Scientific Letter
Occupational Allergic Respiratory Disease and Eosinophilic Esophagitis by Wheat Flour in a Baker
Enfermedad respiratoria alérgica ocupacional y esofagitis eosinófila por harina de trigo en un panadero
Elisa Gómez Torrijos
, Lucia Moreno Lozano, Rosa Garcia Rodriguez
Corresponding author
Allergy Section, Hospital General Universitario, Ciudad Real, Spain
Read
2286
Timeswas read the article
846
Total PDF
1440
Total HTML
Share statistics
array:23 [ "pii" => "S0300289619300079" "issn" => "03002896" "doi" => "10.1016/j.arbres.2019.01.003" "estado" => "S300" "fechaPublicacion" => "2019-10-01" "aid" => "2063" "copyright" => "SEPAR" "copyrightAnyo" => "2019" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Arch Bronconeumol. 2019;55:541-2" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 61 "formatos" => array:2 [ "HTML" => 40 "PDF" => 21 ] ] "itemSiguiente" => array:18 [ "pii" => "S0300289619300948" "issn" => "03002896" "doi" => "10.1016/j.arbres.2019.02.011" "estado" => "S300" "fechaPublicacion" => "2019-10-01" "aid" => "2107" "copyright" => "SEPAR" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Arch Bronconeumol. 2019;55:542-4" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 37 "formatos" => array:2 [ "HTML" => 19 "PDF" => 18 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>" "titulo" => "Idiopathic Constrictive Pericarditis After Single Lung Transplantation" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "542" "paginaFinal" => "544" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Pericarditis constrictiva idiopática después del trasplante de pulmón unilateral" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Flavio Pola dos Reis, Ellen Caroline Toledo Nascimento, Paulo Manoel Pego-Fernandes, Marcos Naoyuki Samano" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Flavio" "apellidos" => "Pola dos Reis" ] 1 => array:2 [ "nombre" => "Ellen Caroline Toledo" "apellidos" => "Nascimento" ] 2 => array:2 [ "nombre" => "Paulo Manoel" "apellidos" => "Pego-Fernandes" ] 3 => array:2 [ "nombre" => "Marcos Naoyuki" "apellidos" => "Samano" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289619300948?idApp=UINPBA00003Z" "url" => "/03002896/0000005500000010/v1_201910021029/S0300289619300948/v1_201910021029/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S0300289619301188" "issn" => "03002896" "doi" => "10.1016/j.arbres.2019.03.007" "estado" => "S300" "fechaPublicacion" => "2019-10-01" "aid" => "2129" "copyright" => "SEPAR" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Arch Bronconeumol. 2019;55:539-40" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 394 "formatos" => array:2 [ "HTML" => 252 "PDF" => 142 ] ] "es" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Carta Científica</span>" "titulo" => "Necesidad de titular el oxígeno portátil mediante pruebas de marcha de 6 minutos" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "539" "paginaFinal" => "540" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Need for Portable Oxygen Titration During 6-Minute Walk Tests" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Tamara Lourido-Cebreiro, Francisco J. González-Barcala, José Manuel Álvarez-Dobaño, Tara Pereiro-Brea, Romina Abelleira-Paris, Luis Valdés" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Tamara" "apellidos" => "Lourido-Cebreiro" ] 1 => array:2 [ "nombre" => "Francisco J." "apellidos" => "González-Barcala" ] 2 => array:2 [ "nombre" => "José Manuel" "apellidos" => "Álvarez-Dobaño" ] 3 => array:2 [ "nombre" => "Tara" "apellidos" => "Pereiro-Brea" ] 4 => array:2 [ "nombre" => "Romina" "apellidos" => "Abelleira-Paris" ] 5 => array:2 [ "nombre" => "Luis" "apellidos" => "Valdés" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1579212919302472" "doi" => "10.1016/j.arbr.2019.03.010" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212919302472?idApp=UINPBA00003Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289619301188?idApp=UINPBA00003Z" "url" => "/03002896/0000005500000010/v1_201910021029/S0300289619301188/v1_201910021029/es/main.assets" ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>" "titulo" => "Occupational Allergic Respiratory Disease and Eosinophilic Esophagitis by Wheat Flour in a Baker" "tieneTextoCompleto" => true "saludo" => "Dear Editor," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "541" "paginaFinal" => "542" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Elisa Gómez Torrijos, Lucia Moreno Lozano, Rosa Garcia