array:24 [
  "pii" => "S030028961730323X"
  "issn" => "03002896"
  "doi" => "10.1016/j.arbres.2017.08.020"
  "estado" => "S300"
  "fechaPublicacion" => "2018-05-01"
  "aid" => "1741"
  "copyright" => "SEPAR"
  "copyrightAnyo" => "2017"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "crp"
  "cita" => "Arch Bronconeumol. 2018;54:286-7"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 1696
    "formatos" => array:3 [
      "EPUB" => 159
      "HTML" => 1157
      "PDF" => 380
    ]
  ]
  "Traduccion" => array:1 [
    "en" => array:19 [
      "pii" => "S157921291830140X"
      "issn" => "15792129"
      "doi" => "10.1016/j.arbr.2017.08.021"
      "estado" => "S300"
      "fechaPublicacion" => "2018-05-01"
      "aid" => "1741"
      "copyright" => "SEPAR"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "crp"
      "cita" => "Arch Bronconeumol. 2018;54:286-7"
      "abierto" => array:3 [
        "ES" => false
        "ES2" => false
        "LATM" => false
      ]
      "gratuito" => false
      "lecturas" => array:2 [
        "total" => 1129
        "formatos" => array:3 [
          "EPUB" => 133
          "HTML" => 720
          "PDF" => 276
        ]
      ]
      "en" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Scientific letter</span>"
        "titulo" => "Leser-Tr&#233;lat Sign Secondary to Thymic Carcinoma"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "286"
            "paginaFinal" => "287"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "es" => array:1 [
            "titulo" => "Signo de Leser-Tr&#233;lat secundario a carcinoma t&#237;mico"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Fig&#46; 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 2189
                "Ancho" => 2500
                "Tamanyo" => 483584
              ]
            ]
            "descripcion" => array:1 [
              "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Photograph showing multiple eruptive seborrheic keratoses in the patient&#39;s trunk&#46; &#40;B&#41; Axial&#44; &#40;C&#41; coronal and &#40;D&#41; sagittal computed tomography images showing a heterogeneous mass in the anterior mediastinum in close contact with aorta&#44; partially compressing the left pulmonary artery&#46; The mass also infiltrate the left paratracheal space&#44; through the aortopulmonary window&#44; determining elevation of the left hemidiaphragm&#44; probably due to a phrenic nerve injury&#46; Left necrotic supraclavicular lymph-node enlargement &#40;arrows&#41; is also visible&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Gustavo Braga Mendes, Gl&#225;ucia Zanetti, Edson Marchiori"
            "autores" => array:3 [
              0 => array:2 [
                "nombre" => "Gustavo Braga"
                "apellidos" => "Mendes"
              ]
              1 => array:2 [
                "nombre" => "Gl&#225;ucia"
                "apellidos" => "Zanetti"
              ]
              2 => array:2 [
                "nombre" => "Edson"
                "apellidos" => "Marchiori"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S030028961730323X"
          "doi" => "10.1016/j.arbres.2017.08.020"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S030028961730323X?idApp=UINPBA00003Z"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157921291830140X?idApp=UINPBA00003Z"
      "url" => "/15792129/0000005400000005/v1_201804290447/S157921291830140X/v1_201804290447/en/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S0300289617303903"
    "issn" => "03002896"
    "doi" => "10.1016/j.arbres.2017.10.001"
    "estado" => "S300"
    "fechaPublicacion" => "2018-05-01"
    "aid" => "1744"
    "copyright" => "SEPAR"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Arch Bronconeumol. 2018;54:288-9"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1281
      "formatos" => array:3 [
        "EPUB" => 149
        "HTML" => 792
        "PDF" => 340
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Scientific letter</span>"
      "titulo" => "Morgagni Hernia as a Reversible Cause of Hypercapnic Respiratory Failure"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "288"
          "paginaFinal" => "289"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Hernia diafragm&#225;tica de Morgagni como causa reversible de insuficiencia respiratoria hiperc&#225;pnica"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 860
              "Ancho" => 2083
              "Tamanyo" => 223099
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Computer tomography scan before and immediately after surgery showing the right lung expansion &#40;at the right&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Patr&#237;cia Dion&#237;sio, Susana Moreira, Rita Pinto Basto, Paula Pinto"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Patr&#237;cia"
