Scientific Letter
Successful Lobectomy in Preterm With Diffuse Persistent Interstitial Pulmonary Emphysema
Lobectomía realizada con éxito en prematuro con enfisema pulmonar intersticial persistente difuso
Ana Isabel Garrido Ocañaa,
, Marta González Fernández-Palaciosa, José Antonio Matute de Cárdenasb, María Luisa Rosso Gonzáleza, Elena Merchante Garcíac, José Alberto García Bolañosd, María José Moreno Valerae
Corresponding author
a Neonatal Intensive Care Unit, Virgen del Rocio University Hospital, Spain
b Pediatric Airway Surgical Unit, Virgen del Rocio University Hospital, Spain
c Department of Pediatric Radiology, Virgen del Rocio University Hospital, Spain
d Department of Pathology, Virgen del Rocio University Hospital, Spain
e Pediatric Pulmonology Unit, Virgen del Rocio University Hospital, Spain
Read
1713
Timeswas read the article
643
Total PDF
1070
Total HTML
Share statistics
array:23 [ "pii" => "S0300289619305903" "issn" => "03002896" "doi" => "10.1016/j.arbres.2019.10.029" "estado" => "S300" "fechaPublicacion" => "2020-07-01" "aid" => "2340" "copyright" => "SEPAR" "copyrightAnyo" => "2020" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Arch Bronconeumol. 2020;56:461-3" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:18 [ "pii" => "S0300289620300235" "issn" => "03002896" "doi" => "10.1016/j.arbres.2020.01.003" "estado" => "S300" "fechaPublicacion" => "2020-07-01" "aid" => "2393" "copyright" => "SEPAR" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Arch Bronconeumol. 2020;56:463-4" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 6 "formatos" => array:2 [ "HTML" => 2 "PDF" => 4 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>" "titulo" => "Measles-Associated Pneumonia" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "463" "paginaFinal" => "464" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Neumonia asociada al sarampión" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1500 "Ancho" => 1874 "Tamanyo" => 242996 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Photograph showing a confluent maculopapular rash on the trunk. (B and C) Axial and (D) coronal computed tomography images demonstrating multiple peripheral consolidations, mainly in both lungs.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Pablo Rydz Pinheiro Santana, Glenda Fanstone Planard, Gláucia Zanetti, Edson Marchiori" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Pablo Rydz Pinheiro" "apellidos" => "Santana" ] 1 => array:2 [ "nombre" => "Glenda Fanstone" "apellidos" => "Planard" ] 2 => array:2 [ "nombre" => "Gláucia" "apellidos" => "Zanetti" ] 3 => array:2 [ "nombre" => "Edson" "apellidos" => "Marchiori" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289620300235?idApp=UINPBA00003Z" "url" => "/03002896/0000005600000007/v2_202007230732/S0300289620300235/v2_202007230732/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S0300289620300144" "issn" => "03002896" "doi" => "10.1016/j.arbres.2019.12.027" "estado" => "S300" "fechaPublicacion" => "2020-07-01" "aid" => "2384" "copyright" => "SEPAR" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Arch Bronconeumol. 2020;56:460-1" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 7 "formatos" => array:2 [ "HTML" => 5 "PDF" => 2 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Carta Científica</span>" "titulo" => "Diagnóstico mediante EBUS-TBNA de reacción granulomatosa secundaria a Surgicel en adenopatía mediastínica" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "460" "paginaFinal" => "461" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "EBUS-TBNA diagnosis of a granulomatous reaction to Surgicel in mediastinal adenopathy" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1512 "Ancho" => 2500 "Tamanyo" => 317107 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A) TAC de tórax donde se aprecia aumento en estación ganglionar 4R. B) PET/TAC con aumento de metabolismo en adenopatía subcarinal. C) Células gigantes con material birrefringente (×400) correspondiente al primer caso. D) Material amorfo birrefringente con luz polarizada correspondiente al segundo caso.