of re-admissions and exacerbation recurrence, and find better ways to prevent exacerbations. These concepts were both identified as top-ten research priorities in a shared patient-clinician research prioritisation exercise for exacerbations of COPD.<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">11</span></a> In the meantime, practical advice for front-line clinicians must be to identify and optimise common co-morbidities, and deploy evidence-based interventions to reduce COPD exacerbations. Importantly, for pharmacotherapy, this includes not just using the right drugs but selecting the optimal device: patients with severe COPD, and those recovering from severe exacerbations may not generate sufficient inspiratory flow to activate dry-powder inhalers, and critical inhaler errors are associated with increased risk of hospital care for COPD.<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">12</span></a> A reduction in admissions for COPD exacerbations in association with COVID-19 restrictions has highlighted the potential value of respiratory viral infection control measures to reduce exacerbations,<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">13</span></a> but these have yet to be recommended in guidelines.</p><p id="par0035" class="elsevierStylePara elsevierViewall">An important question is to what extent re-admission reflect a failure of care. Financial penalties to reduce reimbursement for re-admissions assume this to be the case. However, there is evidence that people with COPD are at highest risk for a recurrent exacerbation in the period immediately following a first exacerbation, even when that first event has completely recovered.<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">14</span></a> It may be time to add a paradigm of ‘high risk time-periods’ when considering exacerbation risk, to the familiar strategy of identifying high-risk patients.<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">15</span></a> Financial incentives might better focus on care quality, as has been implemented with the UK national COPD audit.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">1</span></a> Discharge from hospital care back to the community represents a vulnerable time for our sickest patients and it is incumbent on us all to ask if the communication and care we provide and receive at this time is optimal. Early re-admissions, therefore, may be different from late re-admissions, and may require different strategies to mitigate them. We are not alone in facing these challenges: 30 day re-admissions for heart failure are similar to those for COPD, and there is a similar strategy to better implement effective therapies.<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">16</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">To conclude, COPD re-admissions are a challenging problem. We don’t yet have all the answers to provide a solution. The minimum we can currently achieve is to optimise COPD care and co-morbidity prior to discharge, and ensure effective transfer of care across hospital-based and community teams. Ultimately, we need further prospective research in this area, to identify novel and simple interventions that are effective and implementable at scale. Only by doing this can we reduce the burden of COPD re-admissions. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 6 | 1 | 7 |
| 2024 October | 51 | 24 | 75 |
| 2024 September | 60 | 14 | 74 |
| 2024 August | 65 | 39 | 104 |
| 2024 July | 55 | 11 | 66 |
| 2024 June | 70 | 38 | 108 |
| 2024 May | 72 | 28 | 100 |
| 2024 April | 51 | 18 | 69 |
| 2024 March | 73 | 16 | 89 |
| 2024 February | 68 | 29 | 97 |
| 2024 January | 61 | 27 | 88 |
| 2023 December | 69 | 20 | 89 |
| 2023 November | 97 | 27 | 124 |
| 2023 October | 67 | 30 | 97 |
| 2023 September | 73 | 40 | 113 |
| 2023 August | 52 | 25 | 77 |
| 2023 July | 55 | 29 | 84 |
| 2023 June | 54 | 9 | 63 |
| 2023 May | 56 | 23 | 79 |
| 2023 April | 74 | 34 | 108 |
| 2023 March | 83 | 29 | 112 |
| 2023 February | 70 | 24 | 94 |
| 2023 January | 56 | 58 | 114 |
| 2022 December | 88 | 54 | 142 |
| 2022 November | 78 | 21 | 99 |
| 2022 October | 103 | 45 | 148 |
| 2022 September | 67 | 43 | 110 |
| 2022 August | 75 | 42 | 117 |
| 2022 July | 79 | 57 | 136 |
| 2022 June | 78 | 52 | 130 |
| 2022 May | 92 | 35 | 127 |
| 2022 April | 104 | 64 | 168 |
| 2022 March | 229 | 91 | 320 |
| 2022 February | 510 | 90 | 600 |
| 2022 January | 1 | 2 | 3 |
| 2021 December | 10 | 2 | 12 |
| 2021 September | 3 | 4 | 7 |
| 2021 August | 2 | 0 | 2 |
| 2021 July | 2 | 2 | 4 |
| 2021 June | 0 | 8 | 8 |
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