              "apellidos" => "Dion&#237;sio"
            ]
            1 => array:2 [
              "nombre" => "Susana"
              "apellidos" => "Moreira"
            ]
            2 => array:2 [
              "nombre" => "Rita"
              "apellidos" => "Pinto Basto"
            ]
            3 => array:2 [
              "nombre" => "Paula"
              "apellidos" => "Pinto"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S1579212918301411"
        "doi" => "10.1016/j.arbr.2017.10.026"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212918301411?idApp=UINPBA00003Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289617303903?idApp=UINPBA00003Z"
    "url" => "/03002896/0000005400000005/v1_201805020858/S0300289617303903/v1_201805020858/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S0300289617303204"
    "issn" => "03002896"
    "doi" => "10.1016/j.arbres.2017.09.013"
    "estado" => "S300"
    "fechaPublicacion" => "2018-05-01"
    "aid" => "1738"
    "copyright" => "SEPAR"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Arch Bronconeumol. 2018;54:285-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2005
      "formatos" => array:3 [
        "EPUB" => 142
        "HTML" => 1355
        "PDF" => 508
      ]
    ]
    "es" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fica</span>"
      "titulo" => "F&#237;stula biliobronquial&#44; una complicaci&#243;n tard&#237;a de la cirug&#237;a hep&#225;tica"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "285"
          "paginaFinal" => "286"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Bronchobiliary Fistula&#44; a Late Complication of Liver Surgery"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figura 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1139
              "Ancho" => 1500
              "Tamanyo" => 221621
            ]
          ]
          "descripcion" => array:1 [
            "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Cortes de reconstrucci&#243;n multiplanar coronal en TC&#44; realizada con contraste intravenoso&#46; &#40;A&#41; Muestra el trayecto fistuloso del &#225;rbol biliar a bronquio de l&#243;bulo inferior derecho&#46; &#40;B&#41; Colecci&#243;n subfr&#233;nica derecha&#46; &#40;C&#41; Colecci&#243;n subhep&#225;tica&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Mario Miranda Garc&#237;a, Al&#237; Martakoush Mar&#237;a, Mar&#237;a Cobos Briz"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Mario"
              "apellidos" => "Miranda Garc&#237;a"
            ]
            1 => array:2 [
              "nombre" => "Al&#237;"
              "apellidos" => "Martakoush Mar&#237;a"
            ]
            2 => array:2 [
              "nombre" => "Mar&#237;a"
              "apellidos" => "Cobos Briz"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S1579212918300764"
        "doi" => "10.1016/j.arbr.2017.09.015"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212918300764?idApp=UINPBA00003Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289617303204?idApp=UINPBA00003Z"
    "url" => "/03002896/0000005400000005/v1_201805020858/S0300289617303204/v1_201805020858/es/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Scientific letter</span>"
    "titulo" => "Leser-Tr&#233;lat Sign Secondary to Thymic Carcinoma"
    "tieneTextoCompleto" => true
    "saludo" => "Dear Editor&#58;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "286"
        "paginaFinal" => "287"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Gustavo Braga Mendes, Gl&#225;ucia Zanetti, Edson Marchiori"
        "autores" => array:3 [
          0 => array:2 [
            "nombre" => "Gustavo Braga"
            "apellidos" => "Mendes"
          ]
          1 => array:2 [
            "nombre" => "Gl&#225;ucia"
            "apellidos" => "Zanetti"
          ]
          2 => array:4 [
            "nombre" => "Edson"
            "apellidos" => "Marchiori"
            "email" => array:1 [
              0 => "edmarchiori&#64;gmail&#46;com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Department of Radiology&#44; Federal University of Rio de Janeiro&#44; Rio de Janeiro&#44; Brazil"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Signo de Leser-Tr&#233;lat secundario a carcinoma t&#237;mico"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 2189
            "Ancho" => 2500
            "Tamanyo" => 483584