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Jose Manuel Díaz López, Alberto Caballero Vázquez, Javier Luis López Hidalgo, Bélgica Márquez Lobo" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Jose Manuel" "apellidos" => "Díaz López" ] 1 => array:2 [ "nombre" => "Alberto" "apellidos" => "Caballero Vázquez" ] 2 => array:2 [ "nombre" => "Javier Luis" "apellidos" => "López Hidalgo" ] 3 => array:2 [ "nombre" => "Bélgica" "apellidos" => "Márquez Lobo" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1579212920301087" "doi" => "10.1016/j.arbr.2019.12.010" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212920301087?idApp=UINPBA00003Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289620300144?idApp=UINPBA00003Z" "url" => "/03002896/0000005600000007/v2_202007230732/S0300289620300144/v2_202007230732/es/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>" "titulo" => "Successful Lobectomy in Preterm With Diffuse Persistent Interstitial Pulmonary Emphysema" "tieneTextoCompleto" => true "saludo" => "Dear Editor:" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "461" "paginaFinal" => "463" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Ana Isabel Garrido Ocaña, Marta González Fernández-Palacios, José Antonio Matute de Cárdenas, María Luisa Rosso González, Elena Merchante García, José Alberto García Bolaños, María José Moreno Valera" "autores" => array:7 [ 0 => array:4 [ "nombre" => "Ana Isabel" "apellidos" => "Garrido Ocaña" "email" => array:1 [ 0 => "anabel.garrido@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Marta" "apellidos" => "González Fernández-Palacios" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "José Antonio" "apellidos" => "Matute de Cárdenas" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "María Luisa" "apellidos" => "Rosso González" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "Elena" "apellidos" => "Merchante García" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 5 => array:3 [ "nombre" => "José Alberto" "apellidos" => "García Bolaños" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 6 => array:3 [ "nombre" => "María José" "apellidos" => "Moreno Valera" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] ] ] ] "afiliaciones" => array:5 [ 0 => array:3 [ "entidad" => "Neonatal Intensive Care Unit, Virgen del Rocio University Hospital, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Pediatric Airway Surgical Unit, Virgen del Rocio University Hospital, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Department of Pediatric Radiology, Virgen del Rocio University Hospital, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Department of Pathology, Virgen del Rocio University Hospital, Spain" "etiqueta" => "d" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Pediatric Pulmonology Unit, Virgen del Rocio University Hospital, Spain" "etiqueta" => "e" "identificador" => "aff0025" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Lobectomía realizada con éxito en prematuro con enfisema pulmonar intersticial persistente difuso" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2051 "Ancho" => 1500 "Tamanyo" => 315052 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A and B) Coronal (A), axial (B) CT images show areas of regional cystic hyper radiolucent and hyper expansion that involve right upper and lower pulmonary lobes and mediastinal displacement to the left. Note solid linear structure in the air filled cyst (arrow in B). (C) CT 3D volume rendering images before surgery. Hyper radiolucent cystic structures occupy right upper and lower lobes with hyper expansion and herniation of the right lung toward the left. (D) CT 3D volume rendering images after surgery. Right lung volume reduction and persistence of lower lobe cyst structure with minor hyper expansion. (E) Chest radiograph after surgery demonstrates right lung volume and mediastinal shift reduction with persistence of bullae in the right lower lobe. (F) Histologic examination (magnification ×40) of the upper right lobe shows severe evolved emphysema areas with marked alveolar hyper expansion due to air trapping, compressed parenchyma and generalized loss of interstitial connective tissue.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Persistent interstitial pulmonary emphysema (PIPE) is a rare condition with a high degree of mortality and morbidity.<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">1,2</span></a> It is associated with prematurity, distress respiratory syndrome, severe bronchopulmonary dysplasia and prolonged mechanical ventilation. However, it has also been reported in both non ventilated infants and full term infants.<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">3,4</span></a> Emphysema arises from accumulation of air in the pulmonary interstitium which is due to a break in the alveolar wall that leads to air leakage and compression of adjacent structures.<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">4–6</span></a> PIPE has two different forms: diffuse or localized in one pulmonary lobe (the lobes most commonly affected are the left upper and the right middle and lower lobes).<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">1,5</span></a> Diffuse PIPE is most commonly associated with bronchopulmonary dysplasia.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">4</span></a> PIPE is clinically and histologically distinct from congenital lobar emphysema.