Rodriguez" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Elisa" "apellidos" => "Gómez Torrijos" "email" => array:1 [ 0 => "egomezt.cr@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Lucia" "apellidos" => "Moreno Lozano" ] 2 => array:2 [ "nombre" => "Rosa" "apellidos" => "Garcia Rodriguez" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Allergy Section, Hospital General Universitario, Ciudad Real, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Enfermedad respiratoria alérgica ocupacional y esofagitis eosinófila por harina de trigo en un panadero" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Wheat can cause both immediate and delayed reactions. Immediate, IgE-mediated reactions may be triggered, after eating foods that contain this cereal, or by inhalation of wheat flour (WF), as in baker's asthma (BA).<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1,2</span></a> The delayed reactions are not IgE-mediated, cause digestive symptoms, as it happens in eosinophilic esophagitis (EoE).<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3–6</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We describe a 49-year-old man who worked as a baker for 30 years. He was referred to the allergology clinic by nasoocular itching, watery eyes, sneezing, runny nose, nasal obstruction, dry cough and dyspnea. His symptoms began after handling WF in his workplace, improving during weekends or holidays. He was treated with antihistamines and inhaled budesonide (400<span class="elsevierStyleHsp" style=""></span>μg/day), with good control for 10 years. In the last 5 years he worsened, needing to increase the dose of inhaled corticosteroids and adding salbutamol as rescue medication.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Simultaneously, he began with symptoms of esophageal dysfunction (SED) (dysphagia, chocking and heartburn). He was treated with omeprazole, 40 daily/20 years, with improvement and resolution of his symptoms but was never studied by a gastroenterologist.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Allergy study, skin prick tests (SPT) and specific IgE (sIgE) were negative (mean SPT wheal <3<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>3<span class="elsevierStyleHsp" style=""></span>mm and sIg E <0.35<span class="elsevierStyleHsp" style=""></span>kU/L) to pollens (grass, <span class="elsevierStyleItalic">Olea europaea</span> and <span class="elsevierStyleItalic">Salsola kali</span>), mites (<span class="elsevierStyleItalic">D. pteronyssinus</span>, <span class="elsevierStyleItalic">D. farinae</span> and <span class="elsevierStyleItalic">L. detructor</span>), molds (<span class="elsevierStyleItalic">A. alternata</span>, <span class="elsevierStyleItalic">Cladosporum</span> and <span class="elsevierStyleItalic">Aspergyllus</span>) and animal dander (cat, dog). SPTs were positive with WF commercial extract (ALK-Abelló, Madrid) and in prick by prick test. Total serum IgE: 135<span class="elsevierStyleHsp" style=""></span>kU/L. and specific IgE to WF 2.5<span class="elsevierStyleHsp" style=""></span>kU/L. Specific IgE to gluten, r-ω-5-gliadin, α-amylase and Tri a 14 were all negative (ImmunoCAP, ThermoFisher, Uppsala, Sweden).</p><p id="par0025" class="elsevierStylePara elsevierViewall">The basal spirometry was normal. The methacholine bronchial test with an abbreviated method<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> was positive (PD20: 0.20<span class="elsevierStyleHsp" style=""></span>mg cumulative dose) while he was working, but, after 3 months of sick leave, it was negative. Chest X-ray was normal.</p><p id="par0030" class="elsevierStylePara elsevierViewall">A specific bronchial test was carried out with WF, tipping it from one tray into another for 15<span class="elsevierStyleHsp" style=""></span>min. Spirometries were performed at baseline and at 2, 5, 10, 15, 20, 30, 45 and 60<span class="elsevierStyleHsp" style=""></span>min after the exposure to WF. Peak expiratory flow was measured at baseline and over a period of 24<span class="elsevierStyleHsp" style=""></span>h (respecting sleeping patterns). A 23% fall in FEV1 was observed 15<span class="elsevierStyleHsp" style=""></span>min after exposure to WF. The patient did not have any late reaction. A bronchial control test with saline carried out on the previous day was negative.</p><p id="par0035" class="elsevierStylePara elsevierViewall">A sodium dodecyl sulphate polyacrylamide gel electrophoresis immunoblot analysis with WF extract was performed using the Laemmle method.