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Photograph showing multiple eruptive seborrheic keratoses in the patient&#39;s trunk&#46; &#40;B&#41; Axial&#44; &#40;C&#41; coronal and &#40;D&#41; sagittal computed tomography images showing a heterogeneous mass in the anterior mediastinum in close contact with aorta&#44; partially compressing the left pulmonary artery&#46; The mass also infiltrate the left paratracheal space&#44; through the aortopulmonary window&#44; determining elevation of the left hemidiaphragm&#44; probably due to a phrenic nerve injury&#46; Left necrotic supraclavicular lymph-node enlargement &#40;arrows&#41; is also visible&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 64-year-old woman presented with left hemithorax pain&#44; cough and weight loss of approximately 20<span class="elsevierStyleHsp" style=""></span>kg over a 4-month period&#46; She had a history of smoking &#40;40 packs&#47;year&#41; and chronic hypertension&#46; On physical examination&#44; she was eupneic on room air&#44; with normal pulmonary auscultation&#44; and presented left supraclavicular lymph-node enlargement&#46; Multiple brownish warty plaques with verrucous texture were present on the patient&#39;s skin&#59; they predominated in the anterior trunk &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#44; with onset about 6 months previously&#46; The patient also reported mild signs and symptoms of dysphonia&#44; dysphagia and hoarseness&#46; Blood tests revealed mild anemia&#46; Other laboratory data were unremarkable&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Chest computed tomography showed an irregular mass in the anterior mediastinum&#44; in close contact with the aortic arch&#44; with heterogeneous contrast enhancement&#46; The mass infiltrate the left paratracheal space&#44; through the aortopulmonary window&#46; The left hemidiaphragm was elevated&#44; probably due to a phrenic nerve injury&#46; Lymph node enlargement was observed&#44; predominantly in the left supraclavicular region&#44; with necrotic centers &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>C and D&#41;&#46; A biopsy of the supraclavicular lymph node with immunohistochemical study revealed a poorly differentiated malignant neoplasm compatible with thymic carcinoma&#46; The skin lesions were characterized as seborrheic keratoses&#46; Given these features&#44; a diagnosis of Leser-Tr&#233;lat sign was made&#46; The patient was referred for treatment of thymic carcinoma&#46; Her condition worsened&#44; and she died 2 months later&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Seborrheic keratoses are benign dermatological lesions characterized by proliferation of immature keratinocytes&#44; which develop normally and gradually in some patients&#44; especially those in the fifth and sixth decades of life&#46; They present in well-defined&#44; rounded or ovoid shapes and they are hyperpigmented&#44; brownish or blackish with raised&#44; verrucous and wrinkled surfaces&#46; Preferred locations are the trunk&#44; extremities&#44; face and neck&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Leser-Tr&#233;lat sign refers to the sudden onset and rapid growth in number and size of multiple lesions of seborrheic keratoses&#44; sometimes associated with pruritus&#44; which precede&#44; succeed or occur concomitantly with a neoplasm&#44; whether hidden or known&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">2&#44;3</span></a> About 20&#37; of patients present associated acanthosis nigricans&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> Classically&#44; the sign is related to adenocarcinomas&#44; especially those of the gastrointestinal tract and breast&#44; but also those of the lung&#44; kidney&#44; liver&#44; pancreas&#44; ovary&#44; uterus and prostate&#44; as well as lymphoproliferative diseases&#44; among others&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">2&#8211;4</span></a> The pathophysiological mechanism is not completely understood&#44; but the sign is believed to be caused by cytokine stimuli&#44; growth or humoral factors produced by or in response to the tumor&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> Some authors have also reported associations with benign conditions&#44; such as pregnancy and some benign tumors&#46; Histopathological findings are similar to those of usual seborrheic keratosis&#46; No specific treatment is available for the lesions&#44;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> but regression occurs with treatment of the underlying disease in some cases&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">In conclusion&#44; the sudden onset and rapid growth of eruptive seborrheic keratoses &#40;Leser-Tr&#233;lat sign&#41; may lead to the early diagnosis of an occult cancer&#46; These lesions may coincide with the diagnosis of cancer&#44; or follow or precede it by months or years&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "multimedia" => array:1 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 2189
