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Clinical Image
Endobronchial Papillomatosis of the Central Airways
Papillomatosis endobronquial de las vías aereas centrales
Vicente Espinosaa, Ilaria Bolognab,
Corresponding author
, Maurizio Bernasconia
a Division of Pulmonology, Department of Medicine, Hospital of Bellinzona, Switzerland
b Division of Internal Medicine, Department of Medicine, Hospital of Bellinzona, Switzerland
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We present the case of a 47-year-old male known for COPD who developed an 8-month history of nonproductive cough and dyspnea&#46; CT scan showed a mass on the distal trachea and left main bronchus projecting into the lumen&#44; thus resulting in a partial atelectasis of the left lower lobe&#46; Bronchoscopy revealed an exophytic lesion arising from the mucosa of the distal trachea and the left main bronchus almost completely occluding the latter&#46; Rigid bronchoscopy was performed for debulking and allowed complete recanalization of the left main bronchus&#46; Pathology and microbiology results were compatible with endoluminal papillomatosis caused by human papilloma virus 11 &#40;HPV11&#41;&#46; At 3 months&#8217; follow up&#44; recurrence was visible&#59; intralesional injection of cidofovir was therefore performed&#44; allowing substantial regression of the lesions at 18 months&#8217; follow up &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">The term recurrent respiratory papillomatosis &#40;RRP&#41; describes the presence of papillomas involving the respiratory epithelium&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">1&#44;2</span></a> Although benign&#44; disease course is often characterized by recurrence of lesions and risk for airway compromise&#46; No curative therapy is available&#59; surgery therefore remains the mainstay for treatment&#46; However&#44; adjunctive pharmacological treatment&#44; in particular with intralesional cidofovir&#44; can decrease the need for repeated surgical intervention and has even demonstrated complete regression of papillomas&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">1</span></a></p></span>"
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                          "autores" => array:5 [
                            0 => "R&#46; Ivanic"
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                      "Revista" => array:4 [
                        "tituloSerie" => "Curr Opin Otolaryngol Head Neck Surg"
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Article information
ISSN: 03002896
Original language: English
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