<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">5,7</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The diagnosis is suspected by clinical signs and chest radiography, and confirmed by chest computed tomography (CT).</p><p id="par0015" class="elsevierStylePara elsevierViewall">Currently, there is not satisfactory treatment for this condition in infants, especially when the formation of bullae has led to mechanical problems in ventilation, pulmonary hypertension and compresses adjacent lobes. In severe emphysema in adults, one of the most promising approaches is lung volume reduction surgery (LVRS), in which lobar emphysema is resected to allow adjacent lung tissue to expand and improve respiratory function. Nevertheless, experiences with children are limited.<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">8</span></a> Surgery could be an option when conservative treatment does not obtain satisfactory results, although indications for LVRS in infants need to be defined.<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">1–3</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">A case of severe PIPE in a patient with bronchopulmonary dysplasia successfully treated with surgery is detailed next.</p><p id="par0025" class="elsevierStylePara elsevierViewall">The female patient was born with a gestational age of 26<span class="elsevierStyleSup">+5</span> weeks with a birth weight of 788<span class="elsevierStyleHsp" style=""></span>g after a controlled pregnancy and a spontaneous vaginal delivery. Partial pulmonary maturation was administered.</p><p id="par0030" class="elsevierStylePara elsevierViewall">She had a 1<span class="elsevierStyleHsp" style=""></span>min Apgar score of 6, being necessary orotracheal intubation due to ineffective respiratory effort.</p><p id="par0035" class="elsevierStylePara elsevierViewall">She developed hyaline membrane disease, receiving a dose of surfactant. She was extubated 6<span class="elsevierStyleHsp" style=""></span>h after birth, being supported with continuous positive airway (CPAP). She needed several reintubations in the context of apneas of prematurity, sepsis and intestinal volvulus needing aggressive ventilation parameters. She <span class="elsevierStyleItalic">met</span> criteria of severe bronchopulmonary dysplasia at 36 weeks corrected gestational age (CPAP, 30% FiO<span class="elsevierStyleInf">2</span>). At the age of 150 days, the patient had an exacerbation of her bronchopulmonary dysplasia with a new reintubation. She presented many recurrent airway obstruction episodes, which were refractory to treatment and caused hemodynamic instability to the patient. These symptoms and the radiological image suggested acquired interstitial emphysema. High resolution CT (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A–C) confirmed PIPE with mainly affected right upper lobe, with severe mediastinal displacement. Bronchoscopy excluded an intrinsic airway obstruction. The patient was clinically unstable and had regular episodes of air trapping with desaturation and hypercapnia of difficult management, so surgical treatment was decided. Thoracotomy and lobectomy of right upper lobe was performed at the age of 160 days. The evolution after the surgery was favorable. She was extubated 5 days later. Afterwards, she remained in spontaneous breathing, with 25% FiO<span class="elsevierStyleInf">2</span>.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">Histology confirmed the diagnosis of severe evolved emphysema (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>F). CT and chest radiography after surgery demonstrated the resolution of mediastinal displacement with persistence of bullae in the right lower lobe (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>D and E).</p><p id="par0045" class="elsevierStylePara elsevierViewall">The patient was discharged at the age of 224 days with minimal oxygen supplementation and proper oral feeding.</p><p id="par0050" class="elsevierStylePara elsevierViewall">PIPE which must be considered in the case of a compatible radiological image in CT in preterm infant with a history of respiratory distress, prolonged need for mechanical ventilation, bronchopulmonary dysplasia and torpid evolution from the respiratory point of view.<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">1,2,5</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">The pathophysiology of this disorder was first described by Macklin and Macklin in 1944. PIPE is due to the disruption of the basement membrane of the alveolar wall, probably secondary to the aspiration of foreign material or partial or total occlusion of bronchi or bronchioles, which allows the entry of air into the interstitial space, conditioning compression of adjacent structures, as well as the appearance of emphysema.