            "Ancho" => 2500
            "Tamanyo" => 483584
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Photograph showing multiple eruptive seborrheic keratoses in the patient&#39;s trunk&#46; &#40;B&#41; Axial&#44; &#40;C&#41; coronal and &#40;D&#41; sagittal computed tomography images showing a heterogeneous mass in the anterior mediastinum in close contact with aorta&#44; partially compressing the left pulmonary artery&#46; The mass also infiltrate the left paratracheal space&#44; through the aortopulmonary window&#44; determining elevation of the left hemidiaphragm&#44; probably due to a phrenic nerve injury&#46; Left necrotic supraclavicular lymph-node enlargement &#40;arrows&#41; is also visible&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:5 [
            0 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Seborrheic keratosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46; Hafner"
                            1 => "T&#46; Vogt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1610-0387.2008.06788.x"
                      "Revista" => array:5 [
                        "tituloSerie" => "J Dtsch Dermatol Ges"
                        "fecha" => "2008"
                        "volumen" => "6"
                        "paginaInicial" => "664"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18801147"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sign of Leser-Tr&#233;lat"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46;A&#46; Schwartz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0190-9622(96)90502-2"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "1996"
                        "volumen" => "35"
                        "paginaInicial" => "88"
                        "paginaFinal" => "95"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8682971"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Paraneoplastic dermatoses"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Boyce"
                            1 => "J&#46; Harper"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatol Clin"
                        "fecha" => "2002"
                        "volumen" => "20"
                        "paginaInicial" => "523"
                        "paginaFinal" => "532"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12170885"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous manifestations of internal malignancies&#58; an overview"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46;A&#46; Pipkin"
                            1 => "P&#46;A&#46; Lio"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.det.2007.08.002"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatol Clin"
                        "fecha" => "2008"
                        "volumen" => "26"
                        "paginaInicial" => "1"
                        "paginaFinal" => "15"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18023767"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Paraneoplastic cutaneous manifestations&#58; concepts and updates"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;A&#46; Silva"
                            1 => "K&#46;de C&#46; Mesquita"
                            2 => "A&#46;C&#46; Igreja"
                            3 => "I&#46;C&#46; Lucas"
                            4 => "A&#46;F&#46; Freitas"
                            5 => "S&#46;M&#46; Oliveira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "An Bras Dermatol"
                        "fecha" => "2013"
                        "volumen" => "88"
                        "paginaInicial" => "09"
                        "paginaFinal" => "22"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/03002896/0000005400000005/v1_201805020858/S030028961730323X/v1_201805020858/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "49741"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Scientific Letters / Cartas cient&#237;ficas"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/03002896/0000005400000005/v1_201805020858/S030028961730323X/v1_201805020858/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S030028961730323X?idApp=UINPBA00003Z"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Scientific letter
Leser-Trélat Sign Secondary to Thymic Carcinoma
Signo de Leser-Trélat secundario a carcinoma tímico
Gustavo Braga Mendes, Gláucia Zanetti, Edson Marchiori
Corresponding author
edmarchiori@gmail.com

Corresponding author.