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> A specific binding was detected between 37 and 70<span class="elsevierStyleHsp" style=""></span>kDa. Glutenins in within the range of these molecular weights.</p><p id="par0040" class="elsevierStylePara elsevierViewall">Endoscopy (E)1: without taking omeprazole, during a working period and ingesting WF. E2: working, ingesting WF and omeprazole; E3: without ingesting neither WF nor omeprazole and without exposure (sick leave); E4: without omeprazole, without exposure but with ingestion of WF; E5: without omeprazole, working, and without ingesting WF. E6: without omeprazole, without exposure and ingesting a gluten-free diet (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). The diagnosis was made according to the updated international consensus diagnostic criteria for EoE: AGREE conference.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> Remission is confirmed <15<span class="elsevierStyleHsp" style=""></span>eos/cga (total and partial remission: <5 and 5–14<span class="elsevierStyleHsp" style=""></span>eos/hpf, respectively).</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">In E1, >15<span class="elsevierStyleHsp" style=""></span>eosinophils/hpf were detected in the esophagus and <3<span class="elsevierStyleHsp" style=""></span>eosinophils/hpf in the stomach and duodenum. <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows the patient's responses to omeprazole, to a wheat-free diet, and to the environmental exposure to WF. The avoidance of WF, both by the digestive and the bronchial route, were capable to solve the EoE.</p><p id="par0050" class="elsevierStylePara elsevierViewall">The patient was diagnosed with occupational allergic respiratory disease (OARD)<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> and occupational EoE<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">5,6</span></a> caused by WF. The evolution of the patient has been very good; after being retired from his job and on a wheat-free diet, he is asymptomatic.</p><p id="par0055" class="elsevierStylePara elsevierViewall">EoE and OARD are frequently found as comorbidities along with other atopic manifestations. These two conditions have similar T helper type 2 responses-driven pathophysiology and share common management strategies<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a>; this case is a clear example of the multiorganic clinical manifestations of atopy.</p><p id="par0060" class="elsevierStylePara elsevierViewall">EoE experts have so far questioned whether this disease could be caused by the inhalation of allergens. The case described suggests that the answer would be affirmative.<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">5,6</span></a> The small number of reported cases caused by aeroallergens could be justified because, until now, some doctors who treat atopic patients have little experience in the diagnosis and management of EoE.</p><p id="par0065" class="elsevierStylePara elsevierViewall">In Spanish bakers, sensitization to grass pollen and to rTria 14 is frequent, however, our patient is only sensitized to WF. The positive methacholine test, confirms that patient has bronchial asthma and the positive specific bronchial challenge test indicates that it is an OARD by WF.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">OARD to wheat proteins is very frequent and its prevalence does not seem to be declining. The researchers on BA point out the strong limitations of its diagnosis and treatment; they think that the isolation and characterization of cereal allergens associated with BA, particularly from WF would allow us to better define major and minor allergens, what would help to provide an adequate diagnostic panel of molecular markers.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">The EoE responded to omeprazole<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> but the patient had to follow a gluten-free cereal exclusion diet and to avoid WF inhalation simultaneously to achieve remission. Neither diet nor being off-work separately were sufficient for the resolution of the EoE.</p><p id="par0080" class="elsevierStylePara elsevierViewall">In patients with SED, it is important to study if they have EoE or gastroesophageal reflux disease or both, because can worsen asthma.