<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">1,6</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">PIPE may be diffuse or localized in one lobe. In this case, the patient presented diffuse PIPE, with greater involvement of the right upper lobe.</p><p id="par0065" class="elsevierStylePara elsevierViewall">The diagnosis will be made according to the clinical findings and the suggestive simple chest X-ray. Chest CT is required to confirm the diagnosis, being an excellent indicator of the severity of the disease. CT findings of this condition include multiple thin-walled, air-filled cystic structures (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>C). The line-and-dot pattern has been considered as a specific sign of PIPE.<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">5,9</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">The therapeutic strategy to be followed in the case of PIPE is not clearly defined, especially in diffuse cases, and it will depend on the severity of respiratory symptoms and the stability of the patient.<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">1–3</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">The conservative treatment of diffused cases includes mechanical ventilation in lateral decubitus position and selective bronchial intubation,<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">1,10,11</span></a> high frequency oscillation ventilation, liquid ventilation and extracorporeal membrane oxygenation.<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">12–14</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">In refractory cases there is the possibility of LVRS. Localized lesions are more frequently diagnosed and surgically resected. There are only some exceptional cases described in the literature about diffuse PIPE treated by lobectomy or pneumonectomy with favorable evolution.<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">1,3</span></a> We consider that surgical treatment favoring the re-expansion of the adjacent pulmonary parenchyma must be taken into account in these patients despite all the existing conservative therapeutic measures, since they may fail in this disorder. However, more studies would be needed, in order to establish the precise indications and the most appropriate time for surgery in both, located and diffuse cases and the fully monitoring of the evolution after it.</p><p id="par0085" class="elsevierStylePara elsevierViewall">The patient presented in this article had a respiratory situation at the age of 5 months of difficult management with conservative measures and a vital risk due to the great pulmonary and hemodynamic compromise. The radiological findings were compatible with PIPE, so that performing a lobectomy to reduce the emphysematous area was decided. The pathological findings of the resected piece confirmed the diagnosis.</p><p id="par0090" class="elsevierStylePara elsevierViewall">Thirty months after surgery, the evolution has been satisfactory with home intermittent oxygen therapy.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2051 "Ancho" => 1500 "Tamanyo" => 315052 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A and B) Coronal (A), axial (B) CT images show areas of regional cystic hyper radiolucent and hyper expansion that involve right upper and lower pulmonary lobes and mediastinal displacement to the left. Note solid linear structure in the air filled cyst (arrow in B). (C) CT 3D volume rendering images before surgery. Hyper radiolucent cystic structures occupy right upper and lower lobes with hyper expansion and herniation of the right lung toward the left. (D) CT 3D volume rendering images after surgery. Right lung volume reduction and persistence of lower lobe cyst structure with minor hyper expansion. (E) Chest radiograph after surgery demonstrates right lung volume and mediastinal shift reduction with persistence of bullae in the right lower lobe. (F) Histologic examination (magnification ×40) of the upper right lobe shows severe evolved emphysema areas with marked alveolar hyper expansion due to air trapping, compressed parenchyma and generalized loss of interstitial connective tissue.