Department of Radiology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
Read
7253
Times
was read the article
1989
Total PDF
5264
Total HTML
Share statistics
 array:24 [
  "pii" => "S030028961730323X"
  "issn" => "03002896"
  "doi" => "10.1016/j.arbres.2017.08.020"
  "estado" => "S300"
  "fechaPublicacion" => "2018-05-01"
  "aid" => "1741"
  "copyright" => "SEPAR"
  "copyrightAnyo" => "2017"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "crp"
  "cita" => "Arch Bronconeumol. 2018;54:286-7"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 1696
    "formatos" => array:3 [
      "EPUB" => 159
      "HTML" => 1157
      "PDF" => 380
    ]
  ]
  "Traduccion" => array:1 [
    "en" => array:19 [
      "pii" => "S157921291830140X"
      "issn" => "15792129"
      "doi" => "10.1016/j.arbr.2017.08.021"
      "estado" => "S300"
      "fechaPublicacion" => "2018-05-01"
      "aid" => "1741"
      "copyright" => "SEPAR"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "crp"
      "cita" => "Arch Bronconeumol. 2018;54:286-7"
      "abierto" => array:3 [
        "ES" => false
        "ES2" => false
        "LATM" => false
      ]
      "gratuito" => false
      "lecturas" => array:2 [
        "total" => 1129
        "formatos" => array:3 [
          "EPUB" => 133
          "HTML" => 720
          "PDF" => 276
        ]
      ]
      "en" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Scientific letter</span>"
        "titulo" => "Leser-Tr&#233;lat Sign Secondary to Thymic Carcinoma"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "286"
            "paginaFinal" => "287"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "es" => array:1 [
            "titulo" => "Signo de Leser-Tr&#233;lat secundario a carcinoma t&#237;mico"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Fig&#46; 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 2189
                "Ancho" => 2500
                "Tamanyo" => 483584
              ]
            ]
            "descripcion" => array:1 [
              "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Photograph showing multiple eruptive seborrheic keratoses in the patient&#39;s trunk&#46; &#40;B&#41; Axial&#44; &#40;C&#41; coronal and &#40;D&#41; sagittal computed tomography images showing a heterogeneous mass in the anterior mediastinum in close contact with aorta&#44; partially compressing the left pulmonary artery&#46; The mass also infiltrate the left paratracheal space&#44; through the aortopulmonary window&#44; determining elevation of the left hemidiaphragm&#44; probably due to a phrenic nerve injury&#46; Left necrotic supraclavicular lymph-node enlargement &#40;arrows&#41; is also visible&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Gustavo Braga Mendes, Gl&#225;ucia Zanetti, Edson Marchiori"
            "autores" => array:3 [
              0 => array:2 [
                "nombre" => "Gustavo Braga"
                "apellidos" => "Mendes"
              ]
              1 => array:2 [
                "nombre" => "Gl&#225;ucia"
                "apellidos" => "Zanetti"
              ]
              2 => array:2 [
                "nombre" => "Edson"
                "apellidos" => "Marchiori"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S030028961730323X"
          "doi" => "10.1016/j.arbres.2017.08.020"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S030028961730323X?idApp=UINPBA00003Z"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157921291830140X?idApp=UINPBA00003Z"
      "url" => "/15792129/0000005400000005/v1_201804290447/S157921291830140X/v1_201804290447/en/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S0300289617303903"
    "issn" => "03002896"
    "doi" => "10.1016/j.arbres.2017.10.001"
    "estado" => "S300"
    "fechaPublicacion" => "2018-05-01"
    "aid" => "1744"
    "copyright" => "SEPAR"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Arch Bronconeumol. 2018;54:288-9"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1281
      "formatos" => array:3 [
        "EPUB" => 149
        "HTML" => 792
        "PDF" => 340
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Scientific letter</span>"
      "titulo" => "Morgagni Hernia as a Reversible Cause of Hypercapnic Respiratory Failure"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "288"
          "paginaFinal" => "289"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Hernia diafragm&#225;tica de Morgagni como causa reversible de insuficiencia respiratoria hiperc&#225;pnica"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 860
              "Ancho" => 2083
              "Tamanyo" => 223099
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Computer tomography scan before and immediately after surgery showing the right lung expansion &#40;at the right&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Patr&#237;cia Dion&#237;sio, Susana Moreira, Rita Pinto Basto, Paula Pinto"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Patr&#237;cia"
              "apellidos" => "Dion&#237;sio"
            ]
            1 => array:2 [