</p><p id="par0085" class="elsevierStylePara elsevierViewall">We present an unusual case in which WF triggers EoE and an occupational OARD in the same patient, in which the inhalation of WF triggered the two diseases and EoE is caused by the oral and inhalation routes. When we diagnose an OARD, we should ask the patient for SED, since an early diagnosis and treatment will improve the prognosis and the quality of life of these patients.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Omeprazole \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Exposure to inhaled wheat flour at work \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Wheat flour-intake \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Eos/hpf in the 3 sections of the esophagus \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">>15 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><3 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><5 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">>15 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">>15 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Gluten-free diet-intakeYes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><5 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2141040.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Esophagoscopies and number of eosinophils in esophageal biopsies.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0055" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Wheat allergy: diagnosis and management" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A. Cianferoni" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2147/JAA.S81550" "Revista" => array:7 [ "tituloSerie" => "J Asthma Allergy" "fecha" => "2016" "volumen" => "9" "paginaInicial" => "13" "paginaFinal" => "25" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26889090" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673602093273" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0060" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Wheat allergens associated with Baker's asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G. Salcedo" 1 => "S. Quirce" 2 => "A. Diaz-Perales" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Investig Allergol Clin Immunol" "fecha" => "2011" "volumen" => "21" "paginaInicial" => "81" "paginaFinal" => "92" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21462797" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0735109713060294" "estado" => "S300" "issn" => "07351097" ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0065" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Summary of the updated international consensus diagnostic criteria for eosinophilic esophagitis: AGREE conference" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "participants of AGREE" "etal" => true "autores" => array:6 [ 0 => "J.M. Spergel" 1 => "E.S. Dellon" 2 => "C.A. Liacouras" 3 => "I. Hirano" 4 => "J. Molina-Infante" 5 => "A.J. Bredenoord" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S1081-1206(10)62016-9" "Revista" => array:4 [ "tituloSerie" => "Ann Allergy Asthma Immunol" "fecha" => "2018" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11926628" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0735109712047730" "estado" => "S300" "issn" => "07351097" ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0070" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "An etiological role for aeroallergens and eosinophils in experimental esophagitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Mishra" 1 => "S.P. Hogan" 2 => "E.B. Brandt" 3 => "M.E. Rothenberg" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1172/JCI10224" "Revista" => array:6 [ "tituloSerie" => "J Clin Investig" "fecha" => "2001" "volumen" => "107" "paginaInicial" => "83" "paginaFinal" => "90" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11134183" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0075" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Occupational asthma and eosinophilic esophagitis in a patient with egg-bird syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E. Gomez Torrijos" 1 => "C. García Rodriguez" 2 => "J. Rodriguez" 3 => "F. De la Roca" 4 => "R. Cárdenas" 5 => "F. Alfaya" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Investig Allergol Clin Immunol" "fecha" => "2015" "volumen" => "25" "paginaInicial" => "61" "paginaFinal" => "62" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0080" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Occupational allergic multiorgan disease induced by wheat flour" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "E. Gomez-Torrijos" 1 => "J. Rodriguez-Sanchez" 