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:14 [ 0 => array:3 [ "identificador" => "bib0075" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diffuse persistent interstitial pulmonary emphysema treated by lobectomy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R. Matta" 1 => "J. Matta" 2 => "P. Hage" 3 => "Y. Nassif" 4 => "N. Mansour" 5 => "N. Diab" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.athoracsur.2011.04.071" "Revista" => array:6 [ "tituloSerie" => "Ann Thorac Surg" "fecha" => "2011" "volumen" => "92" "paginaInicial" => "e73" "paginaFinal" => "e75" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21958834" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0080" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lung volume reduction surgery in preterm infants with bronchopulmonary dysplasia. A case report" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J. de Laffolie" 1 => "M. Hirschburger" 2 => "J. Bauer" 3 => "L.D. Berthold" 4 => "D. Faas" 5 => "M. Heckmann" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ccr3.35" "Revista" => array:6 [ "tituloSerie" => "Clin Case Rep" "fecha" => "2013" "volumen" => "1" "paginaInicial" => "96" "paginaFinal" => "99" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25356221" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0085" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Persistent interstitial pulmonary emphysema requiring pneumonectomy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "E. Belcher" 1 => "M.A. Abbasi" 2 => "D.M. Hansell" 3 => "L. Ffolkes" 4 => "A.G. Nicholson" 5 => "P. Goldstraw" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jtcvs.2008.06.013" "Revista" => array:6 [ "tituloSerie" => "J Thorac Cardiovasc Surg" "fecha" => "2009" "volumen" => "138" "paginaInicial" => "237" "paginaFinal" => "239" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19577089" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0090" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A case of localized persistent interstitial pulmonary emphysema" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.H. Oh" 1 => "M.Y. Kim" 2 => "W.S. Shim" 3 => "S.S. Oh" 4 => "B.K. Shin" 5 => "S.J. Cho" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3346/jkms.2001.16.2.225" "Revista" => array:6 [ "tituloSerie" => "J Korean Med Sci" "fecha" => "2001" "volumen" => "16" "paginaInicial" => "225" "paginaFinal" => "228" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11306752" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0095" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Spontaneous resolution of diffuse persistent pulmonary interstitial emphysema" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.S. Jassal" 1 => "J.E. Benson" 2 => "P.J. Mogayzel Jr." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ppul.20820" "Revista" => array:6 [ "tituloSerie" => "Pediatr Pulmonol" "fecha" => "2008" "volumen" => "43" "paginaInicial" => "615" "paginaFinal" => "619" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18433048" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0100" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Malignant interstitial emphysema of the lungs and mediastinum as an important occult complication in many respiratory diseases and other conditions: an interpretation of clinical literature in the light of laboratory experiment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.T.M.C. Macklin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Medicine" "fecha" => "1944" "volumen" => "23" "paginaInicial" => "281" "paginaFinal" => "358" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0105" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Surgical salvage of acquired lung lesions in extremely premature infants" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "G.D. Sacks" 1 => "K. Chung" 2 => "K. Jamil" 3 => "M. Garg" 4 => "J.C. Dunn" 5 => "D.A. DeUgarte" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00383-014-3482-1" "Revista" => array:6 [ "tituloSerie" => "Pediatr Surg Int" "fecha" => "2014" "volumen" => "30" "paginaInicial" => "573" "paginaFinal" => "576" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24525614" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0110" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lung volume reduction surgery in bronchopulmonary dysplasia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J. Siaplaouras" 1 => "M. Heckmann" 2 => "I. Reiss" 3 => "T. Schaible" 4 => "K.L. Waag" 5 => "L. Gortner" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Acta Paediatr" "fecha" => "2003" "volumen" => "92" "paginaInicial" => "754" "paginaFinal" => "756" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0115" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Localized radiolucent chest lesions in neonates: causes and differentiation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "L.F. Donnelly" 1 => "D.P. Frush" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2214/ajr.172.6.10350310" "Revista" => array:6 [ "tituloSerie" => "AJR Am J