              "nombre" => "Susana"
              "apellidos" => "Moreira"
            ]
            2 => array:2 [
              "nombre" => "Rita"
              "apellidos" => "Pinto Basto"
            ]
            3 => array:2 [
              "nombre" => "Paula"
              "apellidos" => "Pinto"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S1579212918301411"
        "doi" => "10.1016/j.arbr.2017.10.026"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212918301411?idApp=UINPBA00003Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289617303903?idApp=UINPBA00003Z"
    "url" => "/03002896/0000005400000005/v1_201805020858/S0300289617303903/v1_201805020858/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S0300289617303204"
    "issn" => "03002896"
    "doi" => "10.1016/j.arbres.2017.09.013"
    "estado" => "S300"
    "fechaPublicacion" => "2018-05-01"
    "aid" => "1738"
    "copyright" => "SEPAR"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Arch Bronconeumol. 2018;54:285-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2005
      "formatos" => array:3 [
        "EPUB" => 142
        "HTML" => 1355
        "PDF" => 508
      ]
    ]
    "es" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fica</span>"
      "titulo" => "F&#237;stula biliobronquial&#44; una complicaci&#243;n tard&#237;a de la cirug&#237;a hep&#225;tica"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "285"
          "paginaFinal" => "286"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Bronchobiliary Fistula&#44; a Late Complication of Liver Surgery"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figura 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1139
              "Ancho" => 1500
              "Tamanyo" => 221621
            ]
          ]
          "descripcion" => array:1 [
            "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Cortes de reconstrucci&#243;n multiplanar coronal en TC&#44; realizada con contraste intravenoso&#46; &#40;A&#41; Muestra el trayecto fistuloso del &#225;rbol biliar a bronquio de l&#243;bulo inferior derecho&#46; &#40;B&#41; Colecci&#243;n subfr&#233;nica derecha&#46; &#40;C&#41; Colecci&#243;n subhep&#225;tica&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Mario Miranda Garc&#237;a, Al&#237; Martakoush Mar&#237;a, Mar&#237;a Cobos Briz"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Mario"
              "apellidos" => "Miranda Garc&#237;a"
            ]
            1 => array:2 [
              "nombre" => "Al&#237;"
              "apellidos" => "Martakoush Mar&#237;a"
            ]
            2 => array:2 [
              "nombre" => "Mar&#237;a"
              "apellidos" => "Cobos Briz"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S1579212918300764"
        "doi" => "10.1016/j.arbr.2017.09.015"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212918300764?idApp=UINPBA00003Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289617303204?idApp=UINPBA00003Z"
    "url" => "/03002896/0000005400000005/v1_201805020858/S0300289617303204/v1_201805020858/es/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Scientific letter</span>"
    "titulo" => "Leser-Tr&#233;lat Sign Secondary to Thymic Carcinoma"
    "tieneTextoCompleto" => true
    "saludo" => "Dear Editor&#58;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "286"
        "paginaFinal" => "287"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Gustavo Braga Mendes, Gl&#225;ucia Zanetti, Edson Marchiori"
        "autores" => array:3 [
          0 => array:2 [
            "nombre" => "Gustavo Braga"
            "apellidos" => "Mendes"
          ]
          1 => array:2 [
            "nombre" => "Gl&#225;ucia"
            "apellidos" => "Zanetti"
          ]
          2 => array:4 [
            "nombre" => "Edson"
            "apellidos" => "Marchiori"
            "email" => array:1 [
              0 => "edmarchiori&#64;gmail&#46;com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Department of Radiology&#44; Federal University of Rio de Janeiro&#44; Rio de Janeiro&#44; Brazil"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Signo de Leser-Tr&#233;lat secundario a carcinoma t&#237;mico"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 2189
            "Ancho" => 2500
            "Tamanyo" => 483584