2 => "A. Diaz-Perales" 3 => "R. Garcia" 4 => "J.F. Feo" 5 => "C. Garcia" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaci.2015.03.047" "Revista" => array:7 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "2015" "volumen" => "136" "paginaInicial" => "1114" "paginaFinal" => "1116" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26025131" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673607617784" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0085" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Methacholine challenge-comparison of an ATS protocol to a new rapid single concentration technique" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J. Schulze" 1 => "M. Rosewich" 2 => "C. Riemer" 3 => "M. Dressler" 4 => "M.A. Rose" 5 => "S. Zielen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.rmed.2009.06.007" "Revista" => array:6 [ "tituloSerie" => "Respir Med" "fecha" => "2009" "volumen" => "103" "paginaInicial" => "1898" "paginaFinal" => "1903" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19596563" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0090" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cleavage of structural protein during the assembly of the head of bacteriophage T4" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "U.K. Laemmli" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/227680a0" "Revista" => array:6 [ "tituloSerie" => "Nature" "fecha" => "1970" "volumen" => "227" "paginaInicial" => "680" "paginaFinal" => "685" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5432063" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0095" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Allergic respiratory disease (ARD), setting forth the basics: proposals of an expert consensus report" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "on behalf of the ARD Study Group" "etal" => false "autores" => array:6 [ 0 => "A.M. Navarro" 1 => "J. Delgado" 2 => "R.M. Muñoz-Cano" 3 => "M.T. Dordal" 4 => "A. Valero" 5 => "S. Quirce" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Transl Allergy" "fecha" => "2017" "volumen" => "18" "paginaInicial" => "7" "paginaFinal" => "16" "itemHostRev" => array:3 [ "pii" => "S002191501200130X" "estado" => "S300" "issn" => "00219150" ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0100" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Is eosinophilic esophagitis a member of the atopic march?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D.A. Hill" 1 => "J.M. Spergel" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.anai.2017.10.003" "Revista" => array:6 [ "tituloSerie" => "Ann Allergy Asthma Immunol" "fecha" => "2018" "volumen" => "120" "paginaInicial" => "113" "paginaFinal" => "114" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29413330" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/03002896/0000005500000010/v1_201910021029/S0300289619300079/v1_201910021029/en/main.assets" "Apartado" => array:4 [ "identificador" => "49741" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Scientific Letters / Cartas científicas" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/03002896/0000005500000010/v1_201910021029/S0300289619300079/v1_201910021029/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289619300079?idApp=UINPBA00003Z" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 3 | 2 | 5 |
| 2024 October | 42 | 20 | 62 |
| 2024 September | 39 | 22 | 61 |
| 2024 August | 57 | 61 | 118 |
| 2024 July | 36 | 28 | 64 |
| 2024 June | 61 | 38 | 99 |
| 2024 May | 93 | 27 | 120 |
| 2024 April | 39 | 19 | 58 |
| 2024 March | 49 | 22 | 71 |
| 2024 February | 46 | 27 | 73 |
| 2023 March | 19 | 5 | 24 |
| 2023 February | 78 | 14 | 92 |
| 2023 January | 41 | 24 | 65 |
| 2022 December | 62 | 33 | 95 |
| 2022 November | 69 | 20 | 89 |
| 2022 October | 75 | 33 | 108 |
| 2022 September | 45 | 22 | 67 |
| 2022 August | 39 | 48 | 87 |
| 2022 July | 65 | 40 | 105 |
| 2022 June | 69 | 38 | 107 |
| 2022 May | 68 | 42 | 110 |
| 2022 April | 63 | 31 | 94 |
| 2022 March | 44 | 39 | 83 |
| 2022 February | 37 | 30 | 67 |
| 2022 January | 43 | 31 | 74 |
| 2021 December | 39 | 33 | 72 |
| 2021 November | 34 | 36 | 70 |
| 2021 October | 40 | 36 | 76 |
| 2020 October | 0 | 2 | 2 |
| 2020 April | 1 | 2 | 3 |
| 2020 March | 1 | 0 | 1 |
| 2020 February | 3 | 0 | 3 |
| 2019 December | 1 | 0 | 1 |
| 2019 November | 1 | 2 | 3 |
| 2019 October | 35 | 17 | 52 |
| 2019 September | 1 | 0 | 1 |
| 2019 June | 1 | 0 | 1 |
| 2019 April | 1 | 2 | 3 |
Show all