Roentgenol" "fecha" => "1999" "volumen" => "172" "paginaInicial" => "1651" "paginaFinal" => "1658" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10350310" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0120" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Selective unilateral lung ventilation in preterm infants with acquired bullous emphysema: a series of nine cases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Jakob" 1 => "C. Bender" 2 => "M. Henschen" 3 => "U. Saueressig" 4 => "M. Uhl" 5 => "M. Kruger" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ppul.22530" "Revista" => array:6 [ "tituloSerie" => "Pediatr Pulmonol" "fecha" => "2013" "volumen" => "48" "paginaInicial" => "14" "paginaFinal" => "19" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22431428" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0125" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lateral decubitus position as therapy for persistent focal pulmonary interstitial emphysema in neonates: a preliminary report" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R.S. Cohen" 1 => "D.W. Smith" 2 => "D.K. Stevenson" 3 => "P.S. Moskowitz" 4 => "C.B. Graham" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/s0022-3476(84)81113-0" "Revista" => array:6 [ "tituloSerie" => "J Pediatr" "fecha" => "1984" "volumen" => "104" "paginaInicial" => "441" "paginaFinal" => "443" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6707799" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0130" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "High-frequency oscillatory ventilation with low oscillatory frequency in pulmonary interstitial emphysema" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K.A. Squires" 1 => "A.G. De Paoli" 2 => "C. Williams" 3 => "P.A. Dargaville" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000353376" "Revista" => array:6 [ "tituloSerie" => "Neonatology" "fecha" => "2013" "volumen" => "104" "paginaInicial" => "243" "paginaFinal" => "249" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24060678" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0135" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diffuse persistent pulmonary interstitial emphysema secondary to mechanical ventilation in bronchiolitis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B. Toledo Del Castillo" 1 => "I. Gordillo" 2 => "E. Rubio Garcia" 3 => "S.N. Fernandez Lafever" 4 => "R. Gonzalez Cortes" 5 => "J. Urbano Villaescusa" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/s12890-016-0299-9" "Revista" => array:5 [ "tituloSerie" => "BMC Pulm Med" "fecha" => "2016" "volumen" => "16" "paginaInicial" => "139" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27809884" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0140" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Liquid ventilation in an infant with persistent interstitial pulmonary emphysema" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C. Dani" 1 => "M.F. Reali" 2 => "G. Bertini" 3 => "E. Martelli" 4 => "F.F. Rubaltelli" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1515/JPM.2001.022" "Revista" => array:6 [ "tituloSerie" => "J Perinat Med" "fecha" => "2001" "volumen" => "29" "paginaInicial" => "158" "paginaFinal" => "162" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11344676" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/03002896/0000005600000007/v2_202007230732/S0300289619305903/v2_202007230732/en/main.assets" "Apartado" => array:4 [ "identificador" => "49741" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Scientific Letters / Cartas científicas" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/03002896/0000005600000007/v2_202007230732/S0300289619305903/v2_202007230732/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289619305903?idApp=UINPBA00003Z" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 7 | 7 | 14 |
| 2024 October | 57 | 30 | 87 |
| 2024 September | 76 | 18 | 94 |
| 2024 August | 68 | 44 | 112 |
| 2024 July | 57 | 17 | 74 |
| 2024 June | 54 | 32 | 86 |
| 2024 May | 71 | 31 | 102 |
| 2024 April | 29 | 21 | 50 |
| 2024 March | 48 | 23 | 71 |
| 2024 February | 33 | 21 | 54 |
| 2024 January | 1 | 0 | 1 |
| 2023 March | 5 | 5 | 10 |
| 2023 February | 45 | 16 | 61 |
| 2023 January | 31 | 23 | 54 |
| 2022 December | 42 | 26 | 68 |
| 2022 November | 69 | 24 | 93 |
| 2022 October | 47 | 30 | 77 |
| 2022 September | 36 | 22 | 58 |
| 2022 August | 34 | 37 | 71 |
| 2022 July | 34 | 36 | 70 |
| 2022 June | 32 | 36 | 68 |
| 2022 May | 49 | 30 | 79 |
| 2022 April | 41 | 24 | 65 |
| 2022 March | 54 | 38 | 92 |
| 2022 February | 19 | 22 | 41 |
| 2021 April | 3 | 0 | 3 |
| 2021 March | 1 | 0 | 1 |
| 2020 October | 0 | 8 | 8 |
| 2020 September | 1 | 4 | 5 |
| 2020 August | 6 | 3 | 9 |
| 2020 July | 15 | 13 | 28 |
| 2020 May | 1 | 0 | 1 |
| 2020 April | 4 | 2 | 6 |
Show all