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Photograph showing multiple eruptive seborrheic keratoses in the patient&#39;s trunk&#46; &#40;B&#41; Axial&#44; &#40;C&#41; coronal and &#40;D&#41; sagittal computed tomography images showing a heterogeneous mass in the anterior mediastinum in close contact with aorta&#44; partially compressing the left pulmonary artery&#46; The mass also infiltrate the left paratracheal space&#44; through the aortopulmonary window&#44; determining elevation of the left hemidiaphragm&#44; probably due to a phrenic nerve injury&#46; Left necrotic supraclavicular lymph-node enlargement &#40;arrows&#41; is also visible&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 64-year-old woman presented with left hemithorax pain&#44; cough and weight loss of approximately 20<span class="elsevierStyleHsp" style=""></span>kg over a 4-month period&#46; She had a history of smoking &#40;40 packs&#47;year&#41; and chronic hypertension&#46; On physical examination&#44; she was eupneic on room air&#44; with normal pulmonary auscultation&#44; and presented left supraclavicular lymph-node enlargement&#46; Multiple brownish warty plaques with verrucous texture were present on the patient&#39;s skin&#59; they predominated in the anterior trunk &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#44; with onset about 6 months previously&#46; The patient also reported mild signs and symptoms of dysphonia&#44; dysphagia and hoarseness&#46; Blood tests revealed mild anemia&#46; Other laboratory data were unremarkable&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Chest computed tomography showed an irregular mass in the anterior mediastinum&#44; in close contact with the aortic arch&#44; with heterogeneous contrast enhancement&#46; The mass infiltrate the left paratracheal space&#44; through the aortopulmonary window&#46; The left hemidiaphragm was elevated&#44; probably due to a phrenic nerve injury&#46; Lymph node enlargement was observed&#44; predominantly in the left supraclavicular region&#44; with necrotic centers &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>C and D&#41;&#46; A biopsy of the supraclavicular lymph node with immunohistochemical study revealed a poorly differentiated malignant neoplasm compatible with thymic carcinoma&#46; The skin lesions were characterized as seborrheic keratoses&#46; Given these features&#44; a diagnosis of Leser-Tr&#233;lat sign was made&#46; The patient was referred for treatment of thymic carcinoma&#46; Her condition worsened&#44; and she died 2 months later&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Seborrheic keratoses are benign dermatological lesions characterized by proliferation of immature keratinocytes&#44; which develop normally and gradually in some patients&#44; especially those in the fifth and sixth decades of life&#46; They present in well-defined&#44; rounded or ovoid shapes and they are hyperpigmented&#44; brownish or blackish with raised&#44; verrucous and wrinkled surfaces&#46; Preferred locations are the trunk&#44; extremities&#44; face and neck&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Leser-Tr&#233;lat sign refers to the sudden onset and rapid growth in number and size of multiple lesions of seborrheic keratoses&#44; sometimes associated with pruritus&#44; which precede&#44; succeed or occur concomitantly with a neoplasm&#44; whether hidden or known&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">2&#44;3</span></a> About 20&#37; of patients present associated acanthosis nigricans&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> Classically&#44; the sign is related to adenocarcinomas&#44; especially those of the gastrointestinal tract and breast&#44; but also those of the lung&#44; kidney&#44; liver&#44; pancreas&#44; ovary&#44; uterus and prostate&#44; as well as lymphoproliferative diseases&#44; among others&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">2&#8211;4</span></a> The pathophysiological mechanism is not completely understood&#44; but the sign is believed to be caused by cytokine stimuli&#44; growth or humoral factors produced by or in response to the tumor&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> Some authors have also reported associations with benign conditions&#44; such as pregnancy and some benign tumors&#46; Histopathological findings are similar to those of usual seborrheic keratosis&#46; No specific treatment is available for the lesions&#44;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> but regression occurs with treatment of the underlying disease in some cases&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">In conclusion&#44; the sudden onset and rapid growth of eruptive seborrheic keratoses &#40;Leser-Tr&#233;lat sign&#41; may lead to the early diagnosis of an occult cancer&#46; These lesions may coincide with the diagnosis of cancer&#44; or follow or precede it by months or years&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "multimedia" => array:1 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 2189
            "Ancho" => 2500
            "Tamanyo" => 483584
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Photograph showing multiple eruptive seborrheic keratoses in the patient&#39;s trunk&#46; &#40;B&#41; Axial&#44; &#40;C&#41; coronal and &#40;D&#41; sagittal computed tomography images showing a heterogeneous mass in the anterior mediastinum in close contact with aorta&#44; partially compressing the left pulmonary artery&#46; The mass also infiltrate the left paratracheal space&#44; through the aortopulmonary window&#44; determining elevation of the left hemidiaphragm&#44; probably due to a phrenic nerve injury&#46; Left necrotic supraclavicular lymph-node enlargement &#40;arrows&#41; is also visible&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:5 [
            0 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Seborrheic keratosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46; Hafner"
                            1 => "T&#46; Vogt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1610-0387.2008.06788.x"
                      "Revista" => array:5 [
                        "tituloSerie" => "J Dtsch Dermatol Ges"
                        "fecha" => "2008"
                        "volumen" => "6"
                        "paginaInicial" => "664"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18801147"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sign of Leser-Tr&#233;lat"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46;A&#46; Schwartz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0190-9622(96)90502-2"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "1996"
                        "volumen" => "35"
                        "paginaInicial" => "88"
                        "paginaFinal" => "95"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8682971"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Paraneoplastic dermatoses"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Boyce"
                            1 => "J&#46; Harper"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatol Clin"
                        "fecha" => "2002"
                        "volumen" => "20"
                        "paginaInicial" => "523"
                        "paginaFinal" => "532"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12170885"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous manifestations of internal malignancies&#58; an overview"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46;A&#46; Pipkin"
                            1 => "P&#46;A&#46; Lio"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.det.2007.08.002"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatol Clin"
                        "fecha" => "2008"
                        "volumen" => "26"
                        "paginaInicial" => "1"
                        "paginaFinal" => "15"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18023767"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Paraneoplastic cutaneous manifestations&#58; concepts and updates"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;A&#46; Silva"
                            1 => "K&#46;de C&#46; Mesquita"
                            2 => "A&#46;C&#46; Igreja"
                            3 => "I&#46;C&#46; Lucas"
                            4 => "A&#46;F&#46; Freitas"
                            5 => "S&#46;M&#46; Oliveira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "An Bras Dermatol"
                        "fecha" => "2013"
                        "volumen" => "88"
                        "paginaInicial" => "09"
                        "paginaFinal" => "22"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/03002896/0000005400000005/v1_201805020858/S030028961730323X/v1_201805020858/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "49741"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Scientific Letters / Cartas cient&#237;ficas"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/03002896/0000005400000005/v1_201805020858/S030028961730323X/v1_201805020858/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S030028961730323X?idApp=UINPBA00003Z"
]
Article information
ISSN: 03002896
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 5 7 12
2024 October 46 21 67
2024 September 46 29 75
2024 August 76 40 116
2024 July 54 22 76
2024 June 70 27 97
2024 May 83 29 112
2024 April 62 34 96
2024 March 52 25 77
2024 February 59 21 80
2023 March 21 4 25
2023 February 93 22 115
2023 January 64 33 97
2022 December 102 23 125
2022 November 101 38 139
2022 October 90 56 146
2022 September 60 31 91
2022 August 91 49 140
2022 July 79 45 124
2022 June 77 43 120
2022 May 86 50 136
2022 April 97 46 143
2022 March 91 44 135
2022 February 61 27 88
2022 January 145 48 193
2021 December 80 48 128
2021 November 99 48 147
2021 October 83 57 140
2021 September 84 46 130
2021 August 69 39 108
2021 July 72 32 104
2021 June 102 41 143
2021 May 115 45 160
2021 April 205 127 332
2021 March 200 31 231
2021 February 157 21 178
2021 January 363 21 384
2020 December 116 31 147
2020 November 91 33 124
2020 October 82 33 115
2020 September 52 14 66
2020 August 67 22 89
2020 July 60 37 97
2020 June 53 22 75
2020 May 100 24 124
2020 March 24 15 39
2020 February 54 21 75
2020 January 63 25 88
2019 December 53 10 63
2019 November 68 22 90
2019 October 38 12 50
2019 September 80 18 98
2019 August 46 19 65
2019 July 69 32 101
2019 June 62 18 80
2019 May 72 21 93
2019 April 89 33 122
2019 March 109 33 142
2019 February 67 27 94
2019 January 85 27 112
2018 December 102 27 129
2018 November 104 31 135
2018 October 9 4 13
2018 September 2 0 2
2018 May 7 8 15
Show all

Follow this link to access the full text of the article

Archivos de Bronconeumología

Are you a health professional able to prescribe or dispense drugs?